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1. 发明申请

WO0166155A8 ACTINIUM-225 COMPLEXES AND CONJUGATES FOR RADIOIMMUNOTHERAPY 审中-公开
标题翻译： ACTINIUM-225复合物和结合物用于放射治疗
公开(公告)号：WO0166155A8
公开(公告)日：2002-02-07
申请号：PCT/US0105927
申请日：2001-02-23
申请人： MA DANGSHE , MCDEVITT MICHAEL R , SCHEINBERG DAVID A , SIMON JAIME , KIEFER GARRY E , FRANK R KEITH , GULYAS GYONGYI
发明人： MA DANGSHE , MCDEVITT MICHAEL R , SCHEINBERG DAVID A , SIMON JAIME , KIEFER GARRY E , FRANK R KEITH , GULYAS GYONGYI
IPC分类号： A61K51/04 , A61K51/10
CPC分类号： A61K51/1093 , A61K51/0482 , A61K51/0497 , A61K51/1027
摘要： Actinium-225 ( Ac) complexes with functionalized chelants of the formula (I) wherein: each Q is independently hydrogen or (CHR )pCO2R; Q is hydrogen or (CHR )wCO2R; each R independently is hydrogen, benzyl or C1-C4 alkyl; with the proviso that at least two of the sum of Q and Q must be other than hydrogen; each R independently is hydrogen; C1-C4 alkyl or (C1-C2 alkyl)phenyl; X and Y are each independently hydrogen or may be taken with an adjacent X and Y to form an additional carbon-carbon bond; n is 0 or 1; m is an integer from 0 to 10 inclusive; p is 1 or 2; r is 0 or 1; w is 0 or 1; with the proviso that n is only 1 when X and/or Y form an additional carbon to carbon bond, and the sum of r and w is 0 or 1; L is a linker/spacer group covalently bonded to, and replaces one hydrogen atom of one of the carbon atoms to which it is joined, said linker/spacer group being represented by the formula (1) wherein s is an integer of 0 or 1; t is an integer of 0 to 20 inclusive; R is an electrophilic or nucleophilic moiety which allows for covalent attachment to an antibody or fragment thereof, or synthetic linker which can be attached to an antibody or fragment thereof, or precursor thereof; and Cyc represents a cyclic aliphatic moiety, aromatic moiety, aliphatic heterocyclic moiety, or aromatic heterocyclic moiety, each of said moieties optionally substituted with one or more groups which do not interfere with binding to an antibody or antibody fragment; with the proviso that when s, t, m, r, and n are 0, then R is other than carboxyl; their pharmaceutically acceptable salts, their conjugates and the use thereof for radioimmunotherapy is disclosed.
摘要翻译：与式（I）的官能化螯合剂的锕-265（225Aa）络合物，其中：各Q独立地为氢或（CHR 5）pCO 2 R; Q 1是氢或（CHR 5）w CO 2 R; 每个R独立地是氢，苄基或C 1 -C 4烷基; 条件是Q和Q 1之和中的至少两个必须不是氢; 每个R 5独立地是氢; C 1 -C 4烷基或（C 1 -C 2烷基）苯基; X和Y各自独立地为氢，也可以与相邻的X和Y一起形成附加的碳 - 碳键; n为0或1; m为0〜10的整数，包括0和10; p为1或2; r为0或1; w为0或1; 条件是当X和/或Y形成额外的碳与碳键时，n仅为1，r和w的和为0或1; L是与其连接的一个碳原子上的一个氢原子共价连接并取代其连接的一个氢原子的连接体/间隔基，所述连接体/间隔基由式（1）表示，其中s为0或1的整数 ; t为0〜20的整数， R 1是亲电或亲核部分，其允许共价连接到抗体或其片段，或可以连接到抗体或其片段或其前体的合成接头; Cyc表示环状脂肪族部分，芳香族部分，脂肪族杂环部分或芳香族杂环部分，所述部分中的每一个任选地被一个或多个不干扰与抗体或抗体片段结合的基团取代; 条件是当s，t，m，r和n为0时，R 1不是羧基; 公开了其药学上可接受的盐，它们的缀合物及其用于放射免疫疗法的用途。

