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1. 发明申请

WO2009089192A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的2-苯基苯氧基酸
公开(公告)号：WO2009089192A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030172
申请日：2009-01-06
申请人： LIGAND PHARMACEUTICALS INC. , MCGUINNESS, Brian F. , LE, Thuy X.H. , DUO, Jingqi , HO, Koc-Kan
发明人： MCGUINNESS, Brian F. , LE, Thuy X.H. , DUO, Jingqi , HO, Koc-Kan
IPC分类号： C07C233/22 , C07C233/73 , C07C237/22 , C07C271/16 , C07C271/22 , C07C271/48 , C07C275/24 , C07C275/28 , C07C311/17 , C07D213/65 , C07D213/70 , C07D213/75 , C07D213/82 , C07D277/28 , A61K31/17
CPC分类号： C07C271/22 , C07C233/22 , C07C233/73 , C07C237/22 , C07C271/16 , C07C271/48 , C07C275/24 , C07C275/28 , C07C311/17 , C07D213/70 , C07D213/75 , C07D213/82 , C07D277/28
摘要： The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I):
摘要翻译：本发明提供了可用于预防和治疗炎症性疾病（包括影响呼吸系统和皮肤的那些）的新型苯氧基乙酸。该化合物具有通式（I）：

2. 发明申请

WO2010008777A2 FUSED AZABICYCLIC PYRIDINES 审中-公开
标题翻译：熔化的亚硫酸吡啶
公开(公告)号：WO2010008777A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/048062
申请日：2009-06-19
申请人： LIGAND PHARMACEUTICALS INC. , LETOURNEAU, Jeffrey, John , FLOYD, David, M. , HO, Koc-Kan , OLSON, John, T. , RIVIELLO, Christopher, Mark
发明人： LETOURNEAU, Jeffrey, John , FLOYD, David, M. , HO, Koc-Kan , OLSON, John, T. , RIVIELLO, Christopher, Mark
CPC分类号： C07D471/04 , C07D495/04 , C07D519/00
摘要： Azabicyclic pyridine derivatives and pharmaceutically acceptable salts thereof are disclosed herein. These compounds are useful as EP2 antagonists. Uses of these compounds and pharmaceutical compositions thereof are also disclosed.
摘要翻译：氮杂双环吡啶衍生物及其药学上可接受的盐在本文中公开。这些化合物可用作EP2拮抗剂。还公开了这些化合物及其药物组合物的用途。

3. 发明申请

WO2008060301A1 7-SUBSTITUTED PURINE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译：用于免疫抑制的7-取代的嘌呤衍生物
公开(公告)号：WO2008060301A1
公开(公告)日：2008-05-22
申请号：PCT/US2006/061004
申请日：2006-11-16
申请人： PHARMACOPEIA , INC. , OHLMEYER, Michael , BOHNSTEDT, Adolph , KINGSBURY, Celia , HO, Koc-Kan , QUINTERO, Jorge
发明人： OHLMEYER, Michael , BOHNSTEDT, Adolph , KINGSBURY, Celia , HO, Koc-Kan , QUINTERO, Jorge
IPC分类号： C07D487/04 , C07D519/00 , A61K31/522 , A61P37/06
CPC分类号： C07D487/04
摘要： The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula (III).
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮及其相关衍生物。该化合物具有通式（III）。

4. 发明申请

WO2008051547A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS 审中-公开
标题翻译： 2,4-二氨基嘧啶作为ALK和C-MET抑制剂的熔融双相衍生物
公开(公告)号：WO2008051547A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/022496
申请日：2007-10-23
申请人： CEPHALON, INC. , PHARMACOPEIA DRUG DISCOVERY, INC. , AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
发明人： AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R 1，R 2，R 3， R 4，R 5，A 1，A 2，A 3， A 4 S 4和A 5 5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，可用于治疗增殖性疾病。

