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1. 发明申请

WO2006026570A8 USE OF STEM CELLS TO GENERATE INNER EAR CELLS 审中-公开
标题翻译：使用干细胞产生内耳细胞
公开(公告)号：WO2006026570A8
公开(公告)日：2008-06-26
申请号：PCT/US2005030714
申请日：2005-08-30
申请人： MASSACHUSETTS EYE & EAR INFIRM , LI HUAWEI , EDGE ALBERT , HELLER STEFAN
发明人： LI HUAWEI , EDGE ALBERT , HELLER STEFAN
IPC分类号： A61K48/00 , A61K35/12 , A61K38/17 , C12N5/0793 , C12N15/85 , C12Q1/68 , G01N33/53
CPC分类号： A61K35/30 , A61K9/0046 , A61K35/12 , A61K35/55 , A61K38/1709 , C12N5/0619 , C12N5/062 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/41 , C12N2506/02 , G01N33/5073
摘要： This invention relates generally to methods and compositions for inducing stem cell or progenitor cell differentiation, and more particularly to methods and compositions for inducing differentiation of stem cells and/or progenitor cells into cells that function within the inner ear.
摘要翻译：本发明一般涉及用于诱导干细胞或祖细胞分化的方法和组合物，并且更具体地涉及用于诱导干细胞和/或祖细胞分化成在内耳中发挥功能的细胞的方法和组合物。

2. 发明申请

WO2006026570A2 USE OF STEM CELLS TO GENERATE INNER EAR CELLS 审中-公开
标题翻译：使用干细胞来生成内细胞
公开(公告)号：WO2006026570A2
公开(公告)日：2006-03-09
申请号：PCT/US2005030714
申请日：2005-08-30
申请人： MASSACHUSETTS EYE & EAR INFIRM , LI HUAWEI , EDGE ALBERT , HELLER STEFAN
发明人： LI HUAWEI , EDGE ALBERT , HELLER STEFAN
IPC分类号： A61K38/17 , A61K35/12 , A61K48/00 , C12N5/0793 , C12Q1/68
CPC分类号： A61K35/30 , A61K9/0046 , A61K35/12 , A61K35/55 , A61K38/1709 , C12N5/0619 , C12N5/062 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/41 , C12N2506/02 , G01N33/5073
摘要： This invention relates generally to methods and compositions for inducing stem cell or progenitor cell differentiation, and more particularly to methods and compositions for inducing differentiation of stem cells and/or progenitor cells into cells that function within the inner ear.
摘要翻译：本发明一般涉及用于诱导干细胞或祖细胞分化的方法和组合物，更具体地涉及用于诱导干细胞和/或祖细胞分化成在内耳内起作用的细胞的方法和组合物。

3. 发明申请

WO2007030743A3 COCHLEAR IMPLANTS CONTAINING BIOLOGICAL CELLS AND USES THEREOF 审中-公开
标题翻译：含有生物细胞的耳蜗植物及其用途
公开(公告)号：WO2007030743A3
公开(公告)日：2007-07-05
申请号：PCT/US2006035117
申请日：2006-09-08
申请人： MASSACHUSETTS EYE & EAR INFIRM , EDGE ALBERT , HELLER STEFAN
发明人： EDGE ALBERT , HELLER STEFAN
IPC分类号： A61N1/00
CPC分类号： A61N1/0541 , A61L27/3633 , A61L27/3834 , A61L27/54 , A61L2300/414 , A61L2430/14 , A61N1/326 , A61N1/36036 , A61N1/36121
摘要： This invention generally relates to cochlear implants containing or supporting stem-cell derived neural cells, and methods of making and using the cochlear implants.
摘要翻译：本发明一般涉及含有或支持干细胞衍生神经细胞的人工耳蜗植入物，以及制造和使用人工耳蜗植入物的方法。

