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1. 发明申请

WO2004044170A3 A PANCREATIC ISLET TRANSCRIPTION FACTOR AND USES THEREOF 审中-公开
标题翻译：胰蛋白酶转录因子及其用途
公开(公告)号：WO2004044170A3
公开(公告)日：2005-01-13
申请号：PCT/US0336131
申请日：2003-11-13
申请人： METABOLEX INC , JOHNSON JEFFREY D , PALMA JOHN F , SCHWEITZER ANTHONY C , BLUME JOHN E
发明人： JOHNSON JEFFREY D , PALMA JOHN F , SCHWEITZER ANTHONY C , BLUME JOHN E
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
摘要翻译：本发明提供胰岛转录因子和治疗和诊断糖尿病的方法。

2. 发明申请

WO2005041903A3 METHODS AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF DIABETES 审中-公开
标题翻译：糖尿病诊断和治疗方法和试剂
公开(公告)号：WO2005041903A3
公开(公告)日：2006-03-23
申请号：PCT/US2004036822
申请日：2004-11-03
申请人： METABOLEX INC , PALMA JOHN F , JOHNSON JEFFREY D , BLUME JOHN E , SCHWEITZER ANTHONY , NHONTHACHIT PHETS
发明人： PALMA JOHN F , JOHNSON JEFFREY D , BLUME JOHN E , SCHWEITZER ANTHONY , NHONTHACHIT PHETS
IPC分类号： A61K20060101 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/1709 , A61K38/28 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/042 , A61K2300/00
摘要： The invention relates to methods and reagents for diagnosing and treating diabetes.
摘要翻译：本发明涉及用于诊断和治疗糖尿病的方法和试剂。

3. 发明申请

WO2012016021A3 METHODS OF DETERMINING ACUTE MYELOID LEUKEMIA RESPONSE TO TREATMENT WITH FARNESYLTRANSFERASE INHIBITORS 审中-公开
标题翻译：确定急性髓磷脂抑制剂治疗胰岛素抵抗药物抑制剂的方法
公开(公告)号：WO2012016021A3
公开(公告)日：2012-05-03
申请号：PCT/US2011045693
申请日：2011-07-28
申请人： VERIDEX LLC , VENER TATIANA I , DERECHO CARLO C , PALMA JOHN F , RAPONI MITCH
发明人： VENER TATIANA I , DERECHO CARLO C , PALMA JOHN F , RAPONI MITCH
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： The disclosed method rapidly identifies with desired accuracy AML patients, including elderly AML patients, likely to respond to treatment with a combination of a farnesyltransferase inhibitor and one or more of etoposide, teniposide, tamoxifen, sorafenib, paclitaxel, temozolomide, topotecan, trastuzumab and cisplatinum. In an embodiment, the improvements include the use of whole blood rather than the customary bone marrow sample, thus making the assay more accurate, rapid, less intrusive, less expensive as well as less painful. The method includes evaluation of a two-gene expression ratio (RASGRP1 :APTX), which with a corresponding threshold, provides sufficient accuracy for predicting the response to the combination treatment. In the preferred embodiment the combination treatment combines tipifarnib (Rl 15777, ZARNESTRA®) with etoposide. Further, the elderly AML patients identified as being likely responsive to the combination treatment with tipinifarb and etoposide have a complete recovery rate comparable to the best therapy available for younger patients.
摘要翻译：所公开的方法快速鉴定具有所需精确度的AML患者，包括老年AML患者，其可能对法呢基转移酶抑制剂和依托泊苷，替尼泊苷，他莫昔芬，索拉非尼，紫杉醇，替莫唑胺，托泊替康，曲妥珠单抗和顺铂的一种或多种组合的治疗作出反应。在一个实施方案中，改进包括使用全血而不是常规骨髓样品，因此使测定更准确，快速，更少侵入，更便宜以及更少的疼痛。该方法包括评估双基因表达比（RASGRP1：APTX），其具有相应的阈值，为预测组合治疗的应答提供足够的准确性。在优选的实施方案中，组合治疗组合了替伐非尼（R115777，ZARNESTRA？）与依托泊苷。此外，鉴定为可能对tipinifarb和依托泊苷组合治疗有反应的老年AML患者的完全恢复率与可用于年轻患者的最佳疗法相当。

