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1. 发明申请

WO2007041171A2 METHOD OF IDENTIFYING MEMBRANE LG SPECIFIC ANTIBODIES AND USE THEREOF FOR TARGETING IMMUNOGLOBULIN-PRODUCING PRECURSOR CELLS 审中-公开
标题翻译：识别膜特异性抗体的方法及其用于靶向产生免疫球蛋白的前体细胞的方法
公开(公告)号：WO2007041171A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/037724
申请日：2006-09-28
申请人： MEDIMMUNE, INC. , WU, Herren , KIENER, Peter , CHOWDHURY, Partha, S. , YOUNG, James, F.
发明人： WU, Herren , KIENER, Peter , CHOWDHURY, Partha, S. , YOUNG, James, F.
IPC分类号： G01N33/53 , C07K16/42
CPC分类号： G01N33/56972 , A61K2039/505 , C07K16/4291 , C07K2317/52 , C07K2317/55 , Y10S424/805 , Y10S530/862 , Y10S530/868
摘要： The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell -mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
摘要翻译：本发明涉及结合存在于膜锚定的免疫球蛋白上并与B细胞和浆细胞表面上的这些新表位结合的抗体的发现。此外，本发明的抗体可以介导ADCC，并且可用于消耗表达本发明的新表位的那些B细胞和浆细胞。本发明的抗体可用于治疗由B细胞的单克隆扩增引起的B细胞介导的疾病和疾病。因此，本发明还提供了用于预防，治疗或改善由B细胞的单克隆扩增引起的B细胞介导的疾病和疾病的组合物和方法。

2. 发明申请

WO2006050166A2 METHODS OF PREVENTING AND TREATING RSV INFECTIONS AND RELATED CONDITIONS 审中-公开
标题翻译：预防和治疗RSV感染的方法及相关条件
公开(公告)号：WO2006050166A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039091
申请日：2005-10-31
申请人： MEDIMMUNE, INC. , LOSONSKY, Genevieve , CONNOR, Edward, M. , YOUNG, James, F. , WU, Herren , DALL'ACQUA, William
发明人： LOSONSKY, Genevieve , CONNOR, Edward, M. , YOUNG, James, F. , WU, Herren , DALL'ACQUA, William
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/543 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/92 , C07K2317/94
摘要： The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (k on ) of at least 2 x 10 5 M -1 s -1 and a dissociation rate (k off ) of less than 5 x 10 -4 S -1 .
摘要翻译：本发明提供了用于预防，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URI））和/或下呼吸道感染（LRI）的方法，），中耳炎（优选来源于，由RSV感染引起或与RSV感染相关联，例如RSV URI和/或LRI），和/或与其相关的症状或呼吸病症（例如，哮喘，喘息和/或反应性气道疾病（RAD）），包括向所述人施用有效量的一种或多种以高亲和力和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体。在一些实施方案中，一种或多种抗体包含修饰的IgG恒定结构域或其FcRn结合片段，导致更长的体内血清半衰期。在具体实施方案中，本发明的方法包括施用有效量的一种或多种经免疫特异性结合一种或多种RSV抗原的修饰的抗体，其具有至少2× 10 5 S -1 S 0 -1和小于5×10 5的解离速率（k ） S-SOD S-1 。

