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1. 发明申请

WO2004073513A3 IMPLANTABLE MEDICAL DEVICE FOR ASSESSING HEART FAILURE 审中-公开
标题翻译：用于评估心脏衰竭的可植入医疗装置
公开(公告)号：WO2004073513A3
公开(公告)日：2004-10-07
申请号：PCT/US2004004782
申请日：2004-02-18
申请人： MEDTRONIC INC , BENNETT TOMMY D , DUFFIN EDWIN G , MULLIGAN LAWRENCE J , HAMLEN ROBERT C , ABO-AUDA WAEL
发明人： BENNETT TOMMY D , DUFFIN EDWIN G , MULLIGAN LAWRENCE J , HAMLEN ROBERT C , ABO-AUDA WAEL
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/0245 , A61B5/0452 , A61B5/02 , A61B5/04
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/0215 , A61B5/0245 , A61B5/0452
摘要： An implantable heart monitor (100) implanted in a patient's body having electrogram (EGM) sense electrodes (26) coupled with EGM sense circuitry (112) to generate sense events (S100) and a blood pressure measurement transducer (20) disposed in a heart chamber (10) and coupled with blood pressure measurement circuitry (112) operates to assess heart failure state (S144) as a function of mechanical pulsus alternans (MPA). MPA episodes are detected (S116), and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory (124, 128) associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.
摘要翻译：一种植入式心脏监测器（100），其植入患者体内，其具有与EGM感测电路（112）耦合的电描记图（EGM）感测电极（26）以产生设置在心脏中的感测事件（S100）和血压测量换能器（20）腔室（10）并与血压测量电路（112）耦合，用于评估作为机械脉动交替（MPA）的函数的心力衰竭状态（S144）。检测到MPA发作（S116），MPA发作的MPA特征单独使用或作为HF状态的诊断标记使用。 MPA情节数据集可以存储在与时间和日期戳相关联的存储器（124,128）中。可以比较或绘制在一段时间内收集的一系列MPA数据集中的每个MPA数据集的MPA特性，以确定指示HF状态变化的趋势是否可辨别。

2. 发明申请

WO2011059824A3 METHODS AND MATERIALS FOR OPTIMIZED HEPATITIS C THERAPEUTIC REGIMENS 审中-公开
标题翻译：优化乙型肝炎治疗方案的方法和材料
公开(公告)号：WO2011059824A3
公开(公告)日：2011-07-21
申请号：PCT/US2010054755
申请日：2010-10-29
申请人： MEDTRONIC INC , VAN ANTWERP WILLIAM P , HAMLEN ROBERT C , GROVENDER ERIC A
发明人： VAN ANTWERP WILLIAM P , HAMLEN ROBERT C , GROVENDER ERIC A
IPC分类号： G06F19/00
CPC分类号： A61K38/212 , G06F19/10 , G06F19/3456
摘要： Methodologies relating to the treatment of hepatitis C infections are provided. In one embodiment, a bolus of interferon is administered to a patient, and the resultant exogenous interferon serum levels are then observed for a period of 24-72 hours. Data obtained during this time period is then used to predict the concentration of exogenous interferon-a in the serum of a patient that will result from administering exogenous interferon-a dosing via a continuous administration regimen. This information can then be used to design optimized patient-specific therapeutic regimens.
摘要翻译：提供了有关治疗丙型肝炎感染的方法。在一个实施方案中，向患者施用大剂量的干扰素，然后观察所得到的外源性干扰素血清水平24-72小时。然后将在该时间段期间获得的数据用于预测通过连续给药方案施用外源性干扰素给药导致的患者血清中外源性干扰素-α的浓度。然后可以将该信息用于设计优化的患者特异性治疗方案。

3. 发明申请

WO2009120991A3 METHOD AND SYSTEM TO DEFINE PATIENT SPECIFIC THERAPEUTIC REGIMENS BY MEANS OF PHARMACOKINETIC AND PHARMACODYNAMIC TOOLS 审中-公开
标题翻译：通过药物动力学和药物动力学工具定义患者特异性治疗方案的方法和系统
公开(公告)号：WO2009120991A3
公开(公告)日：2010-02-18
申请号：PCT/US2009038617
申请日：2009-03-27
申请人： MEDTRONIC INC , VAN ANTWERP WILLIAM P , HAMLEN ROBERT C , GROVENDER ERIC A
发明人： VAN ANTWERP WILLIAM P , HAMLEN ROBERT C , GROVENDER ERIC A
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , A61K38/212 , G06F19/325 , G16H40/63 , G16H50/50
摘要： Methods for treating Hepatitis infections are provided. In one embodiment, an initial dosage of interferon is administered to a patient, and interferon serum levels and viral load data is collected over time. This data can be used to determine patient- specific pharmacokinetic and pharmacodynamic parameters and then construct patient-specific interferon delivery profiles. Patient- specific delivery profiles can then be used to design patient-specific therapeutic regimens.
摘要翻译：提供了治疗肝炎感染的方法。在一个实施方案中，将干扰素的初始剂量施用于患者，并随时间收集干扰素血清水平和病毒载量数据。该数据可用于确定患者特异性药代动力学和药效学参数，然后构建患者特异性干扰素递送谱。然后可以将患者特异性的输送曲线用于设计患者特异性治疗方案。

4. 发明申请

WO0207810A3 CATHETER FOR TARGET SPECIFIC DRUG DELIVERY 审中-公开
标题翻译：用于目标特定药物递送的导管
公开(公告)号：WO0207810A3
公开(公告)日：2002-06-13
申请号：PCT/US0123434
申请日：2001-07-26
申请人： MEDTRONIC INC
发明人： ELSBERRY DENNIS D , CHRISTIANSEN CHRIS , MORRIS MARY M , HANKNER DOUGLAS O , HAMLEN ROBERT C
IPC分类号： A61M5/142 , A61M5/168 , A61M25/00 , A61M39/02
CPC分类号： A61M5/14276 , A61M5/16877 , A61M25/007 , A61M39/02 , A61M2025/0057
摘要： A medical catheter (22) comprising a proximal end (24) having an opening for fluid containing a therapeutic drug, a distal end (26), the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical catheter comprises a proximal end having an opening for fluid containing a therapeutic drug, at least two distal ends (26, 26'), the proximal end connected to the two distal ends with a connector (50), the distal ends each defining at least one opening, a diffuser covering the opening of each distal end, and a separate restrictor downstream of the connector and upstream of each distal end to provide substantially equal flow through each distal end. An additional restrictor can also be placed upstream of the connector. In another embodiment, a combination diffuser and restrictor covers the opening of each distal end.
摘要翻译：医疗导管（22）包括具有用于含有治疗药物的流体的开口的近端（24），远端（26），限定至少一个开口的远端以及覆盖由远端限定的开口的多孔部分结束。在一个实施例中，医用导管包括具有用于含有治疗药物的流体的开口的近端，至少两个远端（26,26'），近端通过连接器（50）连接到两个远端，各自限定至少一个开口的远端，覆盖每个远端的开口的扩散器，以及位于连接器下游和每个远端上游的单独限流器，以通过每个远端提供基本相等的流动。另外的限流器也可以放置在连接器的上游。在另一个实施例中，组合扩散器和限流器覆盖每个远端的开口。

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