专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015200119A8 COVALENTLY BONDED DIABODIES HAVING IMMUNOREACTIVITY WITH PD-1 AND LAG-3, AND METHODS OF USE THEREOF 审中-公开
标题翻译：具有PD-1和LAG-3的具有免疫反应性的双重结合的双歧杆菌及其使用方法
公开(公告)号：WO2015200119A8
公开(公告)日：2017-03-30
申请号：PCT/US2015036634
申请日：2015-06-19
申请人： MACROGENICS INC
发明人： BONVINI EZIO , JOHNSON LESLIE S , SHAH KALPANA , LA MOTTE-MOHS ROSS , MOORE PAUL A , KOENIG SCOTT
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/31 , C07K2317/626 , C07K2317/74
摘要： The present invention is directed to bi-specific diabodies that comprise two or more polypeptide chains and which possess at least one Epitope-Binding Site that is immunospecific for an epitope of PD-1 and at least one Epitope-Binding Site that is immunospecific for an epitope of LAG-3 (i.e., a "PD-I x LAG-3 bi-specific diabody"). More preferably, the present invention is directed to bi-specific diabodies that comprise four polypeptide chains and which possess two Epitope-Binding Sites that are immunospecific for one (or two) epitope(s) of PD-1 and two Epitope-Binding Site that are immunospecific for one (or two) epitope(s) of LAG-3 (i.e., a "PD-1 x LAG-3 bi-specific, tetra-valent diabody").
摘要翻译：本发明涉及包含两个或多个多肽链并且具有至少一个针对PD-1的表位具有免疫特异性的表位结合位点和至少一个对于一个或多个具有免疫特异性的表位结合位点的表位的双抗体 LAG-3表位（即，“PD-1×LAG-3双特异性双抗体”）。更优选地，本发明涉及包含四个多肽链并且具有对PD-1的一个或两个表位和两个表位结合位点具有免疫特异性的两个表位结合位点的双特异性双抗体，对于一个（或两个）LAG-3表位（即，“PD-1×LAG-3双特异性四价双抗体”）是免疫特异性的。

2. 发明申请

WO2015026894A3 BI-SPECIFIC MONOVALENT DIABODIES THAT ARE CAPABLE OF BINDING TO GPA33 AND CD3, AND USES THEREOF 审中-公开
标题翻译：可以与GPA33和CD3结合的双特异性单价糖尿病及其用途
公开(公告)号：WO2015026894A3
公开(公告)日：2015-04-16
申请号：PCT/US2014051793
申请日：2014-08-20
申请人： MACROGENICS INC
发明人： MOORE PAUL A , LI JONATHAN , CHEN FRANCINE ZHIFEN , JOHNSON LESLIE S , SHAH KALPANA , BONVINI EZIO
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/545 , C07K16/2803 , C07K16/2809 , C07K16/3046 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a "gpA33 x CD3 bi-specific monovalent diabody"). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain ("bi- specific monovalent Fc diabodies") and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a "gpA33 x CD3 bi-specific monovalent Fc diabody"). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.
摘要翻译：本发明涉及包含两条多肽链并具有至少一个对CD3表位特异性的结合位点和一个特异于gpA33表位的结合位点的双特异性单抗双抗体（即，“gpA33×CD3双 - 特异性单价双抗体“）。本发明还涉及包含免疫球蛋白Fc结构域（“双特异性单价Fc双抗体”）的双特异性单抗双抗体，并且由三条多肽链组成，并且具有至少一个对gpA33的表位具有特异性的结合位点和一个特异于CD3表位的结合位点（即“gpA33×CD3双特异性单价Fc双抗体”）。本发明的双特异性单价双抗体和双特异性单价Fc双抗体能够同时结合gpA33和CD3。本发明涉及含有这种双特异性单价双抗体或这种双特异性单价Fc双抗体的药物组合物。本发明另外涉及使用这种双抗体治疗癌症和其它疾病和病症的方法。

3. 发明申请

WO2017019846A8 PD-1-BINDING MOLECULES AND METHODS OF USE THEREOF 审中-公开
标题翻译： PD-1-结合分子及其使用方法
公开(公告)号：WO2017019846A8
公开(公告)日：2018-01-25
申请号：PCT/US2016044430
申请日：2016-07-28
申请人： MACROGENICS INC
发明人： SHAH KALPANA , SMITH DOUGLAS H , LA MOTTE-MOHS ROSS , JOHNSON LESLIE S , MOORE PAUL A , BONVINI EZIO , KOENIG SCOTT
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： A61K39/00 , A61K39/395 , C07K16/2803 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/76
摘要： The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1 : PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1 -binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1 -binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.
摘要翻译：本发明涉及能够结合食蟹猴PD-1和人PD-1两者的所选抗PD-1抗体：PD-1mAb 1，PD-1mAb 2，PD-1mAb 3，PD- 1 mAb 4，PD-1 mAb 5，PD-1 mAb 6，PD-1 mAb 7，PD-1 mAb 8，PD-1 mAb 9，PD-1 mAb 10，PD-1 mAb 11，PD-1 mAb 12，PD-1mAb13，PD-1mAb14或PD-1mAb15，以及这些抗体的人源化和嵌合形式。本发明另外涉及PD-1结合分子，其包含这样的抗PD-1抗体，免疫缀合物的PD-1结合片段和双特异性分子（包括双抗体，BiTE，双特异性抗体等），其包含（i）这样的PD-1-结合片段，和（ii）能够结合参与调节免疫细胞表面上存在的免疫检查点的分子的表位的结构域的结构域。本发明还涉及使用结合PD-1的分子来刺激免疫应答的方法，以及检测PD-1的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式