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1. 发明申请

WO2010136799A3 DEVICE POSITIONING SYSTEM 审中-公开
标题翻译：设备定位系统
公开(公告)号：WO2010136799A3
公开(公告)日：2011-03-17
申请号：PCT/GB2010050871
申请日：2010-05-26
申请人： MAGSTIM CO LTD , ROGUE RES IN , THOMAS ANDREW , COMEAU ROCH
发明人： THOMAS ANDREW , COMEAU ROCH
IPC分类号： A61B19/00 , A61B17/00
CPC分类号： A61B34/70 , A61B90/11 , A61B90/50 , A61B2017/00022 , A61B2017/00398 , A61B2017/00535 , A61B2017/00557 , A61B2034/304 , A61N2/02
摘要： A positioning system (1) for positioning a scientific or medical device (particularly a TMS coil (2) ) in a predetermined location with respect to a living subject, includes a manipulator arrangement (5) which is movable to position the device and a mounting platform (3) for mounting the device. The mounting platform includes a displacement device (14) for displacing the device with respect to the manipulator arrangement; the displacement device being a variable volume displacement device (such as a bag or pouch for example) supplied with a fluid.
摘要翻译：一种用于将科学或医疗装置（特别是TMS线圈（2））定位在相对于活体的预定位置的定位系统（1）包括可移动以定位所述装置的机械手装置（5）平台（3）用于安装设备。安装平台包括用于相对于操纵器装置移动装置的位移装置（14）; 位移装置是一个可变体积排出装置（例如，一个袋子或袋子），供给流体。

2. 发明申请

WO2011106312A3 CHARGE PUMP WITH GLITCHLESS TERMINAL CURRENTS 审中-公开
标题翻译：带无端子电流的充电泵
公开(公告)号：WO2011106312A3
公开(公告)日：2012-11-22
申请号：PCT/US2011025704
申请日：2011-02-22
申请人： LINEAR TECHN INC , SOUSA JOSEPH , THOMAS ANDREW
发明人： SOUSA JOSEPH , THOMAS ANDREW
IPC分类号： H02M3/07
CPC分类号： H02M3/07 , H02M1/15
摘要： Circuits and methods for maintaining a substantially constant input and output current for a charge pump circuit are provided which reduce current variation during switching intervals. The charge pump circuitry of the present invention maintains a current flow path from a current source to the charge pump output which minimizes or eliminates spikes normally associated with the switching intervals
摘要翻译：提供了用于为电荷泵电路保持基本恒定的输入和输出电流的电路和方法，其减少了切换间隔期间的电流变化。本发明的电荷泵电路保持从电流源到电荷泵输出的电流流动路径，其最小化或消除通常与切换间隔相关联的尖峰

3. 发明申请

WO2007054444A2 3-ARYL-ISOXAZOLE-4-CARBONYL-BENZOFURAN DERIVATIVES 审中-公开
标题翻译： 3-芳基 - 异恶唑-4-羰基苯并呋喃衍生物
公开(公告)号：WO2007054444A2
公开(公告)日：2007-05-18
申请号：PCT/EP2006067879
申请日：2006-10-27
申请人： HOFFMANN LA ROCHE , BUETTELMANN BERND , HAN BO , KNUST HENNER , NETTEKOVEN MATTHIAS , THOMAS ANDREW
发明人： BUETTELMANN BERND , HAN BO , KNUST HENNER , NETTEKOVEN MATTHIAS , THOMAS ANDREW
IPC分类号： C07D413/06 , A61K31/42 , A61P25/28 , C07D413/14
CPC分类号： C07D413/06 , C07D413/14
摘要： The present invention is concerned with 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives of formula (I) wherein R1 is hydrogen or halogen; R2 is hydrogen, halogen, hydroxy, lower alkoxy, OCF3, -OCH2-R, R3 is hydrogen or lower alkoxy; or R2 and R3 form together with the carbon atom to which they are attached a ring with -CH=CH-CH=-CH-; R is aryl or heteroaryl, optionally substituted by halogen or lower alkyl, or is C(O)NH-lower alkyl, or is -C(O)-heteroaryl, wherein the heteroaryl group is optionally substituted by lower alkyl or phenyl, and with their pharmaceutically acceptable acid addition salts. It has been found that this class of compounds show high affinity and selectivity for GABA A cc5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及其中R 1为氢或卤素的式（I）的3-芳基 - 异恶唑-4-羰基 - 苯并呋喃衍生物; R2是氢，卤素，羟基，低级烷氧基，OCF3，-OCH2-R，R3是氢或低级烷氧基; 或者R2和R3与它们所连接的碳原子一起形成具有-CH = CH-CH = -CH-的环; R 2为芳基或杂芳基，任选被卤素或低级烷基取代，或为C（O）NH-低级烷基，或为-C（O） - 杂芳基，其中杂芳基任选被低级烷基或苯基取代，其药学上可接受的酸加成盐。已经发现，这类化合物对GABA A cc5受体结合位点显示出高亲和力和选择性，并可用作认知增强剂或用于治疗认知障碍如阿尔茨海默氏病。