2. 发明申请

WO0166155A3 ACTINIUM-225 COMPLEXES AND CONJUGATES FOR RADIOIMMUNOTHERAPY 审中-公开
标题翻译： ACTINIUM-225配合物和缀合物用于放射性免疫治疗
公开(公告)号：WO0166155A3
公开(公告)日：2002-06-06
申请号：PCT/US0105927
申请日：2001-02-23
申请人： MA DANGSHE , MCDEVITT MICHAEL R , SCHEINBERG DAVID A , SIMON JAIME , KIEFER GARRY E , FRANK R KEITH , GULYAS GYONGYI
发明人： MA DANGSHE , MCDEVITT MICHAEL R , SCHEINBERG DAVID A , SIMON JAIME , KIEFER GARRY E , FRANK R KEITH , GULYAS GYONGYI
IPC分类号： A61K51/04 , A61K51/10
CPC分类号： A61K51/1093 , A61K51/0482 , A61K51/0497 , A61K51/1027
摘要： Actinium-225 ( Ac) complexes with functionalized chelants of the formula (I) wherein: each Q is independently hydrogen or (CHR )pCO2R; Q is hydrogen or (CHR )wCO2R; each R independently is hydrogen, benzyl or C1-C4 alkyl; with the proviso that at least two of the sum of Q and Q must be other than hydrogen; each R independently is hydrogen; C1-C4 alkyl or (C1-C2 alkyl)phenyl; X and Y are each independently hydrogen or may be taken with an adjacent X and Y to form an additional carbon-carbon bond; n is 0 or 1; m is an integer from 0 to 10 inclusive; p is 1 or 2; r is 0 or 1; w is 0 or 1; with the proviso that n is only 1 when X and/or Y form an additional carbon to carbon bond, and the sum of r and w is 0 or 1; L is a linker/spacer group covalently bonded to, and replaces one hydrogen atom of one of the carbon atoms to which it is joined, said linker/spacer group being represented by the formula (1) wherein s is an integer of 0 or 1; t is an integer of 0 to 20 inclusive; R is an electrophilic or nucleophilic moiety which allows for covalent attachment to an antibody or fragment thereof, or synthetic linker which can be attached to an antibody or fragment thereof, or precursor thereof; and Cyc represents a cyclic aliphatic moiety, aromatic moiety, aliphatic heterocyclic moiety, or aromatic heterocyclic moiety, each of said moieties optionally substituted with one or more groups which do not interfere with binding to an antibody or antibody fragment; with the proviso that when s, t, m, r, and n are 0, then R is other than carboxyl; their pharmaceutically acceptable salts, their conjugates and the use thereof for radioimmunotherapy is disclosed.
摘要翻译：吖啶-225（225Ac）与式（I）的官能化螯合剂络合，其中：每个Q独立地为氢或（CHR 5）pCO 2 R; Q 1是氢或（CHR 5）wCO 2 R; 每个R独立地为氢，苄基或C 1 -C 4烷基; 条件是Q和Q 1的总和中的至少两个必须不是氢; 每个R 5独立地为氢; C1-C4烷基或（C1-C2烷基）苯基; X和Y各自独立地为氢或可以与相邻的X和Y一起形成额外的碳 - 碳键; n是0或1; m是从0到10的整数，包括0和10; p是1或2; r是0或1; w是0或1; 条件是当X和/或Y形成另外的碳 - 碳键时，n仅为1，并且r和w之和为0或1; L是与其所连接的碳原子中的一个碳原子共价键合并且取代其中一个碳原子的一个氢原子的连接基团/间隔基团，所述连接基团/间隔基团由式（1）表示，其中s是0或1的整数 ; t是0〜20的整数， R 1是允许共价连接至抗体或其片段或可以连接至抗体或其片段或其前体的合成连接体的亲电或亲核部分; 并且Cyc表示环状脂族部分，芳族部分，脂族杂环部分或芳族杂环部分，所述部分中的每一个任选地被一个或多个不干扰与抗体或抗体片段结合的基团取代; 条件是当s，t，m，r和n为0时，则R 1不是羧基; 其药学上可接受的盐，它们的缀合物及其用于放射免疫疗法的用途。

