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1. 发明申请

WO2012082752A2 ANTI-CCL25 AND ANTI-CCR9 ANTIBODIES FOR THE PREVENTION AND TREATMENT OF CANCER AND CANCER CELL MIGRATION 审中-公开
标题翻译：用于预防和治疗癌症和癌细胞迁移的抗CCL25和抗CCR9抗体
公开(公告)号：WO2012082752A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064667
申请日：2011-12-13
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
发明人： LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： C07K16/24 , C07K16/2866 , C07K2317/73
摘要： Methods for prevention or inhibition of the growth or metastasis of cancer cells in a subject are disclosed. One method comprises the step of administering to the subject a therapeutically effective amount of an antibody to the chemokine CCL25 and/or the chemokine receptor CCR9. Another method comprises the step of administering to the subject a therapeutically effective amount of an expression vector that expresses an antibody to the chemokine CCL25 and/or the chemokine receptor CCR9.
摘要翻译：公开了用于预防或抑制受试者中癌细胞的生长或转移的方法。一种方法包括向受试者施用治疗有效量的趋化因子CCL25和/或趋化因子受体CCR9的抗体的步骤。另一种方法包括向受试者施用治疗有效量的表达趋化因子CCL25和/或趋化因子受体CCR9抗体的表达载体的步骤。

2. 发明申请

WO2012074577A3 COMPOSITIONS AND METHODS FOR DETECTION AND MANAGEMENT OF MALARIA 审中-公开
公开(公告)号：WO2012074577A3
公开(公告)日：2012-06-07
申请号：PCT/US2011/043058
申请日：2011-07-06
申请人： MOREHOUSE SCHOOL OF MEDICINE , STILES, Jonathan, K. , LILLARD, James, W. , ARMAH, Henry Benjamin, A. , WILSON, Nana, O. , UDHAYAKUMAR, Venkatachalam
发明人： STILES, Jonathan, K. , LILLARD, James, W. , ARMAH, Henry Benjamin, A. , WILSON, Nana, O. , UDHAYAKUMAR, Venkatachalam
IPC分类号： G01N33/68 , G01N33/569 , C12Q1/68
摘要： Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCLIO, VEGF, PGDF, IL-lRa, IL-8, ΜΙΡ-Ι β, sFas, Fas-L, sTNF-R2, and sTNF-Rl as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCLIO and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.

3. 发明申请

WO2012166588A2 CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF 审中-公开
标题翻译：化合物 - 免疫球蛋白融合多肽，组合物，制备和使用方法
公开(公告)号：WO2012166588A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/039550
申请日：2012-05-25
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W.
发明人： LILLARD, James, W.
IPC分类号： A61K38/16 , A61K38/17 , A61K48/00 , A61P35/00
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/521 , C07K2319/30 , Y02A50/401
摘要： This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
摘要翻译：本申请涉及趋化因子 - 免疫球蛋白融合多肽和趋化因子 - 聚合物缀合物。融合多肽和缀合物可用于治疗趋化因子受体介导的病症并调节炎症，炎性细胞运动，癌细胞运动或癌细胞存活。

4. 发明申请

WO2014003744A1 ANTI-CXCL9, ANTI-CXCL 10, ANTI-CXCL 11, ANTI-CXCL 13, ANTI-CXCR3 AND ANTI-CXCR5 AGENTS FOR INFLAMMATORY DISORDER 审中-公开
标题翻译：抗CXCL9，抗CXCL10，抗CXCL11，抗CXCL13，抗CXCR3和抗CXCR5抗炎药物
公开(公告)号：WO2014003744A1
公开(公告)日：2014-01-03
申请号：PCT/US2012/044475
申请日：2012-06-27
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W.
发明人： LILLARD, James, W.
IPC分类号： A61K39/395 , A61K48/00 , A61K38/17 , A61P29/00 , A61P3/10
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/76 , G01N33/6893 , G01N2333/7158 , G01N2800/52
摘要： A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a biological sample obtained from the subject; and (b) comparing the level of expression of said one or more inflammatory disease markers in the biological sample to a normal level of expression of the one or more inflammatory disease markers, wherein the one or more inflammatory disease markers comprise one or more markers selected from the group consisting of CXCL9, CXCLIO, CXCLl 1, CXCLl 3, CXCR3 and CXCR5. Also disclosed are a method for monitoring the course of treatment for an inflammatory disease in a subject and a kit for detecting an inflammatory disease in a subject.
摘要翻译：公开了一种用于检测受试者的炎性疾病的方法。该方法包括以下步骤：（a）检测从受试者获得的生物样品中的一种或多种炎性疾病标志物的表达水平; 和（b）将生物样品中所述一种或多种炎性疾病标志物的表达水平与一种或多种炎症性疾病标志物的正常水平的表达进行比较，其中所述一种或多种炎性疾病标志物包括选择的一种或多种标志物由CXCL9，CXCLIO，CXCL11，CXCL13，CXCR3和CXCR5组成。还公开了一种用于监测受试者的炎性疾病的治疗过程的方法和用于检测受试者的炎性疾病的试剂盒。