4. 发明申请

WO2005072328A3 SYSTEM AND METHOD FOR MANAGING THE DELIVERY OF ORDERS FOR GOODS 审中-公开
标题翻译：用于管理物品订单交付的系统和方法
公开(公告)号：WO2005072328A3
公开(公告)日：2005-12-22
申请号：PCT/US2005002299
申请日：2005-01-25
申请人： WW GRAINGER INC , THOMAS ANDREW
发明人： THOMAS ANDREW
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q10/08 , G06Q10/00 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A system and method (10) for managing the delivery of goods (12) provides for manifesting and controlling route-based delivery of orders or packages (12) from a vendor (14) to one or more locations (16) accessible by customers (18). The locations (16) may include automated, self-service vending machines (20) and/or will-call lockers (22), under the control of a centralized system (10) that can automatically receive and actively manage manifest information.
摘要翻译：用于管理货物交付（12）的系统和方法（10）提供了显示和控制从供应商（14）到由客户可访问的一个或多个位置（16）的订单或包裹（12）的基于路线的交付 18）。在集中式系统（10）的控制下，位置（16）可以包括自动化的自助服务自动售货机（20）和/或待命储物柜（22），其可以自动接收和主动管理清单信息。

5. 发明申请

WO2007074078A2 ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES 审中-公开
标题翻译： ARYL-ISOXAZOL-4-Y-IMIDAZOLE DERIVATIVES
公开(公告)号：WO2007074078A2
公开(公告)日：2007-07-05
申请号：PCT/EP2006069722
申请日：2006-12-14
申请人： HOFFMANN LA ROCHE , BUETTELMANN BERND , HAN BO , KNUST HENNER , THOMAS ANDREW
发明人： BUETTELMANN BERND , HAN BO , KNUST HENNER , THOMAS ANDREW
CPC分类号： C07D413/04
摘要： The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula (I), wherein R 1 to R 3 are each independently hydrogen or halogen; R 4 is hydrogen, lower alkyl, cycloalkyl, -(CH 2 ) n -O-lower alkyl or lower alkyl substituted by hydroxy; R 5 is -(CH 2 ) m -aryl or -(CH 2 ) m -heteroaryl which are optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylsulfanyl, lower alkyl substituted by halogen, -C(O)-lower alkyl, -C(O)-O-lower alkyl, -NH-C(O)-O-lower alkyl or -C(O)-NH-R', wherein R' is lower alkynyl or lower alkyl substituted by halogen, or is -(CH 2 ) n -cycloalkyl, -(CH 2 ) n -heterocyclyl, -(CH 2 ) n -heteroaryl or -(CH 2 ) n -aryl, optionally substituted by halogen; R 6 is hydrogen, -C(O)H, -(CH 2 ) n -O-lower alkyl, -C(O)O-lower alkyl, lower alkyl substituted by hydroxy or halogen, or is cycloalkyl, aryl, or is -(CH 2 ) n -O-CH 2 -aryl, optionally substituted by halogen or lower alkyl, or is -(CH 2 ) n -O-CH 2 -heteroaryl, optionally substituted by halogen, lower alkyl or lower alkyl substituted by halogen, or is -(CH 2 ) n -NH-(CH 2 ) o -heterocyclyl; n is 0, 1, 2 or 3 m is 0 or 1; o is 1, 2 or 3; as well as with pharmaceutically acceptable acid addition salts thereof. It has been found that this class of compounds show high affinity and selectivity for GABA A a5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及式（I）的芳基 - 异恶唑-4-基 - 咪唑衍生物，其中R 1至R 3各自独立地为氢或卤素; R 4是氢，低级烷基，环烷基， - （CH 2）n -O- -O-低级烷基或被羟基取代的低级烷基; R 5是 - （CH 2）2 - 或 - （CH 2 CH 2）m - 任选地被一个或多个选自卤素，氰基，硝基，低级烷基，低级烷氧基，低级烷基硫烷基，被卤素取代的低级烷基，-C（O） - 低级烷基， -C（O）-O-低级烷基，-NH-C（O）-O-低级烷基或-C（O）-NH-R'，其中R'为低级炔基或被卤素取代的低级烷基， - （CH 2）n - 环烷基， - （CH 2）n - 杂环基， - （CH 2 CH 2） - （CH 2）n - 芳基，任选被卤素取代; - （CH 2）n - R 6是氢，-C（O）H， - （CH 2）n -O-低级烷基，-C（O） O-低级烷基，被羟基或卤素取代的低级烷基，或是环烷基，芳基或 - （CH 2）n -O-CH 2，或任选被卤素或低级烷基取代的芳基，或为 - （CH 2）n -O-CH 2 - 杂芳基任选被卤素取代的低级烷基或被卤素取代的低级烷基，或者是 - （CH 2 CH 2）n -NH-（CH 2））_{0 - 杂环基; n为0,1,2或3m为0或1; o是1,2或3; 以及其药学上可接受的酸加成盐。已经发现，这类化合物显示出对GABA A a5受体结合位点的高亲和力和选择性，并且可用作认知增强剂或用于治疗认知障碍如阿尔茨海默氏病。}

