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1. 发明申请

WO2006047689A3 DOSAGE FORMS HAVING A MICRORELIEFED SURFACE AND METHODS AND APPARATUS FOR THEIR PRODUCTION 审中-公开
公开(公告)号：WO2006047689A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038794
申请日：2005-10-26
申请人： MCNEIL-PPC, INC. , BUNICK, Frank J. , CHEN, Jen-Chi
发明人： BUNICK, Frank J. , CHEN, Jen-Chi
IPC分类号： A61K9/20 , A61J3/00
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

2. 发明申请

WO2006049683A1 IMMEDIATE RELEASE FILM COATING 审中-公开
标题翻译：立即发布电影涂料
公开(公告)号：WO2006049683A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/031170
申请日：2005-08-30
申请人： MCNEIL-PPC, INC. , CHEN, Jen-Chi , BUNICK, Frank, J.
发明人： CHEN, Jen-Chi , BUNICK, Frank, J.
IPC分类号： A61K9/34 , A61K9/36
CPC分类号： A61K9/286 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to a composition having a shell-forming component that contains a low-molecular weight water-soluble polymer and at least one gum capable of forming or contributing to the formation of thermoreversible gel, wherein the water-soluble polymer has a cloud point in an aqueous system within a temperature range of about 20°C and about 90°C. The compositions are particularly suited for forming shell coatings on medicinal dosage forms.
摘要翻译：本发明涉及具有壳形成组分的组合物，其含有低分子量水溶性聚合物和至少一种可形成或有助于形成热可逆凝胶的胶，其中所述水溶性聚合物具有在约20℃和约90℃的温度范围内的水系统中的浊点。组合物特别适用于在药物剂型上形成壳涂层。

3. 发明申请

WO2009039049A1 DIP COATED COMPOSITIONS CONTAINING COPOLYMER OF POLYVINYL ALCOHOL AND POLYETHYLENE GLYCOL AND A GUM 审中-公开
标题翻译：含有聚乙烯醇和聚乙烯甘油和葡萄糖的共聚物的DIP涂覆组合物
公开(公告)号：WO2009039049A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/076342
申请日：2008-09-15
申请人： MCNEIL-PPC, INC. , CHEN, Jen-Chi
发明人： CHEN, Jen-Chi
IPC分类号： A61K9/28
CPC分类号： A61K9/2886 , A61K9/2072 , A61K9/2893
摘要： In one aspect, the present invention features a method of making a coated tablet, by dipping a core including an active agent into a coating liquid and drying the dipped core to form a outer-coating on said core, wherein the coating liquid includes (i) at least one copolymer of polyvinyl alcohol and polyethylene glycol, (ii) at least one gum, and (iii) a solvent for the at least one copolymer of polyvinyl alcohol and polyethylene glycol and the at least one gum and coated tablets manufactured by such method.
摘要翻译：一方面，本发明的特征在于一种制备包衣片剂的方法，该方法是通过将包含活性剂的核心浸渍在涂布液中并干燥浸渍的芯部以形成所述核心上的外涂层，其中涂覆液体包括（i ）至少一种聚乙烯醇和聚乙二醇的共聚物，（ii）至少一种胶，和（iii）用于至少一种聚乙烯醇和聚乙二醇共聚物的溶剂和由其制备的至少一种胶和包衣片方法。

4. 发明申请

WO2006047692A3 DOSAGE FORMS HAVING A MICRORELIEFED SURFACE AND METHODS AND APPARATUS FOR THEIR PRODUCTION 审中-公开
公开(公告)号：WO2006047692A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038799
申请日：2005-10-26
申请人： MCNEIL-PPC, INC. , BUNICK, Frank, J. , CHEN, Jen-Chi
发明人： BUNICK, Frank, J. , CHEN, Jen-Chi
IPC分类号： A61K9/20 , A61K9/28 , A61K9/00
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made in a variety of ways to incorporate the optical elements therein.

5. 发明申请

WO2006047690A2 DOSAGE FORMS HAVING A MICRORELIEFED SURFACE AND METHODS AND APPARATUS FOR THEIR PRODUCTION 审中-公开
标题翻译：具有微生物表面的剂型及其生产方法及装置
公开(公告)号：WO2006047690A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038795
申请日：2005-10-26
申请人： MCNEIL-PPC, INC. , BUNICK, Frank, J. , CHEN, Jen-Chi
发明人： BUNICK, Frank, J. , CHEN, Jen-Chi
IPC分类号： A61K9/20 , A61K9/28 , A61J3/00 , B29C33/30 , B29C33/42
CPC分类号： A61J3/007 , A61J3/005 , A61K9/2072 , A61K9/2095 , A61K9/2893 , B29C33/565 , B29C45/2673 , B29C45/372 , B29K2105/0035 , B41F17/36
摘要： The present invention provides an edible dosage form that incorporates optical elements (e.g., printed patterns, microrelief gratings, and/or macrorelief gratings), capable of producing unique optical effects and images in order to enable a user to better identify and differentiate the dosage forms, as well as to improve the detection of counterfeit production thereof, wherein the edible dosage forms may be made of ways to incorporate the optical elements therein.
摘要翻译：本发明提供了一种可食用剂型，其包含能够产生独特的光学效果和图像的光学元件（例如，印刷图案，微纤维格栅和/或宏观光栅），以使用户能够更好地识别和区分剂型，以及改进其假冒生产的检测，其中可食用剂型可以由其中结合光学元件的方式制成。

