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1. 发明申请

WO2008124303A2 BIFURCATED CATHETER JOINTS 审中-公开
标题翻译：双重导管接头
公开(公告)号：WO2008124303A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/058275
申请日：2008-03-26
申请人： MEDTRONIC VASCULAR INC. , HENNESSY, Joe , VARMA, Ashish , MURRAY, Robert , CLARKE, Gerry , GUINAN, Terry , DUANE, Patrick
发明人： HENNESSY, Joe , VARMA, Ashish , MURRAY, Robert , CLARKE, Gerry , GUINAN, Terry , DUANE, Patrick
IPC分类号： A61M25/10 , A61F2/84
CPC分类号： A61M25/0009 , A61F2/95 , A61F2240/001 , A61M25/0023 , A61M25/0029 , A61M25/0032 , A61M25/10 , A61M2025/0183 , A61M2025/1045
摘要： A rapid exchange catheter includes an exchange joint that is coupled between a proximal shaft and first and second distal shafts. The exchange joint includes a proximal end that is configured to be coupled to the proximal shaft, and a distal end that is configured to be coupled to the first distal shaft and the second distal shaft. The distal end includes a first portion that includes a first guidewire lumen, and a second portion that includes a second guidewire lumen. The exchange joint also includes a guidewire port that is configured to provide access for a first guidewire into the first distal inner lumen via the first guidewire lumen and a second guidewire into the second distal inner lumen via the second guidewire lumen.
摘要翻译：快速交换导管包括耦合在近端轴和第一和第二远端轴之间的交换接头。交换接头包括构造成联接到近侧轴的近端，以及构造成联接到第一远端轴和第二远端轴的远端。远端包括包括第一导丝管腔的第一部分和包括第二导丝管腔的第二部分。所述交换接头还包括导丝端口，所述导丝端口被构造成经由所述第一导丝管线将第一导丝提供到所述第一远端内腔中，并且经由所述第二导丝管线将第二导丝提供到所述第二远端内腔中。

2. 发明申请

WO2007106190A3 RAPID EXCHANGE CATHETER HAVING A UNIFORM DIAMETER EXCHANGE JOINT 审中-公开
公开(公告)号：WO2007106190A3
公开(公告)日：2007-09-20
申请号：PCT/US2006/061844
申请日：2006-12-11
申请人： MEDTRONIC VASCULAR, INC. , HENNESSY, Joe , VARMA, Ashish , MURRAY, Robert
发明人： HENNESSY, Joe , VARMA, Ashish , MURRAY, Robert
IPC分类号： A61M25/00
摘要： A rapid exchange catheter includes an elongate proximal shaft comprising a proximal lumen, an elongate distal shaft defining an distal outer lumen, an elongate distal inner lumen inside the distal shaft, and an exchange joint (80) coupled between the elongate proximal shaft and the elongate distal shaft. The exchange joint includes a guidewire port (82) providing external access for a guidewire into the elongate distal inner lumen, and a transition lumen (84) in communication with the proximal lumen and the distal outer lumen. The transition lumen has a crescent-shaped cross-section at least at the exchange joint distal end.

3. 发明申请

WO2011106007A1 UPDATING COMPUTER FILES 审中-公开
标题翻译：更新计算机文件
公开(公告)号：WO2011106007A1
公开(公告)日：2011-09-01
申请号：PCT/US2010/025420
申请日：2010-02-25
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , MOTTA, Giovanni , VARMA, Ashish , O'NEILL, Brian , McGHEE, LaShawn
发明人： MOTTA, Giovanni , VARMA, Ashish , O'NEILL, Brian , McGHEE, LaShawn
IPC分类号： G06F9/44
CPC分类号： G06F8/65
摘要： A method of updating computer software includes identifying an orphaned computer file in a second version of computer software, the orphaned computer file having a name that does not correspond to any name of a computer file in a first version of computer software and computing symmetric divergence between the orphaned computer file and each computer file in the first version of computer software. The method also includes choosing a file from the computer files in the first version of computer software that yields a minimum value of symmetric divergence between the file and the orphaned computer file and using the file as a reference file for compressing the orphaned computer file.
摘要翻译：更新计算机软件的方法包括在计算机软件的第二版本中识别孤立的计算机文件，所述孤立的计算机文件具有与计算机软件的第一版本中的计算机文件的任何名称不对应的名称，并且计算在第孤立的计算机文件和计算机软件的第一个版本中的每个计算机文件。该方法还包括从第一版本的计算机软件中的计算机文件中选择文件，该文件产生文件与孤立计算机文件之间的对称分歧的最小值，并使用该文件作为压缩孤立计算机文件的参考文件。

