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1. 发明申请

WO2006029176A3 CANCER-TESTIS ANTIGENS 审中-公开
标题翻译：癌 - 睾丸抗原
公开(公告)号：WO2006029176A3
公开(公告)日：2006-08-31
申请号：PCT/US2005031770
申请日：2005-09-08
申请人： LUDWIG INST CANCER RES , CORNELL RES FOUNDATION INC , SLOAN KETTERING INST CANCER , SCANLAN CYNTHIA H , CHEN YAO-TSENG , OLD LLOYD J , SIMPSON ANDREW J G , JONGENEEL C VICTOR
发明人： CHEN YAO-TSENG , OLD LLOYD J , SIMPSON ANDREW J G , JONGENEEL C VICTOR , SCANLAN MATTHEW
IPC分类号： A61K39/00 , A61P35/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/505 , C07K14/4748 , G01N33/574
摘要： The invention relates to cancer-testis antigens and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof in methods and compositions for the diagnosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of novel cancer-testis (CT) antigens.
摘要翻译：本发明涉及癌 - 睾丸抗原和编码它们的核酸分子。本发明进一步涉及核酸分子，多肽和其片段在用于诊断和治疗疾病例如癌症的方法和组合物中的用途。更具体地说，本发明涉及新型癌症 - 睾丸（CT）抗原的发现。

2. 发明申请

WO0153349A3 SMALL CELL LUNG CANCER ASSOCIATED ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：小细胞肺癌相关抗原及其用途
公开(公告)号：WO0153349A3
公开(公告)日：2002-01-10
申请号：PCT/US0102015
申请日：2001-01-19
申请人： LUDWIG INST CANCER RES , SLOAN KETTERING INST CANCER , CORNELL RES FOUNDATION INC
发明人： STOCKERT ELISABETH , SCANLAN MATTHEW J , JAGER DIRK , OLD LLOYD J , GURE ALI O , CHEN YAO-TSENG
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , C07K14/4748 , G01N33/57423
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, inter alia , isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的小细胞肺癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有小细胞肺癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

3. 发明申请

WO0147959A3 ISOLATED NUCLEIC ACID MOLECULES ENCODING CANCER ASSOCIATED ANTIGENS, THE ANTIGENS PER SE, AND USES THEREOF 审中-公开
标题翻译：分离的核酸分子编码癌相关抗原，抗体及其用途及其用途
公开(公告)号：WO0147959A3
公开(公告)日：2002-05-16
申请号：PCT/US0042334
申请日：2000-11-29
申请人： LUDWIG INST CANCER RES , SLOAN KETTERING INST CANCER , CORNELL RES FOUNDATION INC , JAGER DIRK , STOCKERT ELISABETH , SCANLAN MATTHEW , KNUTH ALEXANDER , OLD LLOYD , GURE ALI , CHEN YAO TSENG
发明人： JAGER DIRK , STOCKERT ELISABETH , SCANLAN MATTHEW , KNUTH ALEXANDER , OLD LLOYD , GURE ALI , CHEN YAO-TSENG
IPC分类号： G01N33/566 , A61K39/00 , A61K39/39 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/574 , G01N33/577 , G01N33/58 , A61K48/00 , C07K16/30 , G01N33/50 , G01N33/53
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译：本发明涉及新鉴定的癌症相关抗原。已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。该观察结果也是本发明的一部分。

4. 发明申请

WO02090986A9 COLON CANCER ANTIGEN PANEL 审中-公开
标题翻译：结肠癌抗原面板
公开(公告)号：WO02090986A9
公开(公告)日：2003-01-30
申请号：PCT/US0213994
申请日：2002-05-02
申请人： LUDWIG INST CANCER RES , CORNELL RES FOUNDATION INC , CHEN YAO-TSENG , OLD LLOYD J , SCANLAN MATTHEW J , STOCKERT ELISABETH
发明人： CHEN YAO-TSENG , OLD LLOYD J , SCANLAN MATTHEW J , STOCKERT ELISABETH
IPC分类号： A61K38/00 , C07K14/47 , C07K16/30 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/577 , G01N37/00 , C07K14/435 , C07K16/18 , C07K16/32 , C12N15/12 , C12P19/34
CPC分类号： G01N33/57419 , A61K38/00 , C07K14/4748 , C07K16/3046 , C12Q1/6886 , C12Q2600/156
摘要： The invention provides methods for diagnosing cancer including colon cancer, based on the identification of certain colon cancer-associated polypeptides as antigens that elicit immune responses in colon cancer. The identified antigens can be utilized as markers for diagnosing colon cancer, and for following the course of treatment of colon cancer.
摘要翻译：本发明基于鉴定某些结肠癌相关多肽作为在结肠癌中引起免疫应答的抗原，提供诊断包括结肠癌的癌症的方法。所鉴定的抗原可用作诊断结肠癌的标志物，以及用于治疗结肠癌的过程。

