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1. 发明申请

WO2009046205A1 PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：WO2009046205A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078606
申请日：2008-10-02
申请人： MGI GP, INC. , XU, Weizheng , DELAHANTY, Greg , WEI, Ling , ZHANG, Jie
发明人： XU, Weizheng , DELAHANTY, Greg , WEI, Ling , ZHANG, Jie
IPC分类号： A01N43/54
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy- induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治疗化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射进行放射增敏的用途。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

2. 发明申请

WO2006078711A2 DIAZABENZO[DE]ANTHRACEN-3-ONE COMPOUNDS AND METHODS FOR INHIBITING PARP 审中-公开
标题翻译： DIAZABENZO [DE] ANTHRACEN-3-ONE化合物和抑制PARP的方法
公开(公告)号：WO2006078711A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001729
申请日：2006-01-19
申请人： MGI GP, INC. , XU, Weizheng , DELAHANTY, Greg , ZHANG, Jie
发明人： XU, Weizheng , DELAHANTY, Greg , ZHANG, Jie
IPC分类号： A61K31/502
CPC分类号： C07D491/06 , A61K31/495 , A61K31/5025
摘要： The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase ("PARP"), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（“PARP”）的二氮杂苯并[de]蒽-3-酮化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述条件的效果。

3. 发明申请

WO2004105700A2 COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 审中-公开
标题翻译：化合物，方法和用于抑制PARP的药物组合物
公开(公告)号：WO2004105700A2
公开(公告)日：2004-12-09
申请号：PCT/US2004/016524
申请日：2004-05-26
申请人： GUILDFORD PHARMACEUTICALS, INC. , KALISH, Vincent, J. , ZHANG, Jie , XU, Weizheng , LI (James), Jia-He , XING, Amy, D.
发明人： KALISH, Vincent, J. , ZHANG, Jie , XU, Weizheng , LI (James), Jia-He , XING, Amy, D.
IPC分类号： A61K
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase ("PARP"), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供抑制聚（ADP-核糖）聚合酶（“PARP”），含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述病症的作用的方法的化合物。

4. 发明申请

WO2005053609A2 METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS 审中-公开
标题翻译： NAD +依赖性脱乙酰酶抑制剂的方法
公开(公告)号：WO2005053609A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/039220
申请日：2004-11-23
申请人： GUILFORD PHARMACEUTICALS INC. , ZHANG, Jie , XU, Weizheng
发明人： ZHANG, Jie , XU, Weizheng
IPC分类号： A61K
CPC分类号： A61K31/54 , A61K31/12 , A61K31/38
摘要： The present invention relates to methods of treating cancer, cardiovascular disorders, and neurological disorders using NAD+-dependent deacetylase inhibitors.
摘要翻译：本发明涉及使用NAD +依赖性脱乙酰酶抑制剂治疗癌症，心血管疾病和神经障碍的方法。

5. 发明申请

WO2003057666A2 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
标题翻译：二磷酸二肽酶抑制剂IV
公开(公告)号：WO2003057666A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041469
申请日：2002-12-26
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
IPC分类号： C07D
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了新的二肽基肽酶IV抑制剂（DPP IV），包含治疗有效量的DPP IV新型抑制剂的药物组合物，以及治疗医学病症的新方法。本文所述的新型DPP IV抑制剂可用于治疗神经疾病，糖尿病，炎性疾病如关节炎，肥胖症，骨质疏松症，以及可用DPP IV抑制剂治疗的其他计数疾病。

6. 发明申请

WO2003057666A3 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
公开(公告)号：WO2003057666A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041469
申请日：2002-12-26
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
IPC分类号： C07D403/06
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.

7. 发明申请

WO2003014121A1 COMPOUNDS, DERIVATIVES, COMPOSITIONS, PREPARATION AND USES 审中-公开
标题翻译：化合物，衍生物，组合物，制剂和用途
公开(公告)号：WO2003014121A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/024857
申请日：2002-08-06
申请人： GUILFORD PHARMACEUTICALS INC. , XU, Weizheng , FERRARIS, Dana, V. , LI, Jia-He , KALISH, Vincent, J.
发明人： XU, Weizheng , FERRARIS, Dana, V. , LI, Jia-He , KALISH, Vincent, J.
IPC分类号： C07D487/22
CPC分类号： A61K49/0008 , C07D471/04 , C07D471/06 , C07D513/06
摘要： This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
摘要翻译：本发明涉及化合物，药物组合物和使用所公开的化合物抑制PARP的方法。

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