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1. 发明申请

WO2008137552A2 ANTI-RAGE ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗RA抗体及其使用方法
公开(公告)号：WO2008137552A2
公开(公告)日：2008-11-13
申请号：PCT/US2008062231
申请日：2008-05-01
申请人： MEDIMMUNE LLC , MAO SU-YAU , CHEN BO , CHANG CHEW-SHUN , TIAN JANE , CHOWDHURY PARTHA , COYLE ANTHONY , SIMS GARY
发明人： MAO SU-YAU , CHEN BO , CHANG CHEW-SHUN , TIAN JANE , CHOWDHURY PARTHA , COYLE ANTHONY , SIMS GARY
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C07K2317/56 , C07K2319/30
摘要： Antibodies that bind RAGE and inhibit the binding between RAGE and HMGBl complexed with CpG DNA are disclosed. The antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range conditions characterized by the presence of DNA immune complexes and/or associated with the expression of one or more type-I IFN- inducible gene.
摘要翻译：公开了结合RAGE并抑制RAGE与与CpG DNA复合的HMGB1之间的结合的抗体。本发明的抗体和包含其的药物组合物可用于许多目的，例如作为治疗剂，其针对特征在于存在DNA免疫复合物和/或与一种或多种I型 IFN-诱导型基因。

2. 发明申请

WO2007079316A3 INDICATORS FOR A SPECTROPHOTOMETRIC SYSTEM 审中-公开
标题翻译：分光光度计系统的指标
公开(公告)号：WO2007079316A3
公开(公告)日：2007-11-29
申请号：PCT/US2006061678
申请日：2006-12-06
申请人： CAS MEDICAL SYSTEMS INC , BENNI PAUL , CHEN BO , KERSEY ANDREW
发明人： BENNI PAUL , CHEN BO , KERSEY ANDREW
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0073 , A61B5/14553 , A61B5/4076 , A61B5/742
摘要： A near-infrared spectrophotometpc system (e g, a cerebral oximeter) includes a sensor portion and a monitor portion The monitor portion includes a processor that runs an algorithm which utilizes the amount of detected light to determine the value of the oxygen concentration The monitor portion also includes a visual display that displays the determined oxygen concentration values in vanous formats The monitor portion may also include an audible device (e g, a speaker), that provides audible indications of the determined oxygen concentration values Vanous visual indicators may include, for example, color-coded graphs of the determined oxygenation values to alert the system user whether one hemisphere or region of the brain is in danger of adverse and potentially permanent damage Also, data may be pre-processed by selecting the most clinically concerning sensor value (e g, the sensor with the lowest value), and displaying only that sensor value and its identification on the display screen.
摘要翻译：近红外分光光度计系统（例如，脑血氧计）包括传感器部分和监视部分。监视器部分包括运行利用检测光量来确定氧浓度值的算法的处理器。监视器部分还包括以肮脏格式显示确定的氧浓度值的视觉显示。监视器部分还可以包括提供所确定的氧浓度值的可听指示的可听设备（例如，扬声器）。多个可视指示符可以包括例如颜色确定的氧合值的编码图，以警告系统用户脑中的一个半球或区域是否存在不利和潜在的永久性损伤的危险。另外，可以通过选择临床上最为关键的传感器值来预处理数据（例如，传感器具有最低值），并且仅在显示屏上显示该传感器值及其识别 ñ。

3. 发明申请

WO2012075419A3 NON-INVASIVE FAT REDUCTION BY HYPERTHERMIC TREATMENT 审中-公开
标题翻译：通过高温处理进行的非侵入性减脂
公开(公告)号：WO2012075419A3
公开(公告)日：2013-01-24
申请号：PCT/US2011063113
申请日：2011-12-02
申请人： CYNOSURE INC , CHEN BO , MIRKOV MIRKO GEORGIEV
发明人： CHEN BO , MIRKOV MIRKO GEORGIEV
IPC分类号： A61B18/20 , A61N5/067
CPC分类号： A61B18/20 , A61B2018/00023 , A61B2018/00464 , A61B2018/00797 , A61N5/062
摘要： The present disclosure relates systems and methods for tissue remodeling, that ameliorate fat deposits by disrupting adipocytes through low-temperature extended treatment time approaches, in conjunction with selective treatment and/or localized cooling of the treatment site to prevent or minimize damage to non-target tissues.
摘要翻译：本公开涉及用于组织重塑的系统和方法，其通过低温延长治疗时间方法破坏脂肪细胞来改善脂肪沉积，结合治疗部位的选择性治疗和/或局部冷却以防止或最小化对非目标的损伤组织。

