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1. 发明申请

WO1995011880A1 SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS 审中-公开
标题翻译：作为TACHYKININ ANTAGONISTS的替代药物
公开(公告)号：WO1995011880A1
公开(公告)日：1995-05-04
申请号：PCT/GB1994002342
申请日：1994-10-24
申请人： MERCK SHARP & DOHME LIMITED , CHAMBERS, Mark, Stuart , HARRISON, Timothy , OWENS, Andrew, Pate , TEALL, Martin, Richard , WILLIAMS, Brian, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07C233/29
CPC分类号： C07D233/64 , C07C233/11 , C07C233/13 , C07C233/22 , C07C235/34 , C07C235/46
摘要： A class of substituted amide compounds of formula (I), are antagonists of tachykinins, especially substance P, and are therefore of use in the treatment or prevention of physiological disorders associated with an excess of tachykinins, such as inflammation, pain, migraine and emesis. In formula (I) Ar and Ar each independently represents a phenyl group optionally substituted by one, two or three groups selected from halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, trifluoromethyl, cyano, nitro, SR , SOR , SO2R , OR , NR R , NR COR , NR CO2R , CO2R or CONR R , wherein R and R are each independently H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, phenyl or trifluoromethyl; Q represents Ar or a group of formula Het-(CH2)n-, where n is 1 or 2 and Het is a five or six membered nitrogen containing heterocyclic group with 1, 2 or 3 heteroatoms selected from nitrogen, oxygen or sulphur with at most one oxygen or sulphur atom, which group may have the residue of a further 5 or 6 membered aromatic ring fused thereto, and which group may be optionally substituted by a group selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, oxo, thioxo, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, OR , SR , SOR , SO2R , NR R , NR COR , NR CO2R , CO2R , CONR R or phenyl optionally substituted by 1, 2 or 3 groups selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, OR , SR , SOR , SO2R , NR R , NR COR , CO2R , or CONR R , where R and R are each independently H, C1-6alkyl, trifluoromethyl or phenyl; X represents a -CO-NR- or -NR-CO- group, where R is hydrogen, C1-6alkyl, or methyl substituted by a C2-6alkenyl or C2-6alkynyl group; one of Y and Y is a bond or C1-4alkylene group and the other is a C1-4alkylene group; with the proviso that when Ar and Q are dimethoxyphenyl, -Y -X-Y -Ar is not -CH2CON(CH3)CH2C6H5.
摘要翻译：一类取代的式（I）酰胺化合物是速激肽，特别是物质P的拮抗剂，因此可用于治疗或预防与超速激肽相关的生理紊乱症，例如炎症，疼痛，偏头痛和呕吐。在式（I）中，Ar 1和Ar 2各自独立地表示任选被一个，两个或三个选自卤素，C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基，C 3 -6环烷基C 1-4烷基，三氟甲基，氰基，硝基，SR a，SOR a，SO 2 R a，OR a，NR a R b，NR a COR b，NR 其中R a和R b各自独立地为H，C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3 -C 10环烷基 C 3-6环烷基C 1-4烷基，苯基或三氟甲基; Q表示Ar 1或式Het-（CH 2）n - 的基团，其中n为1或2，Het为含有1,2或3个选自氮，氧或氧的杂原子的5或6元含氮杂环基具有至多一个氧或硫原子的硫，该基团可以具有与其稠合的另外5或6元芳环的残基，该基团可以任选地被选自C 1-6烷基，C 2-6烯基， 6-炔基，C3-7环烷基，C3-7环烷基C 1-4烷基，氧代，硫代，卤素，氰基，硝基，三氟甲基，三甲基甲硅烷基，OR c，SR c，SOR c，SO 2 R c，NR c， R d，NR c，C d，NR c CO 2 R d，CO 2 R c，CONR c R d或任选被1,2或3个选自C 1的基团取代的苯基 C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-7环烷基，C 3-7环烷基C 1-4烷基，卤素，氰基，硝基，三氟甲基，三甲基甲硅烷基，OR c， NR c，R c，R c，R d，CO 2 R c或CONR c R d，其中R c和R d各自独立地为H，Cl -6-烷基，三氟甲基或苯基; X表示-CO-NR-或-NR-CO-基，其中R是氢，C 1-6烷基或被C 2-6烯基或C 2-6炔基取代的甲基; Y 1和Y 2之一是键或C 1-4亚烷基，另一个是C 1-4亚烷基; 条件是当Ar 1和Q是二甲氧基苯基时，-Y 1 -X-Y 2 -Ar 2不是-CH 2 CON（CH 3）CH 2 C 6 H 5。