3. 发明申请

WO2005049096A3 PROTEIN AND POLYMER CONJUGATES AS CHELANTS WITH ENHANCED BLOOD RETENTION 审中-公开
标题翻译：蛋白质和聚合物作为具有增强血液保持力的药物
公开(公告)号：WO2005049096A3
公开(公告)日：2005-12-29
申请号：PCT/US2004037769
申请日：2004-11-12
申请人： DOW GLOBAL TECHNOLOGIES INC , ATHEY PHILLIP S , KIEFER GARRY E , SIMON JAIME , FRANK R KEITH , ADAIR CHRISTOPHER , GULYAS GYONGYI
发明人： ATHEY PHILLIP S , KIEFER GARRY E , SIMON JAIME , FRANK R KEITH , ADAIR CHRISTOPHER , GULYAS GYONGYI
IPC分类号： A61K49/08 , A61K49/14 , A61K51/04 , A61K51/06 , A61K51/08
CPC分类号： A61K51/065 , A61K49/085 , A61K49/126 , A61K49/14 , A61K51/0497 , A61K51/088
摘要： The present invention is a pharmaceutical composition that exhibits enhanced IP blood retention, the composition comprising: a biotargeting molecule; and a chelating agent conjugated to the biotargeting molecule; wherein the composition exhibits a half-life in the bloodstream of from 15 minutes to 24 hours. The present invention is also directed to the use of functionalized chelants to modify the pharmacokinetics of radiopharmaceuticals. Compared with non-functionalized chelants, chelants functionalized with bulky and/or lipophilic groups can slow down the renal clearance and enhance the blood retention of metals complexed therewith. This enhanced blood retention leads to increased uptake of metal in target tissue.
摘要翻译：本发明是一种具有增强的IP血液保留性的药物组合物，该组合物包含：生物靶向分子; 和与生物靶向分子缀合的螯合剂; 其中所述组合物在血液中的半衰期为15分钟至24小时。本发明还涉及功能化螯合剂用于改变放射性药物的药代动力学的用途。与非官能化螯合剂相比，用大体积和/或亲脂基团官能化的螯合剂可以减慢肾清除率并增强与其结合的金属的血液保持性。这种增强的血液保留导致靶组织中金属的摄取增加。

4. 发明申请

WO2012009120A3 CURABLE RESIN COMPOSITIONS 审中-公开
标题翻译：可固化树脂组合物
公开(公告)号：WO2012009120A3
公开(公告)日：2012-04-12
申请号：PCT/US2011041566
申请日：2011-06-23
申请人： DOW GLOBAL TECHNOLOGIES LLC , CARTER JAMES WELLS , MARKS MAURICE J , VALETTE LUDOVIC , GULYAS GYONGYI
发明人： CARTER JAMES WELLS , MARKS MAURICE J , VALETTE LUDOVIC , GULYAS GYONGYI
IPC分类号： C08G59/24 , C08G59/02 , C08G59/68
CPC分类号： C09D11/101 , C08G59/027 , C08G59/24 , C08G59/68 , C08G59/687 , C08G59/688 , C08G63/664 , C08K5/10
摘要： A photocationically-curable composition including (a) at least one divinylarene dioxide, (b) at least one cationic photoinitiator, and (c) at least one cyclic ester compound; a process for making the curable composition; and a cured product made therefrom. The cured product made from the above curable composition offers improved properties and are useful for various applications including ink formulations.
摘要翻译：一种光固化组合物，其包含（a）至少一种二乙烯基芳烃二氧化物，（b）至少一种阳离子光引发剂和（c）至少一种环酯化合物; 制备可固化组合物的方法; 和由其制成的固化产物。由上述可固化组合物制成的固化产物具有改进的性能，可用于各种应用，包括油墨配方。

5. 发明申请

WO2012009118A2 CURABLE RESIN COMPOSITIONS 审中-公开
标题翻译：可固化树脂组合物
公开(公告)号：WO2012009118A2
公开(公告)日：2012-01-19
申请号：PCT/US2011041543
申请日：2011-06-23
申请人： DOW GLOBAL TECHNOLOGIES LLC , CARTER JAMES WELLS , MARKS MAURICE J , VALETTE LUDOVIC , GULYAS GYONGYI
发明人： CARTER JAMES WELLS , MARKS MAURICE J , VALETTE LUDOVIC , GULYAS GYONGYI
IPC分类号： C08L63/00 , C08K3/22 , C08K5/05 , C08K5/053 , C08K5/1525 , C08K5/3417 , C09D11/00 , C09J163/00
CPC分类号： C08G59/22 , C08G59/245 , C08G59/68 , C08G65/18 , C09D11/101 , C09D11/322
摘要： A curable divinylarene dioxide resin composition including (a) at least one divinylarene dioxide, (b) at least one cationic photoinitiator, and (c) optionally, at least one pigment material; a process for making the curable divinylarene dioxide resin composition; and a cured divinylarene dioxide resin composition made therefrom. The cured product made from the above curable divinylarene dioxide resin composition offers improved properties and are useful for various applications including ink formulations.
摘要翻译：一种可固化的二乙烯基芳烃二氧化物树脂组合物，其包含（a）至少一种二乙烯基芳烃二氧化物，（b）至少一种阳离子光引发剂和（c）任选的至少一种颜料材料; 制备可固化的二乙烯基芳烃二氧化物树脂组合物的方法; 和由其制成的固化的二乙烯基芳烃二氧化物树脂组合物。由上述可固化的二乙烯基芳烃二氧化物树脂组合物制成的固化产品提供改进的性能，并且可用于包括油墨配方的各种应用。

