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1. 发明申请

WO2020152611A2 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2020152611A2
公开(公告)日：2020-07-30
申请号：PCT/IB2020/050515
申请日：2020-01-23
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , SOHN, Zev , SCHWAMMENTHAL, Ehud , LUBINSKY, Gad , TROSHIN, Victor , MUSTACCHI, Shaul , ELISHA, Yinnon , SUDIN, Yuri , ZEMER HAREL, Hagit , ROZENFELD, Avi
IPC分类号： A61M1/10
摘要： Apparatus and methods are described including a left-ventricular assist device (20) that includes a tube (24) configured to traverse a subject's aortic valve, with a distal portion of the tube disposed within the subject's left ventricle. A frame (34) is disposed within the distal portion of the tube. A pump (50) disposed within the frame pumps blood through the tube. A distal-tip element (107) defines a straight proximal portion (346) that defines a longitudinal axis (348), and a curved distal portion that is shaped such as to curve in a first direction with respect to the longitudinal axis before passing through an inflection point and curving in a second direction with respect to the longitudinal axis (348), such that the curved distal portion defines a bulge (351) on one side of the longitudinal axis (348). Other applications are also described.

2. 发明申请

WO2018061002A1 BLOOD VESSEL TUBE 审中-公开
标题翻译：血管管
公开(公告)号：WO2018061002A1
公开(公告)日：2018-04-05
申请号：PCT/IL2017/051092
申请日：2017-09-28
申请人： MAGENTA MEDICAL LTD.
发明人： TUVAL, Yosi , SCHWAMMENTHAL, Ehud , GLOZMAN, Daniel , LUBINSKY, Gad
IPC分类号： A61F2/06 , A61F2/07
摘要： Apparatus and methods are described including a tube (20) that defines a flared downstream portion (30) that diverges toward a downstream end (32) of the tube, and a flared upstream portion (26) that diverges toward an upstream end (28) of the tube, such that a central portion (34) of the tube is narrower than at the ends of the tube. The tube defines a plurality of lateral openings (36). A support frame (24) supports the tube within a subject's vena cava, such that the downstream portion is sealed with respect to the wall of the vena cava downstream of junctions of the vena cava with all of the subject's renal veins, and the upstream portion is sealed with respect to the inner wall of the vena cava upstream of junctions of the vena cava with all of the subject's renal veins. Other applications are also described.
摘要翻译：描述了包括限定向管的下游端（32）扩散的扩张的下游部分（30）的管（20）和扩张的上游部分（26）的扩张的上游部分（26）的装置和方法，朝向管的上游端（28）发散，使得管的中心部分（34）比在管的端部处窄。该管限定多个侧向开口（36）。支撑框架（24）将管子支撑在对象的腔静脉内，使得下游部分相对于腔静脉的连接部下游与所有对象的肾静脉的连接处的腔壁密封，并且上游部分相对于腔静脉连接处上游的腔静脉内壁与所有患者的肾静脉密封。还介绍了其他应用程序。

3. 发明申请

WO2019138350A3 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2019138350A3
公开(公告)日：2019-07-18
申请号：PCT/IB2019/050186
申请日：2019-01-10
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , SOHN, Zev , SCHWAMMENTHAL, Ehud , LUBINSKY, Gad
IPC分类号： A61M1/10 , A61M1/12
摘要： Apparatus and methods are described including a blood pump (20) configured to be placed inside a body of subject, the blood pump including an impeller (50) that includes proximal and distal bushings (64, 58), and a frame (34) disposed around the impeller, the frame including proximal and distal bearings (116, 118). An axial shaft (92) passes through the proximal and distal bearings (116, 118) of the frame and the proximal and distal bushings (64, 58) of the impeller (50). The impeller (50) defines a radially-constrained configuration in which the impeller (50) is introduced into the subject's body and a non-radially-constrained configuration in which the impeller (50) is configured to pump blood within the subject's body. The impeller (50) changes from its radially-constrained configuration to its non-radially constrained configuration by the distal bushing (58) sliding over the axial shaft (92). Other applications are also described.

