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    • 4. 发明申请
    • IMPLANTABLE CO-FIRED ELECTRICAL FEEDTHROUGHS
    • 可植入式电动发电机
    • WO2007035445A1
    • 2007-03-29
    • PCT/US2006/035928
    • 2006-09-15
    • MEDTRONIC, INC.BURDON, Jeremy W.YAMAMOTO, Joyce K.NYGREN, Lea A.WOLF, William D.
    • BURDON, Jeremy W.YAMAMOTO, Joyce K.NYGREN, Lea A.WOLF, William D.
    • H01G4/35A61N1/375
    • A61N1/3754A61N1/375H01G9/10
    • The invention includes a family of miniaturized, hermetic electrical feedthrough assemblies adapted for implantation within a biological system. An electrical feedthrough assembly according to the invention can be used as a component of an implantable medical device such as an implantable pulse generator, cardioverter-defibrillator, physiologic sensor, drug-delivery system and the like. Such assemblies require biocompatibility and resistance to degradation under applied bias current or voltage. Such an assembly is fabricated by interconnected electrical pathways, or vias, of a conductive metallic paste disposed between ceramic green-state material. The layers are stacked together and sintered to form a substantially monolithic dielectric structure with at least one embedded metallization pathway extending through the structure. The metallization pathway reliably conducts electrical signals even when exposed to body fluids and tissue and providing reliable electrical communication. After sintering the structure is hermetically diffusion bonded to a part of a ferrule and/or adjacent support member.
    • 本发明包括一系列适于植入生物系统的小型化,密封电气馈通组件。 根据本发明的电馈通组件可以用作可植入医疗装置的组件,例如可植入脉冲发生器,心律转复除颤器,生理传感器,药物递送系统等。 这样的组件需要在施加的偏置电流或电压下的生物相容性和耐劣化性。 这种组件由布置在陶瓷绿色材料之间的导电金属膏的互连电路或通路制成。 层叠在一起并烧结以形成具有延伸穿过该结构的至少一个嵌入金属化路径的基本上单片的电介质结构。 即使暴露于体液和组织并且提供可靠的电通信,金属化路径也可靠地传导电信号。 在烧结之后,结构气密地扩散粘合到套圈和/或相邻的支撑构件的一部分上。
    • 5. 发明申请
    • SPINAL ROD C HARACTERIZED BY A TIME-VARYING STIFFNESS
    • 脊柱受到时间变化的影响
    • WO2008030634A1
    • 2008-03-13
    • PCT/US2007/063025
    • 2007-03-01
    • MEDTRONIC, INC.NYGREN, Lea A.KNOWLES, Shawn D.
    • NYGREN, Lea A.KNOWLES, Shawn D.
    • A61B17/70
    • A61B17/7019A61B5/042A61B17/7002A61B17/7029A61B17/7032A61B2017/00004A61L31/148A61N1/056A61N1/3716
    • A spinal rod (1 0) characterized by a time-varying stiffness. The rod comprises a first member (22,28,34,48,52,66,74,84,86,92,94) and at least one second member (24,26,35,40,44,50,54,60,68,72,76,82,90) that is mechanically coupled to the first member through a time-varying interface (30,36,38,56,58,59,80). The interface features a binding mechanism that degrades after surgical installation. For instance, the interface may be bioabsorbable and dissolve upon exposure to bodily fluids. In another instance, the second member may be comprised of a bioabsorbable material. In another embodiment, the interface may fail under cyclic loadig. In another embodiment, degradation of the bioabsorbable material may be inhibited through the application of a current source. The second member may be disposed within the first member. Alternatively, the first member and the second member may be disposed aside one another. The first member and the second member may be substantially similar in shape. One or more bioabsorbable plugs (62,66) may be used to at least temporarily seal the second member from bodily fluids once the spinal rod is installed.
    • 脊柱杆(10),其特征在于时变刚度。 杆包括第一构件(22,28,34,48,52,66,74,84,86,92,94)和至少一个第二构件(24,26,35,40,44,50,54, 其通过时变界面(30,36,38,56,58,59,80)机械耦合到第一构件。 界面具有手术安装后降解的结合机制。 例如,界面可以是生物可吸收的并且在暴露于体液时溶解。 在另一种情况下,第二构件可以由生物可吸收材料构成。 在另一个实施例中,界面可能在循环负载下失败。 在另一个实施方案中,可通过施加电流源来抑制生物可吸收材料的降解。 第二构件可以设置在第一构件内。 或者,第一构件和第二构件可以彼此搁置。 第一构件和第二构件的形状可以基本相似。 一旦一个或多个生物可吸收塞子(62,66)可以用于在安装脊椎杆杆之后至少临时密封第二构件与体液。