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1. 发明申请

WO1996033269A1 VECTORS AND PROKARYOTES WHICH AUTOCATALYTICALLY DELETE ANTIBIOTIC RESISTANCE 审中-公开
标题翻译：自动消除抗生素耐药性的载体和作品
公开(公告)号：WO1996033269A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005250
申请日：1996-04-16
申请人： MEDIMMUNE, INC. , ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , UNIVERSITY OF PITTSBURGH
发明人： MEDIMMUNE, INC. , ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , UNIVERSITY OF PITTSBURGH , HAUN, Shirley, L. , STOVER, Charles, K. , HATFULL, Graham , HANSON, Mark, S. , JACOBS, William, R.
IPC分类号： C12N15/00
CPC分类号： A61K39/04 , A61K39/00 , A61K39/39 , A61K2039/523 , C07K14/35 , C12N15/74 , C12R1/34
摘要： A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.
摘要翻译：载体和由其转化的原核生物，其包括使编码抗生素抗性表型的核苷酸序列的自动催化缺失成为可能的核酸序列。原核生物可以是细菌，特别是分枝杆菌。这种转化的分枝杆菌可以用于疫苗中，从而消除了包括抗生素抗性标记在内的疫苗的风险。

2. 发明申请

WO1993019775A1 ADMINISTRATION OF LIPOSOMES CONTAINING PEPTIDES OR PROTEINS INCLUDING CTL EPTITOPES OF HIV PROTEINS 审中-公开
标题翻译：含有蛋白质或蛋白质的脂蛋白的管理，包括艾滋病毒蛋白质的CTL抗体
公开(公告)号：WO1993019775A1
公开(公告)日：1993-10-14
申请号：PCT/US1993002978
申请日：1993-03-25
申请人： MEDIMMUNE, INC. , DEPARTMENT OF ARMY
发明人： MEDIMMUNE, INC. , DEPARTMENT OF ARMY , ALVING, Carl, R. , CASSATT, David , KOENIG, Scott , WASSEF, Nabila , WHITE, Wendy
IPC分类号： A61K37/22
CPC分类号： C07K14/005 , A61K9/127 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/572 , C12N2740/16122 , C12N2740/16134
摘要： A method of inducing a CTL response in an animal against HIV comprising administering to the animal lipid vesicles (e.g., liposomes) containing at least one peptide or protein including at least one CTL epitope of an HIV protein.
摘要翻译：诱导动物针对HIV的CTL应答的方法，包括对含有至少一种包含HIV蛋白质的CTL表位的肽或蛋白质的动物脂质囊泡（例如，脂质体）施用。

3. 发明申请

WO1992021374A1 INDUCTION OF IMMUNE RESPONSE AGAINST TETANUS TOXIN THROUGH ADMINISTRATION OF MYCOBACTERIA EXPRESSING TETANUS TOXIN OR FRAGMENTS 审中-公开
标题翻译：通过管理表达青霉素或片段的MYCOBACTERIA来诱导对台湾毒素的免疫应答
公开(公告)号：WO1992021374A1
公开(公告)日：1992-12-10
申请号：PCT/US1992005023
申请日：1992-06-01
申请人： MEDIMMUNE, INC.
发明人： MEDIMMUNE, INC. , STOVER, Charles, K. , DELA CRUZ, Vidal
IPC分类号： A61K39/02
CPC分类号： C07K14/33 , A61K39/00
摘要： A method of inducing an immune response to a tetanus toxin in an animal which comprises administering to the animal mycobacteria transformed with at least one DNA sequence which encodes a protein or polypeptide which elicits antibodies against tetanus toxin or a fragment or derivative thereof. In one embodiment, the immune response to tetanus toxin is induced by administering to an animal a vaccine including BCG which have been transformed with an expression vector DNA sequence which encodes Fragment C of tetanus toxin.
摘要翻译：一种在动物体内诱导针对破伤风毒素的免疫应答的方法，其包括向动物分泌细菌施用，所述分枝细菌用至少一个编码引起抗破伤风毒素抗体的蛋白质或多肽的DNA序列或其片段或衍生物转化。在一个实施方案中，通过向动物施用已经用编码破伤风毒素片段C的表达载体DNA序列转化的BCG的疫苗来诱导对破伤风毒素的免疫应答。

