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1. 发明申请

WO2008134106A1 FLUID SENSOR FOR ABLATION THERAPY 审中-公开
标题翻译：流体传感器用于治疗
公开(公告)号：WO2008134106A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/053396
申请日：2008-02-08
申请人： MEDTRONIC, INC. , ELMOUELHI, Ahmed , KRATOSKA, Paul, S.
发明人： ELMOUELHI, Ahmed , KRATOSKA, Paul, S.
IPC分类号： A61B18/14 , A61B18/00 , A61B17/00 , A61B18/12
CPC分类号： A61B18/1477 , A61B18/1233 , A61B18/1815 , A61B2017/00274 , A61B2018/00011 , A61B2018/00029 , A61B2018/00083 , A61B2018/00196 , A61B2018/00517 , A61B2018/00547 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00726 , A61B2018/00863 , A61B2018/00982 , A61B2018/1425 , A61B2018/1472 , A61B2018/1475 , A61B2090/064 , A61B2218/002
摘要： The disclosure describes a method and a system that may be used to provide feedback regarding the flow of fluid during ablation therapy. The system includes a generator that generates energy to ablate at least a portion of a target tissue, a needle that delivers the energy to the target tissue, a return electrode that receives energy dispersed from the needle, a catheter that houses at least a portion of the needle, a pump that delivers a fluid to the target tissue via the catheter, a sensor that detects a fluid parameter indicative of at least one of flow or pressure of the fluid, and a processor that analyzes the fluid parameter detected by the sensor. The sensor may be located between the pump and the target tissue. The fluid parameter detected by the system may be pressure or flow. In particular, the system may be used to treat benign prostatic hypertrophy.
摘要翻译：本公开描述了可用于在消融治疗期间提供关于流体流动的反馈的方法和系统。该系统包括产生能量以消除目标组织的至少一部分的能量的发生器，将能量传递到目标组织的针，接收从针分散的能量的返回电极，容纳至少一部分针，通过导管将流体输送到目标组织的泵，检测指示流体的流动或压力中的至少一个的流体参数的传感器，以及分析由传感器检测到的流体参数的处理器。传感器可以位于泵和目标组织之间。系统检测到的流体参数可能是压力或流量。特别地，该系统可用于治疗良性前列腺肥大。

2. 发明申请

WO2007090074A1 SENSING NEEDLE FOR ABLATION THERAPY 审中-公开
标题翻译：感应针治疗
公开(公告)号：WO2007090074A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/061199
申请日：2007-01-29
申请人： MEDTRONIC, INC. , KRATOSKA, Paul, S. , ELMOUELHI, Ahmed
发明人： KRATOSKA, Paul, S. , ELMOUELHI, Ahmed
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1492 , A61B2017/00274 , A61B2018/00547 , A61B2018/00678 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1475
摘要： The disclosure describes a method and a system that may be used to provide feedback on the progress of ablation therapy. The system includes a first needle that penetrates a target tissue to deliver radio frequency energy, with or without a conductive fluid, that heats and ablates the target tissue and a second needle that penetrates the target tissue and detects a tissue property indicative of the ablation progress. Temperature, impedance, or another parameter may be the tissue property detected and measured by the system. In addition, more than one sensor may be positioned on the first or second needle. The system may provide real-time monitoring of the tissue property or use the tissue property measurement to automatically terminate the ablation therapy. In particular, the system may be used to treat benign prostatic hypertrophy.
摘要翻译：本公开描述了可用于提供关于消融治疗进展的反馈的方法和系统。该系统包括穿透靶组织以输送射频能量的第一针，具有或不具有导电流体，其加热和消融靶组织，以及穿透靶组织并检测指示消融进展的组织特性的第二针。温度，阻抗或其他参数可以是系统检测和测量的组织特性。此外，可以将多于一个的传感器定位在第一或第二针上。系统可以提供组织属性的实时监测或使用组织性质测量来自动终止消融治疗。特别地，该系统可用于治疗良性前列腺肥大。

3. 发明申请

WO1997040873A1 PROPELLANT MIXTURE FOR IMPLANTABLE DRUG PUMP 审中-公开
标题翻译：用于可植入液体泵的PROPELLANT混合物
公开(公告)号：WO1997040873A1
公开(公告)日：1997-11-06
申请号：PCT/US1997007170
申请日：1997-04-28
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , JOHNSON, Bruce, C. , NORGON, Dennis , KRATOSKA, Paul, S.
IPC分类号： A61M05/155
CPC分类号： A61M5/14276 , A61M5/155
摘要： The present invention disclosure describes a propellant for a fluid delivery system that comprises a mixture of a plurality of substances, the precise by-weight or by-molar combination of which is used to set the propellant pressure within a desirable pressure range. The disclosure further describes a method for filling the pump reservoir with the propellant mixture to ensure that the desired and selected pressure setting for any pump is accurately achieved. At least one of the plurality of propellant substances is a relatively higher vapor pressure fluid; and at least one of the plurality of propellant substances is a relatively lower vapor pressure fluid. The mixing process of the present invention enables the constituent substances of the plurality to be mixed without permitting the higher vapor pressure substance (which has a relatively lower boiling point) to boil off, altering the mixture and its characteristic pressure away from the desired pressure. Specifically, one step of the mixing and filling process involves keeping the temperature of the drug pump, of the tubing connecting the drug pump to the propellant supplies, and the supplies of the plurality of propellant substances at a sufficiently cool temperature throughout propellant filling and propellant chamber sealing to ensure that each of the plurality of propellant fluids is maintained at a temperature below the lowest boiling point.
摘要翻译：本发明公开内容描述了一种用于流体输送系统的推进剂，其包括多种物质的混合物，其精确的重量或摩尔比的组合用于将推进剂压力设定在期望的压力范围内。本公开进一步描述了用推进剂混合物填充泵储存器的方法，以确保任何泵的期望和选择的压力设置被准确地实现。多个推进剂物质中的至少一个是相对较高的蒸气压流体; 并且多个推进剂物质中的至少一个是相对较低的蒸气压流体。本发明的混合方法能够使多种成分物质混合，而不允许较高蒸气压物质（其沸点相对较低）沸腾，使混合物及其特征压力远离所需压力。具体来说，混合和填充过程的一个步骤包括将药物泵的温度，连接药物泵的管道的温度保持在推进剂供应中，并且在推进剂填充和推进剂中充分冷却的温度下供应多种推进剂物质室密封以确保多个推进剂流体中的每一个保持在低于最低沸点的温度。

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