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1. 发明申请

WO2017100374A1 SPATIAL GENOMICS WITH CO-REGISTERED HISTOLOGY 审中-公开
标题翻译：具有共同注册的组织学的空间基因组学
公开(公告)号：WO2017100374A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065461
申请日：2016-12-07
申请人： MITRA, Partha, P.
发明人： MITRA, Partha, P.
IPC分类号： G01N35/00 , G01N33/68 , G01N33/48 , G01N33/50 , G01N33/62 , G01N33/92
CPC分类号： G06F19/18 , C12Q1/6806 , C12Q1/6869 , G01N1/06 , G01N1/286 , G01N1/36 , G01N2001/2873 , G02B21/34 , G02B21/367 , C12Q2535/122
摘要： Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, altemate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
摘要翻译：通过基因组学和转录组学或两者在空间上分析三维肿瘤体积。用切片机使用胶带转移技术切割薄切片，以使薄切片部分相对于它们在原始组织中的位置顺序地保持没有任何变形或变形，从而可以将三维坐标系固定到每个组织部分。使用坐标系作为网格，利用已知的x，y，z位置从支撑物中的非常精确的位置提取或冲压组织的小样本，并对其进行基因组测序。使用三维坐标系分析序列数据，从而将原始组织分析为三维系统体积。同时，可以对组织切片进行染色和成像，以进行组织化学分析。

2. 发明申请

WO2017176601A2 AUTOMATED SYSTEM AND METHOD FOR ADVANCING TAPE TO TRANSPORT CUT TISSUE SECTIONS 审中-公开
标题翻译：自动化系统和方法，以促进胶带运输切割组织切片
公开(公告)号：WO2017176601A2
公开(公告)日：2017-10-12
申请号：PCT/US2017/025638
申请日：2017-04-01
申请人： CLARAPATH, INC. , ZHANG, Cong , FASCIANO, Mark , MITRA, Partha, P.
发明人： ZHANG, Cong , FASCIANO, Mark , MITRA, Partha, P.
IPC分类号： G01N1/28 , G01N35/00
CPC分类号： G01N1/2813 , G01N35/00009 , G01N2001/2833
摘要： An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
摘要翻译：一种自动化带传送设备，其包括：将连续长度的粘合带馈送通过自动化带传送设备的带馈送机构;以及将粘合带施加到样本块的切割面上的带施加器，其中，样品块的一部分在从样品块切割出部分之后粘附到胶带上。一个滑台将切割后的部分从胶带转移到滑板上。

3. 发明申请

WO2017100373A3 SPATIALLY INDEXED TISSUE BIOBANK WITH MICROSCOPIC PHENOTYPE-BASED RETRIEVAL SYSTEM 审中-公开
公开(公告)号：WO2017100373A3
公开(公告)日：2017-06-15
申请号：PCT/US2016/065460
申请日：2016-12-07
申请人： MITRA, Partha, P.
发明人： MITRA, Partha, P.
IPC分类号： G01N35/00 , G01N1/06
摘要： The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalogue of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the catalogued three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.

4. 发明申请

WO2017176601A3 SYSTEM AND METHOD FOR ADVANCING ADHESIVE TAPE TO TRANSPORT CUT TISSUE SECTIONS 审中-公开
标题翻译：用于将粘合带推进至运输切割组织切片的系统和方法
公开(公告)号：WO2017176601A3
公开(公告)日：2017-10-12
申请号：PCT/US2017/025638
申请日：2017-04-01
申请人： CLARAPATH, INC. , ZHANG, Cong , FASCIANO, Mark , MITRA, Partha, P.
发明人： ZHANG, Cong , FASCIANO, Mark , MITRA, Partha, P.
IPC分类号： G01N1/28 , G01N35/00 , G01N1/06
摘要： An automated tape transfer apparatus (1) including a tape feed mechanism (3) feeding a continuous length of an adhesive tape (2) through the automated tape transfer apparatus (1) and a tape applicator (7) applying the adhesive tape (2) to a cutting face (401) of a sample block (20, 402), wherein a section (600) of the sample block (20, 402) is adhered to the adhesive tape (2) after cutting of the section (600) from the sample block (20, 402). A slide station (5) transfers the cut section (600) from the adhesive tape (2) to a slide (115, 515).
摘要翻译：一种自动带传送装置（1），其包括通过自动带传送装置（1）和带施加器（7）供给连续长度的粘合带（2）的带进给机构（3））将粘合带（2）施加到样本块（20,402）的切割面（401）上，其中样本块（20,402）的部分（600）粘合到粘合带（2）从样本块（20,402）切割部分（600）。滑动台（5）将切割部分（600）从胶带（2）转移到滑动件（115,515）。

5. 发明申请

WO2017100373A2 SPATIALLY INDEXED TISSUE BIOBANK WITH MICROSCOPIC PHENOTYPE-BASED RETRIEVAL SYSTEM 审中-公开
标题翻译：具有显微表型的检索系统的空间诱变组织双库
公开(公告)号：WO2017100373A2
公开(公告)日：2017-06-15
申请号：PCT/US2016/065460
申请日：2016-12-07
申请人： MITRA, Partha, P.
发明人： MITRA, Partha, P.
IPC分类号： C12Q1/00 , G06T7/00
CPC分类号： G06F19/18 , C12Q1/6806 , C12Q1/6869 , G01N1/06 , G01N1/286 , G01N1/36 , G01N2001/2873 , G02B21/34 , G02B21/367 , C12Q2535/122
摘要： The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalogue of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the catalogued three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.
摘要翻译：本发明涉及样品块的顺序，迭代和有序薄片段的保存的连续组，以及从该组片段的一个或多个子系列取得的图像目录，以及组织起来以创建样本块的微观结构的三维轮廓。连续，迭代和有序薄切片的连续组是通过切割和成像该样本块的薄切片来制备的，以便薄切片保持严格按顺序迭代的顺序从样本切割下来块。从编目的三维图像创建空间索引，其可通过基于本地内容的图像检索（LCBIR）进行搜索。 LCBIR查询用于在三维指标内定位微观结构特征，从而使得该部分样本可用于进一步分析和/或提取。

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