5. 发明申请

WO2012082742A2 DETECTING CANCER WITH ANTI-CCL25 AND ANTI-CCR9 ANTIBODIES 审中-公开
标题翻译：用抗CCL25和抗CCR9抗体检测癌症
公开(公告)号：WO2012082742A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064653
申请日：2011-12-13
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
发明人： LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
IPC分类号： G01N33/574 , G01N33/68 , G01N33/53
CPC分类号： G01N33/57496 , C07K16/24 , C07K16/2866 , C07K2317/73 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57407 , G01N33/57426 , G01N33/5743 , G01N33/57488 , G01N33/57492 , G01N2333/521 , G01N2333/522 , G01N2333/7158 , G01N2800/52
摘要： Methods for detecting cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprise CCL25 or CCR9 or both CCL25 and CCR9.
摘要翻译：公开了用于检测受试者中癌症的方法。该方法包括检测从受试者获得的生物样品中一种或多种癌症标志物的表达水平; 以及将生物样品中的一种或多种癌症标志物的表达水平与一种或多种癌症标志物的正常表达水平进行比较。一种或多种癌症标志物包括CCL25或CCR9或CCL25和CCR9两者。

6. 发明申请

WO2012082494A2 THE USE OF ANTI-CXCL13 AND ANTI-CXCR5 ANTIBODIES FOR THE TREATMENT OR DETECTION OF CANCER 审中-公开
标题翻译：抗-CXCL13和抗CXCR5抗体用于治疗或检测癌症的用途
公开(公告)号：WO2012082494A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/063761
申请日：2011-12-07
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
发明人： LILLARD, James, W. , SINGH, Shailesh , SINGH, Rajesh
IPC分类号： G01N33/574 , G01N33/68 , G01N33/53
CPC分类号： G01N33/57407 , G01N2333/7158
摘要： The use of anti-CXCL13 and anti-CXCR5 antiboies for the treatment or dectection of in a subject is disclosed.
摘要翻译：公开了使用抗CXCL13和抗CXCR5抗体治疗或检测受试者。

7. 发明申请

WO2014051567A1 CHIMERIC NEUREGULINS AND METHOD OF MAKING AND USE THEREOF 审中-公开
标题翻译： CHIMERIC NEUREGULINS及其制备和使用方法
公开(公告)号：WO2014051567A1
公开(公告)日：2014-04-03
申请号：PCT/US2012/057272
申请日：2012-09-26
申请人： MOREHOUSE SCHOOL OF MEDICINE , FORD, Byron, D. , LILLARD, James, W.
发明人： FORD, Byron, D. , LILLARD, James, W.
IPC分类号： C07K19/00 , C07K14/475 , A61K38/18 , A61P25/16
CPC分类号： C07K14/4756 , A61K38/00 , C07K2319/00 , C07K2319/74
摘要： Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin.
摘要翻译：公开了含有嵌合神经调节蛋白多肽的组合物和制备此类多肽的方法。嵌合神经调节蛋白包含至少10个氨基酸的第一部分，其中第一部分衍生自第一多肽; 和至少5个氨基酸的第二部分，其中第二部分衍生自第二个多肽; 其中所述第一多肽是神经调节蛋白，并且所述嵌合神经调节蛋白与整合素，Erb 3或Erb 4相比，与第一神经调节蛋白的结合亲和力增强。

