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1. 发明申请

WO2014099586A1 4-PYRIDINONETRIAZINE DERIVATIVES AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：作为艾滋病毒整合酶抑制剂的4-吡啶二酮衍生物
公开(公告)号：WO2014099586A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/074590
申请日：2013-12-12
申请人： MERCK SHARP & DOHME CORP. , EMBREY, Mark, W. , GRAHAM, Thomas, H. , WALJI, Abbas , WADDELL, Sherman, T. , YU, Tao , ZHANG, Yonglian , LIU, Wensheng , COLEMAN, Paul, J. , WAI, John , STEELE, Thomas , DI MARCO, Christina
发明人： EMBREY, Mark, W. , GRAHAM, Thomas, H. , WALJI, Abbas , WADDELL, Sherman, T. , YU, Tao , ZHANG, Yonglian , LIU, Wensheng , COLEMAN, Paul, J. , WAI, John , STEELE, Thomas , DI MARCO, Christina
IPC分类号： C07D498/04
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/53 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/10 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14 , C07F9/6521
摘要： The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R 1 , R 2 , R 3 and R 5 are as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.
摘要翻译：本发明涉及式（I）的4-吡啶酮三嗪衍生物; 其中A，X，Y，R 1，R 2，R 3和R 5如本文所定义。本发明还涉及包含至少一种4-吡啶酮三嗪衍生物的组合物，以及使用4-吡啶酮三嗪衍生物治疗或预防受试者中HIV感染的方法。

2. 发明申请

WO2015089847A1 SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：作为艾滋病毒整合抑制剂的螺环化合物
公开(公告)号：WO2015089847A1
公开(公告)日：2015-06-25
申请号：PCT/CN2013/090156
申请日：2013-12-20
申请人： MERCK SHARP & DOHME CORP. , GRAHAM, Thomas H. , LIU, Wensheng , YU, Tao , ZHANG, Yonglian , WADDELL, Sherman T. , WAI, John S. , COLEMAN, Paul J. , SANDERS, John M. , EMBREY, Mark W. , WALJI, Abbas , FERGUSON, Ronald Dale II , MARCO, Christina Ng Di , STEELE, Thomas , HU, Lihong , PENG, Xuanjia
发明人： GRAHAM, Thomas H. , LIU, Wensheng , YU, Tao , ZHANG, Yonglian , WADDELL, Sherman T. , WAI, John S. , COLEMAN, Paul J. , SANDERS, John M. , EMBREY, Mark W. , WALJI, Abbas , FERGUSON, Ronald Dale II , MARCO, Christina Ng Di , STEELE, Thomas , HU, Lihong , PENG, Xuanjia
IPC分类号： C07D471/20 , C07D493/20 , C07D495/20 , C07D471/22 , A61K31/499 , A61K31/53 , A61K31/55 , A61P31/18
CPC分类号： A61K31/53 , A61K31/427 , A61K31/499 , A61K31/513 , A61K31/52 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/20 , C07D471/22 , C07D475/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D495/20 , C07F9/65616 , A61K2300/00
摘要： Disclosed are Spirocyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, where A, B, X, Y, R 1 , R 2 and R 11 are as defined herein. Composition comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject are also disclosed.
摘要翻译：公开了式（I）的螺环杂环化合物及其药学上可接受的盐，其中A，B，X，Y，R 1，R 2和R 11如本文所定义。还公开了包含至少一种螺环杂环化合物的组合物，以及使用螺环杂环化合物治疗或预防受试者中HIV感染的方法。

3. 发明申请

WO2013052526A1 TRIAZOLYL PDE10 INHIBITORS 审中-公开
标题翻译： TRIAZOLYL PDE10抑制剂
公开(公告)号：WO2013052526A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/058525
申请日：2012-10-03
申请人： MERCK SHARP & DOHME CORP. , COX, Christopher, D. , DUDKIN, Vadim, Y. , KIM, June, J. , KUDUK, Scott, D. , MCVEAN, Carol , REGER, Thomas , STEEN, Justin , STEELE, Thomas
发明人： COX, Christopher, D. , DUDKIN, Vadim, Y. , KIM, June, J. , KUDUK, Scott, D. , MCVEAN, Carol , REGER, Thomas , STEEN, Justin , STEELE, Thomas
IPC分类号： A01N43/38
CPC分类号： C07D487/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted triazolyl compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译：本发明涉及可用作治疗与磷酸二酯酶10（PDE10）相关的中枢神经系统疾病的治疗剂的取代的三唑基化合物。本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症，精神病或亨廷顿氏病以及与纹状体功能减退或基底神经节功能障碍相关的疾病的用途。

