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1. 发明申请

WO2010136780A1 METHOD TO DETECT AND SEQUENCE POST TRANSLATIONALLY MODIFIED PEPTIDES 审中-公开
标题翻译：检测和序列后翻译修饰肽的方法
公开(公告)号：WO2010136780A1
公开(公告)日：2010-12-02
申请号：PCT/GB2010/001077
申请日：2010-05-28
申请人： MICROMASS UK LIMITED , HUGHES, Christopher, John , MCKENNA, Thérèse , GORDON, David , KENNY, Daniel, James
发明人： HUGHES, Christopher, John , MCKENNA, Thérèse , GORDON, David , KENNY, Daniel, James
IPC分类号： G01N33/68 , H01J49/00
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/0045 , Y10T436/24
摘要： A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan (1) is performed. A negative ion high resolution MS scan (4) is then performed and then MRM channels in positive ion mode are determined and monitored (5). A positive ion MS/MS scan is then performed.
摘要翻译：公开了一种检测和测序翻译后修饰的肽的方法，其中进行负离子前体扫描（1）。然后执行负离子高分辨率MS扫描（4），然后确定和监测正离子模式中的MRM通道（5）。然后进行正离子MS / MS扫描。

2. 发明申请

WO2012164314A3 ION INLET FOR A MASS SPECTROMETER 审中-公开
公开(公告)号：WO2012164314A3
公开(公告)日：2012-12-06
申请号：PCT/GB2012/051261
申请日：2012-06-01
申请人： MICROMASS UK LIMITED , GORDON, David , KENNY, Daniel James , PRINGLE, Steven Derek
发明人： GORDON, David , KENNY, Daniel James , PRINGLE, Steven Derek
IPC分类号： H01J49/24 , H01J49/06
摘要： An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice (12) and an atmospheric pressure orifice (13). One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice (12) by a pump (14) so that the gas exits via the one or more gas outlets.

3. 发明申请

WO2010136826A1 A METHOD OF DERIVING IMPROVED DATA FROM A MASS SPECTROMETER 审中-公开
标题翻译：从质谱仪中提取改进数据的方法
公开(公告)号：WO2010136826A1
公开(公告)日：2010-12-02
申请号：PCT/GB2010/050926
申请日：2010-06-01
申请人： MICROMASS UK LIMITED , GORDON, David , LITTLE, David Richard , FAROOQ, Amir
发明人： GORDON, David , LITTLE, David Richard , FAROOQ, Amir
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/004 , H01J49/0027 , H01J49/42 , H02M7/48 , H02M2001/008
摘要： The invention relates to a method of deriving improved data from a mass spectrometer. The method includes operating the mass spectrometer in a mode enabling quantitation; assigning a threshold value for the total ion current (TIC) above which at least MS and/or MSMS data is desired; and triggering the mass spectrometer out of the mode enabling quantitation into at least an MS and/or MSMS mode when said TIC rises above the threshold but triggering only at such time at or after a confirmed TIC maxima has been reached.
摘要翻译：本发明涉及从质谱仪导出改进的数据的方法。该方法包括以能够定量的方式操作质谱仪; 为总离子电流（TIC）分配阈值，高于该阈值至少需要MS和/或MSMS数据; 并且当所述TIC升高到阈值以上时触发质谱仪，使得能够定量化为至少MS和/或MSMS模式，但仅在达到确认的TIC最大值之后或之后的时间触发。

4. 发明申请

WO2019158931A1 QUADRUPOLE DEVICES 审中-公开
公开(公告)号：WO2019158931A1
公开(公告)日：2019-08-22
申请号：PCT/GB2019/050405
申请日：2019-02-15
申请人： MICROMASS UK LIMITED
发明人： GREEN, Martin Raymond , GORDON, David , LANGRIDGE, David
IPC分类号： H01J49/42
摘要： A method of operating a quadrupole device is disclosed. The method comprises applying a main drive voltage to the quadrupole device and applying three or more auxiliary drive voltages to the quadrupole device. The three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages.

5. 发明申请

WO2015189548A1 SECONDARY ELECTROSPRAY IONIZATION AT REDUCED PRESSURE 审中-公开
标题翻译：降低压力的二次电沉积离子化
公开(公告)号：WO2015189548A1
公开(公告)日：2015-12-17
申请号：PCT/GB2015/000176
申请日：2015-06-12
申请人： MICROMASS UK LIMITED
发明人： BROWN, Jeffery Mark , GORDON, David , KENNY, Daniel James , MURRAY, Paul
IPC分类号： H01J49/14 , H01J49/16
CPC分类号： H01J49/165 , G01N27/622 , H01J49/0031 , H01J49/145 , H01J49/24
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte (2) in a vacuum housing (5); electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions (4); conveying the charged droplets and/or reagent ions (4) into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analysing the analyte ions with a mass analyser and/or ion mobility analyser (6). Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.
摘要翻译：公开了一种质谱法或离子迁移光谱法，其包括：在真空壳体（5）中提供气相分析物（2）; 在真空壳体外部电喷雾试剂溶液，以形成试剂溶液和/或试剂离子（4）的带电液滴; 将带电的液滴和/或试剂离子（4）输送到真空壳体中并使其与分析物反应以形成分析物离子; 并用质量分析器和/或离子迁移率分析仪（6）分析分析物离子。使试剂溶液和/或试剂离子与分析物在低于大气压的压力下反应提高了反应条件。

6. 发明申请

WO2020084296A1 ION DETECTOR 审中-公开
公开(公告)号：WO2020084296A1
公开(公告)日：2020-04-30
申请号：PCT/GB2019/053008
申请日：2019-10-22
申请人： MICROMASS UK LIMITED
发明人： GORDON, David , KENNY, Daniel James , MOULDS, Richard Barrington , LANGRIDGE, David J.
IPC分类号： H01J49/00 , H01J49/02
摘要： A dual-mode ion detector for a mass and/or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and/or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detecting negative ions.

