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1. 发明申请

WO2007139291A1 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF WOUNDS CONTAINING BLOOD PLASMA COMPONENT 审中-公开
标题翻译：用于治疗含有血浆等离子体组分的伤口的药物组合物
公开(公告)号：WO2007139291A1
公开(公告)日：2007-12-06
申请号：PCT/KR2007/002243
申请日：2007-05-08
申请人： MEDIGENES CO., LTD , LEE, Sang Yup , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene , KIM, Kyoung Soon
发明人： LEE, Sang Yup , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene , KIM, Kyoung Soon
IPC分类号： A61K35/16 , C12N5/06
CPC分类号： A61K35/16
摘要： The present invention relates to a pharmaceutical composition for wound healing, which contains a blood plasma fraction. More specifically, relates to a pharmaceutical composition for wound healing, which contains a blood plasma fraction remaining after separating useful components, such as albumin, thrombin and fibrinogen, from blood plasma. According to the disclosed invention, the blood plasma fraction obtained by separating expensive useful substances from blood plasma shows a high wound-healing effect, and thus wounds can be healed in a more economic and efficient manner.
摘要翻译：本发明涉及含有血浆级分的伤口愈合用药物组合物。更具体地，涉及用于伤口愈合的药物组合物，其含有从血浆中分离有用成分如白蛋白，凝血酶和纤维蛋白原后留下的血浆级分。根据所公开的发明，通过从血浆中分离昂贵的有用物质而获得的血浆级分显示出高的伤口愈合效果，因此可以以更经济和有效的方式治愈伤口。

2. 发明申请

WO2006112619A1 COMPOSITIONS FOR TREATING ALOPECIA OR PROMOTING HAIR GROWTH 审中-公开
标题翻译：用于治疗ALOPECIA或促进头发生长的组合物
公开(公告)号：WO2006112619A1
公开(公告)日：2006-10-26
申请号：PCT/KR2006/001093
申请日：2006-03-24
申请人： MEDIGENES CO., LTD. , YOO, Won-Min , YOO, Nae-Choon , KEUM, Ki-Chang , LEE, Sang-Yup , LEE, Gene
发明人： YOO, Won-Min , YOO, Nae-Choon , KEUM, Ki-Chang , LEE, Sang-Yup , LEE, Gene
IPC分类号： A61K8/98 , A61K35/16 , A61P17/14 , A61Q7/00
CPC分类号： A61K35/16 , A61K8/983 , A61Q7/00
摘要： The present invention relats to a composition for treating alopecia or promoting hair growth, which contains the blood plasma or serum as an active ingredient. The inventive composition is effective in hair growth, hair growth promotion and hair loss prevention.
摘要翻译：本发明涉及用于治疗脱发或促进毛发生长的组合物，其含有血浆或血清作为活性成分。本发明的组合物在毛发生长，促进毛发生长和脱发中是有效的。

3. 发明申请

WO2007083929A1 MARKER AND METHOD FOR CANCER DIAGNOSIS 审中-公开
标题翻译：癌症诊断标记和方法
公开(公告)号：WO2007083929A1
公开(公告)日：2007-07-26
申请号：PCT/KR2007/000300
申请日：2007-01-18
申请人： MEDIGENES Co., LTD , LEE, Sang-Yup , YOO, Nae-Choon , YOO, So Young , KEUM, Ki-Chang , YOO, Won-Min
发明人： LEE, Sang-Yup , YOO, Nae-Choon , YOO, So Young , KEUM, Ki-Chang , YOO, Won-Min
IPC分类号： C12N15/12 , G01N33/574 , C12Q1/68
CPC分类号： C07K14/535 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to a diagnostic cancer marker using variation of a granulocyte colony stimulating factor (G-CSF) gene and a method for preparing the same, and more specifically, relates to a method for diagnosing cancer and/or assessing the state of cancer progression using an oligonucleotide having the 3'- terminal end of exon 2 region linked to the 5 '-terminal end of exon 4 region of a G- CSF gene as a diagnostic cancer marker. According to the present invention, cancer can be quickly and exactly diagnosed using variation in a G-CSF gene expression.
摘要翻译：本发明涉及使用粒细胞集落刺激因子（G-CSF）基因变异的诊断性癌症标志物及其制备方法，更具体地涉及诊断癌症和/或评价癌症状态的方法使用具有与G-CSF基因的外显子4区的5'末端连接的外显子2的3'末端的寡核苷酸作为诊断性癌症标志物进行。根据本发明，可以使用G-CSF基因表达的变化快速且准确地诊断癌症。

