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1. 发明申请

WO2006077407A2 TARGETS FOR THERAPY 审中-公开
标题翻译：治疗目标
公开(公告)号：WO2006077407A2
公开(公告)日：2006-07-27
申请号：PCT/GB2006/000181
申请日：2006-01-19
申请人： MEDICAL RESEARCH COUNCIL , MELINO, Gennaro , ROSSI, Mario , SALOMONI, Paolo
发明人： MELINO, Gennaro , ROSSI, Mario , SALOMONI, Paolo
IPC分类号： A61P35/00 , A61P17/00 , A61P37/00 , G01N33/573 , G01N33/574
CPC分类号： G01N33/573 , A61K45/06 , C12N9/93 , C12N15/1137 , C12N2310/14 , C12Y603/02019 , G01N2333/9015 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including cancer treatment and modulation of skin differentiation.
摘要翻译：本发明涉及鉴定用于治疗包括癌症的疾病的新药物靶标。特别地，本发明涉及E3泛素连接酶瘙痒的抑制作为治疗疾病的手段。此外，本发明涉及细胞中p63和p73稳定性的调节。特别地，本发明涉及通过调节瘙痒的表达或活性调节细胞p63和p73的稳定性。此外，本发明涉及使用瘙痒作为开发能够调节p63或p73稳定性的试剂的靶标，特别是能够调节瘙痒和p63或p73相互作用的试剂。这样的药剂可用于治疗应用，包括癌症治疗和皮肤分化调节。

2. 发明申请

WO2016071852A1 WC WITH LOW NOISE 审中-公开
标题翻译：低噪音厕所
公开(公告)号：WO2016071852A1
公开(公告)日：2016-05-12
申请号：PCT/IB2015/058528
申请日：2015-11-04
申请人： ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： E03D11/08 , E03D11/17 , E03D11/13
CPC分类号： E03D11/08 , E03D11/13 , E03D2201/20
摘要： A WC (1) comprising a structure (2) defining at least one bowl (3) and a flushing water supply duct (5) obtained in a rear portion (2a) of the structure (2) to be connected to a water supply network, extending along an axis X and communicating with the bowl (3) so as to allow the flushing water to flow through. The flushing water supply duct (5) is defined at least by a flowing portion (8) and by an outlet portion (9) directly connected to the flowing portion and in a lateral wall (10) of which a single flushing opening (6) is obtained for the flowing of flushing water from the duct (5) to the bowl (3). The opening (6) has a flow-through section with an area ranging from 20 to 50% of the area of the flow-through section of the outlet portion (9) and the outlet portion (9) has a flow-through section with an area ranging from 35 to 65% of the area of the flow-through section of said flowing portion ( 8 ).
摘要翻译：一种WC（1），包括限定至少一个碗（3）的结构（2）和在所述结构（2）的后部（2a）中获得的冲洗水供应管道，以连接到供水网络沿轴线X延伸并与碗（3）连通，以便冲洗水流过。冲洗水供应管道（5）至少由流动部分（8）和直接连接到流动部分的出口部分（9）以及在侧壁（10）中限定，其中单个冲洗开口（6）获得用于将冲洗水从管道（5）流动到碗（3）。开口（6）具有流出部分，其面积为出口部分（9）的流通部分的面积的20％至50％，并且出口部分（9）具有流通部分所述流动部分（8）的流通部分的面积的35至65％的范围。

3. 发明申请

WO2015110973A1 MANUALLY-OPERATED TOOL 审中-公开
标题翻译：手动工具
公开(公告)号：WO2015110973A1
公开(公告)日：2015-07-30
申请号：PCT/IB2015/050471
申请日：2015-01-21
申请人： ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： A47J43/26
CPC分类号： A47J43/26
摘要： A manually-operated tool (1) comprising two mobile jaws (2, 3) which are reciprocally hinged by a cross pin (7) to form a compass-opening beak (4), and two control handles (5, 6) which are reciprocally hinged to be compass- moveable to one another, and are each connected to a relevant jaw (2, 3) to allow the user to open and close the beak (4) moving the two handles (5, 6); the proximal end of the first handle (5) being rigidly integral to a first jaw (2); the proximal end of the second handle (6) being mechanically connected to the second jaw (3) by an epicyclic gear train (8) which is arranged coaxial to said cross pin (7), inside a cavity (9) formed in the body of the second jaw (3).
摘要翻译：一种手动操作的工具（1），包括由十字销（7）往复铰接以形成罗盘开口喙（4）的两个活动爪（2,3），以及两个控制手柄（5,6）相互铰接成彼此相对定向，并且各自连接到相关的钳口（2,3），以允许使用者打开和关闭移动两把手（5,6）的喙（4）; 第一手柄（5）的近端与第一钳口（2）刚性地成一体; 第二把手（6）的近端通过与所述十字销（7）同轴设置的行星齿轮系（8）与第二钳口（3）机械连接，在形成于本体中的空腔（9）内部的第二钳口（3）。