2. 发明申请

WO1994003429A1 SUBSTITUTED AMINES AS TACHYKININ RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为TACHYKININ受体拮抗剂的替代性氨基酸
公开(公告)号：WO1994003429A1
公开(公告)日：1994-02-17
申请号：PCT/GB1993001601
申请日：1993-07-28
申请人： MERCK SHARP & DOHME LIMITED , TEALL, Martin, Richard
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D213/40
CPC分类号： C07D213/40 , C07D307/52
摘要： Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group =O; Z is O, S or NR9, where R9 is H or C1-6alkyl; R1 represents H or C1-6alkyl; R2 represents C1-6alkyl substituted by CONR7(CH2)pR8 (where R7 is H or C1-6alkyl, R8 is optionally substituted heteroaryl and p is 0, 1, 2, 3, 4, 5 or 6); R3 represents H, C1-6alkyl or C2-6alkynyl; R4 represents H, C1-6alkyl or optionally substituted phenyl; R5 represents optionally substituted phenyl; R6 is H or C1-6alkyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy.
摘要翻译：式（I）化合物及其盐和前药，其中Q为任选取代的苯基或二苯甲基; X和Y各自为H或一起形成基团= O; Z是O，S或NR 9，其中R 9是H或C 1-6烷基; R1表示H或C1-6烷基; R 2表示被CONR 7（CH 2）p R 8取代的C 1-6烷基（其中R 7为H或C 1-6烷基，R 8为任选取代的杂芳基且p为0,1,2,3,4,5或6）。 R3表示H，C1-6烷基或C2-6炔基; R 4表示H，C 1-6烷基或任选取代的苯基; R5代表任选取代的苯基; R6是H或C1-6烷基; q为0,1,2或3; 是用于治疗的速激肽拮抗剂。

3. 发明申请

WO1997018206A1 MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译：吗啉衍生物及其用作治疗药物
公开(公告)号：WO1997018206A1
公开(公告)日：1997-05-22
申请号：PCT/GB1996002766
申请日：1996-11-13
申请人： MERCK SHARP & DOHME LIMITED , SWAIN, Christopher, John , TEALL, Martin, Richard , WILLIAMS, Brian, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , C07D417/04
摘要： The present invention relates to compounds of formula (I) wherein X is a 5- or 6-membered C-linked heteroaromatic ring containing 1 to 4 nitrogen atoms and optionally containing in the ring one oxygen or sulphur atom; Y is a group of the formula -(CH2)nNR R , or a methylene- or ethylene-linked imidazolyl group; Z is hydrogen or C1-4alkyl optionally substituted by a hydroxy group; R , R , R , R , R , R and R are a variety of substituents; R is hydrogen, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4alkyl substituted by C1-4alkoxy or hydroxy; R is hydrogen, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4alkyl substituted by one or two substituents selected from C1-4alkoxy, hydroxy or a 4-, 5- or 6-membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R and R , together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring or a non-aromatic azabicyclic ring system; and n is zero, 1 or 2; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherapeutic neuralgia.
摘要翻译：本发明涉及式（I）化合物，其中X是含有1至4个氮原子并且任选地在环中含有一个氧或硫原子的5-或6-元C-连接的杂芳环; Y是式 - （CH 2）n NR 6 R 7或亚甲基或亚乙基连接的咪唑基的基团; Z是氢或任选被羟基取代的C 1-4烷基; R 1，R 2，R 3，R 4，R 5，R 9a和R 9b是各种取代基; R 6是氢，C 1-6烷基，C 3-7环烷基，C 3-7环烷基C 1-4烷基，苯基或被C 1-4烷氧基或羟基取代的C 2-4烷基; R 7是氢，C 1-6烷基，C 3-7环烷基，C 3-7环烷基C 1-4烷基，苯基或被一个或两个选自C 1-4烷氧基，羟基或4-，5-或6-烷氧基的取代基取代的C 2-4烷基，含有一个或两个选自N，O和S的杂原子的6-元杂脂族环; 或R 6和R 7与它们所连接的氮原子一起形成饱和或部分饱和的杂环或非芳族氮杂双环体系; n为零，1或2; 或其药学上可接受的盐。该化合物特别用于治疗或预防疼痛，炎症，偏头痛，呕吐和治疗后神经痛。

