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1. 发明申请

WO2010028094A1 EVALUATING HEPARIN PREPARATIONS FOR PHARMACEUTICAL USE 审中-公开
标题翻译：评价肝素制剂的药物用途
公开(公告)号：WO2010028094A1
公开(公告)日：2010-03-11
申请号：PCT/US2009055792
申请日：2009-09-02
申请人： MOMENTA PHARMACEUTICALS INC , SCHRIER DAVID , GUNAY NUR SIBEL , SUCATO MEGAN , SMITH STEPHEN , SHRIVER ZACHARY
发明人： SCHRIER DAVID , GUNAY NUR SIBEL , SUCATO MEGAN , SMITH STEPHEN , SHRIVER ZACHARY
IPC分类号： B01D15/08
CPC分类号： G01N30/02 , A61K31/727 , G01N2030/8836 , G06Q10/0635 , B01D15/363
摘要： The disclosure features methods of analyzing preparations of heparin, and materials derived from heparin using strong anion exchange high performance liquid chromatography (SAX-HPLC).
摘要翻译：本公开的特征在于使用强阴离子交换高效液相色谱法（SAX-HPLC）分析肝素制剂和来自肝素的物质的方法。

2. 发明申请

WO2012074679A2 DATA COMMUNICATION SYSTEM FOR A RAIL VEHICLE AND METHOD FOR COMMUNICATING DATA WITH A RAIL VEHICLE 审中-公开
标题翻译：用于铁路车辆的数据通信系统和用于与铁路车辆通信数据的方法
公开(公告)号：WO2012074679A2
公开(公告)日：2012-06-07
申请号：PCT/US2011059676
申请日：2011-11-08
申请人： GEN ELECTRIC , TEETER DAVID CARROL , FOY ROBERT JAMES , BRAND JOHN WILLIAM , COOPER JARED KLINEMAN , WAWRZYNIAK FRANK , GOLDEN SAMUEL , KAPP KEVIN , SMITH STEPHEN , ELDREDGE DAVID
发明人： TEETER DAVID CARROL , FOY ROBERT JAMES , BRAND JOHN WILLIAM , COOPER JARED KLINEMAN , WAWRZYNIAK FRANK , GOLDEN SAMUEL , KAPP KEVIN , SMITH STEPHEN , ELDREDGE DAVID
IPC分类号： B61L3/12
CPC分类号： B61L3/125 , B61L3/127 , B61L15/0027
摘要： A data communication system (100, 600) for a rail vehicle (102, 602) includes a processing module (122, 618) that is configured to interface with the rail vehicle (102, 602) and with a data reading device (120, 616). The data reading device ( 120, 616) is configured to at least one of electromagnetically interrogate or optically read data that is visually presented on a tangible and non- transitory medium (104, 128, 612, 630). The tangible and non-transitory medium (104, 128, 612, 630) is spaced apart from the data reading device (120, 616}. The processing module ( 122, 618) is configured to receive the data from the data reading device (120, 616) and to use the data in connection with one or more operations of the rail vehicle (102, 602).
摘要翻译：一种用于轨道交通工具（102,602）的数据通信系统（100,600）包括处理模块（122,618），其被配置为与轨道交通工具（102,602）接口并与数据读取设备 616）。数据读取装置（120,616）被配置为电磁询问或光学地读取视觉上呈现在有形和非暂时介质（104,128,612,630）上的数据中的至少一个。有形和非暂时介质（104,128,612,630）与数据读取装置（120,616）间隔开，处理模块（122,618）被配置为从数据读取装置（并且使用与铁路车辆（102,602）的一个或多个操作有关的数据。