4. 发明申请

WO1991016074A1 ADMINISTRATION OF MONOCLONAL ANTIBODIES AGAINST RESPIRATORY VIRUSES 审中-公开
标题翻译：对抗呼吸道病毒的单克隆抗体的管理
公开(公告)号：WO1991016074A1
公开(公告)日：1991-10-31
申请号：PCT/US1991002668
申请日：1991-04-18
申请人： MEDIMMUNE, INC. , HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT ... , YOUNG, James, F. , PRINCE, Gregory, A.
发明人： MEDIMMUNE, INC. , HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT ...
IPC分类号： A61K39/42
CPC分类号： C07K16/1027 , A61K38/00
摘要： A process for the prophylaxis and/or treatment of respiratory viruses which comprises administering topically or systemically, to an animal, at least one monoclonal antibody against at least one respiratory virus. The present invention is particularly applicable to the prophylaxis of respiratory syncytial virus, or RSV, by administering at least one monoclonal antibody against a fusion protein of respiratory syncytial virus.
摘要翻译：一种用于预防和/或治疗呼吸道病毒的方法，其包括向动物局部或全身施用针对至少一种呼吸道病毒的至少一种单克隆抗体。本发明特别适用于通过对呼吸道合胞病毒的融合蛋白施用至少一种单克隆抗体来预防呼吸道合胞病毒或RSV。

5. 发明申请

WO1996005229A1 HUMAN-MURINE CHIMERIC ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：人类基因组抗体对抗呼吸道病毒
公开(公告)号：WO1996005229A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010053
申请日：1995-08-09
申请人： MEDIMMUNE, INC.
发明人： MEDIMMUNE, INC. , JOHNSON, Leslie, Sid
IPC分类号： C07K16/08
CPC分类号： C07K16/1027 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： This invention relates to a human antibody which contains the one CDR from each variable heavy and variable light chain of at least one muring monoclonal antibody, against respiratory syncytial virus which is MAb1129 and the use thereof for the prevention and/or treatment of RSV infection.
摘要翻译：本发明涉及一种人抗体，其含有来自至少一种修饰单克隆抗体的每个可变重链和可变轻链的一个CDR，其抗呼吸道合胞病毒是MAb1129，以及其用于预防和/或治疗RSV感染的用途。

6. 发明申请

WO1994017105A1 HUMAN-MURINE CHIMERIC ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：人类基因组抗体对抗呼吸道病毒
公开(公告)号：WO1994017105A1
公开(公告)日：1994-08-04
申请号：PCT/US1993001168
申请日：1993-01-29
申请人： MEDIMMUNE, INC.
发明人： MEDIMMUNE, INC. , JOHNSON, Leslie
IPC分类号： C07K15/28
CPC分类号： C07K16/1027 , C07K2319/00
摘要： This invention relates to a human antibody which contains at least one CDR from each variable heavy and variable light chain of at least one murine monoclonal antibody, (preferably a neutralizing antibody) against respiratory syncytial virus. The invention also relates to the murine antibody being an antibody against RSV-F protein. In a preferred embodiment the CDR contains three complementarity determining regions from the variable heavy and variable light chain of at least one murine antibody against RSV-F protein.
摘要翻译：本发明涉及一种人抗体，其包含至少一种鼠抗体单克隆抗体的每个可变重链和可变轻链的CDR（优选中和抗体）的呼吸道合胞病毒的至少一个CDR。本发明还涉及作为针对RSV-F蛋白的抗体的鼠抗体。在优选的实施方案中，CDR含有至少一种针对RSV-F蛋白的鼠抗体的可变重链和可变轻链的三个互补决定区。

7. 发明申请

WO1994014318A1 METHOD OF PROTECTION AGAINST STREPTOCOCCUS PNEUMONIAE WITH TRANSFORMED MYCOBACTERIA 审中-公开
标题翻译：抗逆转录病毒抗逆转录病毒防治方法
公开(公告)号：WO1994014318A1
公开(公告)日：1994-07-07
申请号：PCT/US1993012504
申请日：1993-12-20
申请人： MEDIMMUNE, INC. , UAB RESEARCH FOUNDATION
发明人： MEDIMMUNE, INC. , UAB RESEARCH FOUNDATION , BRILES, David , STOVER, Charles, K.
IPC分类号： A01N01/00
CPC分类号： A61K39/092 , A61K39/00 , C07K14/3156 , C07K2319/02 , C07K2319/40 , C12N15/74
摘要： A method of protecting an animal against Streptococcus pneumoniae by administering to the animal mycobacteria which are transformed with DNA which includes at least one DNA sequence which encodes a protein or polypeptide which elicits antibodies against Streptococcus pneumoniae. The at least one DNA sequence may encode a surface protein of Streptococcus pneumoniae, and in particular PspA protein or a fragment or derivative thereof. Such mycobacteria may be administered in combination with a pharmaceutical carrier as a vaccine against Streptococcus pneumoniae.
摘要翻译：一种通过对动物分枝杆菌进行保护的方法，所述动物分枝杆菌用DNA转化，所述DNA包括至少一个编码引起针对肺炎链球菌抗体的蛋白质或多肽的DNA序列。所述至少一个DNA序列可以编码肺炎链球菌的表面蛋白质，特别是PspA蛋白质或其片段或衍生物。这样的分枝杆菌可以与作为针对肺炎链球菌的疫苗的药物载体组合施用。