4. 发明申请

WO2018096531A1 BLOOD PUMPS 审中-公开
公开(公告)号：WO2018096531A1
公开(公告)日：2018-05-31
申请号：PCT/IL2017/051273
申请日：2017-11-21
申请人： MAGENTA MEDICAL LTD.
发明人： TUVAL, Yosi , SCHWAMMENTHAL, Ehud , GLOZMAN, Daniel , LUBINSKY, Gad
IPC分类号： A61M1/10 , A61M1/12
摘要： Apparatus and methods are described including a blood pump (24) configured to be placed inside a blood vessel of a subject, the blood pump including an impeller (28) configured to pump blood by rotating. A support cage (254) is shaped to define a narrow portion (256) that is configured to be disposed around the impeller, and to maintain a separation between a wall of the blood vessel and the impeller, and a radial extension (258) from the narrow portion of the support cage that extends radially outward with respect to the narrow portion of the support cage, the radial extension being configured to substantially maintain a longitudinal axis of the impeller in alignment with a local longitudinal axis of the blood vessel by contacting the wall of the blood vessel. Other applications are also described.

5. 发明申请

WO2018078615A1 VENTRICULAR ASSIST DEVICE 审中-公开
标题翻译：心室辅助装置
公开(公告)号：WO2018078615A1
公开(公告)日：2018-05-03
申请号：PCT/IL2017/051158
申请日：2017-10-23
申请人： MAGENTA MEDICAL LTD.
发明人： TUVAL, Yosi , GLOZMAN, Daniel , LUBINSKY, Gad
IPC分类号： A61M1/10 , A61M1/12
摘要： Apparatus and methods are described including placing within a blood vessel of a subject an impeller (50), the impeller including at least one helical elongate element (52), and a spring (54), the spring being disposed inside of, and coaxially with, the helical elongate element. A film of material (56) is supported between the helical elongate element and the spring. Blood is pumped through the subject's blood vessel, using the impeller. Other applications are also described.
摘要翻译：描述了包括在对象的血管内放置叶轮（50）的设备和方法，所述叶轮包括至少一个螺旋细长元件（52）和弹簧（54），所述弹簧布置在螺旋细长元件的内部并与其同轴。材料膜（56）被支撑在螺旋细长元件和弹簧之间。使用叶轮将血液泵入受试者的血管。还介绍了其他应用程序。

6. 发明申请

WO2021205346A2 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2021205346A2
公开(公告)日：2021-10-14
申请号：PCT/IB2021/052857
申请日：2021-04-06
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , ELISHA, Yinnon , ISRAELI, David , LUBINSKY, Gad , TROSHIN, Victor , MUSTACCHI, Shaul , ZIPORY, Yuval , ROZENFELD, Avi , BENADDI, Aurelie , MOISEYEV, Gilad , SUDIN, Yuri
IPC分类号： A61M60/13 , A61M60/237 , A61M60/414 , A61M60/808 , A61M60/523 , A61M60/538 , A61M60/816 , A61M60/857 , A61M60/865 , A61M2207/00
摘要： Apparatus and methods are described including an impeller (50) that includes a proximal bushing (64) and a distal bushing (58). Two or more helical elongate elements (52) extend from the proximal bushing (64) to the distal bushing (58), and an axial structure (54) is disposed inside of the two or more helical elongate elements (52), and along an axis around which the helical elongate elements (52) wind. The impeller (50) includes an impeller-overexpansion-prevention element (72). The impeller-overexpansion-prevention element is a single integrated structure that includes a ring (73) disposed around the axial structure (54), and a plurality of elongate elements (67) each of the elongate elements (67) extending from the ring to a respective helical elongate element (52) and being coupled to the respective helical elongate element (52) so as to prevent radial expansion of the impeller (50). Other applications are also described.

7. 发明申请

WO2020152611A3 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2020152611A3
公开(公告)日：2020-07-30
申请号：PCT/IB2020/050515
申请日：2020-01-23
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , SOHN, Zev , SCHWAMMENTHAL, Ehud , LUBINSKY, Gad , TROSHIN, Victor , MUSTACCHI, Shaul , ELISHA, Yinnon , SUDIN, Yuri , ZEMER HAREL, Hagit , ROZENFELD, Avi
IPC分类号： A61M1/10
摘要： Apparatus and methods are described including a left-ventricular assist device (20) that includes a tube (24) configured to traverse a subject's aortic valve, with a distal portion of the tube disposed within the subject's left ventricle. A frame (34) is disposed within the distal portion of the tube. A pump (50) disposed within the frame pumps blood through the tube. A distal-tip element (107) defines a straight proximal portion (346) that defines a longitudinal axis (348), and a curved distal portion that is shaped such as to curve in a first direction with respect to the longitudinal axis before passing through an inflection point and curving in a second direction with respect to the longitudinal axis (348), such that the curved distal portion defines a bulge (351) on one side of the longitudinal axis (348). Other applications are also described.