4. 发明申请

WO2011159938A3 HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN CYTOMEGALOVIRUS (CMV) GB PROTEIN 审中-公开
标题翻译：人类细胞因子（CMV）GB蛋白的高亲和力人体抗体
公开(公告)号：WO2011159938A3
公开(公告)日：2012-04-19
申请号：PCT/US2011040761
申请日：2011-06-16
申请人： TRELLIS BIOSCIENCE INC , KAUVAR LAWRENCE M , ELLSWORTH STOTE , USINGER WILLIAM , MCCUTCHEON KRISTA MAUREEN , JIANG YING-PING , ZHANG FEN , CHEN BO , SPERINDE GIZETTE , PARK MINHA , FOORD ORIT
发明人： KAUVAR LAWRENCE M , ELLSWORTH STOTE , USINGER WILLIAM , MCCUTCHEON KRISTA MAUREEN , JIANG YING-PING , ZHANG FEN , CHEN BO , SPERINDE GIZETTE , PARK MINHA , FOORD ORIT
IPC分类号： A61K39/00 , A61K39/42
CPC分类号： C07K16/088 , A61K39/245 , A61K2039/505 , C07K16/08 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
摘要翻译：已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。这些抗体的亲和力高于先前报道的最佳抗体。由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。

5. 发明申请

WO2005114708A3 CARBON NANOTUBE-SILICON COMPOSITE STRUCTURES AND METHODS FOR MAKING SAME 审中-公开
标题翻译：碳纳米管 - 硅复合结构及其制备方法
公开(公告)号：WO2005114708A3
公开(公告)日：2006-07-20
申请号：PCT/US2005016102
申请日：2005-05-06
申请人： UNIV RICE WILLIAM M , TOUR JAMES M , DYKE CHRISTOPHER A , MAYA FRANCISCO , STEWART MICHAEL , CHEN BO , FLATT AUSTEN K
发明人： TOUR JAMES M , DYKE CHRISTOPHER A , MAYA FRANCISCO , STEWART MICHAEL , CHEN BO , FLATT AUSTEN K
IPC分类号： H01L51/30 , C01B31/02 , H01L21/00
CPC分类号： B82Y30/00 , B82Y10/00 , H01L51/0048 , Y10S977/847 , Y10S977/892
摘要： The present invention is directed toward methods of attaching or grafting carbon nanotubes (CNTs) to silicon , wherein such attaching or grafting occurs via functional groups on either or both of the CNTs and silicon surface. The present invention is also directed to the novel compositions produced by such methods. In some embodiments, the present invention is directed to afford the covalent attachment of individualized (unroped) SWNTs to Si surfaces.
摘要翻译：本发明涉及将碳纳米管（CNT）附着或接枝到硅上的方法，其中通过碳纳米管和硅表面中的任一个或两者上的官能团进行这种附着或接枝。本发明还涉及通过这些方法制备的新型组合物。在一些实施方案中，本发明旨在提供个体化（未经处理的）SWNT与Si表面的共价连接。

6. 发明申请

WO2006079005A2 METAL-FREE SILICON-MOLECULE-NANOTUBE TESTBED AND MEMORY DEVICE 审中-公开
标题翻译：无金属硅分子 - 纳米管测试和存储器件
公开(公告)号：WO2006079005A2
公开(公告)日：2006-07-27
申请号：PCT/US2006002222
申请日：2006-01-23
申请人： UNIV RICE WILLIAM M , TOUR JAMES M , HE JIANLI , CHEN BO , FLATT AUSTEN K , STEPHENSON JASON J , DOYLE CONDELL D
发明人： TOUR JAMES M , HE JIANLI , CHEN BO , FLATT AUSTEN K , STEPHENSON JASON J , DOYLE CONDELL D
IPC分类号： A22C9/00 , H01L21/34
CPC分类号： G11C13/02 , B82Y10/00 , B82Y30/00 , G11C13/0014 , G11C13/025 , H01L27/283 , H01L51/0048 , H01L51/005 , H01L51/0052 , H01L51/0595
摘要： Work from several laboratories has shown that metal nanofilaments cause problems in some molecular electronics testbeds. A new testbed for exploring the electrical properties of single molecules has been developed to eliminate the possibility of metal nanofilament formation and to ensure that molecular effects are measured. This metal-free system uses single-crystal silicon and single-walled carbon nanotubes as electrodes for the molecular monolayer. A direct Si-arylcarbon grafting method is used. Use of this structure with 7t-conjugated organic molecules results in a hysteresis loop with current-voltage measurements that are useful for an electronic memory device. The memory is non-volatile for more than 3 days, non-destructive for more than 1 ,000 reading operations and capable of more than 1 ,000 write- erase cycles before device breakdown. Devices without 7T-conjugated molecules (Si-H surface only) or with long-chain alkyl-bearing molecules produced no hysteresis, indicating that the observed memory effect is molecularly relevant.
摘要翻译：几个实验室的工作表明，金属纳米丝在一些分子电子测试台中引起问题。已经开发了用于探索单分子的电性质的新试验台，以消除金属纳米丝形成的可能性并确保测量分子效应。该无金属系统使用单晶硅和单壁碳纳米管作为分子单层的电极。使用直接的Si-芳基碳接枝方法。使用这种结构与7t共轭有机分子导致电流 - 电压测量的滞后回路，这对电子存储器件是有用的。存储器非易失性超过3天，对于超过1,000次读取操作无损坏，并且在器件击穿之前能够执行超过1,000次写擦除周期。没有7T共轭分子（仅含Si-H表面）或具有长链烷基的分子的器件没有产生滞后现象，表明观察到的记忆效应是分子相关的。

