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1. 发明申请

WO2011127386A3 IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开
公开(公告)号：WO2011127386A3
公开(公告)日：2011-10-13
申请号：PCT/US2011/031750
申请日：2011-04-08
申请人： LIFE TECHNOLOGIES CORPORATION , CONNER, Thomas, A , LIM, Chee Kiong , PALLAS, Michael, C. , CHING, Chee Wee
发明人： CONNER, Thomas, A , LIM, Chee Kiong , PALLAS, Michael, C. , CHING, Chee Wee
IPC分类号： C12Q1/68 , C12M1/38 , G01N33/50
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

2. 发明申请

WO2008116184A1 ADAPTIVE THERMAL BLOCK TEMPERATURE CONTROL METHOD AND SYSTEM 审中-公开
标题翻译：自适应温度控制方法和系统
公开(公告)号：WO2008116184A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057907
申请日：2008-03-21
申请人： APPLERA CORPORATION , LIM, Chee Kiong , CHING, Chee Wee
发明人： LIM, Chee Kiong , CHING, Chee Wee
IPC分类号： C12P19/34
CPC分类号： B01J19/0046 , B01L7/52 , B01L2200/147 , B01L2300/1827 , C12P19/34 , G05D23/32
摘要： Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature enters a sample window region between a preliminary setpoint temperature and a target setpoint temperature for the sample. Based on thermodynamic behavior of the sample and the predetermined phase of PCR, predicting a time period measured subsequent to the preliminary setpoint temperature when the sample will reach the target setpoint suitable for the predetermined phase of PCR. During this time period, varying the block temperature ramp rate with a series of cooling and heating changes to ensure the block temperature reaches the target setpoint temperature at approximately the same time as the sample reaches the same. Synchronizing the block temperature and sample temperature to the target setpoint temperature reduces undershooting and overshooting of the sample temperature and increases the speed and efficiency of the overall PCR process as it relates to the thermal cycling operations.
摘要翻译：本教导的方面描述了用于自动控制块温度以减少包含在块中并参与聚合酶链式反应（PCR）的样品的低温和过冲的方法和装置。当样品温度进入样品的初步设定点温度和目标设定点温度之间的采样窗口区域时，自适应热块温度控制开始。基于样品的热力学行为和PCR的预定阶段，预测当样品将达到适合于预定阶段的PCR的目标设定点时初始设定点温度之后测量的时间段。在此期间，通过一系列冷却和加热变化来改变块温度升温速率，以确保块体温度在样品达到相同时间大致相同的时间达到目标设定点温度。将块温度和样品温度同步到目标设定点温度可降低样品温度的下冲和过冲，并提高整个PCR过程的速度和效率，因为它与热循环操作有关。

3. 发明申请

WO2004108288A1 THERMAL CYCLING APPARATUS AND METHOD FOR PROVIDING THERMAL UNIFORMITY 审中-公开
标题翻译：热循环装置和提供热均匀性的方法
公开(公告)号：WO2004108288A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/017017
申请日：2004-05-28
申请人： APPLERA CORPORATION , SHIN, Hon Siu , NGUI, Jew Kwee , LIM, Chee Kiong , LAU, Ching Ong , TAN, Lim Hi , KEE, Yang Hooi
发明人： SHIN, Hon Siu , NGUI, Jew Kwee , LIM, Chee Kiong , LAU, Ching Ong , TAN, Lim Hi , KEE, Yang Hooi
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2300/0829 , B01L2300/1822
摘要： An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
摘要翻译：一种快速热循环的装置和方法，包括热扩散板。热扩散板可以通过热电模块在热循环期间在整个热块组件中提供显着的温度均匀性。边缘加热器可以在热循环期间在整个热块组件中提供显着的温度均匀性。

4. 发明申请

WO2015126621A1 APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES 审中-公开
标题翻译：用于提供可扩展热循环和隔离热电装置的装置，系统和方法
公开(公告)号：WO2015126621A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/014357
申请日：2015-02-04
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： LIM, Chee Kiong , LEE, Way Xuang , LOH, Wuh Ken , CHING, Chee Wee , KOO, Chin Yong , KOH, Siew Ying , TOH, Tiong Han , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
摘要翻译：一方面，公开了一种包括样品块和热电装置的热循环仪系统。在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。在各种实施例中，热电装置可操作地耦合到样品块的第二表面。在各种实施例中，提供了热控制单元。在各种实施例中，热控制单元包括计算机处理单元。在各种实施例中，热控制单元包括电流源。在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。

5. 发明申请

WO2015039014A1 APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING THERMOCYCLER THERMAL UNIFORMITY 审中-公开
标题翻译：提供热分解器热稳定性的装置，系统和方法
公开(公告)号：WO2015039014A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055615
申请日：2014-09-15
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： SHIN, Hon Siu , KOO, Chin Yong , LEE, Way Xuang , LIM, Chee Kiong , CHING, Chee Wee , RAMACHANDRAN, Niroshan
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/12 , B01L2300/1822
摘要： A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
摘要翻译：公开了一种包括样品块和两个或更多个热电装置的热块组件。样品块具有构造成容纳多个反应容器和相对的底表面的顶表面。热电装置可操作地耦合到样品块，其中每个热电装置包括用于热传感器的壳体和具有控制器的热控制界面。每个热电装置进一步构造成彼此独立地操作以在整个样品块中提供基本均匀的温度分布。

6. 发明申请

WO2013049702A9 SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
公开(公告)号：WO2013049702A9
公开(公告)日：2013-04-04
申请号：PCT/US2012/058096
申请日：2012-09-28
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/68
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

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