4. 发明申请

WO2005094931A1 TRANSITION SECTION FOR A CATHETER 审中-公开
标题翻译：过渡部分
公开(公告)号：WO2005094931A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/009665
申请日：2005-03-24
申请人： MEDTRONIC VASCULAR, INC.
发明人： VARMA, Ashish , COYLE, Noel , GRIBBONS, Richard
IPC分类号： A61M25/00
CPC分类号： A61M25/0023 , A61M25/0052 , A61M25/0053 , A61M25/0054 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A catheter having a proximal shaft (128) defining a guidewire lumen (230) and an inflation lumen. The inflation lumen is arcuate shaped and reinforced with a tube (435) having an arcuate shaped cross-section or another reinforcing means (436, 474). The catheter also has a distal shaft, with a greater flexibility than the proximal shaft. The catheter also has a transition section. A proximal end of the transition section communicates with the proximal shaft, and a distal end communicating with the distal shaft. The transition section has a gradually increased flexibility from its proximal end to its distal end. The transition section includes a transition means creating the increased flexibility.
摘要翻译：具有限定导丝管腔（230）和充气腔的近端轴（128）的导管。充气腔是弧形的并且具有弓形截面的管（435）或另一个加强装置（436,474）加强。导管还具有远端轴，其具有比近侧轴更大的灵活性。导管还具有过渡部分。过渡部分的近端与近侧轴连通，远端与远侧轴连通。过渡部分从其近端到其远端具有逐渐增加的柔性。过渡部分包括产生增加的灵活性的过渡装置。

5. 发明申请

WO2005065581A1 LOW PROFILE RESORBABLE STENT 审中-公开
标题翻译：低配置可折叠的STENT
公开(公告)号：WO2005065581A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/040365
申请日：2004-12-02
申请人： MEDTRONIC VASCULAR INC.
发明人： VARMA, Ashish
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2210/0004 , A61L31/14 , A61L31/148
摘要： A low profile resorbable stent comprising an oriented, resorbable material, wherein said material has Young's Modulus and tensile strength in the oriented state greater than Young's modulus and tensile strength of unoriented material is disclosed. The low profile resorbable stent has a resorbable material with Young's modulus about 2-300 GPa and/or tensile strength 50-200 MPa. The resorbable material of the present invention is oriented such that the tensile strength and modulus are higher than the unoriented materials allowing for the low profile stent design. Also disclosed is a method of manufacturing a low profile resorbable stent. The method comprises providing an extrudate comprising a resorbable material, inducing molecular alignment in the extrudate to form an oriented extrudate and forming the stent from the oriented extrudate. The extrudate of resorbable material can be a sheet, tube or some other form. The sheet extrudate is stretched axially or biaxially to induce molecular alignment. The tubular extrudate is blow-molded to induce molecular alignment.
摘要翻译：一种薄型可再吸收支架，其包括取向的可吸收材料，其中所述材料具有杨氏模量，并且在取向状态下的拉伸强度大于杨氏模量和非取向材料的拉伸强度。低表面可吸收支架具有可吸收材料，杨氏模量约为2-300GPa和/或拉伸强度为50-200MPa。本发明的可吸收材料被定向成使得拉伸强度和模量高于允许低剖面支架设计的未取向材料。还公开了制造低轮廓可再吸收支架的方法。该方法包括提供包含可再吸收材料的挤出物，在挤出物中诱导分子取向以形成取向的挤出物并从取向的挤出物形成支架。可吸收材料的挤出物可以是片材，管或其它形式。片材挤出物被轴向或双轴拉伸以诱导分子对准。将管状挤出物吹塑成型以诱导分子对准。

6. 发明申请

WO2004093933A1 LOW PROFILE DILATATION BALLOON 审中-公开
标题翻译：低剖面浮选气球
公开(公告)号：WO2004093933A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/012326
申请日：2004-04-22
申请人： MEDTRONIC VASCULAR, INC.
发明人： VARMA, Ashish
IPC分类号： A61L29/04
CPC分类号： A61M25/1029 , A61L29/04 , B29C47/0023 , B29C47/0026 , B29C47/20 , B29C47/8825 , B29K2023/06 , B29K2023/12 , B29K2067/00 , B29K2071/00 , B29K2075/00 , B29K2077/00 , B29K2105/0032 , B29K2105/0038 , B29K2105/0044 , B29K2105/16 , B29K2995/004 , B29L2031/7542 , Y10T428/139
摘要： A process for producing a low-profile, high-strength dilatation catheter balloon is disclosed. The process comprises forming a tubular extrudate and quenching said extrudate in a cryogenic fluid. The quenched extrudate has morphology of a largely disordered material. The crystallinity in the extrudate is no more than 15%. The crystallinity of the extrudate is measured using X-ray crystallography or DSC. The extrudate is further processed in a mold in which the extrudate is longitudinally and radially stretched. The stretched extrudate is finally attached as a balloon to the distal end of a catheter.
摘要翻译：公开了一种生产低轮廓高强度膨胀导管球囊的方法。该方法包括形成管状挤出物并在低温流体中淬灭所述挤出物。淬灭的挤出物具有很大程度上无序的材料的形态。挤出物中的结晶度不超过15％。使用X射线晶体学或DSC测量挤出物的结晶度。挤出物在挤出物纵向和径向拉伸的模具中进一步加工。拉伸的挤出物最终作为气球附着到导管的远端。