6. 发明申请

WO2007047015A2 DIGITAL TIME VARIABLE GAIN CIRCUIT FOR NON-DESTRUCTIVE TEST INSTRUMENT 审中-公开
标题翻译：用于非破坏性测试仪器的数字时间可变增益电路
公开(公告)号：WO2007047015A2
公开(公告)日：2007-04-26
申请号：PCT/US2006036810
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS ANDREW , BESSER STEVEN
发明人： THOMAS ANDREW , BESSER STEVEN
IPC分类号： H03F3/45
CPC分类号： H03G1/0088 , G01N29/36 , G01N29/40 , G01N29/4463 , G01N2291/106 , G01S7/52033 , H03G3/001
摘要： In a non-destructive test instrument, there is provided a time variable gain (TVG) amplifier wherein the gain of the amplifier is dynamically changed to optimize the amplitude of a flaw echo signal. The TVG digital memory for a given TVG curve specifies and controls not only the start gain value, and the end game value, but the gain rate of change slope as well to generate TVG curve line segments.
摘要翻译：在非破坏性测试仪器中，提供了一种时间可变增益（TVG）放大器，其中动态地改变放大器的增益以优化缺陷回波信号的幅度。用于给定TVG曲线的TVG数字存储器不仅指定并控制起始增益值和结束游戏值，而且还对变化斜率的增益率以及产生TVG曲线线段进行控制。

7. 发明申请

WO0191479A2 LOCATION-BASED DATA ACCESS CONTROL 审中-公开
标题翻译：基于位置的数据访问控制
公开(公告)号：WO0191479A2
公开(公告)日：2001-11-29
申请号：PCT/GB0102291
申请日：2001-05-23
申请人： HEWLETT PACKARD CO , CROUCH SIMON EDWIN , VICKERS PAUL , WATERS JOHN DERYK , THOMAS ANDREW , MCDONNELL JAMES THOMAS EDWARD
发明人： CROUCH SIMON EDWIN , VICKERS PAUL , WATERS JOHN DERYK , THOMAS ANDREW , MCDONNELL JAMES THOMAS EDWARD
IPC分类号： B60R25/04 , G06F1/00 , G06F21/00 , H04W4/02 , H04W12/08 , H04Q7/00
CPC分类号： H04W60/00 , B60R2325/101 , B60R2325/205 , G06F21/00 , G06F2221/2111 , H04W8/18 , H04W12/08
摘要： In order to restrict access to content data held on a removable data carrier (83) or included in an electronic file, equipment (70) for accessing this content is arranged only to be enabled upon a location condition being satisfied. This condition is tested for by obtaining current-location data (67) representing the current location of the equipment, and comparing the current-location data with authorised-location data representing a predetermined authorised location or locality for operation of the equipment. The authorized location data may be stored in the equipment itself, in a remote system (42), or in the removable data media or received data file.
摘要翻译：为了限制对可移动数据载体（83）上保存的或包含在电子文件中的内容数据的访问，用于访问该内容的设备（70）仅在满足位置条件时被布置。通过获取表示设备的当前位置的当前位置数据（67）以及将当前位置数据与表示用于设备操作的预定授权位置或位置的授权位置数据进行比较来测试该条件。授权的位置数据可以存储在设备本身，远程系统（42）中，或存储在可移动数据媒体或接收的数据文件中。

