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2. 发明申请

WO2003037370A2 ANTHRAX ANTIGENIC COMPOSITIONS 审中-公开
标题翻译： ANTHRAX抗原组合物
公开(公告)号：WO2003037370A2
公开(公告)日：2003-05-08
申请号：PCT/GB2002/004985
申请日：2002-11-01
申请人： MICROBIOLOGICAL RESEARCH AUTHORITY , HUDSON, Michael, John , ROBINSON, Andrew , SILMAN, Nigel , HALLIS, Bassam , PENN, Charles
发明人： HUDSON, Michael, John , ROBINSON, Andrew , SILMAN, Nigel , HALLIS, Bassam , PENN, Charles
IPC分类号： A61K39/07
CPC分类号： A61K39/07
摘要： An antigenic pharmaceutical composition is provided comprising Protective Antigen (PA) and Lethal Factor (LF), wherein said PA and/or LF lacks a functional binding site, thereby preventing said PA and LF from binding together via said binding site or thereby preventing said PA from binding to a native PA cell receptor via said binding site, and wherein said composition is substantially non-toxic to animal cells. The composition is for preventing or minimising anthrax toxicity in mammals, preferably in humans. Also provided are DNA and RNA based vaccines encoding the antigenic components of said pharmaceutical composition. The present specification also describes antibodies that bind to at least one of PA, LF or EF, which binding thereby prevents:- (i) PA from binding to LF or EF, or to a native PA cell receptor; or (ii) LF from binding to PA; or (iii) EF from binding to PA.
摘要翻译：提供了包含保护性抗原（PA）和致死因子（LF）的抗原性药物组合物，其中所述PA和/或LF缺乏功能性结合位点，从而防止所述PA和LF通过结合所述结合位点或由此阻止所述PA通过所述结合位点与天然PA细胞受体结合，并且其中所述组合物对动物细胞基本无毒。该组合物用于预防或最小化哺乳动物，优选人类的炭疽毒性。还提供了编码所述药物组合物的抗原性组分的基于DNA和RNA的疫苗。本说明书还描述了与PA，LF或EF中的至少一个结合的抗体，其结合从而防止： - （i）PA结合LF或EF或结合天然PA细胞受体; 或（ii）LF与PA结合; 或（iii）EF与PA结合。

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