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1. 发明申请

WO2010081859A1 6-PHENYL-LH-IMIDAZO [4, 5-C] PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS 审中-公开
标题翻译： 6-苯基-LH-咪唑并[4,5-C]吡啶-4-羰基酮衍生物，为CATHEPSIN S和/或CATHEPSIN K抑制剂
公开(公告)号：WO2010081859A1
公开(公告)日：2010-07-22
申请号：PCT/EP2010/050418
申请日：2010-01-14
申请人： N.V. ORGANON , CAI, Jiaqiang , BENNETT, David, Jonathan , ROBINSON, John, Stephen , JONES, Philip, Stephen
发明人： CAI, Jiaqiang , BENNETT, David, Jonathan , ROBINSON, John, Stephen , JONES, Philip, Stephen
IPC分类号： C07D471/04 , A61K31/437 , A61P19/10 , A61P25/02 , A61P29/00 , A61P17/06
CPC分类号： C07D471/04
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I) to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及具有通式（I）的6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物，其中药物组合物包含它们，以及这些衍生物用于制备的药物组合物用于治疗组织蛋白酶S相关疾病如动脉粥样硬化，肥胖，炎症和免疫疾病如类风湿性关节炎，牛皮癣，癌症和慢性疼痛如神经性疼痛的药物。

2. 发明申请

WO2011086125A1 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES 审中-公开
标题翻译： 1H- [1,2,3]三唑[4,5-c]吡啶-4-羰基衍生物
公开(公告)号：WO2011086125A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/050393
申请日：2011-01-13
申请人： N.V. ORGANON , CAI, Jiaqiang , BENNETT, David, Jonathan , JONES, Philip, Stephen
发明人： CAI, Jiaqiang , BENNETT, David, Jonathan , JONES, Philip, Stephen
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R 1 is H or (C 1-3 )alkyl; R 2 is halogen or (C 1-4 )alkyl, optionally substituted with one or more halogens; n is 1 -3; X is O or CH 2 ; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the S n ....S 2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及式（I）的1H- [1,2,3]三唑并[4,5-c]吡啶-4-腈衍生的组织蛋白酶S抑制剂，其中R 1是H或（C 1-3）烷基; R2是卤素或任选被一个或多个卤素取代的（C 1-4）烷基; n为1-3; X是O或CH2; U，V和W是CH; 或U，V和W之一为N; Y是能够与组织蛋白酶S的活性位点的Sn ... S2方位相互作用的基团; 或其药学上可接受的盐用于包含其的药物组合物以及这些衍生物用于制备用于治疗组织蛋白酶S相关疾病如动脉粥样硬化，肥胖症，炎症和免疫疾病如类风湿病的药物中的用途关节炎，牛皮癣，癌症和慢性疼痛，如神经性疼痛。

3. 发明申请

WO2009010491A1 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS 审中-公开
标题翻译： 6-苯基-1H-咪唑并[4,5-C]吡啶-4-羰基酮衍生物作为CATHEPSIN抑制剂
公开(公告)号：WO2009010491A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059172
申请日：2008-07-14
申请人： N.V. ORGANON , CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , FRADERA, Xavier
发明人： CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , FRADERA, Xavier
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , A61P17/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such asatherosclerosis,obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer,and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及具有通式（I）的6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物，涉及包含其的药物组合物以及这些衍生物用于制备用于治疗组织蛋白酶S相关疾病如动脉粥样硬化，肥胖，炎症和免疫疾病如类风湿性关节炎，牛皮癣，癌症和慢性疼痛如神经性疼痛的药物。

4. 发明申请

WO2007080191A1 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS 审中-公开
标题翻译： 6-苯基-1H-咪唑并[4,5-C]吡啶-4-羰基酮衍生物作为CATHEPSIN K和S抑制剂
公开(公告)号：WO2007080191A1
公开(公告)日：2007-07-19
申请号：PCT/EP2007/050356
申请日：2007-01-15
申请人： N.V. ORGANON , CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , CUMMING, Iain , GILLESPIE, Jonathan
发明人： CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , CUMMING, Iain , GILLESPIE, Jonathan
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , C07D519/00 , C07F7/10
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.
摘要翻译：本发明涉及具有通式（I）的6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物，涉及包含其的药物组合物以及这些衍生物用于制备用于治疗组织蛋白酶S和/或组织蛋白酶K相关疾病如骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛如神经性疼痛的药物。

