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1. 发明申请

WO2003089031A1 SUBARACHNOID SPINAL CATHETER FOR TRANSPORTING CEREBROSPINAL FLUID 审中-公开
标题翻译：用于运输骨髓液的子宫颈脊髓导管
公开(公告)号：WO2003089031A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/012171
申请日：2003-04-21
申请人： NEURON THERAPEUTICS , BARNITZ, James, , HESSON, David, , FRAZER, Glenn , PELURA, Timothy, J.
发明人： BARNITZ, James, , HESSON, David, , FRAZER, Glenn , PELURA, Timothy, J.
IPC分类号： A61M5/00
CPC分类号： A61M25/007 , A61M1/0058 , A61M25/003 , A61M27/00 , A61M2025/0007 , A61M2025/0039 , A61M2202/0464
摘要： Provided is a multi-lumen intrathecal catheter capable of use for circulating a fluid through a portion of the spinal cord of a patient and having an insertable portion adapted for insertion into the spinal cord, comprising: a first lumen having a distal and a proximal end, the proximal end being adapted to being connected to a reservoir containing a fluid; a first fluid exchange section connected to the distal end of the first lumen having at least one inlet; a second lumen having a distal and a proximal end; and a second fluid exchange section connected to the distal and of the second lumen having at least one outlet, wherein at least one inlet and at least one outlet are offset from each other.
摘要翻译：本发明提供一种多腔鞘内导管，其能够用于使流体循环通过患者脊髓的一部分并且具有适于插入脊髓的可插入部分，包括：具有远端和近端的第一腔，所述近端适于连接到容纳流体的储存器; 连接到具有至少一个入口的第一管腔的远端的第一流体交换部分; 具有远端和近端的第二腔; 以及连接到所述远端和所述第二管腔的第二流体交换部分，其具有至少一个出口，其中至少一个入口和至少一个出口彼此偏移。

2. 发明申请

WO2003020208A3 TREATMENT OF NEUROLOGIC HEMORRHAGE 审中-公开
公开(公告)号：WO2003020208A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/026868
申请日：2002-08-23
申请人： NEURON THERAPEUTICS, INC.
发明人： HESSON, David, P. , FRAZER, Glenn, D. , PELURA, Timothy, J. , POWERS, Barbara, L. , SHOOK, Bruce
IPC分类号： A61K31/00
摘要： Subarachnoid hemorrhage is treated by circulating a synthetic cerebrospinal fluid containing an emulsifying agent in the cerebrospinal fluid pathway in the vicinity of hemorrhage. The emulsifying agent scavenges blood products and circulation of the synthetic cerebrospinal fluid clears the blood products form the subarachnoid space to reduce cerebral vasospasm.

3. 发明申请

WO2003020208A2 TREATMENT OF NEUROLOGIC HEMORRHAGE 审中-公开
标题翻译：治疗神经病学HEMORRHAGE
公开(公告)号：WO2003020208A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/026868
申请日：2002-08-23
申请人： NEURON THERAPEUTICS, INC.
发明人： HESSON, David, P. , FRAZER, Glenn, D. , PELURA, Timothy, J. , POWERS, Barbara, L. , SHOOK, Bruce
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K31/02 , A61K31/685 , A61K31/7004 , A61K33/00 , A61K33/14 , A61K33/42 , A61K38/38 , A61K2300/00
摘要： Subarachnoid hemorrhage is treated by circulating a synthetic cerebrospinal fluid containing an emulsifying agent in the cerebrospinal fluid pathway in the vicinity of hemorrhage. The emulsifying agent scavenges blood products and circulation of the synthetic cerebrospinal fluid clears the blood products form the subarachnoid space to reduce cerebral vasospasm.
摘要翻译：蛛网膜下腔出血通过在出血附近的脑脊液通路中循环含有乳化剂的合成脑脊液进行治疗。乳化剂清除合成脑脊液的血液制品和循环，使血液制品形成蛛网膜下腔，减少脑血管痉挛。