5. 发明申请

WO2006108103A1 PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译：用于免疫抑制的嘌呤和咪唑吡啶衍生物
公开(公告)号：WO2006108103A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/012824
申请日：2006-04-05
申请人： PHARMACOPEIA DRUG DISCOVERY, INC. , OHLMEYER, Michael , BOHNSTEDT, Adolph , KINGSBURY, Celia , HO, Koc-Kan , QUINTERO, Jorge , YOU, Ming , PARK, Haengsoon , LU, Yingchun
发明人： OHLMEYER, Michael , BOHNSTEDT, Adolph , KINGSBURY, Celia , HO, Koc-Kan , QUINTERO, Jorge , YOU, Ming , PARK, Haengsoon , LU, Yingchun
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/52 , A61P37/06
CPC分类号： C07D473/00 , C07D471/04 , C07D473/32 , C07D487/04
摘要： The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas ( I ) and ( II ).
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤和咪唑并吡啶衍生物。该化合物具有通式（I）和（II）。

6. 发明申请

WO2004071445A2 2-(AMINOMETHYL)ARYLAMIDE ANALGESICS 审中-公开
标题翻译： 2-（氨基甲基）丙酰胺解毒剂
公开(公告)号：WO2004071445A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004017
申请日：2004-02-11
申请人： PHARMACOPEIA DRUG DISCOVERY, INC. , HO, Koc-Kan , BALDWIN, John, J. , BOHNSTEDT, Adolph, C. , KULTGEN, Steven, G. , MCDONALD, Edward , GUO, Tao , MORPHY, John, Richard , RANKOVIC, Zoran , HORLICK, Robert , APPELL, Kenneth, C.
发明人： HO, Koc-Kan , BALDWIN, John, J. , BOHNSTEDT, Adolph, C. , KULTGEN, Steven, G. , MCDONALD, Edward , GUO, Tao , MORPHY, John, Richard , RANKOVIC, Zoran , HORLICK, Robert , APPELL, Kenneth, C.
IPC分类号： A61K
CPC分类号： C07C237/30 , C07C237/32 , C07C311/08 , C07C311/37 , C07C323/42 , C07C2602/10 , C07C2602/12 , C07D207/08 , C07D209/14 , C07D209/16 , C07D209/44 , C07D211/22 , C07D213/81 , C07D217/04 , C07D223/16 , C07D295/155 , C07D401/06 , C07D401/12 , C07D471/04
摘要： A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the Formula I: a representative example is:
摘要翻译：公开了可用作镇痛剂的2-（氨基甲基）芳基酰胺的化学属。该属由公式I表示：一个代表性的例子是：

