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1. 发明申请

WO2016161361A1 COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS 审中-公开
标题翻译：靶向突变K-RAS的组合物和方法
公开(公告)号：WO2016161361A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025697
申请日：2016-04-01
申请人： NANTBIOSCIENCE, INC. , NANTOMICS, LLC , NANT HOLDINGS IP, LLC
发明人： RABIZADEH, Shahrooz , KAYVAN, Niazi , BUZKO, Sasha , WEINGARTEN, Paul , MCFARLANE, Heather , JUNCKER-JENSEN, Anna , GOLOVATO, Justin , SOON-SHIONG, Patrick , TAO, Chunlin , HO, David
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61K31/4725 , A61P35/00
CPC分类号： C07D417/14 , A61P35/00 , C07D277/46 , C07D417/04 , C07D417/12 , C07D471/06 , C07F9/65583
摘要： Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
摘要翻译：提供了抑制K-ras，尤其是突变型K-ras的化合物和组合物。某些化合物优先或甚至选择性抑制特定形式的突变型K-Ras，特别是G12D突变体形式。

2. 发明申请

WO2014071298A1 CYCLIC SULFONAMIDE CONTAINING DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAY 审中-公开
标题翻译：作为HEDGEHOG信号通道的抑制剂的环硫磺酰胺衍生物
公开(公告)号：WO2014071298A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068287
申请日：2013-11-04
申请人： NANT HOLDINGS IP, LLC
发明人： TAO, Chunlin , YU, Chengzhi , ARP, Forrest , WEINGARTEN, Paul , SOON-SHIONG, Patrick
IPC分类号： A61K31/16 , A61K31/18 , A61K31/38
CPC分类号： A61K31/425 , C07D275/02 , C07D279/02 , C07D291/06 , C07D417/12 , C07D419/12 , C07D471/04
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
摘要翻译：本发明一般涉及产生和使用含环状磺酰胺的衍生物以抑制刺猬蛋白信号通路，以及这些化合物用于治疗过度增殖性疾病和血管生成介导的疾病的用途。

3. 发明申请

WO2017024315A1 HETEROCYCLIC THIOSEMICARBAZONE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译：杂环硫代酮衍生物及其治疗应用
公开(公告)号：WO2017024315A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/046078
申请日：2016-08-08
申请人： NANT HOLDINGS IP, LLC , NANTWORKS, LLC
发明人： TAO, Chunlin , WANG, Qinwei , SOON-SHIONG, Patrick
IPC分类号： C07D491/052 , C07D471/04 , C07D491/048 , C07D495/04 , A61K31/4353 , A61K31/4375 , A61K31/4355 , A61K31/4365
CPC分类号： C07D495/04 , C07D471/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.
摘要翻译：提出了制备各种杂环硫代缩氨基脲衍生物的药物化合物，组合物和方法。考虑的化合物将适合于抑制或减少细胞生长或增殖，因此有益于制造治疗肿瘤疾病的药物。

4. 发明申请

WO2016137506A1 PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译：嘧啶衍生物作为激酶抑制剂及其治疗应用
公开(公告)号：WO2016137506A1
公开(公告)日：2016-09-01
申请号：PCT/US2015/018085
申请日：2015-02-27
申请人： NANTBIOSCIENCE, INC.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , HO, David , POLAT, Tulay , ARP, Forrest , WEINGARTEN, Paul
IPC分类号： A61K31/404
CPC分类号： C07D403/12 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.
摘要翻译：本发明提供包含取代的嘧啶衍生物和其药学上可接受的制剂的抗肿瘤剂，制备新化合物的方法和使用该化合物的方法。根据本发明的化合物和组合物可用于治疗多种疾病并具有激酶抑制活性。

5. 发明申请

WO2016205460A1 POLYCYCLIC DERIVATIVES TARGETING RAL GTPASES AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译：靶向RAL GTPASES及其治疗应用的多环衍生物
公开(公告)号：WO2016205460A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037783
申请日：2016-06-16
申请人： NANTBIOSCIENCE, INC.
发明人： TAO, Chunlin , YU, Chengzhi , POLAT, Tulay , YAN, Chao , RABIZADEH, Shahrooz , THEODORESCU, Daniel
IPC分类号： C07D491/052 , C07D471/04 , A61K31/4162 , A61K31/437
CPC分类号： C07D491/052 , A61P35/04 , C07D471/04 , C07D519/00
摘要： Contemplated compounds, compositions and methods are directed to Ral GTPase inhibitors with improved activity.
摘要翻译：考虑的化合物，组合物和方法针对具有改善的活性的Ral GTPase抑制剂。

6. 发明申请

WO2014210611A1 PATHWAY ANALYSIS FOR IDENTIFICATION OF DIAGNOSTIC TESTS 审中-公开
标题翻译：路线分析诊断诊断测试
公开(公告)号：WO2014210611A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044950
申请日：2014-06-30
申请人： NANTOMICS, LLC
发明人： BENZ, Stephen, Charles , RABIZADEH, Shahrooz , SZETO, Christopher , WEINGARTEN, Paul , TAO, Chunlin
IPC分类号： G06F19/10
CPC分类号： G16H50/20 , G06F19/00
摘要： The present inventive subject matter provides apparatus, systems, and methods in which a diagnostic test is identified, where the diagnostic test is for determining whether a particular treatment is effective for a particular patient based on one or more characteristics of a patient's cells. When a treatment is developed with the potential to treat one or more diseases, the drug can have different effects on different cell lines related to the diseases. A machine learning system is programmed to infer a measurable cell characteristic, out of many different measurable cell characteristics, that has a desirable correlation with the sensitivity data of different cell lines to a treatment. The machine learning system is programmed to then determine, based on the correlation, a threshold level of the cell characteristic the patient should exhibit in order to recommend administering the treatment.
摘要翻译：本发明的主题提供了其中识别诊断测试的装置，系统和方法，其中诊断测试用于基于患者细胞的一个或多个特征来确定特定治疗是否对特定患者有效。当开发具有治疗一种或多种疾病潜力的治疗时，该药物可以对与疾病相关的不同细胞系具有不同的作用。机器学习系统被编程为推断出许多不同可测量的细胞特征中的可测量细胞特征，其与不同细胞系对治疗的敏感性数据具有期望的相关性。机器学习系统被编程为然后基于相关性来确定患者应该展示的细胞特征的阈值水平以推荐施用治疗。

7. 发明申请

WO2016138527A1 PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译：嘧啶衍生物作为激酶抑制剂及其治疗应用
公开(公告)号：WO2016138527A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/020095
申请日：2016-02-29
申请人： NANTBIOSCIENCE, INC.
发明人： TAO, Chunlin , POLAT,, Tulay , WEINGARTEN, Paul , NALLAN, Laxman , ARP, Forrest , WANG, Qinwei , HO, David
IPC分类号： A61K31/404 , A61K31/506 , C07D401/12 , C07D403/10
CPC分类号： C07D403/12 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention provides kinase inhibitors with anti-proliferative activity comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof. In addition, the invention provides methods for making novel compounds and methods for using the compounds.
摘要翻译：本发明提供具有抗增殖活性的激酶抑制剂，其包含取代的嘧啶衍生物及其药学上可接受的制剂。此外，本发明提供了制备新化合物的方法和使用该化合物的方法。

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