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1. 发明申请

WO2007142814A2 MULTI-CHANNEL LOW COHERENCE INTERFEROMETER 审中-公开
标题翻译：多通道低相干干扰仪
公开(公告)号：WO2007142814A2
公开(公告)日：2007-12-13
申请号：PCT/US2007012146
申请日：2007-05-22
申请人： MEDEIKON CORP , AJGAONKAR MAHESH , ALPHONSE GERARD A
发明人： AJGAONKAR MAHESH , ALPHONSE GERARD A
CPC分类号： G01B9/0205 , G01B9/02028 , G01B9/0209 , G01B2290/70
摘要： A multi-channel low coherence interferometer having sensing and reference arms, at least one of which has variable delay. The sensing arm includes an optical switch for connecting to two or more probe arms. The distal ends of the probe arms collect source light backscattered from a sample. The backscattered light collected by the distal end of a probe arm is combined with reference light and a low coherence interferometric signal is produced by a sweep of a variable delay of the device or a sweep of a variable frequency laser light source. The interference signal produced by the interaction of reference and sensing light at a detector measures backscattered light, which may be used to characterize the sample. The low coherence interferometric signals can provide information about the morphology, physical nature, composition, and properties of the sample. The device may be used to discriminate between finished surfaces and corroded surfaces, healthy and diseased tissue, and can sample the material or tissue in two or more areas. Versions of the invention include devices that are interferometers and or autocorrelators.
摘要翻译：具有感测和参考臂的多通道低相干干涉仪，其中至少一个具有可变的延迟。感测臂包括用于连接到两个或更多个探针臂的光学开关。探头臂的远端收集从样品反向散射的光源。由探针臂的远端收集的背散射光与参考光合并，并且通过扫描可变延迟器件或扫描可变频率激光光源来产生低相干干涉信号。在检测器处的参考和感测光的相互作用产生的干涉信号测量可以用于表征样品的反向散射光。低相干干涉信号可以提供关于样品的形态，物理性质，组成和性质的信息。该装置可以用于区分完成的表面和腐蚀的表面，健康和患病组织，并且可以在两个或更多个区域中对材料或组织进行采样。本发明的版本包括作为干涉仪和/或自相关器的装置。

2. 发明申请

WO2007112196A3 LOW REFLECTION LATERAL OUTPUT FIBER PROBE 审中-公开
标题翻译：低反射横向输出光纤探头
公开(公告)号：WO2007112196A3
公开(公告)日：2008-07-03
申请号：PCT/US2007063755
申请日：2007-03-12
申请人： MEDEIKON CORP , ALPHONSE GERARD A , AJGAONKAR MAHESH , COMIZZOLI ROBERT , ROHATGI RAJEEV , NGUYEN MICHAEL
发明人： ALPHONSE GERARD A , AJGAONKAR MAHESH , COMIZZOLI ROBERT , ROHATGI RAJEEV , NGUYEN MICHAEL
IPC分类号： G02B6/26
CPC分类号： G02B6/262 , A61B5/0066 , A61B5/02007 , A61B5/6852
摘要： A system and method which integrates a mirror at the fiber tip to the fiber tip and uses a tilted flat at the exit plane to prevent astigmatism caused by the cylindrical curvature of the fiber wall and minimize reflection.
摘要翻译：将光纤尖端的反射镜与光纤尖端集成在一起的系统和方法，并在出射平面处使用倾斜的平面，以防止由纤维壁的圆柱形曲率引起的散光并使反射最小化。

