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1. 发明申请

WO2012030993A2 SKIN COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：皮肤组合物及其使用方法
公开(公告)号：WO2012030993A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050016
申请日：2011-08-31
申请人： LIVING PROOF, INC. , YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
IPC分类号： A61K31/74 , A61K31/795 , A61K8/89 , A61P17/02 , A61Q19/00
CPC分类号： A61K31/765 , A61K8/0204 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/585 , A61K8/891 , A61K8/894 , A61K8/895 , A61K2800/412 , A61K2800/43 , A61K2800/58 , A61K2800/5922 , A61K2800/884 , A61K2800/95 , A61L26/0019 , A61L26/0095 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C08L83/04
摘要： Provided are therapeutic formulations and methods of use thereof.
摘要翻译：提供治疗剂型及其使用方法。

2. 发明申请

WO2012030984A2 SKIN COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：皮肤组合物及其使用方法
公开(公告)号：WO2012030984A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050003
申请日：2011-08-31
申请人： LIVING PROOF, INC. , YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
IPC分类号： A61K8/89 , A61K31/74 , A61K31/795 , A61Q19/00 , A61P17/00
CPC分类号： A61K31/765 , A61K8/0204 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/585 , A61K8/891 , A61K8/894 , A61K8/895 , A61K2800/412 , A61K2800/43 , A61K2800/58 , A61K2800/5922 , A61K2800/884 , A61K2800/95 , A61L26/0019 , A61L26/0095 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C08L83/04
摘要： Provided are body corrective cosmetic formulations and methods of use thereof.
摘要翻译：提供身体矫正化妆品制剂及其使用方法。

3. 发明申请

WO2008134712A2 USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE 审中-公开
标题翻译：在皮肤护理中使用基质金属蛋白酶抑制剂
公开(公告)号：WO2008134712A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/061992
申请日：2008-04-30
申请人： LIVING PROOF, INC. , YU, Betty , NASHAT, Amir , ANDERSON, Daniel, Griffith , PUERTA, David, Thomas , ADAMS, Benjamin , CLARK, Scott , KIM, Yushan , SPENGLER, Eric, George , MCLAUGHLIN, Ronald, P. , BEDFORD, Susan, Eilidh , LI, Zhi
发明人： YU, Betty , NASHAT, Amir , ANDERSON, Daniel, Griffith , PUERTA, David, Thomas , ADAMS, Benjamin , CLARK, Scott , KIM, Yushan , SPENGLER, Eric, George , MCLAUGHLIN, Ronald, P. , BEDFORD, Susan, Eilidh , LI, Zhi
CPC分类号： A61K8/062 , A61K8/0212 , A61K8/0229 , A61K8/064 , A61K8/14 , A61K8/498 , A61K2800/31 , A61K2800/782 , A61Q17/04 , A61Q19/00 , A61Q19/005 , A61Q19/08
摘要： The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).
摘要翻译：基质金属蛋白酶（MMP）抑制剂对皮肤的应用抑制皮肤中发现的蛋白质的降解，包括胶原蛋白，弹性蛋白，以及其他基底膜和细胞外基质蛋白质。 MMP抑制剂可用于化妆品组合物和用于皮肤应用的药物组合物中。 MMP抑制剂与美容上合适的载体或药学上可接受的赋形剂一起配制，用于作为乳膏，洗剂，软膏，溶液，面罩等应用于皮肤。作为化妆品，将本发明的MMP抑制剂组合物施用于皮肤以预防或减少皱纹的出现，色素沉着变化，丧失弹性或与老化或太阳损伤有关的其他影响。作为药物，本发明的MMP抑制剂组合物也可以施用于皮肤以治疗或预防皮肤疾病（例如增殖性疾病，炎性疾病）。