7. 发明申请

WO2012126427A3 LASER WITH TUNABLE OUTER CAVITY AND METHOD FOR USING SAME 审中-公开
标题翻译：具有可控外腔的激光器及其使用方法
公开(公告)号：WO2012126427A3
公开(公告)日：2013-04-18
申请号：PCT/CN2012075816
申请日：2012-05-21
申请人： HUAWEI TECH CO LTD , CHEN BO , GAO LEI , ZHANG GUANGYONG , CHEN XI
发明人： CHEN BO , GAO LEI , ZHANG GUANGYONG , CHEN XI
IPC分类号： H01S5/14 , H01S3/10 , H01S3/13 , H01S3/139
CPC分类号： H01S5/141
摘要： A laser with tunable outer cavity and a method for using same, said laser with tunable outer cavity comprising a gain chip (100), a collimating mirror (200), a wavelength selection element (300), and an optical path for the generation of an optical path difference (400). A cavity surface (1002) of the gain chip is located in a focal plane of the collimating mirror. The wavelength selection element is located between the collimating mirror and the optical path for the generation of an optical path difference. Light beams emitted from the cavity surface of the gain chip are collimated by the collimating mirror to form parallel beams which are sent to the wavelength selection element; the wavelength selection element filters the parallel beams from the collimating mirror and then sends them to the optical path for the generation of an optical path difference. The optical path for the generation of an optical path difference splits the parallel beams entering same into at least two branch beams, and reflects each of said branch beams to the gain chip according to the incident direction. The optical path for the generation of an optical path difference is able to adjust the optical path difference between the optical paths of the branch beams. Since the optical path for the generation of an optical path difference serves to roughly select a mode, there is no need for precise control of adjustment and the process of wavelength tuning and selection is made easier.
摘要翻译：一种具有可调外腔的激光器及其使用方法，所述具有可调谐外腔的激光器包括增益芯片（100），准直镜（200），波长选择元件（300）和用于产生光路差（400）。增益芯片的空腔表面（1002）位于准直镜的焦平面中。波长选择元件位于准直镜和用于产生光程差的光路之间。从增益芯片的空腔表面发射的光束被准直镜准直，以形成被发送到波长选择元件的平行光束; 波长选择元件对来自准直镜的平行光束进行滤波，然后将它们发送到光路以产生光程差。用于产生光路差的光路将入射到其的平行光束分成至少两个分支光束，并根据入射方向将每个所述分支光束反射到增益芯片。用于产生光程差的光路能够调整分支光束的光路之间的光程差。由于用于产生光程差的光路用于粗略地选择模式，所以不需要精确的调整控制，并且使波长调谐和选择的处理变得更容易。