3. 发明申请

WO2005114149B1 LOW COHERENCE INTERFEROMETRY UTILIZING PHASE 审中-公开
标题翻译：低相干干涉利用相
公开(公告)号：WO2005114149B1
公开(公告)日：2006-03-09
申请号：PCT/US2005015372
申请日：2005-05-04
申请人： MEDEIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： G01N21/45 , A61B5/0066 , A61B5/14532 , A61B5/14546 , A61B5/1455 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method for determining a characteristic of an analyte in a biological sample, the method comprising: directing broadband light by means of a sensing light path at the biological sample, at a target depth defined by the sensing light path and a reference light path; and receiving the broadband light reflected from the biological sample by means of the sensing light path. The method also includes: directing the broadband light by means of the reference light path at a reflecting device; receiving the broadband light reflected from the reflecting device by means of the reference light path; and interfering the broadband light reflected from the biological sample and the broadband light reflected from the reflecting device. The method further includes: detecting the broadband light resulting from interference of the broadband light reflected from the biological sample and the broadband light reflected from the reflecting device; and modulating an effective light path length of at least one of the reference light path and the sensing light path to enhance interference of the broadband light reflected from the biological sample and the broadband light reflected from the reflecting device. The method continues with: determining a magnitude of change of the effective light path length introduced by the modulating when interference is enhanced; determining a variation in an index of refraction from a ratio of the magnitude of change of the effective light path length and the target depth; and determining the characteristic of the analyte in the biological sample from the variation in the index of refraction.
摘要翻译：一种用于确定生物样品中的分析物的特征的方法，所述方法包括：在由感测光路和参考光路定义的目标深度处，通过生物样品处的感测光路引导宽带光; 以及通过感测光路接收从生物样品反射的宽带光。该方法还包括：通过参考光路在反射装置处引导宽带光; 通过参考光路接收从反射装置反射的宽带光; 并且干扰从生物样品反射的宽带光和从反射装置反射的宽带光。该方法还包括：检测由生物样品反射的宽带光和从反射装置反射的宽带光的干扰产生的宽带光; 并且调制参考光路和感测光路中的至少一个的有效光路长度，以增强从生物样本反射的宽带光和从反射装置反射的宽带光的干涉。该方法继续：确定当干扰增强时通过调制引入的有效光路长度的变化幅度; 根据有效光路长度的变化幅度与目标深度的比率确定折射率的变化; 以及根据折射率的变化确定生物样品中分析物的特性。

4. 发明申请

WO2008036886A3 IMPROVED ACCURACY LUMEN SIZING AND STENT EXPANSION 审中-公开
标题翻译：改进的准确的流明尺寸和支架扩展
公开(公告)号：WO2008036886A3
公开(公告)日：2008-12-18
申请号：PCT/US2007079144
申请日：2007-09-21
申请人： MEDEIKON CORP , CARLIN DONALD B , ALPHONSE GERARD A , RAPPAPORT FRED , PAUNESCU ALEX
发明人： CARLIN DONALD B , ALPHONSE GERARD A , RAPPAPORT FRED , PAUNESCU ALEX
IPC分类号： A61F2/06
CPC分类号： A61B5/1076 , A61B5/6853 , A61F2/958
摘要： This invention relates to a system, method and device for optically determining the shape and size of a lumen of a vessel or body cavity, and of, for example, a balloon stent as it is inflated. The size and shape determination of the lumen of the vessel or body cavity allows for accurate and safe deployment of a stent within the lumen.
摘要翻译：本发明涉及一种系统，方法和装置，用于光学确定血管或体腔的内腔的形状和尺寸，并且例如当气囊支架膨胀时的形状和尺寸。容器或体腔的内腔的尺寸和形状确定允许在腔内准确和安全地展开支架。