4. 发明申请

WO2015066266A1 SCALE AND ASSOCIATED METRIC FOR TREATMENT OF FACIAL WRINKLES AND RELATED CONDITIONS 审中-公开
标题翻译：用于治疗面部皱纹的比例和相关的公制及相关条件
公开(公告)号：WO2015066266A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063048
申请日：2014-10-30
申请人： LIVING PROOF, INC.
发明人： YU, Betty , BIESMAN, Brian
IPC分类号： A61B5/00
CPC分类号： A61B5/442 , A61B5/4878 , A61K8/0208 , A61K2800/805 , A61Q19/08 , G06F19/00 , G16H50/20
摘要： This invention provides assessment scale devices and methods for assessing the severity of wrinkles and facial swelling and puffiness. Wrinkle and facial swelling/puffiness assessment using the devices, methods, and assessment scales of the invention can be performed in a clinical setting for the purpose of simply characterizing a wrinkle or facial swelling/puffiness, or as part of a treatment plan or course that varies according to the severity of the wrinkle or facial swelling/puffiness. Thus, this invention also provides methods of reducing the appearance of wrinkles and/or facial puffiness, and kits comprising for evaluating and treating wrinkles and/or facial puffiness. Additionally, the present disclosure relates to a devices, methods, and assessment scales for managing expectations of the given treatment plan or course for human facial wrinkles and facial puffiness.
摘要翻译：本发明提供了用于评估皱纹和面部肿胀和浮肿的严重程度的评估尺度装置和方法。为了简单地表征皱纹或面部肿胀/浮肿的目的，或者作为治疗计划或疗程的一部分，可以在临床设置中使用本发明的装置，方法和评估量表进行皱纹和面部肿胀/浮肿评估根据皱纹或面部肿胀/浮肿的严重程度而变化。因此，本发明还提供了减少皱纹和/或面部浮肿的外观的方法以及包含用于评估和治疗皱纹和/或面部浮肿的试剂盒。此外，本公开涉及用于管理针对人类面部皱纹和面部浮肿的给定治疗计划或疗程的期望的装置，方法和评估尺度。

5. 发明申请

WO2013044098A1 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF COMPROMISED SKIN BARRIER FUNCTION 审中-公开
标题翻译：用于治疗皮肤屏障功能障碍的组合物和方法
公开(公告)号：WO2013044098A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056667
申请日：2012-09-21
申请人： LIVING PROOF, INC.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-young , ADAMS, Benjamin, W.
IPC分类号： A61K9/00 , A61K8/891 , A61K47/24 , A61P17/02
CPC分类号： A61K31/80 , A61K9/0014 , A61K9/7015 , A61K45/06 , A61K2300/00
摘要： Compositions and methods of treating conditions of compromised skin barrier function are described.
摘要翻译：描述了治疗受损皮肤屏障功能状况的组合物和方法。

6. 发明申请

WO2013158844A2 COLOR CORRECTING COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：颜色校正组合物及其使用方法
公开(公告)号：WO2013158844A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/037116
申请日：2013-04-18
申请人： LIVING PROOF, INC.
发明人： LOMAKIN, Joseph , KANG, Soo-young , YU, Betty , PILKENTON, Morgan
IPC分类号： A61K8/25
CPC分类号： A61K8/895 , A61K8/25 , A61K8/585 , A61K2800/884 , A61K2800/95 , A61Q1/02 , A61Q17/04
摘要： Compositions and methods of for changing the color of skin or body described.
摘要翻译：改变皮肤或身体颜色的组成和方法。

7. 发明申请

WO2007134219A2 IN SITU POLYMERIZATION FOR SKIN TREATMENT 审中-公开
标题翻译：在皮肤治疗的现场聚合
公开(公告)号：WO2007134219A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068751
申请日：2007-05-11
申请人： ANDORA, INC. , YU, Betty , PUERTA, David, Thomas , BEDFORD, Susan, Eilidh , ANDERSON, Daniel, Griffith
发明人： YU, Betty , PUERTA, David, Thomas , BEDFORD, Susan, Eilidh , ANDERSON, Daniel, Griffith
IPC分类号： G09B19/24
CPC分类号： G09B19/24 , A61K8/8152 , A61Q19/00
摘要： Cosmetics represent a world-wide multi-billion dollar industry. The present invention provides technology for polymerizing monomers on skin in situ to produce desired skin characteristics. For example, the inventive system may be used to reduce the signs of aging or to protect the treated skin from UV light. The polymerization of monomers on skin is typically initiated using a thermal or photoinitiatied free radical initiator. In certain embodiments, the monomers are fluorinated thereby producing a fluorinated polymer on the skin upon polymerization. The invention provides monomers, initiators, methods, and kits for use in treating skin with polymers.
摘要翻译：化妆品代表世界数十亿美元的行业。本发明提供在皮肤上原位聚合单体以产生所需皮肤特征的技术。例如，本发明的系统可以用于减少老化的迹象或者保护经处理的皮肤免受UV光的影响。通常使用热或光引发的自由基引发剂引发单体在皮肤上的聚合。在某些实施方案中，单体是氟化的，从而在聚合时在皮肤上产生氟化聚合物。本发明提供用于用聚合物处理皮肤的单体，引发剂，方法和试剂盒。

