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    • 1. 发明申请
    • A SELECTABLE MULTIWAVELENGTH LASER
    • 可选择的多波长激光
    • WO2006032110A1
    • 2006-03-30
    • PCT/AU2005/001470
    • 2005-09-23
    • MACQUARIE UNIVERSITYPIPER, James, AustinPASK, Helen, Margaret
    • PIPER, James, AustinPASK, Helen, Margaret
    • H01S3/108
    • H01S3/1086H01S3/08022H01S3/0815H01S3/0816H01S3/092H01S3/10H01S3/10092H01S3/11H01S3/30
    • A laser system capable of selecting between at least two different wavelengths of output laser light. The system (100) comprises a resonator cavity (105) comprising at least two reflectors (110, 115), and a laser material (125) located in the cavity. A pump source (120) is located outside of the cavity for pumping the laser material (125) with a pump beam to generate a cavity laser beam. A Raman-active medium (135) is also located in the resonator cavity (105) for shifting the wavelength of the cavity laser beam such that at least two different frequencies are generated. A frequency selector is provided for selecting a single frequency of output laser light by either deselecting all but one of the at least two different frequencies or by selecting one of the at least two different frequencies, and an output coupler is used for outputting the single wavelength of output laser light.
    • 一种能够在至少两个不同波长的输出激光之间进行选择的激光系统。 系统(100)包括谐振器腔(105),其包括至少两个反射器(110,115)和位于空腔中的激光材料(125)。 泵源(120)位于空腔外部,用泵浦泵激励激光材料(125)以产生空腔激光束。 拉曼活性介质(135)也位于谐振器腔(105)中,用于移动腔激光束的波长,使得产生至少两个不同的频率。 提供频率选择器,用于通过取消选择所述至少两个不同频率中的除了所述至少两个不同频率之外的所有其它频率中的一个或选择所述至少两个不同频率中的一个来选择单个频率的输出激光,并且输出耦合器用于输出单个波长 的输出激光。
    • 4. 发明申请
    • A SELECTABLE MULTIWAVELENGTH LASER FOR OUTPUTTING VISIBLE LIGHT
    • 用于输出可见光的可选择的多波长激光器
    • WO2006032105A1
    • 2006-03-30
    • PCT/AU2005/001464
    • 2005-09-23
    • MACQUARIE UNIVERSITYPIPER, James, AustinPASK, Helen, MargaretOGILVY, HamishMILDREN, Richard, Paul
    • PIPER, James, AustinPASK, Helen, MargaretOGILVY, HamishMILDREN, Richard, Paul
    • H01S3/108
    • H01S3/1086H01S3/08086H01S3/109H01S3/11
    • The invention provides a laser system (100) wherein the output may be selected from two or more different wavelengths of output laser light. The system (100) comprises a laser capable of having at least two different wavelengths of laser light resonating in the cavity (105) simultaneously. One of the frequencies is generated by a Raman crystal (135) which shifts the frequency of light generated by the lasing medium (125). A tunable non-linear medium (140), such as LBO, is provided in the cavity for selectively frequency converting at least one of the at least two different wavelengths of laser light. The conversion may be SHG, SFG or DFG for example. A tuner (145) is provided.to tune the non-linear medium to select the particular wavelength to convert. Temperature tuning or angle tuning of the non-linear medium can be used. A Q switch (130) may also be provided in the cavity. The output laser beam can be used for treatment, detection or diagnosis of a selected area on or in a subject, and can b used in ophthalmological and dermatological fields.
    • 本发明提供了一种激光系统(100),其中输出可以选自两个或更多个不同波长的输出激光。 系统(100)包括能够同时具有在空腔(105)中谐振的至少两个不同波长的激光的激光器。 一个频率由拉曼晶体(135)产生,该晶体偏移由激光介质(125)产生的光的频率。 在空腔中提供诸如LBO的可调谐非线性介质(140),用于选择性地对至少两个不同波长的激光中的至少一个进行频率转换。 转换可以是例如SHG,SFG或DFG。 提供调谐器(145)以调谐非线性介质以选择要转换的特定波长。 可以使用非线性介质的温度调节或角度调谐。 也可以在空腔中设置Q开关(130)。 输出激光束可用于治疗,检测或诊断受试者上或受试者中的选定区域,并且可用于眼科和皮肤病学领域。
    • 5. 发明申请
    • FLUORESCENCE DETECTION
    • 荧光检测
    • WO2006089342A1
    • 2006-08-31
    • PCT/AU2005/001606
    • 2005-10-17
    • MACQUARIE UNIVERSITYCONNALLY, RussellPIPER, James, Austin
    • CONNALLY, RussellPIPER, James, Austin
    • G01N21/64
    • G01N21/6458G01N21/6408
    • A fluorescence detection system comprises a light source (22), dichroic mirror (32), excitation port (16), emission port (14), and a detector. The light source (22) is, for example, a pulsed ultraviolet LED, with a light emission that decays sufficiently rapidly to permit gated detection of fluorescence from a fluorescently-labelled species, at a time when it is distinguishable from autofluorescence. The detector is, for example, an electron multiplying CCD, with high gain on- chip amplification. A circuit (26) may be used to control a repeating cycle of (i) generation of a 20-200 microsecond UV. pulse; (ii) a gate delay of 1-5 microseconds; and (iii) a 10-800 microsecond detection period. This allows time- resolved-fluorescence-microscopy with real time or near real time operation.
    • 荧光检测系统包括光源(22),分色镜(32),激发端口(16),发射端口(14)和检测器。 光源(22)例如是脉冲紫外LED,具有足够快速衰减的光发射,以允许在与自发荧光区分时从荧光标记物质进行门控检测。 检测器是例如具有高增益片上放大的电子倍增CCD。 电路(26)可用于控制(i)产生20-200微秒UV的重复循环。 脉冲; (ii)1-5微秒的门延迟; 和(iii)10-800微秒的检测周期。 这允许实时或接近实时操作的时间分辨荧光显微镜。