4. 发明申请

WO1993001160A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY 审中-公开
标题翻译：芳香族化合物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：WO1993001160A1
公开(公告)日：1993-01-21
申请号：PCT/GB1992001213
申请日：1992-07-03
申请人： MERCK SHARP & DOHME LIMITED , SWAIN, Christopher, John , TEALL, Martin, Richard , WILLIAMS, Brian, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07C217/48
CPC分类号： C07D295/185 , A61K38/00 , C07C211/29 , C07C217/48 , C07C217/64 , C07C229/14 , C07C229/36 , C07C233/18 , C07C233/22 , C07C233/73 , C07C237/06 , C07C237/08 , C07C237/20 , C07C255/13 , C07C255/54 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/24 , C07C275/28 , C07C311/04 , C07C2601/02 , C07D207/28 , C07D241/08 , C07D295/092 , C07K5/06026 , Y10S514/886
摘要： Compounds of formula (I), and salts and prodrugs thereof, wherein Q is R?9CR10R11¿ or CH¿2?R?9CR10R11¿ where R9 is H or OH and R?10 and R11¿ are optionally substituted phenyl, optionally substituted benzyl, C¿5-7?cycloalkyl or (C5-7cycloalkyl)methyl; R?1 and R2¿ are H, optionally substituted C¿1-6? alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkenyl, C2-6 alkynyl, COR?a, COORa¿, COC¿1-6?alkylhalo, COC1-6alkylNR?aRb, CONR12C¿1-6alkylCONR?aRb, CONRaRb¿, or SO¿2?R?a, or R1 and R2¿ together form a chain (CH¿2?)q optionally substituted by oxo where one methylene group may optionally be replaced by O or NR?x; R3¿ is H, C¿1-6? alkyl or C2-6alkenyl; R?4¿ is optionally substituted phenyl(C¿1-3? alkyl); X and Y are H, or X and Y together are =O; and Z is O, S, or NR?7¿; are tachykinin antagonists. They and compositions thereof are useful in therapy.
摘要翻译：由式（I）所示的化合物及其盐和前药，其中Q代表R9CR10R11 CH2R9CR10R11或其中R9是H或OH，R10和R11是任选取代的苯基，任选取代的苄基，环烷基或C 1-7环烷基C5- 7甲基; R1和R2是H，任选取代的C 1-6烷基，任选取代的苯基C 1-4烷基，C 2-6烯基，C 2-6炔基，科拉，COORa，COC 1-6烷基卤素，COC 1-6烷基NRARB，CONR12C1-6alkyleCONRaRb， CONRaRb，或SO2Ra，或者R1和R2一起形成一个链（CH 2）●任选地被氧取代，其中一个亚甲基可任选地被O或N rx个取代; R3是H，C1-6烷基或C2-6链烯基; R4代表任选取代的C1-3烷基苯基; X和Y是H，或者X和Y一起是= O; Z是O，S或NR7。所述化合物是速激肽的拮抗剂，并且含有它们的药物组合物具有治疗用途。

5. 发明申请

WO1995018124A1 SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译：取代的吗啉衍生物及其作为治疗剂的用途
公开(公告)号：WO1995018124A1
公开(公告)日：1995-07-06
申请号：PCT/GB1994002819
申请日：1994-12-23
申请人： MERCK SHARP & DOHME LIMITED , BAKER, Raymond , HARRISON, Timothy , MACLEOD, Angus, Murray , OWENS, Andrew, Pate , SEWARD, Eileen, Mary , SWAIN, Christopher, John , TEALL, Martin, Richard
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D413/06
CPC分类号： C07D413/06 , C07D413/14 , C07F9/6533 , C07F9/65583
摘要： The present invention relates to compounds of formula (I), wherein R is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, CF3, NO2, CN, SR , SOR , SO2R , CO2R , CONR R , C2-6 alkenyl, C2-6 alkynyl or C1-4 alkyl substituted by C1-4 alkoxy, where R and R are hydrogen or C1-4 alkyl; R is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy substituted by C1-4 alkoxy or CF3; R is hydrogen, halogen or CF3; R is selected from the definitions of R ; R is selected from the definitions of R ; R is a 5-membered or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =O, =S or a C1-4 alkyl group, and optionally substituted by an aminoalkyl group; R and R are hydrogen or C1-4 alkyl, or R and R are joined to form a C5-7 ring; X is C1-4 alkylene optionally substituted by oxo; and Y is a C1-4 alkyl group optionally substituted by hydroxyl; with the proviso that if Y is C1-4 alkyl, R is substituted at least by an aminoalkyl group; and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis.
摘要翻译：本发明涉及式（I）化合物，其中R 1是氢，卤素，C 1-6烷基，C 1-6烷氧基，CF 3，NO 2，CN，SR a，SOR a，SO 2 R， α，CO 2 R a，CONR a R b，C 2-6烯基，C 2-6炔基或被C 1-4烷氧基取代的C 1-4烷基，其中R a和R b是氢或C 1-4烷基; R 2是氢，卤素，C 1-6烷基，被C 1-4烷氧基或CF 3取代的C 1-6烷氧基; R 3是氢，卤素或CF 3; R 4选自R 1的定义; R 5选自R 2的定义; R 6是含有2或3个氮原子的5元或6元杂环，其任选被= O，= S或C 1-4烷基取代，并且任选被氨基烷基取代; R 9a和R 9b是氢或C 1-4烷基，或R 9a和R 9b连接形成C5-7环; X是任选被氧代取代的C 1-4亚烷基; Y是任选被羟基取代的C 1-4烷基; 条件是如果Y是C 1-4烷基，则R 6至少被氨基烷基取代; 及其药学上可接受的盐和前药。该化合物特别用于治疗疼痛，炎症，偏头痛和呕吐。