5. 发明申请

WO2006064262A2 MEDICINAL PRODUCT ORDER PROCESSING SYSTEM 审中-公开
标题翻译：医药产品订单处理系统
公开(公告)号：WO2006064262A2
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004880
申请日：2005-12-16
申请人： e-SAN LIMITED , TARASSENKO, Lionel , TOWNSEND, Neil, William , JONES, Philip, Stephen
发明人： TARASSENKO, Lionel , TOWNSEND, Neil, William , JONES, Philip, Stephen
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , G16H10/60 , G16H40/63

6. 发明申请

WO2008107675A1 MULTI-MEDIA MESSAGING SYSTEM FOR MOBILE TELEPHONE 审中-公开
标题翻译：用于移动电话的多媒体消息传递系统
公开(公告)号：WO2008107675A1
公开(公告)日：2008-09-12
申请号：PCT/GB2008/000754
申请日：2008-03-06
申请人： COMMUNIGATE LIMITED , HAYTON, Paul, Michael , JONES, Philip, Stephen
发明人： HAYTON, Paul, Michael , JONES, Philip, Stephen
IPC分类号： H04M1/725
CPC分类号： H04M1/72547 , H04M1/72544 , H04M1/72561 , H04M1/7258
摘要： A messaging system for sending formatted pages combining pictures, text, hyperlinks and other web-style content between mobile telephony devices such as mobile telephones or PDAs within a network or community of users. The display of the messages on the mobile terminals is defined by means of command set which allows users to specify message content as occupying a certain percentage of the display screen of the destination device. The command set also includes functionality allowing hyperlinks within a message to be displayable as a separate list of hyperlinks on operation of a soft key on the mobile device for ease of navigation.
摘要翻译：用于在网络或用户社区内的移动电话设备（例如移动电话或PDA）之间发送格式化的页面组合图片，文本，超链接和其他网络样式内容的消息系统。移动终端上的消息的显示通过命令集定义，该命令集允许用户将消息内容指定为占用目标设备的显示屏幕的一定比例。命令集还包括允许消息中的超链接在移动设备上的软键操作上作为单独的超链接列表可显示的功能，以便于导航。

7. 发明申请

WO2007091089A1 MESSAGING SYSTEM 审中-公开
标题翻译：消息传递系统
公开(公告)号：WO2007091089A1
公开(公告)日：2007-08-16
申请号：PCT/GB2007/000466
申请日：2007-02-09
申请人： COMMUNIGATE LIMITED , HAYTON, Paul, Michael , JONES, Philip, Stephen
发明人： HAYTON, Paul, Michael , JONES, Philip, Stephen
IPC分类号： H04L12/16 , H04L12/56 , H04Q7/22
CPC分类号： H04W8/245 , H04L51/38 , H04W4/08 , H04W76/20
摘要： A method of extending a data communications network service provided over cellular telephones or telephony-enabled PDAs and transmitting and receiving messages via the Internet, by providing for an existing user node of the data communications network service to form an invitation message to a potential new user node, which invitation message is sent to a server via the data communications network service, passed by the server to the potential new user node by a different communications service e.g. SMS, and on acceptance by the potential new user node, a software application providing for the new user node to be incorporated into the data communications network service is automatically downloaded to the new user node. Following automatic download of the software application both user nodes are then provided by the server with each other's contact details within the data communications network service by placing dummy messages each appearing to be from the other node in respective inboxes for the user nodes.
摘要翻译：通过提供数据通信网络服务的现有用户节点来向潜在的新用户提供邀请消息来扩展通过蜂窝电话或启用电话的PDA提供的数据通信网络服务并且经由因特网发送和接收消息的方法节点，该邀请消息经由数据通信网络服务被发送到服务器，由服务器通过不同的通信服务传递给潜在的新用户节点，例如 SMS，并且由潜在的新用户节点接受，向新用户节点自动下载提供用于并入数据通信网络服务的新用户节点的软件应用。在自动下载软件应用程序之后，服务器将通过在用户节点的相应收件箱中将来自另一个节点的虚拟消息放在相应的收件箱中，由服务器提供数据通信网络服务中的每个联系人的两个用户节点。

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