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1. 发明申请

WO9711908A3 Process and device for treating water contaminatedwith micro-organisms and/or harmful pollutants 审中-公开
标题翻译： Vorrichting方法和微生物和/或绵羊物质的处理被污染的水
公开(公告)号：WO9711908A3
公开(公告)日：1997-04-24
申请号：PCT/DE9601877
申请日：1996-09-25
申请人： NAT ENGINEERING RES CT FOR URB , GAO TINGYAO , HAN BAIPING , ZHANG DESHENG , LI JIE
发明人： GAO TINGYAO , HAN BAIPING , ZHANG DESHENG , LI JIE
IPC分类号： C02F1/00 , C02F1/28 , C02F1/36 , C02F1/46 , C02F1/461 , C02F1/463 , C02F1/467 , C02F1/72 , C02F1/76 , C02F1/78 , C02F9/00 , C02F1/48
CPC分类号： C02F1/46109 , C02F1/283 , C02F1/36 , C02F1/4602 , C02F1/463 , C02F1/4672 , C02F1/722 , C02F1/76 , C02F1/78 , C02F9/00 , C02F2001/46119 , C02F2001/46133 , C02F2001/46142 , C02F2001/46152 , C02F2001/46157 , C02F2103/003 , C02F2201/4611 , C02F2201/46125 , C02F2201/4615 , C02F2301/024 , C02F2301/026 , C02F2303/04 , C02F2305/023
摘要： The disclosure relates to a process for treating water contaminated with micro-organisms and/or harmful pollutants. A direct current is passed through the water between an anode and a cathode. The anode is provided with a coating containing titanium dioxide. The direct current is set to give a charge of 30 to 60 Coulomb per litre of water. The direct current has a catalytic effect promoting the loss of electrons from the titanium dioxide and the formation of oxygen radicals in the water. The process has a deposition effect promoting the disinfection of the water. The duration of that effect is proportional to the total electrical charge. The process also increases the quantity of dissolved oxygen in the water, which should be between 0.5 and 1.8 mg/l and is dependent specifically on the total charge in the water and on the anode material. Another effect of the process is a dramatic reduction in hard lime deposits on the cathode and in the water system as a whole.

2. 发明申请

WO2006060172A3 METHODS FOR IDENTIFYING GRAFT REJECTION SUPPRESSING COMPOUNDS 审中-公开
标题翻译：鉴定抑制抑制化合物的方法
公开(公告)号：WO2006060172A3
公开(公告)日：2007-10-04
申请号：PCT/US2005041703
申请日：2005-11-16
申请人： IRM LLC , SAUER KARSTEN , LI JIE
发明人： SAUER KARSTEN , LI JIE
IPC分类号： C12Q1/48 , A61K31/40
CPC分类号： G01N33/5082 , G01N2333/91215
摘要： This invention provides novel methods for identifying agents that suppress or prevent graft rejection in a subject. The agents are identified by screening test compounds for ability to modulate a biological activity of PKCI3 (e.g., its kinase activity). The identified PKC(3-mo4ulating compounds can be further examined for their activity in suppressing graft 10 rejection in a test subject. Pharmaceutical compositions comprising these compounds are also provided in the invention. These pharmaceutical compositions can be administered to graft recipients to treat or prevent graft rejections, especially rejection of grafts with minor histocompatibility mismatches.
摘要翻译：本发明提供用于鉴定抑制或预防受试者移植物排斥的药剂的新方法。通过筛选测试化合物以调节PKCI3的生物活性（例如其激酶活性）的能力来鉴定药剂。鉴定的PKC（3个mo4化合物可以进一步检查其在测试对象中抑制移植物10排斥的活性。本发明还提供了包含这些化合物的药物组合物，这些药物组合物可以施用于移植物接受者以治疗或预防移植物排斥反应，特别是具有轻微组织相容性错配的移植物排斥反应。

