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1. 发明申请

WO2005023348A3 UNIT DOSE CARTRIDGE AND DRY POWDER INHALER 审中-公开
公开(公告)号：WO2005023348A3
公开(公告)日：2005-03-17
申请号：PCT/US2004/028699
申请日：2004-09-03
申请人： MANNKIND CORPORATION , STEINER, Solomon, S. , POOLE, Trent, A. , FOG, Per, B. , POHL, Roderike , CRICK, Michael , FELDSTEIN, Robert
发明人： STEINER, Solomon, S. , POOLE, Trent, A. , FOG, Per, B. , POHL, Roderike , CRICK, Michael , FELDSTEIN, Robert
IPC分类号： A61M15/00
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing (20) having an air intake (15), an air flow-control/check-valve (180), a mixing section (30) and a mouthpiece (40). A cartridge loaded with a single dose of medicament can be installed in the mixing section.

2. 发明申请

WO2011049713A2 STABILIZED GLUCAGON SOLUTIONS 审中-公开
标题翻译：稳定的GLUCAGON解决方案
公开(公告)号：WO2011049713A2
公开(公告)日：2011-04-28
申请号：PCT/US2010/050386
申请日：2010-09-27
申请人： BIODEL INC. , STEINER, Solomon, S. , HAUSER, Robert , LI, Ming , FELDSTEIN, Robert , POHL, Roderike
发明人： STEINER, Solomon, S. , HAUSER, Robert , LI, Ming , FELDSTEIN, Robert , POHL, Roderike
IPC分类号： A61K38/26
CPC分类号： A61K9/0019 , A61K9/1075 , A61K38/26 , A61K47/24 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 370C.
摘要翻译：已经设计了由糖如葡萄糖和表面活性剂如肉豆蔻酰溶血磷脂酰胆碱（LMPC）组成的制剂，以在长时间的生理条件下稳定胰高血糖素分子的亲水部分和疏水部分，其浓度与pH和pH足够相似，血浆的渗透压，以免诱发或最小化部位刺激。单糖和表面活性剂的组合在37℃下使胰高血糖素分子在水溶液中稳定7天。

3. 发明申请

WO2007098058A2 METHOD AND DEVICE FOR SUBLINGUAL DRUG DELIVERY USING IONTOPHORESIS 审中-公开
标题翻译：使用IOPOPHORESIS进行次级药物递送的方法和装置
公开(公告)号：WO2007098058A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/004202
申请日：2007-02-15
申请人： BIODEL, INC. , STEINER, Solomon, S. , FELDSTEIN, Robert , POHL, Roderike , RHODES, David , STEINER, Erik
发明人： STEINER, Solomon, S. , FELDSTEIN, Robert , POHL, Roderike , RHODES, David , STEINER, Erik
IPC分类号： A61N1/30 , A61M37/00
CPC分类号： A61N1/306 , A61M2210/0625 , A61M2210/0643
摘要： Methods, devices and kits for sublingual drug delivery using iontophoresis are described herein. An active agent can be administered sublingually by placing a solid oral dosage form containing the active agent in the sublingual region of a patient and applying iontophoresis for a suitable period of time. Preferably up to 4 mA of current are applied to the sublingual region. Different time ranges can be used to administer iontophoresis; preferably iontophoresis is administered for up to 2 minutes at a time. Any suitable device for administering iontophoresis to the sublingual region may be used. The preferred device is a hand-held device that contains a handle, two electrodes, one of which is located on the handle and the other of which is attached to the end of the handle, and a connection to a power source. Optionally, the device contains a timer, which can be used turn off the current at a preset time. The device can be used to administer an active agent by iontophoresis to the sublingual region of a patient, by attaching the second electrode of the device to a solid oral dosage form containing the active agent to be administered. A kit contains the device for administering iontophoresis and one or more solid oral dosage forms, preferably in the form of one or more tabs or wafers. The tabs or wafers may be completely dissolvable or edible, or may contain a non-edible and non-dissolvable component. In a preferred embodiment, the solid oral dosage form contains insulin or an analog thereof and one or more excipients, preferably EDTA and citric acid.
摘要翻译：本文描述了使用离子电渗法进行舌下药物递送的方法，装置和试剂盒。活性剂可以通过将含有活性剂的固体口服剂型置于患者的舌下区域并施用离子电渗疗法适当的时间段来进行舌下给药。优选地，最多将4mA的电流施加到舌下区域。不同的时间范围可用于管理离子电渗疗法; 优选每次一次给予离子电渗疗法达2分钟。可以使用用于向舌下区域施用离子电渗疗法的任何合适的装置。优选的装置是手持装置，其包括手柄，两个电极，其中一个电极位于手柄上，另一个电极连接到手柄的端部，并且连接到电源。可选地，设备包含定时器，其可以在预设时间关闭电流。该装置可用于通过将装置的第二电极连接到含有待施用的活性剂的固体口服剂型，通过离子电渗法向患者的舌下区域施用活性剂。试剂盒包含用于施用离子电渗疗法的装置和一种或多种固体口服剂型，优选以一个或多个片或晶片的形式。标签或晶片可以是完全可溶的或可食用的，或者可以包含不可食用和不可溶的组分。在优选的实施方案中，固体口服剂型含有胰岛素或其类似物和一种或多种赋形剂，优选EDTA和柠檬酸。

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