3. 发明申请

WO03013155A3 METHOD FOR MANAGING A PLURALITY OF RENTAL FACILITIES 审中-公开
标题翻译：管理大量租赁设施的方法
公开(公告)号：WO03013155A3
公开(公告)日：2003-10-02
申请号：PCT/US0220144
申请日：2002-06-26
申请人： CT SHIFT INC , HAFEN JAMES , HOBAN WILLIAM , COCHRANE JAMES , WENGER KARL , SMITH STEPHEN
发明人： HAFEN JAMES , HOBAN WILLIAM , COCHRANE JAMES , WENGER KARL , SMITH STEPHEN
IPC分类号： G06Q10/02 , G06Q10/10 , G06F17/60
CPC分类号： G06Q10/10 , G06Q10/02
摘要： Rental information is stored in a central database. A request to conduct a rental facility transaction is received from a user of web browser over a network. The requested rental transaction is conducted at a central processing center using the rental information. A result for the rental facility transaction is communicated back to the web browser of the user. The rental facility transaction may include operational transactions and management transactions. Changes made by one rental facility transaction are available to subsequent rental facility transactions in real-time.
摘要翻译：出租信息存储在中央数据库中。通过网络从Web浏览器的用户接收到执行租赁设施交易的请求。所要求的租赁交易使用租赁信息在中央处理中心进行。租赁设施交易的结果被传送回用户的网络浏览器。租赁设施交易可能包括经营交易和管理交易。一个租赁设施交易的变更可以随时进行后续的租赁设施交易。

4. 发明申请

WO0107637B1 CONDITIONALLY CONTROLLED, ATTENUATED HIV VACCINE 审中-公开
标题翻译：定期控制，减毒的艾滋病毒疫苗
公开(公告)号：WO0107637B1
公开(公告)日：2001-11-22
申请号：PCT/US0040478
申请日：2000-07-25
申请人： SMITH STEPHEN
发明人： SMITH STEPHEN
IPC分类号： C12N15/09 , A61K31/65 , A61K35/12 , A61K39/21 , A61K48/00 , A61P31/18 , A61P43/00 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/5254 , C12N7/00 , C12N15/85 , C12N2740/16022 , C12N2740/16034 , C12N2740/16043 , C12N2740/16051 , C12N2830/003
摘要： The present invention provides an attenuated HIV vaccine comprising an HIV virus modified to replicate only in the presence of at least one tetracycline analogue. Additionally, the present invention provides a method for immunization of humans against HIV which comprises administering to a human a vaccine including an HIV virus modified to replicate only in the presence of at least one tetracycline analogue. Simultaneously, at least one tetracycline analogue is administered for a period of time to allow replication of the modified HIV virus in vivo sufficient to produce immunity. Preferably, the tetracycline analogue is doxycycline. A replication competent HIV-DoxT virus genome which can be controlled by the presence or absence of doxycycline is produced by preparing a promoter, TetopTCAT; producing a provirus, pHIV-DoxT, using the TetopCAT promoter, and transfecting the pHIV-DoxT in cell lines in the presence of doxycycline. A replication competent HIV-DoxSp virus genome which can be controlled by the presence or absence of doxycycline is produced by preparing a promoter, TetopSpCAT; producing a provirus, pHIV-DoxSp, using the TetopCAT promoter, and transfecting the pHIV-DoxSp in cell lines in the presence of doxycycline. Anti-HIV vaccines are prepared using the HIV-DoxT and HIV-DoxSp virus genomes. These viruses and doxycycline are administered to human hosts. The doxycycline is administered for a time sufficient to build up immunity and then the administration of the drug is stopped so that the doxycycline-dependent viruses will no longer replicate.
摘要翻译：本发明提供了减毒的HIV疫苗，其包含仅在存在至少一种四环素类似物的情况下才被复制的HIV病毒。此外，本发明提供了一种免疫人体抗HIV的方法，该方法包括给人施用包括仅在至少一种四环素类似物存在下才能复制的HIV病毒的疫苗。同时，给予至少一种四环素类似物一段时间以使修饰的HIV病毒体内复制足以产生免疫力。优选地，四环素类似物是多西环素。可通过存在或不存在强力霉素来控制的具有复制能力的HIV-DoxT病毒基因组通过制备启动子TetopTCAT产生; 使用TetopCAT启动子产生前病毒，pHIV-DoxT，并在多西环素存在下在细胞系中转染pHIV-DoxT。可以通过存在或不存在强力霉素来控制的复制型HIV-DoxSp病毒基因组通过制备启动子TetopSpCAT产生; 使用TetopCAT启动子产生前病毒，pHIV-DoxSp，并在多西环素存在下在细胞系中转染pHIV-DoxSp。使用HIV-DoxT和HIV-DoxSp病毒基因组制备抗HIV疫苗。这些病毒和强力霉素被施用于人类宿主。施用强力霉素足够长的时间以建立免疫性，然后停止施用药物，以使强力霉素依赖性病毒不再复制。

