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1. 发明申请

WO2009090544A2 PROCESS FOR PRODUCING AMORPHOUS ATORVASTATIN CALCIUM 审中-公开
标题翻译：生产无花果ATORVASTATIN钙的方法
公开(公告)号：WO2009090544A2
公开(公告)日：2009-07-23
申请号：PCT/IB2009000068
申请日：2009-01-15
申请人： MATRIX LAB LTD , RAO P V SRINIVAS , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR , RAY PURNA CHANDRA , TYAGI OM DUTT
发明人： RAO P V SRINIVAS , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR , RAY PURNA CHANDRA , TYAGI OM DUTT
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Disclosed herein is an improved process for producing amorphous atorvastatin calcium and a method of packaging thereof.
摘要翻译：本文公开了一种生产无定形阿托伐他汀钙的改进方法及其包装方法。

2. 发明申请

WO2006011157A2 A NOVEL METHOD FOR THE PREPARATION OF ARYL PIPERAZINYL-HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：一种制备芳基哌嗪类杂环化合物的新方法
公开(公告)号：WO2006011157A2
公开(公告)日：2006-02-02
申请号：PCT/IN2005000205
申请日：2005-06-16
申请人： LUPIN LTD , TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , CHAUHAN YOGENDRA KUMAR , NALAM VASANTH KUMAR
发明人： TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , CHAUHAN YOGENDRA KUMAR , NALAM VASANTH KUMAR
IPC分类号： C07D417/00
CPC分类号： C07D417/12
摘要： A novel method for preparing a compound of formula (I), which comprises of coupling the piperazine derivative of formula (II), with alkyl halide containing compound of the formula (III), by heating in solvent free conditions or, optionally, in a minimum quantity of non-aqueous suspending liquid, in presence of a catalyst and a neutralizing agent to neutralize the hydrohalic acid.
摘要翻译：一种制备式（I）化合物的新方法，其包括将式（II）的哌嗪衍生物与含烷基卤的式（III）化合物偶联，通过在无溶剂条件下加热，或任选地在在催化剂和中和剂存在下，最少量的非水悬浮液，以中和氢卤酸。

3. 发明申请

WO2005094800A3 A CO-PRECIPITATED CEFEPIME COMPOSITION AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：共沉淀的头峰组合物及其制备方法
公开(公告)号：WO2005094800A3
公开(公告)日：2005-11-24
申请号：PCT/IN2005000095
申请日：2005-03-30
申请人： LUPIN LTD , TYAGI OM DUTT , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR
发明人： TYAGI OM DUTT , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR
IPC分类号： A61K31/546 , C07D501/00
CPC分类号： A61K31/546
摘要： The present invention provides a stable and sterile composition of Cefepime with a pharmaceutically acceptable non-toxic organic and inorganic base in high purity which exhibits good thermal stability which is obtained by co precipitation of composition containing non-sterile Cefepime and non-sterile pharmaceutically acceptable base. The method of preparing the co-precipitated composition of Cefepime with pharmaceutically acceptable non-toxic base comprises of, i) dissolving a composition containing mixture of non sterile Cefepime and a non sterile pharmaceutically acceptable non-toxic organic or inorganic base in water to obtain a clear aqueous solution having a pH in the range of 3.5-7 and ii) filtration of aqueous solution through 0.2 micron membrane filter and then adding the clear aqueous solution to a suitable an organic solvent followed by stirring, filtration and drying.
摘要翻译：本发明提供了具有高纯度的药学上可接受的无毒有机和无机碱的稳定且无菌的头孢吡肟组合物，其显示出良好的热稳定性，其通过共沉淀包含非无菌头孢吡肟和非无菌药学上可接受的碱。制备头孢吡肟与药学上可接受的无毒碱的共沉淀组合物的方法包括：i）将含有非无菌头孢吡肟和非无菌药学上可接受的无毒有机或无机碱的混合物的组合物溶解于水中以获得澄清的pH值为3.5-7的水溶液，和ii）通过0.2微米膜过滤器过滤水溶液，然后将澄清的水溶液加入合适的有机溶剂中，随后搅拌，过滤并干燥。

4. 发明申请

WO2008126105A2 IMPROVED PROCESS FOR THE PREPARATION OF ZOPICLONE AND IT'S ENANTIOMERICALLY ENRICHED ISOMER 审中-公开
标题翻译：改进的ZOPICLONE及其具有良好特征的异构体的方法
公开(公告)号：WO2008126105A2
公开(公告)日：2008-10-23
申请号：PCT/IN2008000239
申请日：2008-04-10
申请人： MATRIX LAB LTD , TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , PRASAD VELLANKI SIVA RAM , RAGHO RANE DNYANDEV , DURGA RAO BANDI NAGA , SRINIVAS REDDY DAGGULA
发明人： TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , PRASAD VELLANKI SIVA RAM , RAGHO RANE DNYANDEV , DURGA RAO BANDI NAGA , SRINIVAS REDDY DAGGULA
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Present invention relates to an improved process for the preparation of Zopiclone and its enantiomerically enriched isomer (Eszopiclone). 6-(5-Chloropyridin-2- yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo [3,4-b] pyrazine is reacted with 1-chloro- carbonyl-4-methylpiperazine in the presence of alkali earth metal carbonates, hydroxides or oxides in a solvent medium to give Zopiclone. It is reacted with optically active acid in a mixture of water and water miscible organic solvent followed by work up to give Eszopiclone. The present invention also relates to process for the conversion of (R) or (S) Zopiclone to 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydro- pyrrolo- [3,4-b] - pyrazine of the intermediate which can be converted to racemic Zopiclone.
摘要翻译：本发明涉及一种改良的佐匹克隆及其对映体富集异构体（依佐替普）的制备方法。 6-（5-氯吡啶-2-基）-5-羟基-7-氧代-5,6-二氢吡咯并[3,4-b]吡嗪在碱存在下与1-氯 - 羰基-4-甲基哌嗪反应土壤金属碳酸盐，氢氧化物或氧化物在溶剂介质中给予佐匹克隆。将其与光学活性酸在水和水混溶性有机溶剂的混合物中反应，随后加工得到依佐替普。本发明还涉及将（R）或（S）佐匹克隆转化成6-（5-氯吡啶-2-基）-5-羟基-7-氧代-5,6-二氢 - 吡咯并[3 ，4-b] - 吡嗪，其可以转化为外消旋佐匹克隆。

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