5. 发明申请

WO2008051587A3 LOW COHERENCE INTERFEROMETRY UTILIZING PHASE 审中-公开
标题翻译：低相干干涉利用相
公开(公告)号：WO2008051587A3
公开(公告)日：2008-07-17
申请号：PCT/US2007022603
申请日：2007-10-25
申请人： MEDEIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： G01B9/02 , A61B5/00 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： G01N21/45 , A61B5/0059 , A61B5/02007 , A61B5/14532 , A61B5/14558 , A61B2562/0242 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method for diagnosing a human condition from a characteristic of a plaque or tissue in a subject is presented The method includes directing broadband light by means of a sensing light path at an area of interest in the subject, at a target depth and further includes steps such as modulating at about a distance of a center wavelength of the broadband light an effective light path length, determining a phase component that is an argument of the cosine function, and determining a change in the phase component angle of said signal resulting from a change of said effective light path length that is itself induced by a change of a property of the area of interest in the subject
摘要翻译：提供了一种用于从受试者的斑块或组织的特征诊断人类状况的方法。该方法包括在目标深度处通过感兴趣区域处的感测光路引导宽带光，并且还包括步骤例如在宽带光的中心波长的距离处调制有效光路长度，确定作为余弦函数的自变量的相位分量，以及确定由变化产生的所述信号的相位分量角度的变化所述有效光路长度本身是由受试者的感兴趣区域的属性的变化引起的

6. 发明申请

WO2006079013B1 LOW COHERENCE INTERFEROMETRY FOR DETECTING AND CHARACTERIZING PLAQUES 审中-公开
标题翻译：用于检测和表征PLA的低相干干涉
公开(公告)号：WO2006079013B1
公开(公告)日：2006-11-09
申请号：PCT/US2006002253
申请日：2006-01-20
申请人： MEDEIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： G01N21/45 , A61B5/0066 , A61B5/0086 , A61B5/02007 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/6852 , A61B2562/0242 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method for determining a characteristic of tissue in a biological sample comprising: directing light at the biological sample at a first depth and receiving that light reflected from the biological; directing the light at a reflecting device (46) and receiving that light reflected from the reflecting device. The method also includes: interfering the light reflected from the biological sample and the light reflected from the reflecting device,- detecting light resulting from the interfering; and determining a first phase associated with the light resulting from the interfering based on the first depth. The method further includes: varying an effective light path length to define a second depth; determining a second phase associated with the light resulting from the interfering based on the second depth; and determining the characteristic of the biological sample from the first phase and the second phase .
摘要翻译：一种用于确定生物样品中组织特征的方法，包括：在第一深度处引导光生物样品并接收从生物学反射的光; 将光引导到反射装置（46）并接收从反射装置反射的光。该方法还包括：干扰从生物样品反射的光和从反射装置反射的光， - 检测由干扰产生的光; 以及基于所述第一深度确定与由所述干扰产生的光相关联的第一阶段。该方法还包括：改变有效光路长度以限定第二深度; 确定与基于所述第二深度的所述干扰产生的光相关联的第二阶段; 以及从第一阶段和第二阶段确定生物样本的特性。

7. 发明申请

WO2005114150B1 LOW COHERENCE INTERFEROMETRIC SYSTEM FOR OPTICAL METROLOGY 审中-公开
标题翻译：用于光学计量学的低相干干涉系统
公开(公告)号：WO2005114150B1
公开(公告)日：2006-03-09
申请号：PCT/US2005015373
申请日：2005-05-04
申请人： MEDEIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： A61B5/14532 , A61B5/0066 , A61B5/1455 , A61B5/1495 , A61B5/6852 , A61B2560/0233 , G01N21/4795
摘要： A system for optical metrology of a biological sample comprising: a broadband light source (22); an optical assembly receptive to the broadband light, the optical assembly configured to facilitate transmission of the broadband light in a first direction and impede transmission of the broadband light a second direction; a sensing light path (44) receptive to the broadband light from the optical assembly; a fixed reflecting device (46); a reference light path (42) receptive to the broadband light from the optical assembly, the reference light path coupled (50, 51) with the sensing light path, the reference light path having an effective light path length longer than an effective light path length of the sensing light path by a selected length corresponding to about a selected target depth within the biological sample; and a detector (28) receptive the broadband light resulting from interference of the broadband light to provide an electrical interference signal thereof.
摘要翻译：一种用于生物样品的光学测量的系统，包括：宽带光源（22）; 接收宽带光的光学组件，所述光学组件被配置为促进宽带光在第一方向的传输并且阻止宽带光的传输第二方向; 感测光路（44），其接收来自光学组件的宽带光; 固定反射装置（46）; 接收来自所述光学组件的宽带光的参考光路（42），所述参考光路与所述感测光路连接（50,51），所述参考光路具有比有效光路长度更长的有效光路长度所述感测光路的选定长度对应于所述生物样品内的所选择的目标深度; 以及接收由宽带光的干扰产生的宽带光以提供其电干扰信号的检测器（28）。

