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2. 发明申请

WO2010060104A2 IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION 审中-公开
标题翻译：可植入脂质体嵌入基质组合物，其用途和聚碳酸酯作为组织再生的辅助剂
公开(公告)号：WO2010060104A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/065797
申请日：2009-11-24
申请人： MOMA THERAPEUTICS , SCHUBERT, Shai, Yehoshua
发明人： SCHUBERT, Shai, Yehoshua
IPC分类号： A61K51/12 , A61L27/54 , A61K38/00 , A61L27/52 , A61K38/39
CPC分类号： A61L27/54 , A61K48/0016 , A61L27/18 , A61L27/222 , A61L27/24 , A61L27/3804 , A61L27/44 , A61L27/48 , A61L27/52 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/426 , A61L2300/438 , A61L2300/45 , A61L2300/626 , A61L2400/06 , C08L67/04
摘要： In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.
摘要翻译：在各种实施方案中，本发明描述了在施用治疗的位置中细胞局部重新编程的材料和方法。本发明可用于替代由于疾病，损伤或遗传缺陷而损伤的组织损失的细胞或恢复功能。在各种实施方案中，治疗包括含有脂质体的半固体水凝胶。脂质体可以含有效应分子或分子。当吞噬细胞如单核细胞渗入水凝胶时，它们遇到脂质体并将携带效应分子的脂质体并入细胞。在一些实施方案中，效应分子可以是编码特异性蛋白质表达的遗传物质，例如转录因子，其表达可以启动细胞的重新编程。在其它实施方案中，效应分子可以诱导血管发生。在其它实施方案中，效应分子是肿瘤抗原。该基质可以包含设计成吸引特定细胞到基质的其他效应分子。当基质降解或通过从基质的活性迁移时，可以从基质中释放细胞。细胞也可以保留在基质中，并且可以通过基质材料扩散到周围组织的秘密分子如蛋白质和激素。

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