6. 发明申请

WO2011119655A2 PROCESS FOR PREPARING DIVINLYLARENE DIOXIDES 审中-公开
标题翻译：制备DIVILLYLARENE DIOXID的方法
公开(公告)号：WO2011119655A2
公开(公告)日：2011-09-29
申请号：PCT/US2011029494
申请日：2011-03-23
申请人： DOW GLOBAL TECHNOLOGIES LLC , GULYAS GYONGYI , WRIGHT ROBERT J , HERNANDEZ MARTHA P , RIPPLINGER ERIC B
发明人： GULYAS GYONGYI , WRIGHT ROBERT J , HERNANDEZ MARTHA P , RIPPLINGER ERIC B
IPC分类号： C08G59/22
CPC分类号： C08G59/027 , C07D301/12 , C07D301/14 , C08G59/22 , C08G59/245
摘要： A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; and (b) at least one peracid oxidant compound, under conditions to form a divinylarene dioxide product; wherein the peracid oxidant compound is capable of providing an increased yield of a divinylarene dioxide product.
摘要翻译：一种制备二乙烯基芳烃二氧化物的方法，包括使（a）至少一种二乙烯基芳烃反应; 和（b）至少一种过酸性氧化剂化合物，在形成二乙烯基二氧化碳产品的条件下; 其中过酸氧化剂化合物能够提供二乙烯基芳烃二氧化物产物的增加的产率。

7. 发明申请

WO2013043363A3 EPOXY-FUNCTIONAL RESIN COMPOSITIONS 审中-公开
标题翻译：环氧官能树脂组合物
公开(公告)号：WO2013043363A3
公开(公告)日：2013-05-30
申请号：PCT/US2012053715
申请日：2012-09-05
申请人： DOW GLOBAL TECHNOLOGIES LLC , MARKS MAURICE J , GULYAS GYONGYI
发明人： MARKS MAURICE J , GULYAS GYONGYI
IPC分类号： C08G59/18 , C08L63/00
CPC分类号： C08G59/245 , C08G59/066 , C08G59/184 , C08L63/00
摘要： An epoxy-functional resin composition including the reaction product of (a) a stoichiometric excess of at least one divinylarene dioxide, and (b) at least one of: a primary (1°) monoamine, a bis-secondary (2°) amine lacking nitrogen atoms, or mixtures thereof; a curable composition including (i) the epoxy-functional resin composition, and (ii) at least one curing agent; and a cured thermoset resin prepared from the curable composition.
摘要翻译：一种环氧官能树脂组合物，其包含（a）化学计量过量的至少一种二乙烯基芳烃二氧化物的反应产物和（b）至少一种：伯（1）单胺，双仲（2°）胺缺少氮原子，或其混合物; 可固化组合物，其包含（i）环氧官能树脂组合物和（ii）至少一种固化剂; 和由可固化组合物制备的固化的热固性树脂。