4. 发明申请

WO2007125552A1 A COOKING CONTAINER WITH REVERSIBLE THERMOCHROMATIC DECORATIONS 审中-公开
标题翻译：具有可逆热稳定装饰的烹饪容器
公开(公告)号：WO2007125552A1
公开(公告)日：2007-11-08
申请号：PCT/IT2006/000298
申请日：2006-04-28
申请人： BIALETTI INDUSTRIE S.p.A. , ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： A47J36/02
CPC分类号： A47J37/101 , A47J36/02 , G01K1/14 , G01K11/12 , G01K2207/08
摘要： The present invention relates to a pan (1) comprising a side wall (4) and a reversible thermochromatic decorative pattern (12) that extends on the outer surface (10) of the side wall (4). Moreover, the present invention relates to a pan (1) for which the decorative pattern (12) is obtained with a reversible thermochromatic coat which, above a threshold temperature, becomes transparent making the underlying decorative pattern visible.
摘要翻译：本发明涉及在侧壁（4）的外表面（10）上延伸的侧壁（4）和可逆热色装饰图案（12）的盘（1）。此外，本发明涉及一种通过可逆的热色涂层获得装饰图案（12）的平底锅（1），其在阈值温度之上变得透明，使下面的装饰图案可见。

5. 发明申请

WO2010013165A1 METHOD AND APPARATUS FOR MULCHING A CROP 审中-公开
标题翻译：用于拼接作业的方法和装置
公开(公告)号：WO2010013165A1
公开(公告)日：2010-02-04
申请号：PCT/IB2009/053094
申请日：2009-07-16
申请人： NOBILI S.p.A. , ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： A01F3/00 , A01G17/02
CPC分类号： A01G3/002 , A01G13/0287 , A01G17/02
摘要： A method for mulching a crop comprises the steps of collecting suitable mulching material from the soil (4) contiguous with the crop soil (3); transferring the mulching material to the crop soil (3); and placing it conveniently on the crop soil (3). An apparatus (11) that implements the method also forms part of the invention.
摘要翻译：一种覆盖作物的方法包括以下步骤：从与作物土壤（3）邻接的土壤（4）收集合适的覆盖材料; 将覆盖物转移到作物土壤（3）; 并将其方便地放置在作物土壤（3）上。实现该方法的装置（11）也构成本发明的一部分。

6. 发明申请

WO2010038208A1 APPARATUS FOR SHREDDING A MATERIAL. 审中-公开
标题翻译：装置材料的装置。
公开(公告)号：WO2010038208A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054295
申请日：2009-10-01
申请人： NOBILI S.p.A. , ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： A01D34/62 , A01D75/20
CPC分类号： A01D34/62 , A01D75/20
摘要： An apparatus (10) for shredding a material, in particular plant material, especially grassy material, comprises a frame (12) that defines a compartment (19) for housing a shredding rotor (20) mounted with its axis of rotation substantially transversal, and having at least one opening (24, 26) for the passage of the material and extending longitudinally of the apparatus. Means, located at the respective longitudinal opening (24, 26), are provided for intercepting the material and being in the form of respective intercepting means that are compliant in a direction substantially perpendicular to the ground.
摘要翻译：用于粉碎材料，特别是植物材料，特别是草料的装置（10）包括框架（12），其限定用于容纳其旋转轴线基本上横向安装的切碎转子（20）的隔室（19），以及具有用于材料通过的至少一个开口（24,26）并且延伸到装置的纵向。设置在相应的纵向开口（24,26）处的装置被设置用于拦截材料并且以相应的拦截装置的形式在基本上垂直于地面的方向上是柔性的。

7. 发明申请

WO2007125559A1 KITCHEN UTENSIL, SUCH AS A COFFEE-MAKER OR A PAN, WITH REVERSIBLE THERMOCHROMATIC DECORATIONS 审中-公开
标题翻译：厨房用品，如作为咖啡或者一个PAN，具有可逆的热像装饰
公开(公告)号：WO2007125559A1
公开(公告)日：2007-11-08
申请号：PCT/IT2007/000094
申请日：2007-02-14
申请人： BIALETTI INDUSTRIE S.P.A. , ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： A47J36/06 , A47J31/30
CPC分类号： A47J37/101 , A47J36/02 , G01K1/14 , G01K11/12 , G01K2207/08
摘要： The present invention relates to a kitchen utensil, such as a coffee-maker or a pan, with reversible thermochromatic decorations. In particular, the coffee- maker comprises a lid (10) having a decorative pattern (20) arranged on the outside surface of the lid, having a reversibly variable aesthetic appearance according to the temperature effective on said decorative pattern.
摘要翻译：本发明涉及具有可逆热色装饰的厨房用具，例如咖啡壶或锅。特别地，咖啡机包括盖子（10），该盖子具有布置在盖的外表面上的装饰图案（20），根据在所述装饰图案上有效的温度具有可逆的美观外观。

