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1. 发明申请

WO2011002814A3 SULFONAMIDO - BIPHENYLOXYACETIC ACID COMPOUNDS 审中-公开
公开(公告)号：WO2011002814A3
公开(公告)日：2011-01-06
申请号：PCT/US2010/040482
申请日：2010-06-29
申请人： LIGAND PHARMACEUTICALS INC. , SMITHKLINE BEECHAM CORPORATION , MCGUINNESS, Brian, F. , HO, Koc-kan , BABU, Suresh , DONG, Guizhen , DUO, Jingqi , LE, Thuy, X., H. , SAIONZ, Kurt, W. , NEEB, Michael, J.
发明人： MCGUINNESS, Brian, F. , HO, Koc-kan , BABU, Suresh , DONG, Guizhen , DUO, Jingqi , LE, Thuy, X., H. , SAIONZ, Kurt, W. , NEEB, Michael, J.
IPC分类号： C07C311/17 , C07C311/19 , A61K31/18 , A61P11/00 , A61P19/02 , A61P17/00
摘要： Some embodiments of the present invention include novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. Some compounds provided include those of the general formula (I), and compounds of general formula (Ia).

2. 发明申请

WO2004074244A2 PYRIMIDINE COMPOUNDS 审中-公开
标题翻译：嘧啶化合物
公开(公告)号：WO2004074244A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/004197
申请日：2004-02-11
申请人： SMITHKLINE BEECHAM CORPORATION , DAVIS-WARD, Ronda , MOOK, Robert, Anthony, Jr. , NEEB, Michael, J. , SALOVICH, James, M.
发明人： DAVIS-WARD, Ronda , MOOK, Robert, Anthony, Jr. , NEEB, Michael, J. , SALOVICH, James, M.
IPC分类号： C07D
CPC分类号： C07D239/42 , C07D239/48 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention provides compounds of formula (I) : wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译：本发明提供式（I）的化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法以及它们作为药物的用途

3. 发明申请

WO2004043917A1 SULFONAMIDES 审中-公开
公开(公告)号：WO2004043917A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035351
申请日：2003-11-06
申请人： SMITHKLINE BEECHAM CORPORATION , BARTON, Linda, S. , DODSON, Jason, W. , GAITANOPOULOS, Dimitri, E. , GIRARD, Gerald, R. , KING, Bryan, W. , MCATEE, John, Jeffrey , NEEB, Michael, J.
发明人： BARTON, Linda, S. , DODSON, Jason, W. , GAITANOPOULOS, Dimitri, E. , GIRARD, Gerald, R. , KING, Bryan, W. , MCATEE, John, Jeffrey , NEEB, Michael, J.
IPC分类号： C07D207/00
CPC分类号： C07D401/12 , C07D207/12 , C07D409/04 , C07D409/14 , C07D417/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

4. 发明申请

WO2004043939A1 AMIDE COMPOUNDS AND METHODS OF USING THE SAME 审中-公开
标题翻译：酰胺化合物及其使用方法
公开(公告)号：WO2004043939A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/009461
申请日：2003-03-26
申请人： SMITHKLINE BEECHAM CORPORATION , THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chun , MARINO, Joseph, P. , NEEB, Michael, J. , WANG, Ning
发明人： THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chun , MARINO, Joseph, P. , NEEB, Michael, J. , WANG, Ning
IPC分类号： C07D265/30
CPC分类号： C07D213/40 , C07C235/34 , C07C235/46 , C07C311/51 , C07D205/04 , C07D207/09 , C07D213/38 , C07D223/04 , C07D233/24 , C07D233/64 , C07D249/08 , C07D261/08 , C07D271/10 , C07D277/28 , C07D295/13 , C07D295/185 , C07D295/192 , C07D307/14 , C07D307/52 , C07D333/20 , C07D333/38
摘要： Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
摘要翻译：公开了具有式（I）的药学上可接受的盐或溶剂化物的化合物和含有该化合物的药物组合物，其中结构变量如本文所定义。本发明的化合物，盐和溶剂化物可用作LXR激动剂。

5. 发明申请

WO2002076985A1 COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开
公开(公告)号：WO2002076985A1
公开(公告)日：2002-10-03
申请号：PCT/US2002/008915
申请日：2002-03-22
申请人： SMITHKLINE BEECHAM CORPORATION , BONDINELL, William, E. , HOLT, Dennis, A. , LAGO, Maria, Amparo , NEEB, Michael, J. , SEMONES, Marcus, A.
发明人： BONDINELL, William, E. , HOLT, Dennis, A. , LAGO, Maria, Amparo , NEEB, Michael, J. , SEMONES, Marcus, A.
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D475/00
摘要： Novel kinase inhibitors and methods of using them are provided.

