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1. 发明申请

WO2022081089A1 METHODS OF PREPARING CELL-DERIVED VESICLES 审中-公开
公开(公告)号：WO2022081089A1
公开(公告)日：2022-04-21
申请号：PCT/SG2021/050613
申请日：2021-10-12
申请人： NATIONAL UNIVERSITY OF SINGAPORE , ETH ZURICH
发明人： FRANCO-OBREGON, Alfredo , TAI, Yee Kit , KURTH, Felix , DITTRICH, Petra Stephanie
IPC分类号： A61K35/12 , A61N2/04 , A61P35/00 , A61K31/22
摘要： The invention relates generally to cell-derived vesicles (CDVs), such as CD Vs from myoblast, wherein the parent cells have been subjected to pulsed electromagnetic field and wherein the vesicles are isolated from the parent cells using actin cytoskeletal disruptors, such as cytochalasin B. The CDVs are enriched for Transient Receptor Potential Channel 1 (TRPC1). The invention further relates to the uses of the CDVs as therapeutic agents in conditions associated with disruptive metabolism and inflammation; for instance, cancer.

2. 发明申请

WO2016178631A1 SYSTEM AND METHOD FOR APPLYING PULSED ELECTROMAGNETIC FIELDS 审中-公开
标题翻译：用于应用脉冲电磁场的系统和方法
公开(公告)号：WO2016178631A1
公开(公告)日：2016-11-10
申请号：PCT/SG2016/050208
申请日：2016-05-05
申请人： NATIONAL UNIVERSITY OF SINGAPORE , ETH ZURICH
发明人： FRANCO-OBREGON, Alfredo , LEE, Chuen Neng , LOH, Wee Chuan Melvin , FRÖHLICH, Jürg Hans , BEYER, Christian , LAI, Tien Min David
IPC分类号： A61N1/40 , A61N1/32 , A61N2/00 , G06F19/00
CPC分类号： A61N1/326 , A61N2/02
摘要： Systems and methods for applying a pulsed electromagnetic fields. A system for applying a pulsed electromagnetic field (PEMF) to a cell, comprising: a sensor for obtaining a characteristic of the cell; a memory module having stored therein a plurality of characteristics and PEMF efficacy window data, each characteristic having its corresponding PEMF efficacy window data; a pulse generator coupled to a set of PEMF coils and configured to generate an output of electrical pulses to drive the set of PEMF coils; and a controller in communication with the sensor, the memory module and the pulse generator, wherein the controller is configured to: retrieve, from the memory module, the PEMF efficacy window data that corresponds to the characteristic of the cell obtained by the sensor; and control the output of the pulse generator based on the retrieved PEMF efficacy window data such that the set of PEMF coils apply a PEMF in accordance with the PEMF efficacy window data.
摘要翻译：应用脉冲电磁场的系统和方法。一种将脉冲电磁场（PEMF）应用于单元的系统，包括：用于获得所述单元的特性的传感器; 其中存储有多个特征和PEMF效能窗口数据的存储器模块，每个特征具有其相应的PEMF效能窗口数据; 脉冲发生器，其耦合到一组PEMF线圈并且被配置为产生电脉冲的输出以驱动该组PEMF线圈; 以及与所述传感器，所述存储器模块和所述脉冲发生器通信的控制器，其中所述控制器被配置为：从所述存储器模块检索对应于由所述传感器获得的所述单元的特性的PEMF效能窗口数据; 并且基于所检索的PEMF效能窗口数据来控制脉冲发生器的输出，使得该组PEMF线圈根据PEMF效能窗口数据应用PEMF。

3. 发明申请

WO2008135269A1 BIOREACTOR TO APPLY MECHANICAL FORCES AS AN ANABOLIC STIMULUS 审中-公开
标题翻译：生物工程师将机械力量应用于无刺激性刺激
公开(公告)号：WO2008135269A1
公开(公告)日：2008-11-13
申请号：PCT/EP2008/003607
申请日：2008-05-06
申请人： ETH ZURICH , STEMMER, Andreas , ASCHWANDEN, Manuel , FRANCO-OBREGON, Alfredo , REY, Antje Gabriele , VONDERHEIT, Andreas , ENNING, Raoul , SAKAI, Miho
发明人： STEMMER, Andreas , ASCHWANDEN, Manuel , FRANCO-OBREGON, Alfredo , REY, Antje Gabriele , VONDERHEIT, Andreas , ENNING, Raoul , SAKAI, Miho
IPC分类号： C12M3/00
CPC分类号： C12M35/04 , C12M25/02
摘要： The current invention describes a bioreactor (1) which could be used in the field of cytomechanics. The bioreactor (1) comprises an electro-active polymer actuator (2), also known as artificial muscle, which is bonded to a deformable, water impermeable biocompatible substrate/matrix (8, 9). This layered structure is the flexible membrane of the bioreactor (1).
摘要翻译：本发明描述了可用于细胞机械学领域的生物反应器（1）。生物反应器（1）包括也称为人造肌肉的电活性聚合物致动器（2），其结合到可变形的不透水的生物相容性基底/基质（8,9）上。这种层状结构是生物反应器（1）的柔性膜。

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