7. 发明申请

WO2014064400A1 IMPROVED REPRODUCIBILITY OF IMPACT-BASED IONIZATION SOURCE FOR LOW AND HIGH ORGANIC MOBILE PHASE COMPOSITIONS USING A MESH TARGET 审中-公开
标题翻译：使用MESH TARGET改善基于冲击的离子源对低和高有机移动相组合物的可重复性
公开(公告)号：WO2014064400A1
公开(公告)日：2014-05-01
申请号：PCT/GB2012/052653
申请日：2012-10-25
申请人： MICROMASS UK LIMITED
发明人： GORDON, David , BAJIC, Stevan
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/16 , H01J49/0431 , H01J49/0445 , H01J49/26
摘要： An ion source is disclosed comprising one or more nebulisers and one or more mesh or grid targets (20). The one or more nebulisers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more mesh or grid targets (20) and to ionise the droplets to form a plurality of ions.
摘要翻译：公开了一种离子源，其包括一个或多个雾化器和一个或多个网格或网格目标（20）。一个或多个雾化器被布置和适于在使用中发射主要是液滴的流，所述液滴被引起撞击到一个或多个网格或网格目标（20）上，并且使液滴离子以形成多个离子。

8. 发明申请

WO2022043695A1 SYSTEM FOR DETERMINING THE CLEANLINESS OF MASS SPECTROMETER ION OPTICS 审中-公开
公开(公告)号：WO2022043695A1
公开(公告)日：2022-03-03
申请号：PCT/GB2021/052222
申请日：2021-08-26
申请人： MICROMASS UK LIMITED
发明人： GORDON, David , LUMLEY, Nicola , BOOTH, Alastair , MOULDS, Richard
IPC分类号： H01J49/00
摘要： A mass spectrometer is disclosed comprising: an ion detector; ion optics for guiding ions to the ion detector; one or more voltage supply for supplying voltages to said ion optics; control circuitry for controlling the one or more voltage supply so as to switch the ion optics between operating in a first mode in which the ion optics are unable to transmit ions having a first mass to charge ratio or first polarity to the ion detector and a second mode in which the ion optics are able to transmit ions having said first mass to charge ratio or first polarity to the ion detector for a time period; and to repeatedly switch between the first and second modes a plurality of times; and a processor and circuitry configured to: (i) determine the intensity of an ion signal detected by the detector at a first time in each of the time periods that the ion optics are in the second mode; and (ii) determine the intensity of the ion signal detected by the detector at a second, later time in each of the time periods that the ion optics are in the second mode.

9. 发明申请

WO2017194974A1 ION GUIDE 审中-公开
标题翻译：离子指南
公开(公告)号：WO2017194974A1
公开(公告)日：2017-11-16
申请号：PCT/GB2017/051348
申请日：2017-05-15
申请人： MICROMASS UK LIMITED
发明人： SLATER, Stephen Patrick , IVESON, John , MALPAS, Oliver John , CHANDE, Bharat , GORDON, David
IPC分类号： H01J49/06
摘要： Disclosed herein is an ion guide comprising a plurality of axially stacked plates, wherein at least some or all of said plates comprise: a first electrically conductive portion; and a second electrically conductive portion, wherein the second electrically conductive portion is electrically isolated from the first electrically conductive portion, the first and second electrically conductive portions being shaped and arranged relative to each other so as to define an opening through which ions are axially transmitted in use; wherein, in use, a first AC or RF voltage is applied to the first electrically conductive portion and a second AC or RF voltage is applied to the second electrically conductive portion in order to confine ions radially within said opening. The first and second electrically conductive portions (1, 2) may be separately formed and interleaved within the ion guide to define the plates. Alternatively the first (41, 43) and second (42, 44) electrically conductive portions may be printed onto a common substrate (4).
摘要翻译：本文公开了一种离子引导件，其包括多个轴向堆叠的板，其中至少一些或所有所述板包括：第一导电部分; 以及第二导电部分，其中所述第二导电部分与所述第一导电部分电隔离，所述第一导电部分和所述第二导电部分相对于彼此成形并且布置以限定离子沿轴向传输通过的开口正在使用; 其中在使用中，将第一AC或RF电压施加到所述第一导电部分，并将第二AC或RF电压施加到所述第二导电部分，以便将离子径向限制在所述开口内。第一导电部分和第二导电部分（1,2）可以分别形成并交错在离子导向器内以限定板。可选地，第一导电部分（41,43）和第二导电部分（42,44）可以被印刷到公共衬底（4）上。

10. 发明申请

WO2015040391A1 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2015040391A1
公开(公告)日：2015-03-26
申请号：PCT/GB2014/052825
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： GORDON, David , KENNY, Daniel James , MOULDS, Richard Barrington
IPC分类号： H01J49/04 , G01F1/68
CPC分类号： H01J49/025 , G01F1/68 , H01J49/0027 , H01J49/0422 , H01J49/10
摘要： Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater (230) for heating a gas flow (224) to the ion source, a temperature sensor for monitoring the temperature of the heater (230), and a control system (236). The control system (236) is arranged and adapted to determine a flow rate of the gas flow (224) by monitoring the power supplied to the heater (230) and the temperature of the heater (230).
摘要翻译：公开了一种用于质谱仪的装置，包括离子源，用于加热到离子源的气流（224）的加热器（230），用于监测加热器（230）的温度的温度传感器，以及控制系统（236））。控制系统（236）被布置和适于通过监视供应给加热器（230）的功率和加热器（230）的温度来确定气流（224）的流量。

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