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1. 发明申请

WO2004087283A1 FLUID SEPARATION 审中-公开
标题翻译：流体分离
公开(公告)号：WO2004087283A1
公开(公告)日：2004-10-14
申请号：PCT/US2004/009451
申请日：2004-03-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GUENTHER, Axel , JENSEN, Klavs, F. , JHUNJHUNWALA, Manish , SCHMIDT, Martin, A.
发明人： GUENTHER, Axel , JENSEN, Klavs, F. , JHUNJHUNWALA, Manish , SCHMIDT, Martin, A.
IPC分类号： B01D11/00
CPC分类号： B01L3/502784 , B01D17/045 , B01D17/048 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/0222 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , B01L2400/0487 , B01L2400/0694 , F16K99/0001 , F16K99/0017 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T436/25375
摘要： A method of separating a first fluid from a second fluid may include prewetting with the first fluid at least one channel defined by a separation device, the at least one channel thereby containing a column of the first fluid along its length. A combined flow of the first fluid and the second fluid may be presented to the separation device, so that the at least one channel is in fluid communication with the combined flow. Fluid pressure may be applied across the combined flow and the separation device, but the applied pressure should not exceed the capillary pressure in the at least one channel. Otherwise, the combined flow may be forced through the separation device. In this manner, the first fluid flows through the at least one channel, and the second fluid is excluded from the at least one channel, thereby separating at least a portion of the first fluid from the second fluid.
摘要翻译：从第二流体分离第一流体的方法可以包括用第一流体预润湿由分离装置限定的至少一个通道，因此至少一个通道沿其长度包含第一流体的柱。可以将第一流体和第二流体的组合流体提供给分离装置，使得至少一个通道与组合流体流体连通。流体压力可以跨过组合的流量和分离装置施加，但施加的压力不应超过至少一个通道中的毛细管压力。否则，组合的流动可能被迫通过分离装置。以这种方式，第一流体流过至少一个通道，并且第二流体从至少一个通道排除，从而将第一流体的至少一部分与第二流体分离。

2. 发明申请

WO2006137878A3 FLOW METHOD AND REACTOR FOR MANUFACTURING NANOCRYSTALS 审中-公开
公开(公告)号：WO2006137878A3
公开(公告)日：2006-12-28
申请号：PCT/US2005/033827
申请日：2005-09-23
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , YEN, Brian, K., H. , GUENTHER, Axel , JENSEN, Klavs, F. , SCHMIDT, Martin , BAWENDI, Moungi, G.
发明人： YEN, Brian, K., H. , GUENTHER, Axel , JENSEN, Klavs, F. , SCHMIDT, Martin , BAWENDI, Moungi, G.
IPC分类号： H01L21/20 , H01L21/36
摘要： A population of nanocrystals having a narrow and controllable size distribution and can be prepared by a segmented-flow method.

3. 发明申请

WO2014176697A1 MICROFLUIDIC DEVICES AND METHODS FOR THE EXTRUSION OF TUBULAR STRUCTURES 审中-公开
标题翻译：微流体装置和挤压管状结构的方法
公开(公告)号：WO2014176697A1
公开(公告)日：2014-11-06
申请号：PCT/CA2014/050413
申请日：2014-04-30
申请人： CHEN, Haotian , JERINIMO, Mark , MCALLISTER, Arianna , GUENTHER, Axel
发明人： CHEN, Haotian , JERINIMO, Mark , MCALLISTER, Arianna , GUENTHER, Axel
IPC分类号： B81C1/00 , B81B1/00 , B81B7/04
CPC分类号： B81C1/00119 , B01L3/502707 , B01L2200/12 , B01L2300/0887 , B81B2201/058
摘要： Methods and devices are disclosed for the controlled formation of structures, including tubular structures, using microfluidic devices. In one embodiment, a microfluidic device includes three or more microfluidic arrays that are provided in a stacking configuration, with an inner streaming layer and an outer streaming layer for flowing a streaming fluid, and at least one intermediate matrix layer for flowing a matrix fluid. Fluid flow in each layer is directed from a peripheral region towards, and distributed around, a common central outlet. Guided by the streaming fluid, a sheath of matrix solution is formed, which may be solidified to form a tubular material. Some embodiments allow for the controlled and continuous extrusion of tubular structures with tailored heterogeneities and/or predictable mechanical and chemical properties. Devices and methods are also provided for the on- and off-chip fixation and optional perfusion of tubular structures.
摘要翻译：公开了用于使用微流体装置控制形成结构（包括管状结构）的方法和装置。在一个实施例中，微流体装置包括以堆叠配置提供的三个或更多个微流体阵列，具有用于流动流体流的内部流动层和外部流动层，以及用于流动基质流体的至少一个中间矩阵层。每个层中的流体流从周边区域引导到共同的中央出口周围并分布在其周围。由流动液引导，形成基质溶液鞘，其可以固化以形成管状材料。一些实施例允许具有定制的异质性和/或可预测的机械和化学性质的管状结构的受控和连续挤出。还提供了用于片外固定和管状结构的可选灌注的装置和方法。

4. 发明申请

WO2009152618A1 DEVICE FOR INVESTIGATION OF A FLOW CONDUIT 审中-公开
标题翻译：用于调查流量的装置
公开(公告)号：WO2009152618A1
公开(公告)日：2009-12-23
申请号：PCT/CA2009/000852
申请日：2009-06-17
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , GUENTHER, Axel , BOLZ, Steffen-Sebastian
发明人： GUENTHER, Axel , BOLZ, Steffen-Sebastian
IPC分类号： G01N33/483 , G01N33/68
CPC分类号： G01N33/4833 , A61F2/06 , A61F2/062 , G01N33/5088
摘要： A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit.
摘要翻译：一种用于调查流动管道的装置，包括：基座; 以及形成在所述基座中的模块，所述模块包括：用于所述流动管道的主通道，所述主通道具有用于装载所述流动管道的加载入口; 在主通道中的用于流动管道的灌注和灌注中的至少一个的培养室; 与主通道连通的至少两条固定线，用于在沿着流动管道的长度的至少两个固定位置处提供流动导管的固定。

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