8. 发明申请

WO2013054151A1 ROOFTOP COVERING STRUCTURE FOR SELF-VENTILATED ROOFS 审中-公开
标题翻译：自给式屋顶的平铺覆盖结构
公开(公告)号：WO2013054151A1
公开(公告)日：2013-04-18
申请号：PCT/IB2011/002437
申请日：2011-10-14
申请人： DEPLIMAX S.R.L. , ROSSI, Mario
发明人： ROSSI, Mario
IPC分类号： E04D13/17
CPC分类号： E04D13/174
摘要： Rooftop covering structure (1) for self-ventilated roofs (2) comprising at least one rectilinear section-bar (9) with a substantially inverted U- or Ω-shaped cross-section, which is suited to be positioned in the longitudinal groove (4) formed by the two slanted pitches (3) of the roof, astride the same slanted pitches (3), so as to surface externally from the longitudinal groove (4) between the impermeable. coverings (7) of the slanted pitches (3), and has the two major side edges (9a) substantially L folded so that each of said side edges can stably rest on the boarding (6) of a respective slanted pitch (3); the rectilinear section-bar (9) has, on at least one of its lateral sides (9b), a series of through-slots (11) and a series of projecting protective hoods (12), each of which protrudes from the outer surface of the section-bar lateral side (9b), immediately above the upper longitudinal edge of -a respective through-slot (11), and then lowers down to substantially the height of the lower longitudinal edge of the same through-slot (11), at a predetermined distance (d) from said lower longitudinal edge, so as to form a protective canopy (12) that covers the through-slot (11).
摘要翻译：用于自通风屋顶（2）的屋顶覆盖结构（1）包括至少一个具有大致倒U形或Ω形横截面的直线截面杆（9），其适于定位在纵向凹槽中 4）由屋顶的两个倾斜的间距（3）形成，横跨相同的倾斜间距（3），从而在纵向凹槽（4）的外部不透水之间。倾斜间距（3）的覆盖物（7），并且两个主要侧边缘（9a）大致L折叠，使得每个所述侧边缘能够稳定地搁置在相应倾斜节距（3）的登机板（6）上; 直线截面杆（9）在其至少一个侧面（9b）上具有一系列通孔（11）和一系列突出的保护罩（12），每个突出的保护罩（12）从外表面（9b）的上纵向边缘的上方，然后降低到相同通孔（11）的下纵向边缘的高度，在距所述下纵向边缘的预定距离（d）处形成覆盖所述通孔（11）的保护罩（12）。

9. 发明申请

WO2012013207A1 LINEAR ACTUATOR 审中-公开
标题翻译：线性执行器
公开(公告)号：WO2012013207A1
公开(公告)日：2012-02-02
申请号：PCT/EP2010/004666
申请日：2010-07-30
申请人： AKTIEBOLAGET SKF , DUITS, Johannes Andrianus Maria , ROSSI, Mario
发明人： DUITS, Johannes Andrianus Maria , ROSSI, Mario
IPC分类号： F16H25/20 , H02K11/00
CPC分类号： H02P31/00 , F16H25/2015 , H02K7/06 , H02K11/21 , H02P6/006
摘要： A linear actuator comprising a spindle, a spindle nut, a transmission, an electrical motor, and an actuation element, is arranged to linearly move the actuation element by means of an interaction of the spindle and the spindle nut, which interaction is being driven by the electrical motor through the transmission. A position of the actuation element, the relative position between spindle and spindle nut, is determined by means of an absolute rotary position sensor and a counter. The counter keeps track of the number of under-flows and over-flows the absolute rotary position sensor generates during movement of the actuation element. A combination of a value from the absolute rotary position sensor and a count from the counter determines the position.
摘要翻译：包括主轴，主轴螺母，变速器，电动马达和致动元件的线性致动器被布置成通过主轴和主轴螺母的相互作用线性移动致动元件，该相互作用由电动机通过变速箱。通过绝对旋转位置传感器和计数器来确定致动元件的位置，主轴和主轴螺母之间的相对位置。计数器跟踪绝对旋转位置传感器在致动元件的运动过程中产生的下流量和过流量。来自绝对旋转位置传感器的值和来自计数器的计数的组合确定位置。

10. 发明申请

WO2004033269A3 A FEEDBACK ASSEMBLY FOR AN ELECTRONICALLY CONTROLLED ELECTRO-MECHANICAL ACTUATING UNIT FOR A MOTOR VEHICLE 审中-公开
公开(公告)号：WO2004033269A3
公开(公告)日：2004-04-22
申请号：PCT/EP2003/011008
申请日：2003-10-06
申请人： AKTIEBOLAGET SKF , DI STEFANO, Enrico , ROSSI, Mario
发明人： DI STEFANO, Enrico , ROSSI, Mario
IPC分类号： B62D5/04
摘要： A feedback assembly (1) for an electronically controlled electro-mechanical actuating unit (2) for a motor vehicle, the feedback assembly (1) having a connection to the actuating unit (2), a shaft (10) , which is angularly fixed to a steering member of the motor vehicle, and an electrical actuator (20), which is angularly coupled to the shaft (10) for exerting a resistant torque on the shaft (10) itself according to the conditions of movement of the motor vehicle; a mechanical transmission (21) with concurrent axes (A, B) being set between the electrical actuator (20) and the shaft (10) .

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