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1. 发明申请

WO2008097317A1 SOLVATING SYSTEM AND SEALANT FOR MEDICAL USE 审中-公开
标题翻译：医疗用途解决系统和密封剂
公开(公告)号：WO2008097317A1
公开(公告)日：2008-08-14
申请号：PCT/US2007/068470
申请日：2007-05-08
申请人： MEDTRONIC XOMED, INC. , HISSONG, James, B. , OLIVER, Dana, A. , LEWIS, Cecil, O. , MYNTTI, Matthew, F. , TIJSMA, Edze, Jan , GONZALEZ LOPEZ, Maria, Nieves , SAUNIER, Janis
发明人： HISSONG, James, B. , OLIVER, Dana, A. , LEWIS, Cecil, O. , MYNTTI, Matthew, F. , TIJSMA, Edze, Jan , GONZALEZ LOPEZ, Maria, Nieves , SAUNIER, Janis
IPC分类号： A61K31/145 , A61K31/191 , A61K33/24 , A61K9/00 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K31/205 , A61P27/16 , A61P31/04
CPC分类号： A61K31/19 , A61K9/0046 , A61K31/205 , A61K33/24
摘要： Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, chronic rhinosinusitis and other bacterial ear, nose or throat conditions may be treated by applying a solvating system to a bacterial biofilm attached or adhered to the treatment site. The biofilm is disrupted and a protective layer of a polymeric film-forming medical sealant is applied to the treatment site.
摘要翻译：可以通过将溶剂化系统应用于附着或附着于治疗部位的细菌生物膜来治疗慢性中耳炎（COME），复发性急性中耳炎（RAOM），胆脂瘤，慢性鼻鼻窦炎和其他细菌耳，鼻或咽喉病症。生物膜被破坏，并且将聚合物成膜医用密封剂的保护层施加到处理部位。

2. 发明申请

WO2007134055A1 ANTIBACTERIAL EXTRACELLULAR POLYSACCHARIDE SOLVATING SYSTEM 审中-公开
标题翻译：抗菌多糖多糖溶解系统
公开(公告)号：WO2007134055A1
公开(公告)日：2007-11-22
申请号：PCT/US2007/068477
申请日：2007-05-08
申请人： MEDTRONIC XOMED, INC. , MYNTTI, Matthew, F. , OLIVER, Dana, A. , LEWIS, Cecil, O.
发明人： MYNTTI, Matthew, F. , OLIVER, Dana, A. , LEWIS, Cecil, O.
IPC分类号： A61P27/16 , A61P31/04 , A61K31/10 , A61K31/19 , A61K33/22 , A61K45/06 , A61K33/24 , A61K33/40
CPC分类号： A61K45/06 , A61K31/10 , A61K31/19 , A61K33/22 , A61K33/24 , A61K33/40
摘要： Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, chronic rhinosinusitis and other bacterial ear, nose or throat conditions may be treated by applying a solvating system to a bacterial biofilm attached or adhered to the treatment site. The solvating system disrupts the biofilm and aids in its removal.
摘要翻译：可以通过将溶剂化系统应用于附着或附着于治疗部位的细菌生物膜来治疗慢性中耳炎（COME），复发性急性中耳炎（RAOM），胆脂瘤，慢性鼻鼻窦炎和其他细菌耳，鼻或咽喉病症。溶剂化系统破坏生物膜并有助于其去除。

3. 发明申请

WO2012054302A1 METHOD AND APPARATUS FOR REMOVING MATERIAL FROM AN INTERVERTEBRAL DISC SPACE AND PREPARING END PLATES 审中-公开
标题翻译：用于从椎间盘间隙移除材料并制备终板的方法和装置
公开(公告)号：WO2012054302A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056183
申请日：2011-10-13
申请人： MEDTRONIC XOMED, INC. , SHADECK, Louis, M. , OLIVER, Dana, A.
发明人： SHADECK, Louis, M. , OLIVER, Dana, A.
IPC分类号： A61B17/32 , A61B17/16
CPC分类号： A61B17/1671 , A61B17/1659 , A61B17/32002 , A61B17/3207 , A61B17/320783 , A61B2017/00261 , A61B2017/320028 , A61B2217/007
摘要： Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A manual decorticating implement is coupled to the outer tubular member and defining a scraping surface. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip. The manual decorticating implement is used to remove intervertebral disc material from an end plate.
摘要翻译：用于从椎间盘去除材料的仪器和方法。该仪器包括外部和内部管状构件。外管状构件限定通道和切割窗。内部管状构件同轴地设置在通道内，并且限定中心腔和切割尖端。切割尖端形成具有多个齿的开口。在组装时，切割尖端暴露在切割窗内组合以限定剃须头。手动脱皮工具联接到外部管状构件并限定刮削表面。动力手持件联接到内部管状构件，并且剃削头被插入到椎间盘中并且定位成使得切割尖端接触目标材料（例如，核，环形和/或端板）。激活手柄以相对于切割窗口旋转切割尖端。在切割窗口的边缘和切割尖端的齿之间剪切接触材料。手动去皮器具用于从端板上去除椎间盘材料。