7. 发明申请

WO2008033764A3 QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES 审中-公开
公开(公告)号：WO2008033764A3
公开(公告)日：2008-03-20
申请号：PCT/US2007/078022
申请日：2007-09-10
申请人： N.V. ORGANON , LETOURNEAU, Jeffrey , JOKIEL, Patrick , NAPIER, Elizabeth , HO, Koc-Kan , OHLMEYER, Michael , MCARTHUR, Duncan, Robert , FIONA, Jeremiah , RATCLIFFE, Paul, David , JURGEN, Schulz
发明人： LETOURNEAU, Jeffrey , JOKIEL, Patrick , NAPIER, Elizabeth , HO, Koc-Kan , OHLMEYER, Michael , MCARTHUR, Duncan, Robert , FIONA, Jeremiah , RATCLIFFE, Paul, David , JURGEN, Schulz
IPC分类号： C07D239/70 , C07D243/08 , C07D217/24 , A61K31/519 , A61K31/5513 , A61K31/472 , A61K31/4725 , A61K31/496 , A61P25/24
摘要： The present invention relates to a quinazolinone or isoquinolinone derivative of formula I, wherein R 1 is C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-3 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, said C 1-6 alkyl, C 3-6 cycloalkyl and C 3-6 cycloalkylC 1-3 alkyl being optionally substituted with hydroxy, C 1-6 alkyloxy, cyano or one or more halogens; R 2 is C 6-10 aryl optionally substituted with one to three substituents selected from halogen, hydroxy, cyano, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy and C 3-6 cycloalkyloxy, said C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyloxy and C 3-6 Cycloalkyloxy being optionally substituted with one or more halogens; or R 2 is a 5-10 membered heteroaryl ring system comprising a heteroatom selected from N, O and S and optionally substituted with a substituent selected from methyl, C 1-6 alkyloxy and halogen; or R 2 is C 4-7 cycloalkyl; R 3 is an optional substituent selected from C 1-6 alkyl, C 1-6 alkyloxy and halogen, said C 1-6 alkyl and C 1-6 alkyloxy being optionally substituted with one or more halogens; R 4 is a group located at the 6- or 7- position of the quinazolinone or isoquinolinone ring having the formula Il, wherein R 5 together with one of R 6 forms a 4-8 membered saturated or unsaturated heterocyclic ring optionally comprising a further heteroatomic moiety selected from O, S and NR 9 , said heterocyclic ring being optionally substituted with one or two substituents selected from methyl, halogen, hydroxy and oxo or R 5 together with one of R 7 and R 8 forms a 6-8 membered heterocyclic ring optionally substituted with one or two substituents selected from methyl, halogen, hydroxy and oxo; Each R 6 is independently H, halogen or C 1-4 alkyl optionally substituted with halogen or SO 2 CH 3 or one of R 6 together with R 5 forms a 4-8 membered saturated or unsaturated heterocyclic ring optionally comprising a further heteroatomic moiety selected from O, S and NR 9 , said heterocyclic ring being optionally substituted with one or two substituents selected from methyl, halogen, hydroxy and oxo; R 7 and R 8 are independently H, C 1-6 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylc 1-3 alkyl, cyanoC 1-3 alkyl, C 6-10 aryl, C 6-10 arylC 1-3 alkyl, C 1-3 alkyloxyC 1-3 alkyl or C 1-6 acyl said C 1-6 alkyl, C 3-6 cycloalkyl and C 3-6 cycloalkylC 1-3 alkyl being optionally substituted with hydroxy, 1 or more halogens or diC 1-2 alkylamino; or R 7 and R 8 together with the nitrogen to which they are bonded form a 4-8 membered saturated or unsaturated heterocyclic ring optionally comprising a further heteroatomic moiety selected from O, S and NR 10 , said heterocyclic ring being optionally substituted with one or two substituents selected from C 1-6 alkyl, halogen, hydroxy,