3. 发明申请

WO2004010935A2 METHODS OF TREATING AND PREVENTING RSV, HMPV, AND PIV USING ANTI-RSV, ANTI-HMPV, AND ANTI-PIV ANTIBODIES 审中-公开
标题翻译：使用抗RSV，抗HMPV和抗PIV抗体治疗和预防RSV，HMPV和PIV的方法
公开(公告)号：WO2004010935A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023376
申请日：2003-07-25
申请人： MEDIMMUNE, INC. , VIRONOVATIVE BV , YOUNG, James, F. , KIENER, Peter , OSTERHAUS, Albertus, D., M., E. , FOUCHIER, Ronaldus, A.M.
发明人： YOUNG, James, F. , KIENER, Peter , OSTERHAUS, Albertus, D., M., E. , FOUCHIER, Ronaldus, A.M.
IPC分类号： A61K
CPC分类号： C07K16/1027 , A61K2039/505
摘要： The present invention relates to methods for broad spectrum prevention and treatment of viral respiratory infections. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with respiratory syncytial virus (RSV), parainfluenza virus (PIV), and/or human metapneumovirus (hMPV) infection, the methods comprising administering to a subject an effective amount of one or more anti-RSV-antigen antibodies or antigen-binding fragments thereof, one or more anti-hMPV-antigen antibodies or antigen-binding fragments thereof, and/or one or more anti-PIV-antigen antibodies or antigen-binding fragments thereof. In certain embodiments, a certain serum titer of the anti-RSV-antigen antibodies, andt-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof is achieved in said subject. In certain specific embodiments, the subject is human and, preferably, the anti-RSV-antigen antibody, anti-PIV-antigen antibody, and/or anti-hMPV-antigen antibodies are human or humanized. The present invention relates further to compositions comprising the anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof. The present invention also relates to detectable or diagnostic compositions comprising the one or more anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen binding fragments thereof and methods for detecting or diagnosing RSV, PIV, and/or hMPV infection utilizing the compositions.
摘要翻译：本发明涉及用于广谱预防和治疗病毒性呼吸道感染的方法。具体而言，本发明涉及用于预防，治疗或改善与呼吸道合胞病毒（RSV），副流感病毒（PIV）和/或人偏肺病毒（hMPV）感染相关的症状的方法，所述方法包括向受试者施用有效量的一种或多种抗RSV抗原或其抗原结合片段，一种或多种抗hMPV抗原抗体或其抗原结合片段，和/或一种或多种抗PIV抗原抗体或抗原结合片段其片段。在某些实施方案中，在所述受试者中实现抗RSV抗原抗体和t-PIV抗原抗体和/或抗hMPV抗原抗体或其抗原结合片段的某种血清效价。在某些具体的实施方案中，所述受试者是人，并且优选地，所述抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV抗原抗体是人或人源化的。本发明还涉及包含抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV抗原抗体或其抗原结合片段的组合物。本发明还涉及包含一种或多种抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV抗原抗体或其抗原结合片段的可检测或诊断组合物，以及用于检测或诊断RSV ，PIV和/或hMPV感染。

4. 发明申请

WO2005022330A2 A SYSTEM AND METHOD FOR PROVIDING COMMUNICATION SERVICES TO MOBILE DEVICE USERS 审中-公开
标题翻译：一种用于向移动设备用户提供通信服务的系统和方法
公开(公告)号：WO2005022330A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027815
申请日：2004-08-27
申请人： JAMBO NETWORKS, INC. , RIBAUDO, Charles, S. , YOUNG, James, F.
发明人： RIBAUDO, Charles, S. , YOUNG, James, F.
IPC分类号： G06F
CPC分类号： H04L67/306 , H04L67/18 , H04L69/329 , H04M1/72566 , H04M3/42348 , H04M3/493 , H04M7/0036 , H04W8/18
摘要： The present disclosure relates generally to communication services, and more specifically to a system and method for providing communication services to mobile device users. In one example, a method of providing communication services to a plurality of mobile device users includes: entering a first set of data into a data center by a user; processing the first set of data in the data center to generate a second set of data; downloading the second set of data to a first mobile device to form a third set of data to be stored on the first mobile device; and detecting, by the first mobile device, a second mobile device according to the third set of data, and the second mobile device is located within a range of the first mobile device, and communication between the first mobile device and the data center after downloading the second set of data is not required foi detecting the second mobile device.
摘要翻译：本公开一般涉及通信服务，更具体地涉及用于向移动设备用户提供通信服务的系统和方法。在一个示例中，向多个移动设备用户提供通信服务的方法包括：用户将第一组数据输入数据中心; 处理数据中心中的第一组数据以产生第二组数据; 将第二组数据下载到第一移动设备以形成要存储在第一移动设备上的第三组数据; 以及由所述第一移动设备根据所述第三组数据检测第二移动设备，并且所述第二移动设备位于所述第一移动设备的范围内，以及在下载之后所述第一移动设备与所述数据中心之间的通信第二组数据不需要用于检测第二移动设备。

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