4. 发明申请

WO2009152374A2 METHOD FOR TREATING CHRONIC WOUNDS 审中-公开
标题翻译：治疗慢性创伤的方法
公开(公告)号：WO2009152374A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/047101
申请日：2009-06-11
申请人： MEDTRONIC XOMED, INC. , MYNTTI, Matthew, F. , OLIVER, Dana, A. , HISSONG, James, B. , MEDINA, Jennifer, G.
发明人： MYNTTI, Matthew, F. , OLIVER, Dana, A. , HISSONG, James, B. , MEDINA, Jennifer, G.
IPC分类号： A61K31/19 , A61K31/192 , A61K31/194 , A61K31/198 , A61K33/22 , A61K45/06 , A61P17/02
CPC分类号： A61B17/3205 , A61B17/3203 , A61B2017/320004 , A61K31/09 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/198 , A61K31/7036 , A61K33/22 , A61K45/06 , A61K47/12 , A61K47/20 , A61K2300/00
摘要： Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.
摘要翻译：慢性伤口可以通过从伤口清除坏死性和其它失活的组织来治疗，并向伤口施用包含金属离子螯合剂，表面活性剂和缓冲剂的细胞外聚合物溶剂化体系。溶剂化系统破坏可能存在于伤口中的生物膜，有助于恢复正常愈合。

5. 发明申请

WO2016200886A1 USEFUL POLYSACCHARIDE AFTER RADIATION STERILIZATION 审中-公开
标题翻译：辐射灭菌后有用的多糖
公开(公告)号：WO2016200886A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036367
申请日：2016-06-08
申请人： MEDTRONIC XOMED, INC.
发明人： GUENTHER, Denise, E. , WEN, Jie , OLIVER, Dana, A.
IPC分类号： C08B37/08 , C08J3/28
CPC分类号： A61L26/008 , A61L26/0023 , A61L26/0076 , B65B55/08 , B65B63/08 , C08B37/003 , C08J3/28
摘要： A purified and sterilized polysaccharide that exhibits enhanced and extended shelf life over conventionally prepared polysaccharides for biomedical applications. The polysaccharide, upon crosslinking, forms a hydrogel that functions as a protective coating or on tissue and structures in the ears, nose, throat, limbs and spinal column.
摘要翻译：一种纯化和灭菌的多糖，与用于生物医学应用的常规制备的多糖相比表现出增强的和延长的保质期。多糖在交联时形成用作保护性涂层或在耳朵，鼻子，咽喉，四肢和脊柱中的组织和结构上的水凝胶。

6. 发明申请

WO2008005671A3 FLEXIBLE BIORESORBABLE HEMOSTATIC PACKING AND STENT 审中-公开
公开(公告)号：WO2008005671A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/071202
申请日：2007-06-14
申请人： MEDTRONIC XOMED, INC. , OLIVER, Dana, A. , HALVORSEN , HODGE, Amiee
发明人： OLIVER, Dana, A. , HALVORSEN , HODGE, Amiee
IPC分类号： A61L31/14
摘要： The invention provides a flexible bioresorbable foam having hemostatic properties. The foam is formed from a carboxymethylcellulose suspension.

7. 发明申请

WO2007065043A1 METHOD AND APPARATUS FOR REMOVING MATERIAL FROM AN INTERVERTEBRAL DISC SPACE, SUCH AS IN PERFORMING A NUCLEOTOMY 审中-公开
标题翻译：用于从椎间盘间隙移除材料的方法和装置，如执行核子
公开(公告)号：WO2007065043A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/060561
申请日：2006-11-06
申请人： MEDTRONIC XOMED, INC. , ADAMS, Kenneth, M. , OLIVER, Dana, A. , FRANCIS, Tom, J.
发明人： ADAMS, Kenneth, M. , OLIVER, Dana, A. , FRANCIS, Tom, J.
IPC分类号： A61B17/32 , A61B17/00 , A61B17/28
CPC分类号： A61B17/32002 , A61B2017/00261 , A61B2017/2904
摘要： Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip.
摘要翻译：用于从椎间盘去除材料的仪器和方法。该仪器包括外部和内部管状构件。外管状构件限定通道和切割窗。内部管状构件同轴地设置在通道内，并且限定中心腔和切割尖端。切割尖端形成具有多个齿的开口。在组装时，切割尖端暴露在切割窗内组合以限定剃须头。动力手持件联接到内部管状构件，并且剃削头被插入到椎间盘中并且被定位成使得切割尖端接触目标材料（例如，细胞核，环带和/或端板）。激活手柄以相对于切割窗口旋转切割尖端。在切割窗口的边缘和切割尖端的齿之间剪切接触材料。