8. 发明申请

WO2007071638A1 COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR 审中-公开
标题翻译：与葡萄糖激素受体相互作用的具有药物作用的化合物
公开(公告)号：WO2007071638A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069814
申请日：2006-12-18
申请人： N.V. ORGANON , PHARMACOPEIA DRUG DISCOVERY, INC. , HAMILTON, Niall Morton , GROVE, Simon James Anthony , KICZUN, Michael John , MORPHY, John, Richard , SHERBORNE, Brad , LITTLEWOOD, Peter Thomas Albert , BROWN, Angus Richard , KINGSBURY, Celia , OHLMEYER, Michael , HO, Koc-Kan , KULTGEN, Steven G.
发明人： HAMILTON, Niall Morton , GROVE, Simon James Anthony , KICZUN, Michael John , MORPHY, John, Richard , SHERBORNE, Brad , LITTLEWOOD, Peter Thomas Albert , BROWN, Angus Richard , KINGSBURY, Celia , OHLMEYER, Michael , HO, Koc-Kan , KULTGEN, Steven G.
IPC分类号： A61K31/18 , A61K31/4439 , C07C311/17 , C07D401/12
CPC分类号： C07C311/17 , C07C311/29 , C07D213/61 , C07D261/10 , C07D307/64 , C07D333/34 , C07D401/12
摘要： The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R 1 is hydrogen, halogen, CN or (1 C-4C)alkyl; R 2 is hydrogen, halogen or optionally fluorinated (1 C-3C)alkoxy; R 3 and R 5 are independently hydrogen, optionally halogenated (1C- 4C)alkyl, optionally halogenated (1 C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1 C-4C)alkenyl or hydroxylmethyl; R 4 is hydrogen, halogen, optionally halogenated (1 C-4C)alkoxy or optionally halogenated aryl(1 C-4C)alkoxy; R 6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1 C-4C)alkyl, or R 6 is optionally halogenated (1 C-4C)alkyl; each R 7 independently is hydrogen, halogen, optionally halogenated (1 C-4C)alkyl or optionally halogenated (1 C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.
摘要翻译：本发明提供具有式I结构的化合物，其中：X是碳原子或氮原子; Ar是苯基或杂芳环; R 1是氢，卤素，CN或（C 1 -C 4）烷基; R 2是氢，卤素或任选氟化的（C 1 -C 3）烷氧基; 卤代（1C-4C）烷基，任选卤代（C 1 -C 4）烷氧基，任意卤代芳基（1C-4C）烷氧基，任选卤代（C 1 -C 4）烯基或羟甲基; R 4是氢，卤素，任选卤代（C 1 -C 4）烷氧基或任选卤代芳基（C 1 -C 4）烷氧基; R 6是氢，任选被一个或多个卤素或（C 1 -C 4）烷基取代的苄基，或R 6任选被卤代（C 1 -C 4）烷基 ; 每个R 7独立地是氢，卤素，任选卤代（C 1 -C 4）烷基或任选卤代（C 1 -C 4）烷氧基及其药学上合适的酸加成盐，用作糖皮质激素受体调节剂，用于特别用于治疗中枢神经系统疾病。

9. 发明申请

WO2004063192A1 IMIDAZOLYL PYRIMIDINE DERIVATIVES USEFUL AS IL-8 RECEPTOR MODULATORS 审中-公开
标题翻译：作为IL-8受体调节剂有用的咪唑啉衍生物衍生物
公开(公告)号：WO2004063192A1
公开(公告)日：2004-07-29
申请号：PCT/US2004/000469
申请日：2004-01-09
申请人： PHARMACOPEIA DRUG DISCOVERY, INC. , VAN DER LOUW, Jaap , OHLMEYER, Michael, H., J. , BOHNSTEDT, Adolph, C. , HO, Koc-Kan , AULD, Douglas, S. , KULTGEN, Steven, G. , ROUGHTON, Andrew, Laird
发明人： VAN DER LOUW, Jaap , OHLMEYER, Michael, H., J. , BOHNSTEDT, Adolph, C. , HO, Koc-Kan , AULD, Douglas, S. , KULTGEN, Steven, G. , ROUGHTON, Andrew, Laird
IPC分类号： C07D405/14
CPC分类号： C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The invention relates to compounds of the formula I, wherein R1, R2, R3 and R4 are each independently selected from H, (1-4C)alkyl, (1-4C)alkoxy, trifluoromethyl, trifluoromethoxy, halogen, amino, sulfonamide, cyano, OH and nitro; R5 is H or (1-6C)alkyl; R6 is H, (1-6C)alkyl or (1-6C)alkoxy; R7 is H or (1-6C)alkyl; R8 is (1-6C)alkyl, optionally substituted with (1-6C)alkoxy; R9 is -(CH 2 ) n R10, wherein n is 1, 2 or 3 and R10 is selected from (1-4C)alkoxy, (1-4C)alkylthio, trifluoromethyl, (3-8C)cycloalkyl, phenyl optionally substituted with (1-4C)alkoxy, -NR11R12 and -O(CH 2 ) 2 NR11R12, wherein one of R11 and R12 is (1-4C)alkoxy, the other being H or (1-4C)alkyl, or R9 is -CH 2 (2-7C)heterocycloalkyl, provided that when at least one heteroatom in the heterocycloalkyl moiety is nitrogen, the distance between this nitrogen and the nitrogen in "NHR9" is at least three carbon atoms, or R9 is -(CH 2 ) 3 (2-7C)heterocycloalkyl or -(CH 2 ) 2 CHR13R14, wherein R13 and R14 together with the carbon atom to which they are attached, are (2-7C)heterocycloalkyl; and X is O, S or NH; or a pharmaceutically acceptable salt thereof. The compounds of the invention are Il-8 receptor modulators, in particular inhibitors thereof, and can be used for treating or preventing Il-8 receptor mediated disorders, such as atherosclerosis, inflammation, rheumatoid arthritis and related disorders.
摘要翻译：本发明涉及式I化合物，其中R 1，R 2，R 3和R 4各自独立地选自H，（1-4C）烷基，（1-4C）烷氧基，三氟甲基，三氟甲氧基，卤素，氨基，磺酰胺，氰基，OH和硝基; R5是H或（1-6C）烷基; R6是H，（1-6C）烷基或（1-6C）烷氧基; R 7为H或（1-6C）烷基; R8是（1-6C）烷基，任选被（1-6C）烷氧基取代; R9为 - （CH2）nR10，其中n为1,2或3，R10选自（1-4C）烷氧基，（1-4C）烷硫基，三氟甲基，（3-8C）环烷基，任选被（1 -4C）烷氧基，-NR11R12和-O（CH2）2NR11R12，其中R11和R12之一为（1-4C）烷氧基，另一个为H或（1-4C）烷基，或R9为-CH2（2-7C ）杂环烷基，条件是当杂环烷基部分中的至少一个杂原子为氮时，“NHR9”中该氮与氮之间的距离为至少三个碳原子，或者R 9为 - （CH 2）3（2-7C）杂环烷基或 - （CH 2）2 CHR 13 R 14，其中R 13和R 14与它们所连接的碳原子一起为（2-7C）杂环烷基; X为O，S或NH; 或其药学上可接受的盐。本发明的化合物是II-8受体调节剂，特别是其抑制剂，并且可用于治疗或预防II-8受体介导的病症，例如动脉粥样硬化，炎症，类风湿性关节炎和相关疾病。