7. 发明申请

WO2005094932A1 TRANSITION SECTION FOR A CATHETER 审中-公开
标题翻译：过渡部分
公开(公告)号：WO2005094932A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/009748
申请日：2005-03-23
申请人： MEDTRONIC VASCULAR INC.
发明人： COYLE, Noel , GRIBBONS, Richard , VARMA, Ashish
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0032 , A61M25/0052 , A61M25/0053 , A61M2025/0063
摘要： A catheter having a proximal shaft defining a guidewire lumen and an inflation lumen. The inflation lumen is arcuate shaped and reinforced with a tube having an arcuate shaped cross-section or another reinforcing means. The catheter also has a distal shaft, with a greater flexibility than the proximal shaft. The catheter also has a transition section. A proximal end of the transition section communicates with the proximal shaft, and a distal end communicating with the distal shaft. The transition section has a gradually increased flexibility from its proximal end to its distal end. The transition section includes a transition means creating the increased flexibility.
摘要翻译：具有限定导丝管腔和充气腔的近端轴的导管。充气腔是弧形的，并用具有弓形截面的管或另一个加强装置加强。导管还具有远端轴，其具有比近侧轴更大的灵活性。导管还具有过渡部分。过渡部分的近端与近侧轴连通，远端与远侧轴连通。过渡部分从其近端到其远端具有逐渐增加的柔性。过渡部分包括产生增加的灵活性的过渡装置。

8. 发明申请

WO2005065582A1 MINIMAL INJURY RESORBABLE STENT 审中-公开
标题翻译：最小伤害可持续发展
公开(公告)号：WO2005065582A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/040369
申请日：2004-12-02
申请人： MEDTRONIC VASCULAR INC.
发明人： VARMA, Ashish
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2210/0004 , A61L31/148 , D01F4/00 , D01F6/62 , D01F6/625
摘要： A minimal injury resorbable stent comprising an oriented resorbable material drawn to a ratio about 7-350 is disclosed. The drawn materials of the present invention have tensile strength of about 50-500 MPa and Young's modulus of about 2-300 GPa. The bioresorbable stents can have cylindrical shape and optionally further comprise one or more of a solvent, plasticizer, biologically active agent and modifier. Also disclosed is a method for manufacturing a minimal injury resorbable stent. The process comprises contacting a resorbable polymer with a solvent to form a polymer mixture, extruding said polymer mixture to form an extrudate, drawing said extrudate to a draw ratio in the range of about 7-350 to form a drawn extrudate and forming said stent from said drawn extrudate. The process optionally further comprises coagulating the extrudate and annealing the extrudate and/or stent.
摘要翻译：公开了一种最小损伤可再吸收支架，其包括被拉伸至约7-350的比例的定向可再吸收材料。本发明的拉伸材料具有约50-500MPa的拉伸强度和约2-300GPa的杨氏模量。生物可再吸收支架可以具有圆柱形形状，并且任选地还包含一种或多种溶剂，增塑剂，生物活性剂和改性剂。还公开了一种用于制造最小损伤可再吸收支架的方法。该方法包括使可再吸收的聚合物与溶剂接触以形成聚合物混合物，挤出所述聚合物混合物以形成挤出物，将所述挤出物拉伸至约7-350范围内的拉伸比，以形成拉伸挤出物并形成所述支架所述拉伸挤出物。该方法任选还包括使挤出物凝结并使挤出物和/或支架退火。

9. 发明申请

WO2004112875A1 CATHETER AND GUIDE WIRE EXCHANGE SYSTEM WITH DECOUPLED GUIDE MEMBER 审中-公开
标题翻译：导管和导线交换系统与解码指导会员
公开(公告)号：WO2004112875A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/019494
申请日：2004-06-17
申请人： MEDTRONIC VASCULAR INC.
发明人： GRIBBONS, Richard , MACNAMARA, John , DUFFY, Niall , VARMA, Ashish , CLARKE, Gerry , CASLEY, Mark , COYLE, Noel , QUINN, David , BOYLE, Kevin , TREACY, Kevin , DUANE, Patrick , BELL, Rodney
IPC分类号： A61M25/00
CPC分类号： A61M25/0029 , A61M25/0032 , A61M25/09041 , A61M25/104 , A61M2025/0034 , A61M2025/107
摘要： A catheter and guide wire exchange system including a catheter (12) having a guide wire lumen with a guide way extending along the length of a stiffened proximal shaft portion, and a guide member (10) slidably disposed about the proximal shaft (22) for directing a guide wire (14) into or out of the guide way and the guide wire lumen (30). The proximal shaft may be slid through the guide member so that the guide wire is contained within the guide wire lumen distal to the guide member and with the guide wire and catheter being separated proximal of the guide member. The guide member has a decoupled body, that allows it to be rotated without affecting the guidewire direction through the guide member.
摘要翻译：导管和导丝线交换系统，其包括导管（12），该导管（12）具有导丝腔，引导线沿着加强的近侧轴部分的长度延伸;以及引导构件（10），其围绕所述近端轴（22）可滑动地设置，将引导线（14）引导到引导方式或引导线腔内以及导丝管腔（30）。近端轴可以滑动穿过引导构件，使得导丝被容纳在远离引导构件的导丝管内，并且导丝和导管被分离在引导构件的近侧。引导构件具有去耦体，其允许其旋转而不影响通过引导构件的导丝方向。

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