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    • 7. 发明申请
    • COMPOSITIONS AND METHODS RELATING TO DRUG DISCOVERY AND DETECTION AND TREATMENT OF GASTROINTESTINAL DISEASES
    • 与药物发现相关的组合物和方法,检测和治疗胃肠疾病
    • WO9738110A2
    • 1997-10-16
    • PCT/IB9700409
    • 1997-04-03
    • KIETA HOLDINGS SACORTHESY THEULAZ IRENE
    • CORTHESY-THEULAZ IRENE
    • A61K38/00C12N9/00C12N9/10C12N15/54C12Q1/68C12Q1/48
    • C12N9/1029A61K38/00C12N9/00C12N9/10C12Q1/689C12Q2600/136
    • A poly-3-hydroxybutyrate metabolic pathway essential for Helicobacter pylori survival in a host is provided. A novel Helicobacter pylori Coenzyme A transferase (Hp CoA-t), thiolase and PHB synthase as well as methods for their preparation and use are provided. Hp CoA-t and thiolase polynucleotides and proteins are provided as well as detection and preparative methods using such molecules. Methods for the determination of a propensity to develop gastritis, peptic ulcer disease, or gastric cancer is provided for by detection methods. Methods are also provided for the use of Hp CoA-t, thiolase or PHB synthase proteins and fragments retaining enzymatic activity in the identification of potential drug candidates for the treatment of some types of gastric disease. Pharmaceutical compositions containing Hp CoA-t protein fragments, antisense nucleic acids or other inhibitors of Hp CoA-t, thiolase and PHB synthase as well as methods for their use in the treatment of some types of gastric disease are also provided.
    • 提供了在宿主中幽门螺杆菌存活所必需的聚-3-羟基丁酸酯代谢途径。 提供了一种新型幽门螺杆菌辅酶A转移酶(Hp CoA-t),硫解酶和PHB合酶以及其制备和使用方法。 提供Hp CoA-t和硫解酶多核苷酸和蛋白质以及使用这种分子的检测和制备方法。 通过检测方法提供测定胃炎,消化性溃疡病或胃癌倾向的方法。 还提供了使用Hp CoA-t,硫解酶或PHB合酶蛋白和保留酶活性的片段鉴定潜在的候选药物用于治疗某些类型的胃病的方法。 还提供了含有Hp CoA-t蛋白片段,反义核酸或其他Hp CoA-t,硫解酶和PHB合酶抑制剂的药物组合物,以及其用于治疗某些类型胃病的方法。