8. 发明申请

WO2011101304A3 PIPERIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO2011101304A3
公开(公告)日：2011-10-20
申请号：PCT/EP2011052101
申请日：2011-02-14
申请人： HOFFMANN LA ROCHE , BAUMANN KARLHEINZ , FLOHR ALEXANDER , GOETSCHI ERWIN , GREEN LUKE , JOLIDON SYNESE , KNUST HENNER , LIMBERG ANJA , LUEBBERS THOMAS , THOMAS ANDREW
发明人： BAUMANN KARLHEINZ , FLOHR ALEXANDER , GOETSCHI ERWIN , GREEN LUKE , JOLIDON SYNESE , KNUST HENNER , LIMBERG ANJA , LUEBBERS THOMAS , THOMAS ANDREW
IPC分类号： C07D401/14 , A61K31/4523 , A61P25/28 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04
摘要： The invention relates to compounds of formula (I). Hetaryl I is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N; hetaryl II is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, or is a two membered ring system containing 1 to 4 heteroatoms selected from S, O or N, wherein at least one ring is aromatic in nature; R1 is lower alkyl, lower alkoxy, lower alkyl substituted by halogen, or halogen; R2 is halogen, lower alkyl, lower alkoxy, hydroxy, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy or benzo[1,3]dioxolyl, or is -(CHR)p-phenyl, optionally substituted by halogen, lower alkyl, lower alkoxy, S(O)2-lower alkyl, cyano, nitro, lower alkoxy substituted by halogen, dimethylamino, -(CH2)P-NHC(O)O-Iower alkyl, or lower alkyl substituted by halogen, and R is hydrogen, halogen, hydroxy or lower alkoxy, or is cycloalkenyl or cycloalkyl, optionally substituted by hydroxy or lower alkyl substituted by halogen, or is a five or six membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N, which is optionally substituted by halogen, lower alkyl, lower alkoxy or dimethylamino, or is O-phenyl, optionally substituted by halogen, or is heterocycloalkyl, optionally substituted by halogen, hydroxy, lower alkyl substituted by halogen or C(O)O-lower alkyl; R3 is hydrogen, lower alkyl, cyano or phenyl; R4 is lower alkoxy, lower alkyl or halogen; p is 0 or 1; n is 0, 1 or 2; if n is 2 then R4 may be the same or different; m is 0, 1 or 2; if m is 2 then R1 may be the same or different; o is 0, 1, 2 or 3, if o is 2 or 3 then R2 may be the same or different; or to pharmaceutically active acid addition salts thereof. The compounds of formula (I) are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of ß-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
摘要翻译：本发明涉及式（I）化合物。芳基I是含有1至3个选自O，S或N的杂原子的五或六元杂芳基; 杂芳基II是含有1至3个选自O，S或N的杂原子的五或六元杂芳基，或是含有1至4个选自S，O或N的杂原子的二元环体系，其中至少一个环本质上是芳香的 R1是低级烷基，低级烷氧基，被卤素取代的低级烷基或卤素; R 2为卤素，低级烷基，低级烷氧基，羟基，被卤素取代的低级烷基，被羟基或苯并[1,3]二氧杂环戊烯取代的低级烷基，或为 - （CHR）对 - 苯基，任选被卤素，低级烷基，低级烷氧基，S（O）2-低级烷基，氰基，硝基，被卤素取代的低级烷氧基，二甲基氨基， - （CH2）P-NHC（O）O-低级烷基或被卤素取代的低级烷基，R是氢，卤素，羟基或低级烷氧基，或是任选被羟基或被卤素取代的低级烷基取代的环烯基或环烷基，或是含有1至3个选自O，S或N的杂原子的五或六元杂芳基，其中或任选被卤素取代的O-苯基，或任选被卤素取代的杂环烷基，羟基，被卤素或C（O）O-低级烷基取代的低级烷基， ; R3是氢，低级烷基，氰基或苯基; R4是低级烷氧基，低级烷基或卤素; p为0或1; n为0,1或2; 如果n为2，则R4可以相同或不同; m为0,1或2; 如果m为2，则R1可以相同或不同; o为0,1,2或3，如果o为2或3，则R2可以相同或不同; 或其药物活性的酸加成盐。式（I）化合物是淀粉样蛋白β的调节剂，因此它们可用于治疗或预防与脑中β-淀粉样蛋白沉积相关的疾病，特别是阿尔茨海默病，以及其他疾病如脑淀粉样血管病，淀粉样变性遗传性脑出血，荷兰型（HCHWA-D），多发性梗死性痴呆，痴呆和唐氏综合征。