3. 发明申请

WO2014141038A3 MARKERS ASSOCIATED WITH WNT INHIBITORS 审中-公开
标题翻译：与WNT抑制剂相关的标记
公开(公告)号：WO2014141038A3
公开(公告)日：2014-11-27
申请号：PCT/IB2014059585
申请日：2014-03-10
申请人： IRM LLC , CHE JIANWEI , HARRIS JENNIFER , HSIN-I HSIEH MINDY , LI JIE , LIU JUN , NG NICHOLAS
发明人： CHE JIANWEI , HARRIS JENNIFER , HSIN-I HSIEH MINDY , LI JIE , LIU JUN , NG NICHOLAS
IPC分类号： G01N33/574 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/444 , A61K31/497 , A61K31/501 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.
摘要翻译：本发明提供监测生物标志物的差异基因表达以确定患者对Wnt抑制剂的敏感性的方法，通过测量生物标志物来测定细胞对Wnt抑制剂的敏感性的方法，筛选候选Wnt抑制剂的方法，用于头部的Wnt抑制剂和颈鳞状细胞癌。

4. 发明申请

WO2006012030A3 COATED ART MATERIAL SYSTEM 审中-公开
标题翻译：有涂层的艺术材料系统
公开(公告)号：WO2006012030A3
公开(公告)日：2006-07-13
申请号：PCT/US2005021271
申请日：2005-06-16
申请人： BINNEY & SMITH INC , LI JIE , KRIEGER CHERYL , URBANSKI ARTHUR N , SKINNER CRAIG , GUYLER KARL , GLASSCOCK STEPHEN D
发明人： LI JIE , KRIEGER CHERYL , URBANSKI ARTHUR N , SKINNER CRAIG , GUYLER KARL , GLASSCOCK STEPHEN D
IPC分类号： C09D11/00 , B32B5/16 , B43L19/00
CPC分类号： B44D2/002 , B43L19/0018 , B44C1/005 , C09D11/50 , Y10T428/24802 , Y10T428/24835 , Y10T428/24868 , Y10T428/24901 , Y10T428/25 , Y10T428/31504 , Y10T428/31551
摘要： The present invention is a system for hiding and later revealing a hidden layer. The system includes a substrate and applicator. As the user moves the applicator around the substrate, a coating is rendered transparent to reveal a hidden layer under the pattern of the user's movement of the applicator. The system comprises a substrate at least partially coated with a generally opaque coating that reacts with an eradicator fluid. A preferred coating as applied to the substrate comprises 20 - 80 wt% water, 0 - 3 wt% defoamer, 0 - 3 wt% surfactant, 0 - 5 wt% wetting agent, 1 - 25 wt% colorant, 1 - 60 wt% resin, and 0 - 4 wt% preservatives. A preferred reducing fluid in such case comprises 30 - 95 wt% water, 1 - 5 wt% pH adjuster, 5 - 15 wt% reducing agent, 0 - 5 wt% surfactant, and 2 - 10 wt% buffer.
摘要翻译：本发明是用于隐藏和稍后显示隐藏层的系统。该系统包括衬底和涂药器。当使用者将涂敷器移动到基板周围时，使涂层变得透明以在使用者移动涂敷器的模式下显示隐藏层。该系统包括至少部分地涂覆有通常不透明的涂层与根除液反应。施加到基材上的优选涂层包含20-80重量％的水，0-3重量％的消泡剂，0-3重量％的表面活性剂，0-5重量％的润湿剂，1-25重量％的着色剂，1-60重量％树脂和0-4wt％防腐剂。在这种情况下，优选的还原流体包含30-95重量％的水，1-5重量％的pH调节剂，5-15重量％的还原剂，0-5重量％的表面活性剂和2-10 wt％缓冲液。

