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1. 发明申请

WO2007084670A3 SPECIFIC THERAPY USING INTEGRIN LIGANDS FOR TREATING CANCER 审中-公开
标题翻译：使用整合配体治疗癌症的特殊治疗
公开(公告)号：WO2007084670A3
公开(公告)日：2007-11-22
申请号：PCT/US2007001446
申请日：2007-01-18
申请人： MERCK PATENT GMBH , GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
发明人： GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
IPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K41/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K38/12 , A61K41/00 , A61K2300/00
摘要： The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.
摘要翻译：本发明涉及用于治疗肿瘤和肿瘤转移的组合疗法，其包括施用整联蛋白配体，优选整联蛋白拮抗剂，以及当与所述配体连续施用时具有协同效力的辅助治疗剂或疗法形式，例如化疗剂和或放射疗法。该疗法导致每种单独治疗剂对肿瘤细胞增殖的抑制作用的协同潜在增加，产生比通过同时或不在本发明的剂量方案中单独施用单独组分而发现的更有效的治疗。

2. 发明申请

WO2007084670A8 SPECIFIC THERAPY USING INTEGRIN LIGANDS FOR TREATING CANCER 审中-公开
标题翻译：使用INTEGRIN LIGANDS治疗癌症的具体治疗方法
公开(公告)号：WO2007084670A8
公开(公告)日：2008-02-28
申请号：PCT/US2007001446
申请日：2007-01-18
申请人： MERCK PATENT GMBH , GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
发明人： GOODMAN SIMON , PICARD MARTIN ANDREAS , MIKKELSEN TOM , NIPPGEN JOHANNES , GRIMM ULRIKE , STUPP ROGER , WELLER MICHAEL , HARSTRICK ANDREAS
IPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K41/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4188 , A61K38/08 , A61K38/12 , A61K41/00 , A61K2300/00
摘要： The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.
摘要翻译：本发明涉及用于治疗肿瘤和肿瘤转移的组合疗法，其包括将整联蛋白配体，优选整联蛋白拮抗剂，以及当与所述配体连续施用时具有协同疗效的共同治疗剂或治疗形式，例如化学治疗剂和或放射治疗。该治疗导致每个单独治疗剂对肿瘤细胞增殖的抑制作用的协同增加，产生比在本发明的剂量方案中同时或不同时单独施用单独组分的治疗更有效的治疗。

3. 发明申请

WO2013040543A3 BODY SUPPORT MODIFIED WITH VISCOUS GEL AND METHOD OF MANUFACTURING A BODY SUPPORT USING THE SAME 审中-公开
标题翻译：用粘性凝胶改性的身体支持物和使用该物质支持物制造身体支持物的方法
公开(公告)号：WO2013040543A3
公开(公告)日：2013-05-10
申请号：PCT/US2012055730
申请日：2012-09-17
申请人： TEMPUR PEDIC MAN INC , MIKKELSEN TOM
发明人： MIKKELSEN TOM
IPC分类号： A47C27/15 , A47C27/00
CPC分类号： A47C27/15 , A47C27/085
摘要： A body support cushion, such as a mattress, mattress topper or overlay, or pillow, is comprised of a layer of flexible foam and further has a volume of gelatinous material, e.g., elastomer gel, applied to a surface thereof. The gelatinous material alters a physical property, such as firmness or feel, of the layer of flexible foam. The gelatinous material can be applied in a number of ways including, but not limited to a spray application whereupon the spray force can be used to control how much gelatinous material penetrates into the layer of foam. The foam layer may be comprised of reticulated or non-reticulated foam. The foam layer may also be comprised of viscoelastic or non-viscoelastic foam.
摘要翻译：诸如床垫，床垫罩或覆盖物或枕头之类的身体支撑垫由一层柔性泡沫构成，并且还具有施加到其表面上的一定体积的凝胶状材料，例如弹性体凝胶。凝胶状材料改变柔性泡沫层的物理性质，例如坚硬度或感觉。凝胶材料可以以多种方式施用，包括但不限于喷涂应用，由此可以使用喷涂力来控制有多少凝胶状材料渗透到泡沫层中。泡沫层可以由网状或非网状泡沫组成。泡沫层也可以由粘弹性或非粘弹性泡沫组成。

4. 发明申请

WO0049871A9 AN ANTI-ANGIOGENIC KRINGLE PROTEIN AND ITS MUTANTS 审中-公开
标题翻译：抗神经生长因子蛋白及其突变体
公开(公告)号：WO0049871A9
公开(公告)日：2002-06-20
申请号：PCT/US0004798
申请日：2000-02-24
申请人： FORD HENRY HEALTH SYSTEM , DOU DEXIAN , CHOPP MICHAEL , WANG LEI , MIKKELSEN TOM
发明人： DOU DEXIAN , CHOPP MICHAEL , WANG LEI , MIKKELSEN TOM
IPC分类号： A61K38/00 , C07K14/78 , C12N9/68 , C12N9/72 , A01N37/18 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C12N9/6435 , A61K38/00 , C07K14/78 , C07K2319/00 , C12N9/6459 , C12Y304/21007 , C12Y304/21069
摘要： There is provided a pharmaceutical composition including at least one kringle protein and a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating a disease by administering an effective amount of a compound from the group consisting of kringle proteins, KED and a kringle derived from the tPA protein.
摘要翻译：提供了包含至少一种三环蛋白和药学上可接受的载体的药物组合物。本发明还提供了一种治疗疾病的方法，该方法是通过施用有效量的由来自tPA蛋白的三环蛋白，KED和三环的组合组成的组。

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