4. 发明申请

WO2012047706A2 METHODS FOR PROMOTIING REINNERVATION OF AUDITORY HAIR CELLS 审中-公开
标题翻译：促进审核头发细胞再培养的方法
公开(公告)号：WO2012047706A2
公开(公告)日：2012-04-12
申请号：PCT/US2011053868
申请日：2011-09-29
申请人： MASSACHUSETTS EYE & EAR INFIRM , EDGE ALBERT
发明人： EDGE ALBERT
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/7105 , A61P27/00 , A61P27/16
CPC分类号： C07K16/2803 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K35/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , A61K2300/00
摘要： This invention relates to methods for promoting reinnervation of auditory hair cells, specifically, by inhibiting Repulsive Guidance Molecule a (RGMa), a repulsive axonal guidance molecule that is expressed in the cochlea, or its receptor, neogenin.
摘要翻译：本发明涉及用于促进听觉毛细胞再感染的方法，具体地，通过抑制排斥导向分子a（RGMa），在耳蜗中表达的排斥性轴索引导分子或其受体，新生素。

5. 发明申请

WO2009100438A2 COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION 审中-公开
标题翻译：加强ATOH-1表达的化合物
公开(公告)号：WO2009100438A2
公开(公告)日：2009-08-13
申请号：PCT/US2009033569
申请日：2009-02-09
申请人： MASSACHUSETTS EYE & EAR INFIRM , BRIGHAM & WOMENS HOSPITAL , EDGE ALBERT , SEYB KATHLEEN , GLICKSMAN MARCIE , QIAO LIXIN , CUNY GREGORY D , JEON SANG-JUN
发明人： EDGE ALBERT , SEYB KATHLEEN , GLICKSMAN MARCIE , QIAO LIXIN , CUNY GREGORY D , JEON SANG-JUN
IPC分类号： A61K31/341 , A61K31/343 , A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/428 , A61P27/16
CPC分类号： A61K31/5377 , A61K9/0046 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/4365 , A61K31/437 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/498 , A61K31/517 , A61K31/519 , A61K35/28 , A61K35/545
摘要： This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.
摘要翻译：本发明通常提供化合物，药物组合物及其使用方法，其包括导致生物细胞中Atoh1基因（例如Hath1）表达增加的方法。更具体地，本发明涉及可以从Atoh1表达增加中受益的疾病和/或病症的治疗，例如与听觉毛细胞丧失相关的听力损伤或不平衡障碍或与异常细胞增殖相关的病症。

6. 发明申请

WO2008076556A3 GENERATION OF INNER EAR CELLS 审中-公开
标题翻译：内耳细胞的产生
公开(公告)号：WO2008076556A3
公开(公告)日：2008-12-24
申请号：PCT/US2007084654
申请日：2007-11-14
申请人： MASSACHUSETTS EYE & EAR INFIRM , EDGE ALBERT
发明人： EDGE ALBERT
IPC分类号： C12N5/071
CPC分类号： C12N5/0627 , C12N5/062 , C12N2501/42 , C12N2506/1353
摘要： Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as compositions including the inner ear cells. Methods for the therapeutic use of the inner ear cells for the treatment of hearing loss are also described.
摘要翻译：提供了从干细胞例如间充质干细胞产生内耳细胞例如毛细胞和支持细胞的方法，以及包括内耳细胞的组合物。还描述了用于治疗听力损失的内耳细胞的治疗用途的方法。

7. 发明申请

WO2015168149A3 SENSORINEURAL HAIR CELL DIFFERENTIATION 审中-公开
标题翻译：传感器毛细胞分化
公开(公告)号：WO2015168149A3
公开(公告)日：2015-12-30
申请号：PCT/US2015028035
申请日：2015-04-28
申请人： MASSACHUSETTS EYE & EAR INFIRM
发明人： EDGE ALBERT , KEMPFLE JUDITH , ABDUL-AZIZ DUNIA
IPC分类号： A01N63/00 , A01N65/00 , A61K38/00
CPC分类号： A61K31/19 , A61K9/0019 , A61K9/0046 , A61K31/165 , A61K31/7088 , A61K38/12 , A61K38/1709 , A61K45/06
摘要： The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of Atoh1 protein.
摘要翻译：本公开提供用于治疗患有或伴有感觉神经性听力损失的受试者的组合物和方法。这样的组合物和方法包括调节细胞的表观遗传状态或蛋白质降解的速率，以增加Atoh1蛋白的表达和/或水平。