5. 发明申请

WO2011110122A3 METHOD, DEVICE AND SYSTEM FOR PROCESSING SHORT MESSAGES 审中-公开
标题翻译：用于处理短消息的方法，装置和系统
公开(公告)号：WO2011110122A3
公开(公告)日：2012-04-19
申请号：PCT/CN2011073175
申请日：2011-04-22
申请人： HUAWEI TECH CO LTD , LI JIE , HE CHAOQUN , FENG LI
发明人： LI JIE , HE CHAOQUN , FENG LI
IPC分类号： H04W4/18 , H04W4/14 , H04W28/14
CPC分类号： H04W4/14
摘要： The present invention provides a method, device and system for processing short messages. The method includes: receiving a short message sent from a Service Provider (SP); judging whether the short message is packet data of a long short message, if yes, storing the packet data in a memory; transmitting all packet data in turn, according to the order of all packet data, to a Short Message Service Centre (SMSC), when all packet data corresponding to the long short message is stored. The method, device and system provided by the present invention enable a terminal to receive the packet data of the long short message according to the right order, thus improving the operation convenience of a user.
摘要翻译：本发明提供了一种处理短消息的方法，装置和系统。该方法包括：接收从服务提供商（SP）发送的短消息; 判断短消息是否是长短消息的分组数据，如果是，则将分组数据存储在存储器中; 当存储与长短消息相对应的所有分组数据时，根据所有分组数据的顺序将所有分组数据依次发送到短消息服务中心（SMSC）。本发明提供的方法，设备和系统使得终端可以根据正确的顺序接收长短消息的分组数据，从而提高用户的操作方便性。

6. 发明申请

WO2006116007A3 METHODS FOR SYNTHESIS OF DICARBAMATE COMPOUNDS AND INTERMEDIATES IN THE FORMATION THEREOF 审中-公开
标题翻译：合成化合物的方法及其形成中的中间体
公开(公告)号：WO2006116007A3
公开(公告)日：2007-01-11
申请号：PCT/US2006014965
申请日：2006-04-20
申请人： MEDPOINTE HEALTHCARE INC , MORTKO HENRY , HE WEIXUAN , ANDERSEN MARC W , DOTSE ANTHONY K , LI JIE
发明人： MORTKO HENRY , HE WEIXUAN , ANDERSEN MARC W , DOTSE ANTHONY K , LI JIE
IPC分类号： C07D413/00 , C07D241/00 , C07D317/00 , C07D333/02
CPC分类号： C07C271/12 , C07C29/147 , C07C33/20 , C07C33/46 , C07C51/09 , C07C67/307 , C07C269/00 , C07C57/58 , C07C69/65
摘要： Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.
摘要翻译：公开了通过还原相应的丙二酸酯化合物制备2-取代-2-卤代-1,3-丙二醇的方法。还公开了通过丙二酸酯化合物的还原，然后进行氨基甲酰化制备2-取代-2-卤代-1,3-二氨基甲酸酯化合物（例如氟硼酸酯的卤代衍生物，包括氟代氨基甲酸酯）的方法。丙二酸酯化合物的还原使用亲电子氢化物试剂进行。

7. 发明申请

WO2012048202A3 METHOD OF PREPARATION OF ANTIVIRAL COMPOUNDS AND USEFUL INTERMEDIATES THEREOF 审中-公开
标题翻译：制备抗病毒化合物的方法及其有用的中间体
公开(公告)号：WO2012048202A3
公开(公告)日：2012-07-26
申请号：PCT/US2011055229
申请日：2011-10-07
申请人： INHIBITEX INC , WANG YANLING , WANG YUAN , HE XUNGUI , LIU CHUANJUN , ZHU JIRANG , LI JIE , CHENG QINGZHONG , YUAN MINGYONG
发明人： WANG YANLING , WANG YUAN , HE XUNGUI , LIU CHUANJUN , ZHU JIRANG , LI JIE , CHENG QINGZHONG , YUAN MINGYONG
IPC分类号： C07D491/048 , A61K31/519 , A61P31/12 , C07H7/06 , C07H19/06 , C07H19/073
CPC分类号： C07H19/24 , A61K31/519 , C07B2200/13 , C07H19/073 , C07H19/23
摘要： The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel intermediate compounds useful in the process. The antiviral compounds are useful in the treatment of herpes zoster (i.e., varicella zoster virus, VZV, shingles) and for the prevention of post herpetic neuralgia (PHN) resulting from this viral infection.
摘要翻译：本发明涉及合成双环核苷抗病毒化合物和合成本方法中使用的中间体的方法。本发明还涉及用于该方法的新型中间体化合物。抗病毒化合物可用于治疗带状疱疹（即，水痘带状疱疹病毒，VZV，带状疱疹）和用于预防由该病毒感染引起的疱疹后神经痛（PHN）。

