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1. 发明申请

WO2008124285A1 A CONTENT ITEM DISTRIBUTION SYSTEM AND METHOD OF DISTRIBUTION THEREFOR 审中-公开
标题翻译：内容项目分配系统及其分配方法
公开(公告)号：WO2008124285A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/058085
申请日：2008-03-25
申请人： MOTOROLA, INC. , WADDINGTON, Simon , BOURNE, David, R. , BOUZID, Makram , BRATU, Ben, M.
发明人： WADDINGTON, Simon , BOURNE, David, R. , BOUZID, Makram , BRATU, Ben, M.
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02
摘要： A content item distribution system comprises a server (101) recommending content items to remote user devices (103). The server (101) stores a hierarchical user cluster structure wherein user clusters at a higher hierarchical level comprise one or more user clusters of a next lower hierarchical level. An initialisation processor (205) selects a first user cluster at a first hierarchical level for a content item. A sample processor (207, 211) recommends the content item to a sample group of user devices (103) of the first user cluster and receives user rating feedback from these. A propagation processor (213) determines if the user rating feedback meets a popularity criterion for the first content item and if so recommends the content item to user devices (103) of a second user cluster which is at a higher hierarchical level than the first hierarchical level and comprises the first user cluster group and at least one other user cluster of the first hierarchical level.
摘要翻译：内容项目分发系统包括向远程用户设备（103）推荐内容项的服务器（101）。服务器（101）存储层次化用户群集结构，其中较高层次级别的用户群集包括下一级别级别的一个或多个用户群集。初始化处理器（205）为内容项选择第一层级的第一用户簇。样本处理器（207,211）将内容项目推荐到第一用户群集的用户设备（103）的样本组，并从其接收用户评级反馈。传播处理器（213）确定用户评级反馈是否满足第一内容项目的流行度标准，如果是，则建议将内容项目推荐到比第一层级更高层级的第二用户集群的用户设备（103）级别并且包括第一用户群集组和第一层级的至少一个其他用户群集。

2. 发明申请

WO2010033346A3 SELECTION OF ASSOCIATED CONTENT FOR CONTENT ITEMS 审中-公开
公开(公告)号：WO2010033346A3
公开(公告)日：2010-03-25
申请号：PCT/US2009/054722
申请日：2009-08-24
申请人： MOTOROLA, INC. , WADDINGTON, Simon , BRATU, Ben , KOMPATSIARIS, Ioannis , MENEMENIS, Fotis , PAPADOPOULOS, Symeon
发明人： WADDINGTON, Simon , BRATU, Ben , KOMPATSIARIS, Ioannis , MENEMENIS, Fotis , PAPADOPOULOS, Symeon
IPC分类号： G06Q50/00 , G06F17/30
摘要： A content device may select associated content, such as adverts, for a user selected content item based on textual characterizing data for the associated content and the user selected content item. A term set characterizing the user selected content item is expanded using semantic graphs and similarity values between the expanded term set and term sets describing associated content is calculated. A specific associated content item is then selected based on the similarity values. The semantic graph based term set expansion may allow improved accuracy in selecting appropriate associated content while providing a process that is suitable for resource constrained scenarios. In particular, communication resource, memory resource, and computational resource usage may be kept low.

3. 发明申请

WO2009098492A2 MODULATION OF ADENOVIRAL TROPISM 审中-公开
标题翻译： ADENOVIRAL TROPISM的调节
公开(公告)号：WO2009098492A2
公开(公告)日：2009-08-13
申请号：PCT/GB2009/000363
申请日：2009-02-09
申请人： BAKER, Andrew , WADDINGTON, Simon , MCVEY, John
发明人： BAKER, Andrew , WADDINGTON, Simon , MCVEY, John
IPC分类号： A61K38/16 , A61K35/58 , C07K16/06 , A61K48/00 , G01N33/569 , G01N33/68 , A61K38/48 , C12N15/861
CPC分类号： A61K38/162 , A61K35/58 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10345 , C12N2810/6018 , C12N2810/857 , G01N33/56983 , G01N2333/075 , G01N2333/745 , G01N2500/02
摘要： The invention provides materials and methods for modulating adenoviral tropism for hepatocytes and other cell types such as splenocytes. It relates to the findings that hypervariable regions (HVRs) of the viral hexon protein interact with the Gla domain of the blood clotting factor FX as part of the infective process in vivo. The invention provides means to disrupt the interaction between hexon and FX, thus reducing infection of hepatocytes and splenocytes, as well as use of targeting agents comprising the Gla domain or a fragment thereof to direct adenoviral vectors to desired target cell or tissue types.
摘要翻译：本发明提供用于调节肝细胞和其他细胞类型如脾细胞的腺病毒向性的材料和方法。它涉及病毒六邻体蛋白的高变区（HVR）与凝血因子FX的Gla结构域作为体内感染过程的一部分相互作用的发现。本发明提供了破坏六邻体和FX之间的相互作用的手段，从而减少肝细胞和脾细胞的感染，以及使用包含Gla结构域或其片段的靶向剂以将腺病毒载体引导至期望的靶细胞或组织类型。

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