8. 发明申请

WO2006079011A8 LOW COHERENCE INTERFEROMETRY FOR DETECTING AND CHARACTERIZING PLAQUES 审中-公开
标题翻译：用于检测和表征PLA的低相干干涉
公开(公告)号：WO2006079011A8
公开(公告)日：2007-08-02
申请号：PCT/US2006002244
申请日：2006-01-20
申请人： MEDIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0242 , G01N21/45 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method and system for determining a characteristic of a biological sample including directing light at the biological sample and receiving that light; directing the light at a reference reflecting device (46) and receiving that light; adjusting an effective light path length to facilitate an interference of the light reflected from the biological sample corresponding to a first depth and the light reflected from the reference reflecting device; and detecting the broadband light resulting from the interference, to provide an interference signal. The method also includes: determining a first phase associated with the interference signal corresponding to the first depth; varying the effective light path length to define a second depth; determining a second phase associated with the interference signal corresponding to the second depth; and determining the characteristic of the biological sample from the phases .
摘要翻译：一种用于确定生物样品的特征的方法和系统，包括将光引导到生物样品并接收该光; 将光引导到参考反射装置（46）并接收该光; 调节有效光路长度以便于对应于第一深度的生物样品反射的光与从参考反射装置反射的光的干涉; 并检测由干扰产生的宽带光，以提供干扰信号。该方法还包括：确定与对应于第一深度的干扰信号相关联的第一阶段; 改变有效光路长度以限定第二深度; 确定与对应于第二深度的干扰信号相关联的第二阶段; 并从相中确定生物样品的特性。

9. 发明申请

WO2006079011B1 LOW COHERENCE INTERFEROMETRY FOR DETECTING AND CHARACTERIZING PLAQUES 审中-公开
标题翻译：低相干干涉法检测和鉴定斑块
公开(公告)号：WO2006079011B1
公开(公告)日：2007-06-14
申请号：PCT/US2006002244
申请日：2006-01-20
申请人： MEDIKON CORP , ALPHONSE GERARD A
发明人： ALPHONSE GERARD A
IPC分类号： A61B5/00 , G01B9/02 , G01N21/45 , G01N21/47 , G01N21/49
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0242 , G01N21/45 , G01N21/474 , G01N21/4785 , G01N21/49
摘要： A method and system for determining a characteristic of a biological sample including directing light at the biological sample and receiving that light; directing the light at a reference reflecting device (46) and receiving that light; adjusting an effective light path length to facilitate an interference of the light reflected from the biological sample corresponding to a first depth and the light reflected from the reference reflecting device; and detecting the broadband light resulting from the interference, to provide an interference signal. The method also includes: determining a first phase associated with the interference signal corresponding to the first depth; varying the effective light path length to define a second depth; determining a second phase associated with the interference signal corresponding to the second depth; and determining the characteristic of the biological sample from the phases .
摘要翻译：一种用于确定生物样本的特征的方法和系统，包括将光引导到生物样本并接收该光; 将光引导到参考反射装置（46）并接收该光; 调整有效光路长度以促进从对应于第一深度的生物样本反射的光与从参考反射装置反射的光的干涉; 并检测由干扰产生的宽带光，以提供干扰信号。该方法还包括：确定与对应于第一深度的干涉信号相关联的第一相位; 改变有效光路长度以限定第二深度; 确定与对应于所述第二深度的所述干涉信号相关联的第二相位; 并从相中确定生物样品的特征。

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