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1. 发明申请

WO2008040753A1 INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 审中-公开
标题翻译：有用的盐酸衍生物作为钾通道调节剂
公开(公告)号：WO2008040753A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060493
申请日：2007-10-03
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
IPC分类号： C07D403/04 , A61K31/4439 , C07D401/04 , A61K31/506 , A61P9/00
CPC分类号： C07D403/04 , C07D401/04
摘要： This invention relates to novel indazolyl derivatives of formula (Ia) and (Ib) useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium- channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart, disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea,narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle' dystrophia, spasticity, xerostomi, diabetes type II, hypehnsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.
摘要翻译：本发明涉及用作钾通道调节剂的式（Ia）和（Ib）的新的吲唑基衍生物及其在制备药物组合物中的用途。此外，本发明涉及可用于治疗或缓解与钾通道活动相关的疾病或病症的药物组合物，特别是呼吸系统疾病，癫痫，抽搐，癫痫发作，不发作，痉挛，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊性肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，勃起功能障碍，胃肠功能障碍，分泌性腹泻，局部缺血，脑缺血，缺血性心脏病，心绞痛，冠心病，孤独症，共济失调，创伤性脑损伤，帕金森氏病阿尔茨海默氏病，肌萎缩性侧索硬化症（ALS），痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，心律失常，心律失常，心律失常，精神病，精神分裂症，焦虑症，抑郁症，躁狂症，高血压，肌强直性肌营养不良，痉挛状态，口干燥，II型糖尿病，早产，秃顶，癌症，肠易激综合征，免疫抑制，偏头痛和疼痛。

2. 发明申请

WO2008116911A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2008116911A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/053651
申请日：2008-03-27
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D473/04 , A61K31/52 , A61P9/00 , A61P11/00
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

3. 发明申请

WO2008116910A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译： PURINY衍生物及其作为钾通道调节剂的应用
公开(公告)号：WO2008116910A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/053649
申请日：2008-03-27
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D473/16 , A61K31/52 , A61P9/00 , A61P11/00
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的嘌呤基衍生物及其作为钾通道调节剂的用途。此外，本发明涉及用于治疗或缓解与钾通道活性有关的疾病或病症的药物组合物。

4. 发明申请

WO2008028935A2 PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 审中-公开
标题翻译：适用于钾通道调节剂的吡啶基吡啶衍生物
公开(公告)号：WO2008028935A2
公开(公告)日：2008-03-13
申请号：PCT/EP2007/059313
申请日：2007-09-06
申请人： NeuroSearch A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , CHRISTOPHERSEN, Palle , JOHANSEN, Tina, Holm
IPC分类号： C07D401/04 , A61K31/506 , A61P11/00
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 嘧啶衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

5. 发明申请

WO2008116909A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2008116909A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/053648
申请日：2008-03-27
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D473/16 , C07D473/24 , A61K31/52 , A61P9/00 , A61P11/00
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

6. 发明申请

WO2008092942A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：吡啶并吡唑衍生物及其作为钾通道调节剂的用途
公开(公告)号：WO2008092942A2
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051233
申请日：2008-02-01
申请人： NeuroSearch A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , HOUGAARD, Charlotte , TEUBER, Lene , PETERS, Dan , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D401/04 , C07D405/14 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 吡唑衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

7. 发明申请

WO2007071632A2 PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：吡啶并喹啉衍生物及其医学用途
公开(公告)号：WO2007071632A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069795
申请日：2006-12-18
申请人： NEUROSEARCH A/S , ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , HOUGAARD, Charlotte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： ERIKSEN, Birgitte, L. , SØRENSEN, Ulrik, Svane , TEUBER, Lene , PETERS, Dan , HOUGAARD, Charlotte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-quinazoline derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 喹唑啉衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

8. 发明申请

WO2008003667A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2008003667A2
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056624
申请日：2007-07-02
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle , REDROBE, John, Paul
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle , REDROBE, John, Paul
IPC分类号： A61K31/445 , A61K31/495 , A61K45/06 , A61P1/00 , A61P25/00 , A61P25/16 , A61P25/30 , A61P43/00
CPC分类号： A61K45/06 , A61K31/445 , A61K31/495 , A61K2300/00
摘要： This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the invention.
摘要翻译：本发明提供包含治疗有效量的单胺再摄取抑制剂和SK抑制剂的药物组合物。另一方面，本发明提供了用于本发明的新的苯并咪唑衍生物。

9. 发明申请

WO2008003752A1 2 -AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL - CONDUCTANCE CALCIUM -ACT IVATED POTASSIUM CHANNELS 审中-公开
标题翻译： 2-氨基苯并咪唑衍生物及其作为小导管钙激活通道的调节剂
公开(公告)号：WO2008003752A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056826
申请日：2007-07-05
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D235/30 , A61K31/416
CPC分类号： C07D235/30
摘要： This invention relates to 2-amino benzimidazole derivatives of Formula (1a) or (1b): which are useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式ia或ib的2-氨基苯并咪唑衍生物：其可用作小电导钙激活钾通道（SK通道）的调节剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

10. 发明申请

WO2007065913A1 NOVEL QUINAZOLINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译：新型喹唑啉-2,4-二胺衍生物及其作为小肠钙激活钾通道调节剂的用途
公开(公告)号：WO2007065913A1
公开(公告)日：2007-06-14
申请号：PCT/EP2006/069380
申请日：2006-12-06
申请人： NEUROSEARCH A/S , SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
发明人： SØRENSEN, Ulrik, Svane , ERIKSEN, Birgitte, L. , TEUBER, Lene , PETERS, Dan , STRØBÆK, Dorte , JOHANSEN, Tina, Holm , CHRISTOPHERSEN, Palle
IPC分类号： C07D239/95 , C07D401/04
CPC分类号： C07D239/95 , C07D401/04
摘要： Quinazoline-2,4-diamine derivatives of formula (I), pharmaceutical compositions thereof and their use for the modulation of small conductance calcium activated potassium channels (SK channels).
摘要翻译：式（I）的喹唑啉-2,4-二胺衍生物，其药物组合物及其用于调节小电导钙活化钾通道（SK通道）的用途。

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