5. 发明申请

WO2008079359A8 HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING 审中-公开
标题翻译：人类IL-12的人体抗体和生产方法
公开(公告)号：WO2008079359A8
公开(公告)日：2009-07-30
申请号：PCT/US2007026212
申请日：2007-12-21
申请人： ABBOTT GMBH & CO KG , SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL EDWARD , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , VELDMAN GEERTRUIDA M , VENTURINI AMY , WIDOM ANGELA , FRIEDRICH STUART , WARNE NICHOLAS W , MYLES ANGELA , ELVIN JOHN GAWAIN , DUNCAN ALEXANDER ROBERT , DERBYSHIRE ELAINE J , CARMEN SARA , HOLTET THOR LAS , DU FOU SARAH LEILA , SMITH STEPHEN
发明人： SALFELD JOCHEN G , ROGUSKA MICHAEL , PASKIND MICHAEL , BANERJEE SUBHASHIS , TRACEY DANIEL EDWARD , WHITE MICHAEL , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , SAKORAFAS PAUL , VELDMAN GEERTRUIDA M , VENTURINI AMY , WIDOM ANGELA , FRIEDRICH STUART , WARNE NICHOLAS W , MYLES ANGELA , ELVIN JOHN GAWAIN , DUNCAN ALEXANDER ROBERT , DERBYSHIRE ELAINE J , CARMEN SARA , HOLTET THOR LAS , DU FOU SARAH LEILA , SMITH STEPHEN
IPC分类号： A61K8/18 , A61Q13/00 , C07K16/24 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译：公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。

6. 发明申请

WO2008065452A2 A METHOD AND SYSTEM FOR TREATING MIXED MUNICIPAL AND SELECTED COMMERCIAL WASTE 审中-公开
标题翻译：一种处理混合市政和商业垃圾的方法和系统
公开(公告)号：WO2008065452A2
公开(公告)日：2008-06-05
申请号：PCT/GB2007050731
申请日：2007-11-30
申请人： FUTURE FUELS INTERNATIONAL LTD , HOOD PETER , SMITH STEPHEN , SKOURIDES IAKOVOS
发明人： HOOD PETER , SMITH STEPHEN , SKOURIDES IAKOVOS
IPC分类号： B09B3/00 , B03B9/06
CPC分类号： B09B3/00 , B02C18/0084 , B02C2201/06 , B03B9/06 , B09B3/0083 , C10L5/46 , C12M27/10 , C12M45/02 , Y02E50/10 , Y02E50/30 , Y02W30/521 , Y02W30/523
摘要： A method of treating municipal solid waste comprising the steps of: shredding the waste to a first particle size; storing the shredded waste in an aerated storage bay for a first period time; shredding at least some of the waste to a second particle size; and agitating the shredded waste in a rotating drum for a second period of time and then outputting the treated waste; wherein biological decomposition under aerobic conditions takes place in the aerated storage bay and the rotating drum.
摘要翻译：一种处理城市固体废物的方法，包括以下步骤：将废物粉碎至第一粒度; 将粉碎的废物在充气储存室中存放第一个时间; 将至少一些废物粉碎至第二粒径; 并在旋转的滚筒中搅拌碎粉废物第二次，然后输出经处理的废物; 其中在有氧条件下的生物分解发生在充气储存室和旋转鼓中。