8. 发明申请

WO2012164350A3 APPARATUS AND METHOD FOR CHARACTERIZING PARAMETERS FOR THE CRACKING, IN-SITU COMBUSTION, AND UPGRADING OF HYDROCARBONS 审中-公开
标题翻译：用于表征裂化，现场燃烧和油层升级的参数的装置和方法
公开(公告)号：WO2012164350A3
公开(公告)日：2013-03-07
申请号：PCT/IB2011052404
申请日：2011-05-31
申请人： SCHLUMBERGER CA LTD , SCHLUMBERGER SERVICES PETROL , SCHLUMBERGER HOLDINGS , SCHLUMBERGER TECHNOLOGY BV , PRAD RES & DEV LTD , UNIV LELAND STANFORD JUNIOR , SAFINYA KAMBIZ , KOVSCEK ANTHONY R , CHEN BO
发明人： SAFINYA KAMBIZ , KOVSCEK ANTHONY R , CHEN BO
IPC分类号： G01N33/24 , B01J19/12 , G01N1/44 , H05B6/80
CPC分类号： G01N33/241 , H05B6/6491 , H05B6/802 , H05B2214/03
摘要： An apparatus for characterizing parameters for the cracking, in-situ combustion, and upgrading of hydrocarbons includes a reactor defining a chamber, a temperature probe operab!y associated with the reactor, and a gas inlet in fluid communication with the chamber. The apparatus further comprises a gas outlet in fluid communication with the chamber and an electromagnetic radiation attenuating materia! configured to heat the reactor when the electromagnetic radiation attenuating material is irradiated by electromagnetic radiation.
摘要翻译：用于表征烃的开裂，原位燃烧和升级的参数的装置包括限定室的反应器，与反应器相关联的温度探针操作和与腔室流体连通的气体入口。该装置还包括与腔室流体连通的气体出口和电磁辐射衰减材料！配置为当电磁辐射衰减材料被电磁辐射照射时加热反应器。

9. 发明申请

WO2012064792A3 PROTEIN COMPLEXES FOR ANTIGEN BINDING AND METHODS OF USE 审中-公开
标题翻译：用于抗原结合的蛋白复合物和使用方法
公开(公告)号：WO2012064792A3
公开(公告)日：2012-07-19
申请号：PCT/US2011059844
申请日：2011-11-09
申请人： ALTIMAB THERAPEUTICS INC , LI ZIJUAN , WU CHUN , BAO JUN , CHEN BO
发明人： LI ZIJUAN , WU CHUN , BAO JUN , CHEN BO
IPC分类号： C07K19/00 , A61K38/17 , A61P35/00 , C07K16/46 , C12N15/62
CPC分类号： C07K16/468 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/248 , C07K16/2803 , C07K16/2809 , C07K16/2878 , C07K16/30 , C07K16/40 , C07K16/46 , C07K2317/30 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/66 , C07K2317/73 , G01N33/6854
摘要： Provided herein in certain embodiments are polypeptide complexes capable of binding to an antigen. Pharmaceutical compositions, method of using the polypeptide complexes are also provided.
摘要翻译：本文在某些实施方案中提供了能够结合抗原的多肽复合物。还提供了药物组合物，使用该多肽复合物的方法。

10. 发明申请

WO2009153671A3 HDMI WITH DETECT PIN 审中-公开
标题翻译：带有检测PIN的HDMI
公开(公告)号：WO2009153671A3
公开(公告)日：2010-04-15
申请号：PCT/IB2009006712
申请日：2009-01-23
申请人： MOLEX INC , CHEN BO
发明人： CHEN BO
IPC分类号： H01R13/703
CPC分类号： H01R13/641 , H01R13/7035
摘要： An electrical connector with an inserting side comprises an insulation body, a plurality of conductive terminals received in the insulation body, a housing shielding the insulation body, and a detecting apparatus. The insulation body includes a main body portion, a connecting portion protruding toward the inserting side from the main body portion, and a detecting room provided on the upper portions of the main body and the connecting portion. The main body portion of the insulation body comprises a front surface facing the inserting side and a rear surface opposite the front surface. The housing comprises a rear cover shielding the rear surface. The detecting apparatus comprises a detecting terminal which comprises a retaining portion, and further comprises a pushing portion and a soldering portion respectively connecting to the retaining portion. As a connection is made, the pushing portion of the detecting terminal is moved against the rear cover of the housing so that the electrical connector can confirm whether the counterpart connected to it is in proper electrical connection. The detecting apparatus can prevent the insertion of the counterpart from having an uncertain connection. Therefore, the connection between them is stable so that any damage to the counterpart resulting from improper operation is prevented.
摘要翻译：具有插入侧的电连接器包括绝缘体，绝缘体中容纳的多个导电端子，屏蔽绝缘体的壳体和检测装置。绝缘体包括主体部分，从主体部分朝向插入侧突出的连接部分，以及设置在主体和连接部分的上部的检测室。绝缘体的主体部分包括面向插入侧的前表面和与前表面相对的后表面。壳体包括屏蔽后表面的后盖。检测装置包括检测端子，其包括保持部分，并且还包括分别连接到保持部分的推动部分和焊接部分。作为连接，检测端子的推动部分抵靠壳体的后盖移动，使得电连接器可以确认与其连接的对应物是否处于适当的电连接。检测装置可以防止对方的插入不具有不确定的连接。因此，它们之间的连接是稳定的，从而防止由于不正确的操作而导致的对方损坏。

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