8. 发明申请

WO2011056381A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES 审中-公开
标题翻译：制备二硝基二氧化物的方法
公开(公告)号：WO2011056381A1
公开(公告)日：2011-05-12
申请号：PCT/US2010052766
申请日：2010-10-15
申请人： 6DOW GLOBAL TECHNOLOGIES LLC 1 , GULYAS GYONGYI , BHARADWAJ ASHWIN R , WRIGHT ROBERT J , NULL MARTY J , RIPPLINGER ERIC B
发明人： GULYAS GYONGYI , BHARADWAJ ASHWIN R , WRIGHT ROBERT J , NULL MARTY J , RIPPLINGER ERIC B
IPC分类号： C07D301/03 , C07D301/12 , C07D301/14
CPC分类号： C07D301/03 , C07D301/12 , C07D301/14 , C08G59/027 , C08G59/22
摘要： A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene with (b) at least one oxidant in the presence of (c) at least one transition metal complex catalyst, and (d) optionally, in the presence of a solvent, and (e) optionally in the presence of a catalyst modifier under conditions to form a divinylarene dioxide product.
摘要翻译：一种制备二乙烯基芳烃二氧化物的方法，包括在（c）至少一种过渡金属络合物催化剂存在下使（a）至少一种二乙烯基芳烃与（b）至少一种氧化剂反应，和（d）任选地，在溶剂和（e）任选地在催化剂改性剂存在下在形成二乙烯基二氧化碳产物的条件下进行。

9. 发明申请

WO2011116177A3 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES 审中-公开
标题翻译：制备二烯丙基二氧化物的方法
公开(公告)号：WO2011116177A3
公开(公告)日：2011-12-15
申请号：PCT/US2011028794
申请日：2011-03-17
申请人： DOW GLOBAL TECHNOLOGIES , GULYAS GYONGYI , NULL MARTY J
发明人： GULYAS GYONGYI , NULL MARTY J
IPC分类号： C07D301/03 , C07D301/12 , C07D407/04 , C08G59/22
CPC分类号： C07D407/04 , C07D301/03 , C07D301/12 , C08G59/027
摘要： A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; (b) at least one oxidant, wherein the at least one oxidant includes a peroxomonosulfate triple salt oxidant, and wherein the at least one oxidant is less than about 2.0 equivalents to C=C; (c) at least one solvent, (d) at least one basic compound, and (e) optionally, at least one catalyst; under conditions to form a divinylarene dioxide product.
摘要翻译：一种制备二乙烯基芳烃二氧化物的方法，包括使（a）至少一种二乙烯基芳烃反应; （b）至少一种氧化剂，其中所述至少一种氧化剂包含过氧单硫酸盐三重盐氧化剂，并且其中所述至少一种氧化剂小于C = C的约2.0当量; （c）至少一种溶剂，（d）至少一种碱性化合物，和（e）任选的至少一种催化剂; 在形成二乙烯基芳烃二氧化物产物的条件下进行。

10. 发明申请

WO2009058715A3 NON-SINTERING ISOCYANATE MODIFIED EPOXY RESIN FOR FUSION BONDED EPOXY APPLICATIONS 审中-公开
标题翻译：非烧结异构化改性环氧树脂用于熔融粘结环氧应用
公开(公告)号：WO2009058715A3
公开(公告)日：2010-06-03
申请号：PCT/US2008081281
申请日：2008-10-27
申请人： DOW GLOBAL TECHNOLOGIES INC , LIAO ZENG KUN , AGUIRRE FABIO VARGAS , HA PHAM Q , GULYAS GYONGYI
发明人： LIAO ZENG KUN , AGUIRRE FABIO VARGAS , HA PHAM Q , GULYAS GYONGYI
IPC分类号： C08G18/00 , C08G18/28 , C08G18/64 , C08G59/40 , C09D5/03
CPC分类号： C08G18/58 , C08G18/003 , C08G18/2845 , C08G18/7664 , C08G2150/20 , C09D5/033 , C09D175/04 , Y10T428/1355
摘要： Thermosetting epoxy-terminated oxazolidinone ring containing polymers which are obtainable by reacting at least one polyisocyanate compound with at least one hydroxy group containing epoxy resin and/or a combination of at least one epoxy resin and at least one di- or multifunctional nucleophilic compound that is capable of forming crosslinks between epoxy groups. The polymers have an onset glass transition temperature of at least about 45°C and are capable of showing an onset glass transition temperature in the cured state at least about 160°C. Powder coating compositions comprising these polymers are also disclosed.
摘要翻译：通过使至少一种多异氰酸酯化合物与至少一种含羟基的环氧树脂和/或至少一种环氧树脂和至少一种二官能或多官能的亲核化合物的组合使至少一种多异氰酸酯化合物与至少一种含羟基的环氧树脂反应而得到的热固性环氧基封端的恶唑烷酮环能够在环氧基之间形成交联。聚合物的起始玻璃化转变温度为至少约45℃，并且能够在至少约160℃的固化状态下显示起始玻璃化转变温度。还公开了包含这些聚合物的粉末涂料组合物。

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