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1. 发明申请

WO2008112891A2 MONOCLONAL ANTIBODY THAT RECOGNIZES A SENECA VALLEY VIRUS (SVV) CELLULAR RECEPTOR AND USES THEREOF 审中-公开
标题翻译：识别SENECA VALLEY病毒（SVV）细胞受体的单克隆抗体及其应用
公开(公告)号：WO2008112891A2
公开(公告)日：2008-09-18
申请号：PCT/US2008/056852
申请日：2008-03-13
申请人： NEOTROPIX, INC. , HALLENBECK, Paul , POLICE, Seshidhar, Reddy , HALES, Laura, M. , BURROUGHS, Kevin
发明人： HALLENBECK, Paul , POLICE, Seshidhar, Reddy , HALES, Laura, M. , BURROUGHS, Kevin
IPC分类号： C12Q1/70
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/1009 , C07K2317/76
摘要： The invention provides a hybridoma cell and a monoclonal antibody produced therefrom, wherein the monoclonal antibody specifically binds and forms a complex with an antigen on the surface of a tumor cell and thereby inhibits Seneca Valley Virus (SVV) entry into the tumor cell. The invention further provides SVV receptors, for example, CXCR4 and the antigen recognized by the monoclonal antibody of the invention. The invention also provides methods of using the monoclonal antibody to determine whether SVV will enter a tumor cell and for determining whether a subject with a tumor will respond to SVV treatment.
摘要翻译：本发明提供了杂交瘤细胞和由其产生的单克隆抗体，其中单克隆抗体与肿瘤细胞表面上的抗原特异性结合并形成复合物，从而抑制塞内卡谷病毒（SVV）进入肿瘤细胞。本发明进一步提供了SVV受体，例如CXCR4和由本发明的单克隆抗体识别的抗原。本发明还提供了使用单克隆抗体确定SVV是否会进入肿瘤细胞并确定患有肿瘤的受试者是否将对SVV治疗有反应的方法。

2. 发明申请

WO2006101841A3 SENECA VALLEY VIRUS BASED COMPOSITIONS AND METHODS FOR TREATING DISEASE 审中-公开
公开(公告)号：WO2006101841A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/009142
申请日：2006-03-13
申请人： NEOTROPIX, INC. , HALLENBECK, Paul , POLICE, Seshidhar, Reddy , HALES, Laura, M.
发明人： HALLENBECK, Paul , POLICE, Seshidhar, Reddy , HALES, Laura, M.
IPC分类号： A61K48/00 , C07H21/04 , C12N7/00 , C12N15/86 , C07K14/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus ("SVV"). The invention provides isolated SW nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of rumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SW nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.

3. 发明申请

WO2007047256A2 SVV-BASED ANIMAL VACCINES AND USES THEREOF 审中-公开
标题翻译：基于SVV的动物疫苗及其用途
公开(公告)号：WO2007047256A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/039523
申请日：2006-10-10
申请人： NEOTROPIX, INC. , HALLENBECK, Paul , HALES, Laura, M.
发明人： HALLENBECK, Paul , HALES, Laura, M.
IPC分类号： A61K48/00 , C07H21/04 , C12N7/00 , C12N15/86 , C07K14/085
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , C07H21/04 , C12N2770/32034
摘要： Seneca Valley Virus (SVV) is a unique picornavirus that can specifically kill certain types of human tumor cells, but cannot infect, replicate within or kill normal human cells. It has been determined that SVV is also permissive to porcine cells, and shares high genomic sequence identity to a number of porcine picornaviruses, herein considered to be members of a group called SVV-like picornaviruses. Antibodies that can neutralize SVV infection of SVV permissive cell lines have been found to be cross-reactive to the SVV-like picornaviruses. Because these SVV-like picornaviruses may be associated with a variety of diseases and sicknesses in pigs, vaccines comprising SVV or S W-like picornaviruses may be useful for the protection of non-primate animals against picornavirus related infection and disease, including disease and sickness that may be associated with SVV and SVV-like picornavirus infection.
摘要翻译：塞尼卡谷病毒（SVV）是一种独特的小核糖核酸病毒，可以特异性杀死某些类型的人类肿瘤细胞，但不能感染，复制或杀死正常人类细胞。已经确定SVV还允许猪细胞，并且与许多猪微小核糖核酸病毒共享高基因组序列同一性，这里被认为是称为SVV样小核糖核酸病毒的组的成员。已经发现可以中和SVV允许细胞系的SVV感染的抗体与SVV样小核糖核酸病毒交叉反应。由于这些SVV样微小核糖核酸病毒可能与猪中的各种疾病和疾病有关，因此包含SVV或S W样小核糖核酸病毒的疫苗可用于保护非灵长动物免受小RNA病毒相关感染和疾病的侵害，包括疾病和疾病这可能与SVV和SVV样微小RNA病毒感染有关。

4. 发明申请

WO2004092396A3 FLAP ENDONUCLEASE 1 (FEN1) REGULATORY SEQUENCES AND USES THEREOF 审中-公开
公开(公告)号：WO2004092396A3
公开(公告)日：2004-10-28
申请号：PCT/US2004/011622
申请日：2004-04-15
申请人： NOVARTIS AG , IRM LLC , HALLENBECK, Paul , HAMPTON, Garret , HAY, Carl , HUANG, Ying , JAKUBCZAK, John , PHIPPS, Sandrina
发明人： HALLENBECK, Paul , HAMPTON, Garret , HAY, Carl , HUANG, Ying , JAKUBCZAK, John , PHIPPS, Sandrina
IPC分类号： C12N15/00
摘要： FEN1 transcriptional regulatory sequences (TREs) are provided. FEN1 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in cancer cells. The FEN1 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in cancer cells.

5. 发明申请

WO2004092397A2 TMPRSS2 REGULATORY SEQUENCES AND USES THEREOF 审中-公开
标题翻译： TMPRSS2法规序列及其用途
公开(公告)号：WO2004092397A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011623
申请日：2004-04-15
申请人： NOVARTIS AG , IRM LLC , HALLENBECK, Paul , HAMPTON, Garret , HAY, Carl , HUANG, Ying , JAKUBCZAK, John
发明人： HALLENBECK, Paul , HAMPTON, Garret , HAY, Carl , HUANG, Ying , JAKUBCZAK, John
IPC分类号： C12Q
CPC分类号： C07K14/4702 , C12N15/85 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2840/007
摘要： TMPRSS2 transcriptional regulatory sequences (TREs) are provided. TMPRSS2 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in prostate cancer cells. The TMPRSS2 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in prostate cancer cells.
摘要翻译：提供TMPRSS2转录调控序列（TRE）。 TMPRSS2 TRE提供依赖于仅在前列腺癌细胞中活跃的转录因子的转录调节。 TMPRSS2 TREs可以用作引入新的遗传能力，特别是与细胞毒性相关的遗传能力，用于前列腺癌细胞中的选择性表达。

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