4. 发明申请

WO2009064901A3 DIAGNOSTIC BIOMARKERS OF DIABETES 审中-公开
标题翻译：糖尿病的诊断生物标志物
公开(公告)号：WO2009064901A3
公开(公告)日：2009-09-24
申请号：PCT/US2008083424
申请日：2008-11-13
申请人： VERIDEX LLC , PALMA JOHN F , BACKUS JOHN W , ZHANG YI , WANG YIXIN , YU JACK X , VENER TATIANA , DERECHO CARLO , LEE DONG U
发明人： PALMA JOHN F , BACKUS JOHN W , ZHANG YI , WANG YIXIN , YU JACK X , VENER TATIANA , DERECHO CARLO , LEE DONG U
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.
摘要翻译：公开了用于鉴定在诊断患有糖尿病前期疾病状态和明显II型糖尿病的患者的PBMC中差异表达的基因集的方法，显示3个基因和10个基因标记准确预测患者的糖尿病疾病状态。该应用还描述了用于在护理点处的患者中快速诊断糖尿病疾病状态的试剂盒。

5. 发明申请

WO2004111197A3 GENE EXPRESSION SIGNATURES, METHODS AND COMPOSITIONS FOR DIAGNOSING DISORDERS OF THE LUNG 审中-公开
标题翻译：用于诊断肺癌病症的基因表达标志，方法和组合物
公开(公告)号：WO2004111197A3
公开(公告)日：2006-07-20
申请号：PCT/US2004018492
申请日：2004-06-10
申请人： UNIV BOSTON , AFFYMETRIX INC , BRODY JEROME S , SPIRA AVRUM , SHAH NILA , PALMA JOHN F
发明人： BRODY JEROME S , SPIRA AVRUM , SHAH NILA , PALMA JOHN F
IPC分类号： G01N30/00 , C12N20060101 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A minimally invasive sample procurement method for obtaining airway epithelial cell RNA that can be analyzed by expression profiling, e.g., by array-based gene expression profiling, is disclosed. These methods can be used to identify patterns of gene expression that are diagnostic of lung disorders, e.g., cancer, to identify subjects at risk for developing lung disorders and to custom design an array, e.g., a microarray, for the diagnosis or prediction of lung disorders or susceptibility to lung disorders. Arrays and informative genes are also disclosed for this purpose.
摘要翻译：公开了一种用于获得可通过表达谱分析的气道上皮细胞RNA的微创样品采购方法，例如通过基于阵列的基因表达谱分析。这些方法可用于鉴定诊断肺部疾病（例如癌症）的基因表达模式，以识别发生肺部疾病风险的受试者，并定制设计阵列，例如微阵列，用于诊断或预测肺部疾病或易患肺部疾病。为此也披露了数组和信息基因。

6. 发明申请

WO03103606A3 METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DIABETES 审中-公开
标题翻译：用于治疗和诊断糖尿病的方法和组合物
公开(公告)号：WO03103606A3
公开(公告)日：2005-07-28
申请号：PCT/US0318446
申请日：2003-06-10
申请人： METABOLEX INC
发明人： JOHNSON JEFFREY D , PALMA JOHN F , SCHWEITZER ANTHONY C , BLUME JOHN E
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , C07H21/04 , C07K14/435 , C07K16/18 , C12N5/00 , G01N33/53
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04 , G01N2500/10
摘要： The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposion for diabetes.
摘要翻译：本发明提供编码钾通道的多核苷酸以及使用钾通道治疗和诊断糖尿病和糖尿病易感性的方法。

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