7. 发明申请

WO2012164312A2 DIATHERMY KNIFE IONISATION SOURCE 审中-公开
标题翻译：永久性灭火源
公开(公告)号：WO2012164312A2
公开(公告)日：2012-12-06
申请号：PCT/GB2012051259
申请日：2012-06-01
申请人： MICROMASS LTD , PRINGLE STEVEN DEREK , MORRIS MICHAEL RAYMOND , SMITH STEPHEN , MCCULLAGH MICHAEL
发明人： PRINGLE STEVEN DEREK , MORRIS MICHAEL RAYMOND , SMITH STEPHEN , MCCULLAGH MICHAEL
IPC分类号： H01J49/04
CPC分类号： H01J49/16 , A61B17/320068 , A61B17/3203 , A61B18/14 , A61B2018/00994 , A61B2018/1412 , A61B2018/1807 , A61B2218/008 , H01J49/0022 , H01J49/0031 , H01J49/04 , H01J49/0459 , H01J49/049 , H01J49/06 , H01J49/10
摘要： A method of detecting one or more compounds, chemicals or contaminants in a substrate (2) by mass spectrometry is disclosed. A non-living substrate (2) is analysed by contacting the substrate (2) with a diathermy knife (1). An electric current is applied to the diathermy knife (1) such that the diathermy knife1 vaporises a portion of the substrate (2). The vapour is aspirated via a sampling tube (6) pumped by a venturi pump (7) into a vacuum chamber of a mass spectrometer (9). Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionised to form analyte ions which are then mass analysed.
摘要翻译：公开了通过质谱法检测底物（2）中的一种或多种化合物，化学物质或污染物的方法。通过使基板（2）与透热刀（1）接触来分析非活体基板（2）。将电流施加到透热刀（1），使得传热刀1蒸发衬底（2）的一部分。蒸汽通过由文丘里泵（7）泵送到质谱仪（9）的真空室中的取样管（6）吸入。分析物分子被吸入真空室中，因此它们影响真空室的表面，并被电离以形成分析物离子，然后进行质量分析。

8. 发明申请

WO0107637A3 Conditionally controlled, attenuated HIV vaccine 审中-公开
标题翻译：有条件控制，减毒的艾滋病毒疫苗
公开(公告)号：WO0107637A3
公开(公告)日：2001-08-23
申请号：PCT/US0040478
申请日：2000-07-25
申请人： SMITH STEPHEN
发明人： SMITH STEPHEN
IPC分类号： C12N15/09 , A61K31/65 , A61K35/12 , A61K39/21 , A61K48/00 , A61P31/18 , A61P43/00 , C12N5/10 , C12N7/04 , C12N15/85 , C12N15/867 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/5254 , C12N7/00 , C12N15/85 , C12N2740/16022 , C12N2740/16034 , C12N2740/16043 , C12N2740/16051 , C12N2830/003
摘要： A live attenuated human immunodeficiency virus type 1 (HIV-1) whose replication is not constitutive but is instead conditionally regulated (such that rounds of reverse transcription with accompanying potential for error are strictly limited) might yield a paradigm that minimizes evolution to virulence and facilitate vaccine development. We have broached the concept of conditional control of HIV-1 through gain-of-function. Here, we describe the design of constitutively inactive HIV-1 genomes (HIV-DoxT and HIV-DoxSp) which can be conditionally resuscitated to an active state by tetracycline or related analogues. The HIV-DoxT construct comprises an inactivating mutation engineered into TAR, thereby rendering the virus non-responsive to Tat, a 302-bp DNA fragment (TetopT) which contains the tet-operator ligated into a position upstream of the HIV TATAA box, in both the 5' and 3' LTRs, and a reverse tetracycline-controlled activator (RTTA) coding sequence in place of the nef coding region. The HIV-DoxSp construct contains three additional Sp1 sites in the TetopT promoter upstream of the TATAA box thereby generating the promoter TetopSp. Genotypically, HIVDoxT is tat(+)tar(-)nef(-)Sp1(-) and HIVDoxSp is tat(+)tar(-)nef(-)Sp1(+). Since both genomes are genetically tar(-), they would ordinarily be expected to be wholly defective in producing viral proteins and/or particles. However, following transfection into an appropriate cell target, both proviruses, in a doxycycline-dependent fashion, capably released Gag and RT from cells. In the absence of doxycycline, no replication competent virus could be recovered. These findings suggest that the heterologous RTTA+Dox mechanism substituted effectively for Tat/TAR. These constructs should prove useful in the development of HIV-specific immunological and diagnostic reagents.

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