4. 发明申请

WO2010033177A1 MOBILE CRUSHING STATION 审中-公开
标题翻译：移动式破碎站
公开(公告)号：WO2010033177A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/005151
申请日：2009-09-16
申请人： FLSMIDTH RAHCO INC. , DAVIS, Glenn , STEELE, Thomas , CULLEY, Jacob
发明人： DAVIS, Glenn , STEELE, Thomas , CULLEY, Jacob
IPC分类号： A01D34/00
CPC分类号： B02C21/026 , B02C23/02
摘要： A mobile crushing station for receiving and comminuting excavated material from earth moving vehicles provides two spaced apart moveable skips connected to a chassis or frame. The skips are configured to move to dump material fed into the skips into a feed hopper. The feed hopper is positioned to guide material onto a feed conveyor, such as an inclined apron conveyor. The feed conveyor is configured to transport material to a feed orifice of a crushing device, such as a sizer, a crusher, or a crushing circuit. The crushing device is configured to crush material fed into the crushing device. The crushing device also has a discharge orifice that is positioned above a portion of a discharge conveyor. The mobile crushing station is configured to be moveable such that the mobile crushing station may be repositioned closer to an excavation site as excavation activities progress.
摘要翻译：用于从地面移动车辆接收和粉碎挖掘的材料的移动破碎站提供连接到底盘或框架的两个间隔开的可移动跳跃。跳槽被配置为移动以将进料到料斗中的料料倾倒到进料斗中。进料斗定位成将材料引导到进料输送机上，例如倾斜的皮圈输送机。进料输送机被配置为将材料输送到破碎装置的进料孔，例如筛分机，破碎机或破碎回路。破碎装置构造成粉碎送入破碎装置的材料。破碎装置还具有位于排出输送机的一部分上方的排出孔。移动破碎站被构造成可移动，使得移动破碎站可以随着挖掘活动的进行而重新定位到更靠近挖掘位置。

5. 发明申请

WO2009078932A1 3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的3,4-取代吡咯烷酮β-分泌酶抑制剂
公开(公告)号：WO2009078932A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/013550
申请日：2008-12-10
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , STACHEL, Shawn, J. , STEELE, Thomas , PETROCCHI, Alessia
发明人： STACHEL, Shawn, J. , STEELE, Thomas , PETROCCHI, Alessia
IPC分类号： C07B61/00 , C12Q1/02
CPC分类号： C07D413/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07D491/10
摘要： The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译：本发明涉及作为β-分泌酶的抑制剂的式（I）的3,4-取代吡咯烷化合物，其可用于治疗其中涉及β-分泌酶的疾病，例如阿尔茨海默病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

6. 发明申请

WO2012082578A2 PROCESSING ADDITIVES AND USES OF SAME IN ROTATIONAL MOLDING 审中-公开
标题翻译：加工添加剂及其在旋转成型中的用途
公开(公告)号：WO2012082578A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064320
申请日：2011-12-12
申请人： CYTEC TECHNOLOGY CORP. , SAMUELS, Sari-Beth , STEELE, Thomas , ENG, J. Mon, Hei , GUPTA, Ram , PENG, Lingqing
发明人： SAMUELS, Sari-Beth , STEELE, Thomas , ENG, J. Mon, Hei , GUPTA, Ram , PENG, Lingqing
IPC分类号： C08J3/20
CPC分类号： B29C41/04 , C08K5/00 , C08K5/005 , C08K5/1545 , C08K5/34 , C08K5/51 , C08L23/0815 , Y02P20/124 , C08L23/02
摘要： The cycle time of polymer compositions subjected to a rotomolding process is improved {i.e., reduced), while the processing window is simultaneously enlarged through the use of a polymer-stabilizing amount of a processing stabilizer system having at least one chroman-based compound according to Formula V:
摘要翻译：经受滚塑过程的聚合物组合物的循环时间得到改善（即减少），同时通过使用聚合物稳定化量的具有至少一种苯并二氢吡喃基化合物的加工稳定剂体系同时扩大加工窗口，根据公式V：

7. 发明申请

WO2009120652A2 MONOCYCLIC CGRP RECEPTOR ANTAGONISTS 审中-公开
标题翻译：单克隆CGRP受体拮抗剂
公开(公告)号：WO2009120652A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038013
申请日：2009-03-24
申请人： MERCK & CO., INC. , SELNICK, Harold, G. , BELL, Ian, M. , MCWHERTER, Melody , STAAS, Donnette, D. , STACHEL, Shawn, J. , STEELE, Thomas , STUMP, Craig , WOOD, Michael, R. , ZARTMAN, C., Blair
发明人： SELNICK, Harold, G. , BELL, Ian, M. , MCWHERTER, Melody , STAAS, Donnette, D. , STACHEL, Shawn, J. , STEELE, Thomas , STUMP, Craig , WOOD, Michael, R. , ZARTMAN, C., Blair
IPC分类号： C07D491/10
CPC分类号： C07D471/10 , C07D403/06 , C07D471/20 , C07D519/00
摘要： The present invention is directed to compounds of the formula (I) : (wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , G 1 , G 2 , G 3 , G 4 , J, Q, E a , E b , E c , R 6 , R 7 , R PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译：本发明涉及式（I）的化合物：（其中变量A1，A2，A3，A4，A5，A6，A7，A8，G1，G2，G3，G4，J，Q，Ea，Eb，Ec ，R6，R7，RPG和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

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