8. 发明申请

WO2010022320A3 POLYMERIC BENZYL CARBONATE-DERIVATIVES 审中-公开
标题翻译：聚合苯乙烯衍生物
公开(公告)号：WO2010022320A3
公开(公告)日：2010-08-19
申请号：PCT/US2009054595
申请日：2009-08-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA , YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
发明人： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
IPC分类号： A61K47/48 , A61P7/00
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译：本发明涉及聚合衍生物，其可以与含氨基的药物缀合以改善其体内特性。随后可以释放聚合物衍生物以产生其天然形式的药物。描述了制备和使用这些聚合物衍生物和药物偶联物的方法。

9. 发明申请

WO2010009402A3 NILOTINIB INTERMEDIATES AND PREPARATION THEREOF 审中-公开
标题翻译： NILOTINIB中间体及其制备
公开(公告)号：WO2010009402A3
公开(公告)日：2010-08-26
申请号：PCT/US2009051001
申请日：2009-07-17
申请人： TEVA PHARMA , TEVA PHARMA , WANG YANLING , LI JIE , KANSAL VINOD KUMAR , ZHU JIRANG , LIFSHITZ-LIRON REVITAL , MISTRY DHIRENKUMAR N , VASOYA SANJAY L , ARIYAMUTHU SUNDARASELVAN , PILARSKI GIDEON , HE XUNGUI
发明人： WANG YANLING , LI JIE , KANSAL VINOD KUMAR , ZHU JIRANG , LIFSHITZ-LIRON REVITAL , MISTRY DHIRENKUMAR N , VASOYA SANJAY L , ARIYAMUTHU SUNDARASELVAN , PILARSKI GIDEON , HE XUNGUI
IPC分类号： C07D233/61 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D233/61 , C07D401/04
摘要： Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl- 5 -(4-methyl- 1 H-imidazole- 1 -yl)-benzeneamine; 3 -(4-(pyridin-3 -yl)pyrimidin-2-ylamino)-4- methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib»3HCl and its crystalline forms are also described.
摘要翻译：制备尼罗替尼中间体，包括例如3-（三氟甲基-5-（4-甲基-1H-咪唑-1-基） - 苯胺），3-（4-（吡啶-3-基）嘧啶-2 -4-甲基苯甲酰基卤代二氢氯化物;和N-（3-溴-5-三氟甲基苯基）-4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基]苯甲酰胺尼洛替尼»3HCl 还描述了其结晶形式。

10. 发明申请

WO2010009402A2 NILOTINIB INTERMEDIATES AND PREPARATION THEREOF 审中-公开
标题翻译：尼罗替尼中间体及其制备
公开(公告)号：WO2010009402A2
公开(公告)日：2010-01-21
申请号：PCT/US2009051001
申请日：2009-07-17
申请人： TEVA PHARMA , TEVA PHARMA , WANG YANLING , LI JIE , KANSAL VINOD KUMAR , ZHU JIRANG , LIFSHITZ-LIRON REVITAL , MISTRY DHIRENKUMAR N , VASOYA SANJAY L , ARIYAMUTHU SUNDARASELVAN , PILARSKI GIDEON , HE XUNGUI
发明人： WANG YANLING , LI JIE , KANSAL VINOD KUMAR , ZHU JIRANG , LIFSHITZ-LIRON REVITAL , MISTRY DHIRENKUMAR N , VASOYA SANJAY L , ARIYAMUTHU SUNDARASELVAN , PILARSKI GIDEON , HE XUNGUI
IPC分类号： C07D401/14 , C07D233/56 , C07D401/04
CPC分类号： C07D401/14 , C07D233/61 , C07D401/04
摘要： Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl- 5 -(4-methyl- 1 H-imidazole- 1 -yl)-benzeneamine; 3 -(4-(pyridin-3 -yl)pyrimidin-2-ylamino)-4- methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib»3HCl and its crystalline forms are also described.
摘要翻译：制备尼罗替尼的中间体，包括例如3-（三氟甲基-5-（4-甲基-1H-咪唑-1-基） - 苯胺; 3-（4-（吡啶-3-基）嘧啶-2 （3-溴-5-三氟甲基苯基）-4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基]苯甲酰胺将盐酸尼洛地平还描述了它的结晶形式。

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