6. 发明申请

WO1995030674A1 MORPHOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF TACHIKININS 审中-公开
标题翻译：吗啉衍生物及其作为TACHIKININS的拮抗剂使用
公开(公告)号：WO1995030674A1
公开(公告)日：1995-11-16
申请号：PCT/GB1995000983
申请日：1995-05-01
申请人： MERCK SHARP & DOHME LIMITED , HAWORTH, Karen, Elizabeth , TEALL, Martin, Richard , SEWARD, Eileen, Mary , SWAIN, Christopher, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D413/06
CPC分类号： C07D413/06
摘要： The present invention relates to compounds of formula (I): wherein X is N or CH; and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis.
摘要翻译：本发明涉及式（I）化合物：其中X是N或CH; 及其药学上可接受的盐和前药。该化合物特别用于治疗疼痛，炎症，偏头痛和呕吐。

7. 发明申请

WO1993024465A1 2/3-(HETEROCYCLIC ALKYL AMINO)-1-(SUBST.-PHENYL-METHOXY)-ETHANES/PROPANES AS TACHYKININ-RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 2 / 3-（杂环烷基氨基）-1-（亚苯基 - 甲氧基） - 乙醇/丙酮作为TACHYKININ-RECEPTOR ANTAGONISTS
公开(公告)号：WO1993024465A1
公开(公告)日：1993-12-09
申请号：PCT/GB1993001072
申请日：1993-05-25
申请人： MERCK SHARP & DOHME LIMITED , OWENS, Andrew, Pate , TEALL, Martin, Richard , WILLIAMS, Brian, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07D233/54
CPC分类号： C07D249/08 , C07D233/76 , C07D257/04 , C07D271/07
摘要： Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR (R is H or C1-6alkyl); R is H, optionally substituted C1-6alkyl, phenyl(C1-4 alkyl), C2-6alkylene, COR , COOR , CONHR , COC1-4alkylNR R , or CONR C1-4alkylCONR R ; R is C1-4alkyl substituted by an optionally substituted aromatic heterocycle; R is H, C1-6alkyl or C2-6alkenyl; R is H, C1-6alkyl or optionally substituted phenyl; R represents optionally substituted phenyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy.
摘要翻译：式（I）化合物及其盐和前药，其中Q表示苯基或二苯甲基; X和Y各自表示H或X和Y一起形成基团= 0; Z是O，S或NR 8（R 8是H或C 1-6烷基）; R 1是H，任选取代的C 1-6烷基，苯基（C 1-4烷基），C 2-6亚烷基，COR a，COOR a，CONHR a，COC 1-4烷基NR a R b，，或CONR a C 1-4烷基CONR a R b; R 2是被任选取代的芳族杂环取代的C 1-4烷基; R 3是H，C 1-6烷基或C 2-6烯基; R 4是H，C 1-6烷基或任选取代的苯基; R 5表示任选取代的苯基; q为0,1,2或3; 是用于治疗的速激肽拮抗剂。