4. 发明申请

WO2002069893A2 TREATMENT OF NEUROLOGICAL DISEASE 审中-公开
标题翻译：治疗神经病
公开(公告)号：WO2002069893A2
公开(公告)日：2002-09-12
申请号：PCT/US2002/006108
申请日：2002-02-28
申请人： NEURON THERAPEUTICS, INC.
发明人： HESSON, David, P. , PELURA, Timothy, J. , FRAZER, Glenn, D.
IPC分类号： A61K
CPC分类号： A61K31/00 , A61K45/06
摘要： Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a physiologically acceptable fluid for cerebrospinal perfusion into a first catheter into the cerebrospinal pathway, which fluid for cerebrospinal perfusion has an therapeutically effective amount an agent, the agent selected for effectiveness against the infection as identified or diagnosed; (b) withdrawing fluid at a second catheter into the cerebrospinal pathway to create a flow and flow pathway between the first and second catheters; and (c) maintaining the flow for a period of time adapted to perfuse at least 1 CSF volume.
摘要翻译：本发明提供了一种治疗动物感染或脑损伤的肿瘤的方法，其特征在于具有死亡风险，该方法包括：（a）将用于脑脊液灌注的生理上可接受的流体注入第一导管进入脑脊液通路，用于脑脊液灌注的液体具有治疗有效量的试剂，所选择的试剂针对鉴定或诊断的感染的有效性; （b）在第二导管处取出流体进入脑脊液通道，以在第一和第二导管之间产生流动和流动通路; 和（c）将流量保持适于灌注至少1个CSF体积的时间段。

5. 发明申请

WO2003049654A1 PROTECTION OF NEUROLOGICAL TISSUE BY DIRECT CNS PERFUSION COOLING 审中-公开
标题翻译：直接CNS灌注冷却保护神经组织
公开(公告)号：WO2003049654A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/039432
申请日：2002-12-09
申请人： NEURON THERAPEUTICS
发明人： FRAZER, Glenn , HESSON, David, P. , PELURA, Timothy, J. , BARNITZ, James, C.
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F2007/0057 , A61F2007/126
摘要： Provided, among other things, is a method of treating, in an animal, an injury that is stroke, traumatic brain injury including traumatic surgical brain injury, brain hemorrhage other than stroke, spinal cord traumatic injury including spinal cord surgical trauma, infection ischemia caused by surgical intervention, CNS injury caused by cardiac arrest, encephalitis or encephalomyelitis not due to infection, comprising: (a) creating a flow pathway, with an instillation catheter and an effluent catheter, that provides liquid flow in the vicinity of the injury; (b) instilling into the flow pathway an cerebrospinal perfusion fluid having a temperature from (i) 4°C as a lower temperature to (ii) 4°C below normal temperature of the animal, and (c) maintaining perfusion through the flow pathway for at least 12 hours of the cerebrospinal perfusion fluid having a temperature, at the point of instillation, from (i) 4°C as a lower temperature (ii) 4°C below normal temperature of the animal.
摘要翻译：除其他之外，提供了在动物中治疗中风，创伤性脑损伤包括外伤性手术脑损伤，中风以外的脑出血，脊髓创伤性损伤的方法脊髓手术创伤，由外科手术干预引起的感染缺血，由心脏骤停引起的CNS损伤，非感染引起的脑炎或脑脊髓炎，包括：（a）建立具有滴注导管和流出导管的流动通路，其提供液体流动在受伤附近; （b）将温度从（i）4℃降低至低于动物正常温度至（ii）低4℃的脑脊液灌注流体注入流动路径，和（c）通过流动路径维持灌注至少12小时的脑脊液灌注液在滴注点具有从（i）4℃作为较低温度（ii）低于动物正常温度4℃的温度。

6. 发明申请

WO2002069893A3 TREATMENT OF NEUROLOGICAL DISEASE 审中-公开
公开(公告)号：WO2002069893A3
公开(公告)日：2002-09-12
申请号：PCT/US2002/006108
申请日：2002-02-28
申请人： NEURON THERAPEUTICS, INC.
发明人： HESSON, David, P. , PELURA, Timothy, J. , FRAZER, Glenn, D.
IPC分类号： A61M25/00
摘要： Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a physiologically acceptable fluid for cerebrospinal perfusion into a first catheter into the cerebrospinal pathway, which fluid for cerebrospinal perfusion has an therapeutically effective amount an agent, the agent selected for effectiveness against the infection as identified or diagnosed; (b) withdrawing fluid at a second catheter into the cerebrospinal pathway to create a flow and flow pathway between the first and second catheters; and (c) maintaining the flow for a period of time adapted to perfuse at least 1 CSF volume.

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