6. 发明申请

WO2009105409A2 DIP COATED COMPOSITIONS CONTAINING A STARCH HAVING A HIGH AMYLOSE CONTENT 审中-公开
标题翻译：含有高淀粉含量的淀粉的DIP涂层组合物
公开(公告)号：WO2009105409A2
公开(公告)日：2009-08-27
申请号：PCT/US2009/034243
申请日：2009-02-17
申请人： MC NEIL-PPC, INC. , CHEN, Jen-Chi
发明人： CHEN, Jen-Chi
IPC分类号： A61K9/34
CPC分类号： A61K9/2893 , A61K9/2072 , A61K9/286 , A61K9/2886
摘要： The present invention features a method of making a coated tablet by dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on the core, wherein the coating liquid contains at least one a starch having an amylose content of at least about 50 percent by weight of said starch.
摘要翻译：本发明的特征在于一种通过将包含活性剂的芯浸入涂布液中并干燥所述浸渍芯以在芯上形成外涂层来制备包衣片的方法，其中所述涂布液含有至少一种具有至少约50重量％的所述淀粉的直链淀粉含量。

7. 发明申请

WO2013166136A1 TABLET COMPRISING A FIRST AND SECOND REGION 审中-公开
标题翻译：包含第一和第二地区的图纸
公开(公告)号：WO2013166136A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039045
申请日：2013-05-01
申请人： MCNEIL-PPC, INC.
发明人： SOWDEN, Harry S. , MCNALLY, Gerard P. , ANDERSON, Oliver , STUHL, William J. , CHEN, Jen-Chi , DAY, Kenneth , SZYMCZAK, Christopher E.
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/209 , A61K9/0056 , A61K9/2072 , A61K9/2086 , A61K31/137 , A61K31/167 , A61K31/4545 , A61K2300/00
摘要： In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet.
摘要翻译：在一个方面，本发明的特征在于包括第一区域和第二区域的片剂，其中：（i）第一区域和第二区域各自包含片剂的至少10体积％（ii）第一区域包括药物活性剂，第一区域的组成与第二区域的组成不同; （iii）第一区域的密度小于约0.8g / cc; 和（iv）第一个区域在不到约30秒内放置在舌头上时在口中分解; 其中所述片剂的形状包括由侧壁分开的两个相对的主面，并且所述第一区域和所述第二区域之间的界面沿着所述片剂的至少一个主面。

8. 发明申请

WO2013166131A2 ORALLY DISINTEGRATING TABLET 审中-公开
标题翻译： ORALLY DISINCAGE TABLET
公开(公告)号：WO2013166131A2
公开(公告)日：2013-11-07
申请号：PCT/US2013/039040
申请日：2013-05-01
申请人： MCNEIL-PPC, INC.
发明人： CHEN, Jen-Chi , DAY, Kenneth , SZYMCZAK, Christopher E.
IPC分类号： A61K9/00
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/2095 , A61K31/167 , A61K31/426 , A61K31/7004 , A61K2300/00
摘要： The present invention features a tablet containing at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein: (a) the first material is a dielectric water-containing material (i) containing from about 1 to about 5 percent, by weight, of bound water and (ii) having a dielectric loss, when measured at a density of between 0.15 and 0.5 g/cc, of from about 0.05 to about 0.7; (b) the second material (i) having a water solubility from about 20 to about 400 g per 100g of water at 25°C, (ii) having a dielectric loss, when measured at a density between 0.5 and 1 g/cc, of less than about 0.05; (c) the tablet contains at least 15%, by weight, of the first material; (d) the combined weight of the at least one first material and the at least one second material is at least 60%, by weight, of the tablet; (e) the ratio of the at least one first material to the at least one second material is from about 20:80 to about 70:30; (f) the tablet has a density less than about 0.8 g/cc; and (g) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.
摘要翻译：本发明的特征在于含有至少一种第一材料，至少一种第二种材料和至少一种药物活性剂的片剂，其中：（a）第一种材料是含电介质水的材料（i），其含有约1至约0.05重量％的结合水和（ii）当以0.15-0.5g / cc的密度测量时介电损耗为约0.05至约0.7; （b）第二材料（i）在25℃下具有约20至约400g / 100g水的水溶性，（ii）当以0.5至1g / cc的密度测量时，其具有介电损耗，小于约0.05; （c）片剂含有至少15重量％的第一种材料; （d）所述至少一种第一材料和所述至少一种第二材料的组合重量为片剂的至少60重量％; （e）所述至少一种第一材料与所述至少一种第二材料的比例为约20:80至约70:30; （f）片剂的密度小于约0.8g / cc; 和（g）片剂在小于约30秒内放置在舌头上时在口中崩解。

9. 发明申请

WO2004028514A1 POLYMER COMPOSITION AND DOSAGE FORMS COMPRISING THE SAME 审中-公开
标题翻译：聚合物组合物和包含其的剂型
公开(公告)号：WO2004028514A1
公开(公告)日：2004-04-08
申请号：PCT/US2003/008960
申请日：2003-03-21
申请人： MCNEIL-PPC, INC.
发明人： CHEN, Jen-Chi , BUNICK, Frank, J. , SOWDEN, Harry, S.
IPC分类号： A61K9/34
CPC分类号： A61K9/284 , A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2893
摘要： A composition comprising a high molecular weight, water soluble polymer having a cloud point from about 20 to about 90° C and a gelling polymer is provided. The composition may be used as a component of a pharmaceutical dosage form, such as the shell of a dosage form, or as an edible matrix, i.e., a pharmaceutical dosage form per se.
摘要翻译：提供了包含具有约20至约90℃的浊点的高分子量水溶性聚合物和胶凝聚合物的组合物。组合物可以用作药物剂型的组分，例如剂型的壳，或作为食用基质，即药物剂型本身。

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