8. 发明申请

WO2016185473A1 BLOOD PUMP 审中-公开
标题翻译：血液泵
公开(公告)号：WO2016185473A1
公开(公告)日：2016-11-24
申请号：PCT/IL2016/050525
申请日：2016-05-18
申请人： MAGENTA MEDICAL LTD.
发明人： SCHWAMMENTHAL, Ehud , TUVAL, Yosi , GLOZMAN, Daniel , SHTENDEL, Tom , LUBINSKY, Gad
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1012 , A61M1/101 , A61M1/1013 , A61M1/1018 , A61M1/1024 , A61M1/1029 , A61M1/1034 , A61M1/1086 , A61M1/122 , A61M1/125
摘要： Apparatus and methods are described, including a catheter (20) configured to be placed inside a blood vessel of a subject. A first impeller (28) is disposed on the catheter, and a second impeller (28) is disposed on the catheter, proximally to the first impeller. A support structure (160) is disposed upon the catheter such that a longitudinal center of the support structure is disposed between the first and second impellers, the support structure being configured to support an inner wall of the blood vessel in an open configuration in a region between the first and second impellers. Other applications are also described.
摘要翻译：描述了设备和方法，包括构造成放置在受试者的血管内部的导管（20）。第一叶轮（28）设置在导管上，第二叶轮（28）设置在导管上，靠近第一叶轮。支撑结构（160）设置在导管上，使得支撑结构的纵向中心设置在第一和第二叶轮之间，支撑结构被构造成在开口构造中支撑血管内壁在第一和第二叶轮之间。还描述了其它应用。

9. 发明申请

WO2023062453A1 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2023062453A1
公开(公告)日：2023-04-20
申请号：PCT/IB2022/058101
申请日：2022-08-30
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , LUBINSKY, Gad , TROSHIN, Victor , ZEMER HAREL, Hagit , FRIEDLAND, Ori , ROSENBLUM, Daniel , ROZENFELD, Avi
IPC分类号： A61M60/818 , A61M60/824 , A61M60/13 , A61M60/237 , A61M60/414 , A61M60/531 , A61M60/81 , A61M60/816 , A61M60/865
摘要： Apparatus and methods are described including a ventricular assist device (20). An impeller (50) is placed inside a left ventricle of a subject, the impeller defining a lumen (62) therethrough. A frame (34) is disposed around the impeller, with a proximal bearing (116) disposed at a proximal end of the frame and a distal bearing (118) disposed at a distal end of the frame. An axial shaft (92) passes through the proximal bearing (116), the lumen (62) defined by the impeller, and the distal bearing (118). A motion-cushioning spring (68) is disposed around the axial shaft (92) between a distal end of the impeller (50) and the distal bearing (118), the motion-cushioning spring (68) being configured to cushion axial motion that the impeller (50) undergoes. Other applications are also described.

10. 发明申请

WO2022189932A1 VENTRICULAR ASSIST DEVICE 审中-公开
公开(公告)号：WO2022189932A1
公开(公告)日：2022-09-15
申请号：PCT/IB2022/051990
申请日：2022-03-07
申请人： MAGENTA MEDICAL LTD
发明人： TUVAL, Yosi , LUBINSKY, Gad , ZEMER HAREL, Hagit , FRIEDLAND, Ori , ROSENBLUM, Daniel , ROZENFELD, Avi
IPC分类号： A61M60/13 , A61M60/237 , A61M60/414 , A61M60/808 , A61M60/81 , A61M60/888 , A61M60/865 , A61M60/857
摘要： Apparatus and methods are described including a left-ventricular assist device that includes an impeller (50) and a frame (34) disposed around the impeller (50). The frame (34) includes strut junctions (33) at a proximal end of the frame, the strut junctions (33) being configured to be maintained in open states, during assembly of the left ventricular assist device, to facilitate insertion of the impeller (50) into the frame (34). A securing element (117) holds the struts junctions in closed states, subsequent to the insertion of the impeller (50) into the frame (34). A pump-outlet tube (24) extends to a distal end of the frame (34) and defines one or more lateral blood inlet openings (108) that are configured to allow blood to flow from the subject's left ventricle into the pump-outlet tube (24). Other applications are also described.

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