8. 发明申请

WO1993007897A1 BACTERIAL EXPRESSION VECTORS CONTAINING DNA ENCODING SECRETION SIGNALS OF LIPOPROTEINS 审中-公开
标题翻译：含有编码脂蛋白分泌信号的细菌表达载体
公开(公告)号：WO1993007897A1
公开(公告)日：1993-04-29
申请号：PCT/US1992009075
申请日：1992-10-21
申请人： MEDIMMUNE, INC.
发明人： MEDIMMUNE, INC. , STOVER, Charles, K.
IPC分类号： A61K39/04
CPC分类号： C07K14/3156 , A61K39/00 , C07K14/20 , C07K14/35 , C07K2319/035 , C07K2319/40 , C07K2319/915 , C12N15/625 , C12N15/74 , Y02A50/401
摘要： An expression vector for expressing a protein or polypeptide in a bacterium, which comprises a first DNA sequence encoding at least a secretion signal of a lipoprotein, and a second DNA sequence encoding a protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. The bacterium expresses a fusion protein of a lipoprotein or lipoprotein segment and the protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. Such expression vectors increase the immunogenicity of the protein or fragment thereof, or polypeptide or peptide by enabling the protein or fragment thereof, or polypeptide or peptide to be expressed on the surface of the bacterium. Bacteria which may be transformed with the expression vector include mycobacteria such as BCG. The expression vectors of the present invention may be employed in the formation of live bacterial vaccines against Lyme disease wherein the bacteria express a surface protein of Borrelia burgdorferi, the causative agent of Lyme disease.
摘要翻译：用于在细菌中表达蛋白质或多肽的表达载体，其包含编码脂蛋白的至少一种分泌信号的第一DNA序列和编码其蛋白质或其片段的第二DNA序列，或与该细菌异源的多肽或肽表达蛋白质或其片段，或多肽或肽。细菌表达脂蛋白或脂蛋白片段的融合蛋白，以及与表达其蛋白质或片段，或多肽或肽的细菌异源的蛋白质或其片段或多肽或肽。这种表达载体通过使蛋白质或其片段或多肽或肽在细菌表面上表达而增加蛋白质或其片段或多肽或肽的免疫原性。可用表达载体转化的细菌包括分枝杆菌如BCG。本发明的表达载体可以用于形成针对莱姆病的活细菌疫苗，其中细菌表达布氏疏螺旋体的表面蛋白，其是莱姆病的致病因子。

9. 发明申请

WO1991004051A1 PEPTIDES INCLUDING CTL EPITOPES OF HIV PROTEINS AND USE THEREOF 审中-公开
标题翻译：包括HIV蛋白的CTL外显子及其用途的肽
公开(公告)号：WO1991004051A1
公开(公告)日：1991-04-04
申请号：PCT/US1990005343
申请日：1990-09-19
申请人： MEDIMMUNE, INC. , UNITED STATES GOVERNMENT as represented by THE ... , FUERST, Thomas , KOENIG, Scott
发明人： MEDIMMUNE, INC. , UNITED STATES GOVERNMENT as represented by THE ...
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Peptide fragments of HIV proteins such as NEF protein, GAG protein, and ENV protein, which include a CTL epitope. Such peptide fragments containing CTL epitopes may be used to induce or augment cellular immune responses against HIV virus to treat or prevent infection of the animal with HIV virus.
摘要翻译： HIV蛋白质的肽片段，例如NEF蛋白质，GAG蛋白质和ENV蛋白质，其包括CTL表位。含有CTL表位的这些肽片段可用于诱导或增加针对HIV病毒的细胞免疫应答，以治疗或预防用HIV病毒感染动物。

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