10. 发明申请

WO2004062609A2 PYRIMIDINE DERIVATIVES AS IL-8 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：嘧啶衍生物作为IL-8受体拮抗剂
公开(公告)号：WO2004062609A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000584
申请日：2004-01-09
申请人： PHARMACOPEIA, INC. , AKZO NOBEL N.V. , ERICKSON, Shawn, David , BALDWIN, John, J. , DOLLE, Ronald, E., III , INGLESE, James , OHLMEYER, Michael H.J. , HO, Koc-Kan , BOHNSTEDT, Adolph, C. , KULTGEN, Steven, G. , WEBB, Maria, L. , AULD, Douglas, S. , ROUGHTON, Andrew, Laird , CONTI, Paolo, Giovanni, Martino, Conti , LEYSEN, Dirk , VAN DER LOUW, Jaap
发明人： ERICKSON, Shawn, David , BALDWIN, John, J. , DOLLE, Ronald, E., III , INGLESE, James , OHLMEYER, Michael H.J. , HO, Koc-Kan , BOHNSTEDT, Adolph, C. , KULTGEN, Steven, G. , WEBB, Maria, L. , AULD, Douglas, S. , ROUGHTON, Andrew, Laird , CONTI, Paolo, Giovanni, Martino, Conti , LEYSEN, Dirk , VAN DER LOUW, Jaap
IPC分类号： A61K
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D249/08 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12
摘要： Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula (I). In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, -O-alkyl or -S-alkyl. A representative example is formula (X).
摘要翻译：公开了含有嘧啶核的化合物及其用于治疗与不适当的白细胞介素-8受体活性有关的疾病和病症的用途。该化合物是式（I）的化合物。在这些化合物中，Q优选是未取代的和取代的杂环基; U通常是氢或氟; 并且V优选为氢，卤素，烷基，-O-烷基或-S-烷基。一个代表性的例子是公式（X）。

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