5. 发明申请

WO9904265A3 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌症相关核酸和多糖
公开(公告)号：WO9904265A3
公开(公告)日：1999-08-26
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574 , C12N15/12 , A61K31/70 , A61K35/12 , A61K38/17 , A61K39/00 , C07K14/705 , C07K16/28 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Tumor cell-specific antigens from melanoma cells have previously been identified using autologous cytolytic T cells clones from the patient, but the same approach did not work well with other tumour types. Here, screening of such antigens was successfully performed using antisera from the patient. Provided are several tumor cell-specific antigens, nucleic acids encoding them, antibodies and CTL's directed against these antigens, antigenic fragments diagnostic kits, etc.
摘要翻译：以前已经使用来自患者的自体细胞溶质T细胞克隆来鉴定来自黑素瘤细胞的肿瘤细胞特异性抗原，但是与其他肿瘤类型相同的方法不能很好地发现。在这里，使用来自患者的抗血清成功地进行了这些抗原的筛选。提供了几种肿瘤细胞特异性抗原，编码它们的核酸，针对这些抗原的抗体和CTL，抗原片段诊断试剂盒等。

6. 发明申请

WO0226778A2 ISOLATED PEPTIDES WHICH BIND TO HLA-C MOLECULES AND USES THEREOF 审中-公开
标题翻译：与HLA-C分子结合的分离的肽和其用途
公开(公告)号：WO0226778A2
公开(公告)日：2002-04-04
申请号：PCT/US0129920
申请日：2001-09-24
申请人： LUDWIG INST CANCER RES
发明人： GNJATIC SACHA , OLD LLOYD J , NAGATA YASUHIRO , JAGER ELKE , CHEN YAO-TSENG , KNUTH ALEXANDER
IPC分类号： C12N5/06 , A61K38/00 , A61K39/00 , C07K7/06 , C07K14/47 , C12N5/08 , C12N15/47 , C07K14/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5158
摘要： The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.
摘要翻译：本发明教导了结合细胞表面上的HLA-Cw3和HLA-Cw6分子的肽表位。肽在诊断和治疗上是有用的，编码它们的DNA分子以及HLA /肽复合物特异性的细胞溶解性T淋巴细胞是有用的。本发明的另一个特征是在使用不同病毒载体的刺激和再刺激的系统中鉴定相关分子（例如本文所述的那些）的方法。

7. 发明申请

WO0020587A2 CANCER ASSOCIATED ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：癌症相关抗原及其用途
公开(公告)号：WO0020587A2
公开(公告)日：2000-04-13
申请号：PCT/US9922873
申请日：1999-10-04
申请人： LUDWIG INST CANCER RES
发明人： OBATA YUICHI , GOUT IVAN , TURECI OZLEM , SAHIN UGAR , PFREUNDSCHUH MICHAEL , SCANLAN MATTHEW J , STOCKERT ELISABETH , CHEN YAO-TSENG , OLD LLOYD J , JAGER ELKE , KNUTH ALEX
IPC分类号： A61K31/711 , A61K35/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/574 , G01N33/577 , A61K31/70 , A61K35/12 , A61K38/13
CPC分类号： G01N33/57492 , A61K35/00 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/11 , C07K14/47 , C12Q1/6886 , C12Q2600/158 , G01N33/57488
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有肾癌的患者中表达的癌相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有那些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，对那些识别蛋白质和肽的那些蛋白质和肽和细胞毒性T淋巴细胞的抗体。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可以用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

8. 发明申请

WO9904265A9 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌相关的核酸和多肽
公开(公告)号：WO9904265A9
公开(公告)日：1999-07-08
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

9. 发明申请

WO9904265A8 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：癌症相关核酸和多糖
公开(公告)号：WO9904265A8
公开(公告)日：1999-05-14
申请号：PCT/US9814679
申请日：1998-07-15
申请人： LUDWIG INST CANCER RES , SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO TSENG , GOUT IVAN , HARE MICHAEL O , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
发明人： SCANLAN MATTHEW J , STOCKERT ELISABETH , GURE ALI , CHEN YAO-TSENG , GOUT IVAN , O'HARE MICHAEL , OBATA YUICHI , PFREUNDSCHUH MICHAEL , TURECI OZLEM , SAHIN UGUR , OLD LLOYD J
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C07K16/46 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/569 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

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