4. 发明申请

WO2008084889A1 DNA CHIP FOR DETECTION OF STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：用于检测油菜的DNA芯片
公开(公告)号：WO2008084889A1
公开(公告)日：2008-07-17
申请号：PCT/KR2007/000125
申请日：2007-01-08
申请人： MEDIGENES CO., LTD , LEE, Sang-Yup , YOO, Seung Min , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , KIM, June-Myung , CHOI, Jun Yong
发明人： LEE, Sang-Yup , YOO, Seung Min , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , KIM, June-Myung , CHOI, Jun Yong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present invention relates to nucleic acid probes specific to Staphylococcus aureus , which is useful for detecting and identifying S. aureus in a biological sample. More particularly, the present invention relates to a DNA chip for detecting and identifying S. aureus , on which nucleic acid probes derived from 23 S rRNA gene of S. aureus are immobilized. The application of the DNA chips according to the present invention allows time-saving and accurate diagnosis of bacterial infection compared with the conventional bacterial culture methods.
摘要翻译：本发明涉及对金黄色葡萄球菌特异性的核酸探针，其可用于检测和鉴定生物样品中的金黄色葡萄球菌。更具体地，本发明涉及用于检测和鉴定金黄色葡萄球菌的DNA芯片，其上固定有金黄色葡萄球菌23S rRNA基因的核酸探针。与常规细菌培养方法相比，根据本发明的DNA芯片的应用允许节省细菌感染的准确诊断。

5. 发明申请

WO2008084888A1 DNA CHIP FOR DETECTION OF ESCHERICHIA COLI 审中-公开
标题翻译：用于检测ESCHERICHIA COLI的DNA芯片
公开(公告)号：WO2008084888A1
公开(公告)日：2008-07-17
申请号：PCT/KR2007/000123
申请日：2007-01-08
申请人： MEDIGENES CO., LTD , LEE, Sang-Yup , YOO, Seung Min , SHIN, So Youn , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , KIM, June-Myung , CHOI, Jun Yong
发明人： LEE, Sang-Yup , YOO, Seung Min , SHIN, So Youn , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , KIM, June-Myung , CHOI, Jun Yong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837
摘要： The present invention relates to nucleic acid probes specific to E. coli, which is useful for detecting and identifying E. coli in a biological sample. More particularly, the present invention relates to a DNA chip for detecting and identifying E. coli, on which nucleic acid probes derived from 23 S rRNA gene of E. coli are immobilized. The application of the DNA chip according to the present invention allows time- saving and accurate diagnosis of bacterial infection compared with the conventional of bacterial culture methods. In addition, it is not affected by antibiotics addition in clinical practice, thus leading to more accurate diagnosis.
摘要翻译：本发明涉及对大肠杆菌特异性的核酸探针，其可用于检测和鉴定生物样品中的大肠杆菌。更具体地，本发明涉及用于检测和鉴定大肠杆菌的DNA芯片，其上固定有大肠杆菌23S rRNA基因的核酸探针。根据本发明的DNA芯片的应用与常规的细菌培养方法相比，可以节省细菌感染的准确诊断。此外，临床实践中不受抗生素添加的影响，从而导致更准确的诊断。

6. 发明申请

WO2007083928A1 DNA CHIP FOR DIAGNOSIS OF CORNEAL DYSTROPHY 审中-公开
标题翻译：用于诊断角膜晶状体的DNA芯片
公开(公告)号：WO2007083928A1
公开(公告)日：2007-07-26
申请号：PCT/KR2007/000299
申请日：2007-01-18
申请人： MEDIGENES CO., LTD , LEE, Sang-Yup , YOO, So Young , KIM, Eung Kweon , KEUM, Ki-Chang , YOO, Won-Min , YOO, Nae-Choon
发明人： LEE, Sang-Yup , YOO, So Young , KIM, Eung Kweon , KEUM, Ki-Chang , YOO, Won-Min , YOO, Nae-Choon
IPC分类号： C07H19/00 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to oligonucleotides for diagnosis of corneal dystrophy. More particularly, the present invention relates to oligonucleotides for detecting mutation of BIGH3 gene for diagnosis of corneal dystrophy including Avelllino corneal dystrophy, which must be precisely diagnosed before vision correction surgery, and a DNA chip for diagnosis of corneal dystrophy, which has the oligonucleotides fixed thereon. According to the present invention, conventional microscopic diagnosis of corneal dystrophy can be replaced with a precise genetic method, which prevents a patient with corneal dystrophy from losing eyesight by eyesight correction surgery after erroneous diagnosis.
摘要翻译：本发明涉及用于诊断角膜营养不良的寡核苷酸。更具体地，本发明涉及用于检测用于诊断角膜营养不良的BIGH3基因的突变的寡核苷酸，其包括视力矫正手术前必须精确诊断的角膜萎缩症，以及用于诊断角膜营养不良的DNA芯片，其具有固定的寡核苷酸在其上。根据本发明，可以用精确的遗传方法代替常规的角膜营养不良症的微观诊断，其可以防止角膜营养不良患者在错误诊断后通过视力矫正手术而失去视力。