8. 发明申请

WO2003040390A3 PROTEASE ASSAY FOR THERAPEUTIC DRUG MONITORING 审中-公开
公开(公告)号：WO2003040390A3
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012631
申请日：2002-11-08
申请人： TIBOTEC PHARMACEUTICALS LTD. , GULNIK, Sergei , YU, Betty , ERICKSON, John, W.
发明人： GULNIK, Sergei , YU, Betty , ERICKSON, John, W.
IPC分类号： C12Q1/37
摘要： The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retroviral protease inhibitors such as HIV inhibitors.

9. 发明申请

WO2020163830A1 SEMI-PERMANENT TATTOOS 审中-公开
公开(公告)号：WO2020163830A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/017371
申请日：2020-02-07
申请人： INKBOX INK INCORPORATED , HANDLEY, Tyler , YU, Betty , DENG, Sunny , CHUA, Jobey , KHALILI, Nazanin , ADAM, Motaz , ZHANG, Hanna Jiamei , CAPUTO, Christopher
发明人： HANDLEY, Tyler , YU, Betty , DENG, Sunny , CHUA, Jobey , KHALILI, Nazanin , ADAM, Motaz , ZHANG, Hanna Jiamei , CAPUTO, Christopher
IPC分类号： A61Q1/02 , A61K8/02 , A61K8/49 , A61K8/9789 , A61K8/34 , A61K8/44 , A61Q19/00 , B32B37/12
摘要： The present disclosure relates to semi-permanent tattoos, and more particularly to genipin-based ink compositions as well as layered adhesive articles and methods for application of the genipin-based, semi-permanent tattoos. In some embodiments, the genipin-based ink composition comprises: purified genipin present in an amount of about 5% to about 10% w/w of the composition; one or more volatile solvents present in an amount of about 70% to about 85% w/w of the composition; one or more semi-volatile semi-permanent colorant solubilizers present in an amount of about 10% to about 20% w/w of the composition; and one or more surface-active agents present in an amount of about 0.25% to about 5% w/w of the composition.

10. 发明申请

WO2005030165A1 DOSAGE FORM FOR CONTROLLED RELEASE OF AN ACTIVE AGENT FORMULATION 审中-公开
标题翻译：用于控制释放活性剂配方的剂型
公开(公告)号：WO2005030165A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031309
申请日：2004-09-23
申请人： ALZA CORPORATION , WISER, Lauren, M. , YU, Betty , CAPELL, Kimberly, R. , LAM, Andrew, C. , HATAMKANY, Zahedeh
发明人： WISER, Lauren, M. , YU, Betty , CAPELL, Kimberly, R. , LAM, Andrew, C. , HATAMKANY, Zahedeh
IPC分类号： A61K9/00
CPC分类号： A61K31/167 , A61K9/0004
摘要： The present invention is directed to a dosage form configured to provide the controlled release of an active agent formulation. A dosage form according to the present invention includes a reservoir containing an active agent formulation and an engine positioned at least partially within the reservoir. In order to reduce the possibility that the engine included in a dosage form of the present invention will separate from the reservoir either during or after fabrication of the dosage form of the present invention, the engine included in a dosage form according to the present invention is bonded to an inside surface of the reservoir. The present invention also includes methods for preparing a controlled release dosage form.
摘要翻译：本发明涉及配制成提供活性剂制剂的受控释放的剂型。根据本发明的剂型包括含有活性剂制剂的储存器和至少部分地位于储存器内的发动机。为了减少包含在本发明的剂型中的发动机在本发明的剂型的制造期间或之后与储存器分离的可能性，包括在根据本发明的剂型中的发动机是结合到储存器的内表面。本发明还包括制备控释剂型的方法。

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