8. 发明申请

WO2017035485A1 SINUS AND NASAL STENT 审中-公开
标题翻译： SINUS和NASAL STENT
公开(公告)号：WO2017035485A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/049042
申请日：2016-08-26
申请人： MEDTRONIC XOMED, INC.
发明人： WEN, Jie , OLIVER, Dana, A.
IPC分类号： A61F2/18 , A61B17/24 , A61F2/90 , A61F2/966
CPC分类号： A61F2/186 , A61B17/24 , A61F2/90 , A61F2/966
摘要： A stent (100) that is sleeved and radially expandable, and which in an expanded state provides a breathable, generally tubular structure sized and shaped for residence in a sinus or nasal cavity or passage, and in an unexpanded state has a cross-sectional diameter suitable for insertion into such cavity or passage. The sleeve limits expansion and outward pressure exerted by the stent and thereby can prevent or reduce the incidence of headache in patients, and can provide increased surface area for improved elution of drugs to nearby mucosal tissue.
摘要翻译：套筒和径向可膨胀的支架（100），其处于膨胀状态，提供一种通气的，通常为管状的结构，其尺寸和形状适于停留在窦或鼻腔或通道中，并且在未膨胀状态下具有截面直径适合插入这种空腔或通道。套筒限制由支架施加的膨胀和向外的压力，从而可以预防或减少患者头痛的发生，并且可以提供增加的表面积，以改善药物对附近的粘膜组织的洗脱。

9. 发明申请

WO2017035483A1 RESORBABLE, DRUG-ELUTING SUBMUCOSAL TURBINATE IMPLANT DEVICE AND METHOD 审中-公开
标题翻译：可拆卸的，药物去除底层涡卷植入装置和方法
公开(公告)号：WO2017035483A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/049030
申请日：2016-08-26
申请人： MEDTRONIC XOMED, INC.
发明人： MEDINA, Jennifer, G. , AMERY, Drew, P. , OLIVER, Dana, A. , WEN, Jie
IPC分类号： A61L31/16 , A61B17/00 , A61K9/00
CPC分类号： A61M5/3287 , A61B17/00 , A61K9/0024 , A61L31/16 , A61M5/3286 , A61M2205/04 , A61M2210/0681
摘要： Implants are placed in turbinate mucosal tissue using a surgical device having a proximal grip portion and a distal sharp needle portion that is manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue. One or more biodegradable, drug- eluting solid implants are disposed within or attached to the needle. The implants have one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along their length. The device is used to deliver one or more of the implants into mucosal turbinate tissue and submucosally bury at least one such tissue-engaging feature therein.
摘要翻译：使用具有近侧握持部分和远侧尖锐针部分的手术装置将植入物放置在鼻甲粘膜组织中，所述近侧抓握部分和远端尖锐针部分使用握持部分被操纵并插入到粘膜下鼻甲组织中。将一种或多种可生物降解的药物洗脱固体植入物置于针内或附着于针上。植入物沿其长度具有一个或多个植入物取出 - 阻止，粘膜组织接合表面特征。该装置用于将一种或多种植入物输送到粘膜鼻甲组织中，并将粘膜下粘附至少一个这样的组织接合特征。

10. 发明申请

WO2010088115A2 SYSTEMS AND METHODS FOR SURGICAL REMOVAL OF BRAIN TUMORS 审中-公开
标题翻译：用于手术切除脑肿瘤的系统和方法
公开(公告)号：WO2010088115A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/021513
申请日：2010-01-20
申请人： MEDTRONIC XOMED, INC. , OLIVER, Dana, A. , SHADECK, Louis, M. , SPETZLER, Robert, A.
发明人： OLIVER, Dana, A. , SHADECK, Louis, M. , SPETZLER, Robert, A.
IPC分类号： A61B17/3205
CPC分类号： A61B17/320783 , A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B2017/32004 , A61B2017/320775
摘要： A method for treating a brain tumor includes providing a surgical instrument having an inner member and an outer member. The outer member has a distal region forming a cutting window. The inner member is rotatably received within the outer member, and has a cutting tip that is exposed at the window. The cutting tip and the distal region of the outer member combine to define a cutting implement. An opening is created through the patient's skull to provide access to a brain tumor target site. The cutting implement is delivered through the opening to the target site. The cutting tip is placed into contact with the tumor and operated to cut the tumor. The target site is selectively aspirated to remove cut tumor tissue.
摘要翻译：治疗脑肿瘤的方法包括提供具有内部构件和外部构件的手术器械。外部构件具有形成切割窗的远侧区域。内部构件可旋转地容纳在外部构件内，并且具有暴露在窗口处的切割尖端。外部构件的切割尖端和远侧区域组合以限定切割工具。通过患者的头骨创建一个开口，以提供对脑肿瘤靶点的访问。切割工具通过开口传送到目标位置。切割尖端与肿瘤接触并操作以切割肿瘤。选择性地吸出靶位点以去除切割的肿瘤组织。

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