7. 发明申请

WO2003094937A1 A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF WOUNDS CONTAINING BLOOD PLASMA OR SERUM 审中-公开
标题翻译：用于治疗含有血浆或血清的伤口的药物组合物
公开(公告)号：WO2003094937A1
公开(公告)日：2003-11-20
申请号：PCT/KR2003/000922
申请日：2003-05-09
申请人： MEDIGENES , LEE, Sang-Yup , CHANG, Kyung-Hee , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene
发明人： LEE, Sang-Yup , CHANG, Kyung-Hee , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene
IPC分类号： A61K35/16
CPC分类号： A61K35/16
摘要： The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site.
摘要翻译：本发明涉及用于治疗含有血浆或血清的伤口的药物组合物和通过将所述组合物施用于伤口部位来有效地治疗伤口的方法，以使位于周围的组织环境正常化。

8. 发明申请

WO2003095677A1 NUCLEIC ACID PROBES FOR DETECTION OF NON-VIRAL ORGANISMS 审中-公开
标题翻译：用于检测非法机构的核酸检测
公开(公告)号：WO2003095677A1
公开(公告)日：2003-11-20
申请号：PCT/KR2003/000923
申请日：2003-05-09
申请人： MEDIGENES , LEE, Sang-Yup , CHANG, Kyung-Hee , YOO, So-Young , YOO, Seung-Min , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene , KIM, June-Myung
发明人： LEE, Sang-Yup , CHANG, Kyung-Hee , YOO, So-Young , YOO, Seung-Min , KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min , LEE, Gene , KIM, June-Myung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more types of infectious diseases comprising said nucleic acid probes.
摘要翻译：本发明涉及衍生自非病毒生物体的rRNA基因的核酸探针，并且可用于检测生物样品中的所述非病毒感染性生物体。此外，本发明涉及可用于诊断包含所述核酸探针的一种或多种感染性疾病的组合物和碎片。

9. 发明申请

WO2003027288A1 DIAGNOSTIC METHOD FOR CANCER CHARACTERIZED IN THE DETECTION OF THE DELETION OF G-CSF EXON 3 审中-公开
标题翻译：检测G-CSF EXON 3缺失的癌症诊断方法
公开(公告)号：WO2003027288A1
公开(公告)日：2003-04-03
申请号：PCT/KR2002/001825
申请日：2002-09-28
申请人： MEDIGENES , LEE, Sang-Yup , JEONG, Ki-Jun , CHUNG, Hyun-Cheol , YOO, Nae-Choon , KEUM, Ki-Chang , YOO, Won-Min
发明人： LEE, Sang-Yup , JEONG, Ki-Jun , CHUNG, Hyun-Cheol , YOO, Nae-Choon , KEUM, Ki-Chang , YOO, Won-Min
IPC分类号： C12N15/12
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译：基于检测G-CSF基因的外显子3区域的缺失或检测G-CSF基因水平的方法，组合物，微阵列，抗体和用于诊断和预后癌症的试剂盒，突变的G-CSF蛋白质，其缺失对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标记物。

10. 发明申请

WO2002013826A1 ANTI-CANCER COMPOSITION COMPOSED OF ANTI-CANCER AND ANTI-MALARIAL DRUGS 审中-公开
标题翻译：抗癌组合物和抗疟药物组成的抗癌组合物
公开(公告)号：WO2002013826A1
公开(公告)日：2002-02-21
申请号：PCT/KR2001/001314
申请日：2001-08-02
申请人： KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min
发明人： KEUM, Ki-Chang , YOO, Nae-Choon , YOO, Won-Min
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K31/704 , A61K33/24 , A61K2300/00
摘要： The present invention relates to complex compositions of anticancer drugs, which are administrated in combination with antimalarial drugs for reducing a minimum IC 50 of anticancer drugs and inhibiting development of drug resistance of cancer cells caused by anticancer drugs, thereby enhancing the effect of the anticancer drugs. More particularly, the present invention relates to complex compositions of anticancer drugs, which are administrated in combination with antimalarial drugs for a minimun IC 50 of anticancer drugs and inhibiting development of drug resistance of cancer cells caused by anticancer drugs, thereby enhancing the effect of the anticancer drugs; in which the anticancer drugs are selected from the group consisting of doxorubicin, cisplatin, and the like and the antimalarial drugs are selected from the group consisting of hydroxchloroquine, chloroquine, primaquine and the like.
摘要翻译：本发明涉及抗癌药物的复合组合物，其与抗疟药物组合施用以降低抗癌药物的最低IC50并抑制由抗癌药物引起的癌细胞耐药性的发展，从而增强抗癌药物的作用。更具体地说，本发明涉及抗癌药物的复合组合物，其与抗疟药联合施用，用于抗癌药物的最小IC50，抑制由抗癌药物引起的癌细胞耐药性的发展，从而增强抗癌作用药物; 其中抗癌药物选自多柔比星，顺铂等，抗疟药选自羟氯喹，氯喹，普氨氨酸等。

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