6. 发明申请

WO2004043948A1 SULFONAMIDES 审中-公开
公开(公告)号：WO2004043948A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035369
申请日：2003-11-06
申请人： SMITHKLINE BEECHAM CORPORATION , DODSON, Jason, W. , MCATEE, John, Jeffrey , NEEB, Michael, J.
发明人： DODSON, Jason, W. , MCATEE, John, Jeffrey , NEEB, Michael, J.
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D207/12 , C07D409/04 , C07D409/14 , C07D417/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

7. 发明申请

WO2004043369A2 SULFONAMIDES 审中-公开
公开(公告)号：WO2004043369A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035364
申请日：2003-11-06
申请人： SMITHKLINE BEECHAM CORPORATION , GIRARD, Gerald, R. , MCATEE, John, Jeffrey , NEEB, Michael, J.
发明人： GIRARD, Gerald, R. , MCATEE, John, Jeffrey , NEEB, Michael, J.
IPC分类号： A61K
CPC分类号： C07D207/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07D513/04
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

8. 发明申请

WO2004043368A3 SULFONAMIDES 审中-公开
公开(公告)号：WO2004043368A3
公开(公告)日：2004-05-27
申请号：PCT/US2003/035357
申请日：2003-11-06
申请人： SMITHKLINE BEECHAM CORPORATION , BARTON, Linda, S. , LOUER, Christopher, T. , MCATEE, John, Jeffrey , NEEB, Michael, J. , WANG, Ning
发明人： BARTON, Linda, S. , LOUER, Christopher, T. , MCATEE, John, Jeffrey , NEEB, Michael, J. , WANG, Ning
IPC分类号： C07D409/02
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

9. 发明申请

WO2004010943A2 SUBSTITUTED BENZANILIDES AS MODULATORS OF THE CCR5 RECEPTOR 审中-公开
标题翻译：作为CCR5受体的调节剂的替代苯扎林
公开(公告)号：WO2004010943A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023524
申请日：2003-07-28
申请人： SMITHKLINE BEECHAM CORPORATION , BONDINELL, William, E. , NEEB, Michael, J.
发明人： BONDINELL, William, E. , NEEB, Michael, J.
IPC分类号： A61K
CPC分类号： C07D413/12 , C07D207/08 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/58 , C07D211/72 , C07D401/12
摘要： This invention relates to substituted benzanilides which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted benzanilides which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor modulators may be useful in the treatment of HIV infection.
摘要翻译：本发明涉及作为CCR5受体的调节剂，激动剂或拮抗剂的取代的苯甲酰苯胺。此外，本发明涉及治疗和预防由CCR5介导的疾病状态，包括但不限于哮喘和特应性疾病（例如特应性皮炎和过敏），类风湿性关节炎，结节病和其他纤维化疾病，动脉粥样硬化，牛皮癣，自身免疫性疾病如多发性硬化和炎症性肠病，全部在哺乳动物中，通过使用作为CCR5受体拮抗剂的取代的苯甲酰苯胺。此外，由于CD8 + T细胞与COPD有牵连，因此CCR5可能在其募集中发挥作用，因此CCR5拮抗剂可为COPD治疗提供潜在的治疗方法。此外，由于CCR5是HIV进入细胞的共同受体，因此选择性受体调节剂可用于治疗HIV感染。

10. 发明申请

WO2004010942A2 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS MODULATORS OF THE CCR5 RECEPTOR 审中-公开
标题翻译：作为CCR5受体的调节剂的取代的杂环化合物
公开(公告)号：WO2004010942A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023523
申请日：2003-07-28
申请人： SMITHKLINE BEECHAM CORPORATION , BONDINELL, William, E. , NEEB, Michael, J.
发明人： BONDINELL, William, E. , NEEB, Michael, J.
IPC分类号： A61K
CPC分类号： C07D295/215 , A61K31/435 , A61K31/495 , A61K31/497
摘要： This invention relates to substituted heterocyclic compounds which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders (for example, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis, or idiopathic pulmonary fibrosis and other fibrotic diseases, atherosclerosis, psoriasis, autoimmune diseases such as multiple sclerosis, treating and/or preventing rejection of transplanted organs, and inflammatory bowel disease, all in mammals, by the use of substituted heterocyclic compounds which are CCR5 receptor antagonists. Furthermore, since CD8+ T cells have been implicated in COPD, CCR5 may play a role in their recruitment and therefore antagonists to CCR5 could provide potential therapeutic in the treatment of COPD. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor modulators may be useful in the treatment of HIV infection.
摘要翻译：本发明涉及作为CCR5受体的调节剂，激动剂或拮抗剂的取代的杂环化合物。此外，本发明涉及由CCR5介导的疾病状态的治疗和预防，包括但不限于哮喘和特应性疾病（例如特应性皮炎和过敏），类风湿性关节炎，结节病或特发性肺纤维化等纤维化疾病，动脉粥样硬化，牛皮癣，自身免疫性疾病如多发性硬化，治疗和/或预防移植器官的排斥，以及哺乳动物的炎症性肠病，都是使用CCR5受体拮抗剂的取代的杂环化合物。此外，由于CD8 + T细胞与COPD有牵连，因此CCR5可能在其募集中发挥作用，因此CCR5拮抗剂可为COPD治疗提供潜在的治疗方法。此外，由于CCR5是HIV进入细胞的共同受体，因此选择性受体调节剂可用于治疗HIV感染。

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