8. 发明申请

WO2014003742A1 ANTI-CXCL9, ANTI-CXCL10, ANTI-CXCL11, ANTI-CXCL13, ANTI-CXCR3 AND ANTI-CXCR5 AGENTS FOR INHIBITION OF INFLAMMATION 审中-公开
标题翻译： ANTI-CXCL9，ANTI-CXCL10，ANTI-CXCL11，ANTI-CXCL13，ANTI-CXCR3和抗CXCR5抑制炎症的药剂
公开(公告)号：WO2014003742A1
公开(公告)日：2014-01-03
申请号：PCT/US2012/044464
申请日：2012-06-27
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W.
发明人： LILLARD, James, W.
IPC分类号： A61K39/395 , A61K48/00 , A61P29/00
CPC分类号： C07K16/24 , A61K2039/505
摘要： Methods for preventing or inhibiting inflammation in a subject are disclosed. In one aspect, the method comprises administering to a subject diagnosed with an inflammatory disease an effective amount of an anti-inflammatory agent that (1) inhibits the expression of CXCL9, CXCL10, CXCL11, CXCL13, CXCR3 and/or CXCR5, or (2) inhibits the interaction between CXCR3 and CXCL9, CXCL10 or CXCL11, or between CXCR5 and CXCLl 3, or (3) inhibits a biological activity of CXCL9, CXCL10, CXCL11, CXCL13, CXCR3 and/or CXCR5, wherein the agent comprises an antibody, antibody fragment, short interfering RNA (siRNA), aptamer, synbody, binding agent, peptide, aptamer-siRNA chimera, single stranded antisense oligonucleotide, triplex forming oligonucleotide, ribozyme, external guide sequence, or an agent-encoding expression vector.
摘要翻译：公开了用于预防或抑制受试者的炎症的方法。一方面，该方法包括向被诊断患有炎性疾病的受试者施用有效量的抗炎剂，其（1）抑制CXCL9，CXCL10，CXCL11，CXCL13，CXCR3和/或CXCR5或（2）的表达）抑制CXCR3与CXCL9，CXCL10或CXCL11之间或CXCR5与CXCL13之间的相互作用，或（3）抑制CXCL9，CXCL10，CXCL11，CXCL13，CXCR3和/或CXCR5的生物学活性，其中该试剂包含抗体，抗体片段，短干扰RNA（siRNA），适体，同体，结合剂，肽，适体 - siRNA嵌合体，单链反义寡核苷酸，三重复合形成寡核苷酸，核酶，外部引导序列或代码编码表达载体。

9. 发明申请

WO2013025418A1 DELIVERY SYSTEM FOR SPECIFICALLY TARGETING CANCER CELLS AND METHOD OF USE THEREOF 审中-公开
标题翻译：用于特异性靶向癌细胞的递送系统及其使用方法
公开(公告)号：WO2013025418A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/049988
申请日：2012-08-08
申请人： MOREHOUSE SCHOOL OF MEDICINE , LILLARD, James, W.
发明人： LILLARD, James, W.
IPC分类号： A61K9/16 , A61K9/14 , A61K48/00 , A61K31/7105 , A61K31/7088 , A61P35/00
CPC分类号： A61K31/282 , A61K31/337 , A61K31/365 , A61K38/00 , A61K47/551 , A61K47/6935
摘要： Methods for prevention, treatment or inhibition of the growth or metastasis of cancer cells in a subject are disclosed. One method comprises the step of administering to the subject a therapeutically effective amount of tumor associated antigen binding ligand-coated planetary ball milled (PBM) nanoparticles containing a cytotoxic agent.
摘要翻译：公开了预防，治疗或抑制受试者中癌细胞生长或转移的方法。一种方法包括向受试者施用治疗有效量的含有细胞毒性剂的肿瘤相关抗原结合配体的行星球磨（PBM）纳米颗粒的步骤。

10. 发明申请

WO2022075991A1 ANTI-VIRAL CLEANING COMPOSITION, METHOD OF MAKING AND USE THEREOF 审中-公开
公开(公告)号：WO2022075991A1
公开(公告)日：2022-04-14
申请号：PCT/US2020/054768
申请日：2020-10-08
申请人： MOREHOUSE SCHOOL OF MEDICINE , DEVMAR PRODUCTS, LLC , INNOVATIVE ENVIRONMENTAL COMPANIES
发明人： HAWKINS, Walter , REYNOLDS, Sharon, W. , LILLARD, James, W.
IPC分类号： A01N65/28 , C11D3/382 , C11D3/48
摘要： A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.

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