8. 发明申请

WO1994015903A1 3,3 DIPHENYL PROP-2-YL AMINO ACID DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS 审中-公开
标题翻译： 3,3 DIPHENYL PROP-2-YL氨基酸衍生物及其作为TACHYKININ ANTAGONISTS的用途
公开(公告)号：WO1994015903A1
公开(公告)日：1994-07-21
申请号：PCT/GB1993002592
申请日：1993-12-17
申请人： MERCK SHARP & DOHME LIMITED , TEALL, Martin, Richard , WILLIAMS, Brian, John
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07C229/14
CPC分类号： C07C229/14
摘要： Compounds of formula (I), or a salt or prodrug thereof, wherein R represents H, C1-4alkyl or CH2COOH; R represents H or C1-4alkyl, with the proviso that R and R are not both H; R and R each independently represent H, C1-6alkyl, C2-6alkenyl, C1-6alkoxy, halo or trifluoromethyl; A , A , A and A each independently represent H, C1-6alkyl, C1-6alkenyl, C1-6alkoxy, halo or trifluoromethyl; and A and A each independently represent H or C1-4alkyl are tachykinin antagonists useful as medicaments.
摘要翻译：式（I）化合物或其盐或前药，其中R 1表示H，C 1-4烷基或CH 2 COOH; R 2表示H或C 1-4烷基，条件是R 1和R 2不同时为H; R 3和R 4各自独立地表示H，C 1-6烷基，C 2-6烯基，C 1-6烷氧基，卤素或三氟甲基; A 1，A 2，A 3和A 4各自独立地表示H，C 1-6烷基，C 1-6烯基，C 1-6烷氧基，卤素或三氟甲基; 并且A 5和A 6各自独立地表示H或C 1-4烷基是用作药物的速激肽拮抗剂。

9. 发明申请

WO1994007843A1 CYCLOHEXYL AMINE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS 审中-公开
标题翻译：环丙基胺衍生物及其作为TACHYKININ拮抗剂的用途
公开(公告)号：WO1994007843A1
公开(公告)日：1994-04-14
申请号：PCT/GB1993001961
申请日：1993-09-16
申请人： MERCK SHARP & DOHME LIMITED , TEALL, Martin, Richard
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： C07C217/52
CPC分类号： C07C237/06 , C07C217/52 , C07C229/14 , C07C2601/14
摘要： Compounds of formula (I), and salts and prodrugs thereof wherein X represents O or S; R represents optionally substituted phenyl; R represents optionally substituted phenyl; R and R each independently represent H, COR , CO2R or C1-6alkyl optionally substituted by a group selected from (CO2R , CONR R , hydroxy, cyano, COR , NR R , and phenyl optionally substituted by C1-6alkyl, C1-6alkoxy, halo or trifluoromethyl); R represents H or XCH2R wherein R represents optionally substituted phenyl and X is as previously defined; R and R are each H or C1-6alkyl; and R and R each independently represent H, C1-6alkyl, phenyl or trifluoromethyl; are tachykinin receptor antagonists useful in therapy.
摘要翻译：式（I）化合物及其盐和前药其中X代表O或S; R 1表示任选取代的苯基; R 2表示任选取代的苯基; R 3和R 4各自独立地表示H，COR a，CO 2 R a或任选被选自（CO 2 R a，CONR a R b，羟基氰基，COR a，NR a R b和任选被C 1-6烷基，C 1-6烷氧基，卤素或三氟甲基取代的苯基）; R 5表示H或XCH 2 R 6，其中R 6表示任选取代的苯基，X如前所定义; R 7和R 8各自为H或C 1-6烷基; R a和R b各自独立地表示H，C 1-6烷基，苯基或三氟甲基; 是用于治疗的速激肽受体拮抗剂。

10. 发明申请

WO1999007374A1 USE OF NK-1 RECEPTOR ANTAGONISTS FOR TREATING AGGRESSIVE BEHAVIOUR 审中-公开
标题翻译：使用NK-1受体拮抗剂治疗缓解行为
公开(公告)号：WO1999007374A1
公开(公告)日：1999-02-18
申请号：PCT/EP1997006689
申请日：1997-11-25
申请人： MERCK SHARP & DOHME LIMITED , RUPNIAK, Nadia, Melanie
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： A61K31/535
CPC分类号： A61K31/5375 , A61K31/439
摘要： The present invention provides the use of an NK-1 receptor antagonist, and optionally an antipsychotic agent, for the manufacture of a medicament for the treatment or prevention of aggressive behaviour, methods of treatment using such an NK-1 receptor antagonist and pharmaceutical compositions and products comprising it.
摘要翻译：本发明提供了NK-1受体拮抗剂和任选的抗精神病药在制备用于治疗或预防攻击行为的药物中的用途，使用这种NK-1受体拮抗剂和药物组合物的治疗方法和包括它的产品。

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