9. 发明申请

WO2007047025A3 ULTRASONIC DETECTION MEASUREMENT SYSTEM USING A TUNABLE DIGITAL FILTER WITH 4X INTERPOLATOR 审中-公开
标题翻译：超声波检测测量系统使用带4X插入式的数字滤波器
公开(公告)号：WO2007047025A3
公开(公告)日：2009-04-23
申请号：PCT/US2006037110
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS ANDREW , BESSER STEVEN , TOOMEY JASON
发明人： THOMAS ANDREW , BESSER STEVEN , TOOMEY JASON
IPC分类号： A61B8/12
CPC分类号： G01N29/262 , G01N29/043 , G01N29/42 , G01N29/44 , G01N29/4463 , G01N29/449 , G01N2291/044 , G01N2291/102
摘要： An ultrasonic inspection system utilizes a tunable digital filter with 4X interpolation. The system is used for scanning objects to be tested and includes a transmit/receive device to generate a test signal and receive an echo signal. A signal processing circuit processes the echo signal with one or more digital to analog converters for converting an analog version of the echo signal to a digital echo signal in the form of streaming digital data which is stored in a memory. The data is stored at a first data rate and read out at the second, slower data rate. An averaging decimator receives and processes the data from the memory and supplies it to an IIR filter and subsequently to an FIR filter and ultimately to a box car filter to effect processing thereon which increases the perceived resolution of the data by a given factor, preferably by a factor of 4.
摘要翻译：超声波检测系统采用4X插值的可调数字滤波器。该系统用于扫描要测试的对象，并且包括发射/接收装置以产生测试信号并接收回波信号。信号处理电路用一个或多个数模转换器来处理回波信号，用于将回波信号的模拟版本转换成存储在存储器中的流式数字数据形式的数字回波信号。数据以第一数据速率存储，并以第二个较慢的数据速率读出。平均抽取器接收并处理来自存储器的数据并将其提供给IIR滤波器并随后提供给FIR滤波器并且最终提供给盒式汽车滤波器以对其进行处理，从而将数据的感知分辨率提高给定因子，优选地通过一个因素4。

10. 发明申请

WO2007047018A3 ULTRASONIC FAULT DETECTION SYSTEM 审中-公开
标题翻译：超声波故障检测系统
公开(公告)号：WO2007047018A3
公开(公告)日：2007-10-11
申请号：PCT/US2006036908
申请日：2006-09-22
申请人： OLYMPUS NDT , THOMAS ANDREW
发明人： THOMAS ANDREW
IPC分类号： G01N29/00
CPC分类号： G01N29/44 , G01N29/043 , G01N29/262 , G01N29/42 , G01N29/4463 , G01N2291/044 , G01N2291/102 , H03M1/188
摘要： A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults.
摘要翻译：用于实现物体的超声波探伤的方法和装置处理在至少三个信号通道中从被测试对象接收的回波信号，其中回波信号沿着每个通道被缩放到不同程度以增加和扩展一个相关的A / D转换器系统，其不需要使用大量模拟高通和低通滤波器和可变增益放大器。这降低了复杂性并避免了性能限制。数模转换器对不同比例的输入信号进行采样，并且选择电路选择从具有最高增益但尚未溢出的模数转换器获得的数字输出的输出。数字输出无缝合并，产生可显示为显示故障位置的扫描显示的输出。

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