8. 发明申请

WO2016022776A3 INCREASING ATOH1 LIFE TO DRIVE SENSORINEURAL HAIR CELL DIFFERENTIANTION 审中-公开
标题翻译：增加ATOH1寿命来驱动感染性毛细胞分化
公开(公告)号：WO2016022776A3
公开(公告)日：2016-03-31
申请号：PCT/US2015043976
申请日：2015-08-06
申请人： MASSACHUSETTS EYE & EAR INFIRM
发明人： EDGE ALBERT , CHENG YEN-FU , KEMPFLE JUDITH , ABDUL-AZIZ DUNIA
IPC分类号： A61K38/48 , A61K38/55
CPC分类号： C12N15/1137 , A61K9/0046 , A61K31/407 , A61K31/69 , A61K31/7105 , A61K31/713 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/12 , A61K38/15 , A61K38/1709 , A61K45/06 , A61K48/0075 , C07K14/47 , C12N15/113 , C12N2310/14 , C12Y603/02019
摘要： The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss by modulating the rate of Atoh1 protein degradation to increase levels of Atoh1 protein.
摘要翻译：本公开提供了通过调节Atoh1蛋白降解的速率以增加Atoh1蛋白的水平来治疗患有感觉神经性听力损失的受试者的组合物和方法。

9. 发明申请

WO2004024750A3 CD44-BINDING LIGANDS 审中-公开
公开(公告)号：WO2004024750A3
公开(公告)日：2004-11-04
申请号：PCT/US0329318
申请日：2003-09-15
申请人： DYAX CORP , RONDON ISAAC J , EDGE ALBERT , BARIBAULT KENT RACHEL
发明人： RONDON ISAAC J , EDGE ALBERT , BARIBAULT KENT RACHEL
IPC分类号： C07K16/28 , C07K16/00 , A61K39/395
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2319/30
摘要： The invention provides CD44-binding proteins, including CD44-binding antibodies, antibody fragments, and pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such proteins. Methods of using the proteins to detect CD44 or to modulate a CD44-expressing cell, e.g., in a subject, are also described.
摘要翻译：本发明提供CD44结合蛋白，包括CD44结合抗体，抗体片段及其药物组合物，以及用于制备这种蛋白质的核酸，重组表达载体和宿主细胞。还描述了使用蛋白质检测CD44或调节表达CD44的细胞（例如受试者）的方法。

10. 发明申请

WO0010580A3 NEURAL RETINAL CELLS AND RETINAL PIGMENT EPITHELIUM CELLS AND THEIR USE IN TREATMENT OF RETINAL DISORDERS 审中-公开
标题翻译：神经视网膜细胞和视网膜色素上皮细胞及其在治疗视网膜病中的应用
公开(公告)号：WO0010580A3
公开(公告)日：2000-06-08
申请号：PCT/US9919583
申请日：1999-08-25
申请人： DIACRIN INC , EDGE ALBERT
发明人： EDGE ALBERT
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C12N5/071 , C12N5/0793 , A61K35/44
CPC分类号： C12N5/0621 , A61K35/12 , A61K38/00 , A61K39/001 , A61K2035/122 , C12N5/062
摘要： Compositions comprising porcine retinal cells and methods for using the compositions to treat retinal disorders are described. The porcine retinal cells are preferably fetal neural retina cells or retinal pigment epithelial cells. The porcine retinal cells can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine retinal cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cell when introduced into the subject. In one embodiment, the porcine retinal cells are obtained from a pig predetermined to be free from organisms which originate in pig and which are capable of transmitting infection or disease to the recipient subject. The porcine retinal cells of the present invention can be used to treat a xenogeneic subject having a retinal disorder (e.g., a human with retinis pigmentosa, light damaged retina and macular degeneration) by introducing the cells into the retina of the subject.
摘要翻译：描述了包含猪视网膜细胞的组合物和使用该组合物治疗视网膜疾病的方法。猪视网膜细胞优选胎儿神经视网膜细胞或视网膜色素上皮细胞。猪视网膜细胞可以被修饰以适合于移植到异种对象如人中。例如，可以修饰猪视网膜细胞，使得细胞表面上能够刺激针对异种受试者中的细胞的免疫应答的抗原（例如，MHC I类抗原）被改变（例如通过与抗-MHC I类抗体或其片段或衍生物）以在引入受试者时抑制细胞排斥。在一个实施方案中，猪视网膜细胞从预先确定为不含源自猪的生物体并且能够将感染或疾病传递至受体个体的猪获得。通过将细胞引入受试者的视网膜，本发明的猪视网膜细胞可以用于治疗具有视网膜疾病的异种受试者（例如，具有视网膜色素变性的人，光损伤的视网膜和黄斑变性）。

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