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1. 发明申请

WO1997020814A1 PROPENONE DERIVATIVES 审中-公开
标题翻译：丙酮衍生物
公开(公告)号：WO1997020814A1
公开(公告)日：1997-06-12
申请号：PCT/JP1996003504
申请日：1996-11-29
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KYOWA HAKKO KOGYO CO., LTD. , IKEDA, Shun-ichi , KANAZAWA, Junji , SASAKI, Kimihito , NUKUI, Etsuko , OKABE, Masami , GOMI, Katsushige , SAITO, Hiromitsu , SATO, Soichiro
IPC分类号： C07D209/12
CPC分类号： C07F7/0812 , C07D209/12 , C07H15/24
摘要： Propenone derivatives represented by general formula (I) or pharmacologically acceptable salts thereof: wherein R represents substituted lower alkyl or YR (where Y represents S or O and R represents optionally substituted lower alkyl, optionally substituted aryl, optionally substituted aromatic heterocyclic group, or optionally substituted cyclic ether residue); R and R may be the same or different and each represents hydrogen, lower alkyl, or optionally substituted aralkyl, or R and R may be bonded to each other to thereby form optionally substituted methylene or ethylene; R represents hydrogen, hydroxy, lower alkyl, optionally substituted aralkyl, lower alkoxy, optionally substituted aralkyloxy, or halogeno; and X represents optionally substituted indolyl.
摘要翻译：由通式（I）表示的丙烯酮衍生物或其药学上可接受的盐：其中R 1表示取代的低级烷基或YR 5（其中Y表示S或O，R 5表示任选取代的低级烷基，任选取代的芳基，任选取代的芳族杂环基或任选取代的环醚残基）; R 2和R 3可以相同或不同，各自表示氢，低级烷基或任选取代的芳烷基，或者R 2和R 3可以彼此键合，从而形成任选取代的亚甲基或乙烯; R 4表示氢，羟基，低级烷基，任选取代的芳烷基，低级烷氧基，任选取代的芳烷氧基或卤素; X表示任选取代的吲哚基。

2. 发明申请

WO1996024592A1 5-AMINOFLAVONE DERIVATIVES 审中-公开
标题翻译： 5-AMINOFLAVONE衍生物
公开(公告)号：WO1996024592A1
公开(公告)日：1996-08-15
申请号：PCT/JP1996000181
申请日：1996-01-31
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KYOWA HAKKO KOGYO CO., LTD. , AKAMA, Tsutomu , IKEDA, Shun-ichi , ISHIDA, Hiroyuki , KIMURA, Uichiro , GOMI, Katsushige , SAITO, Hiromitsu
IPC分类号： C07D311/30
CPC分类号： C07D311/30
摘要： 5-Aminoflavone derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein X represents substituted lower alkyl, (un)substituted lower alkoxy, or NR R (wherein R and R represent each independently hydrogen or (un)substituted lower alkyl, or are combined together with N to represent an (un)substituted heterocyclic group); and Y and Y represent each independently hydrogen, halogeno or lower alkyl.
摘要翻译：由通式（I）表示的5-氨基黄酮衍生物或其药学上可接受的盐，其中X表示取代的低级烷基，（未）取代的低级烷氧基或NR 1 R 2（其中R 1和R 2 独立地表示氢或（未）取代的低级烷基，或与N一起代表（未）取代的杂环基）。 Y 1和Y 2各自独立地表示氢，卤代或低级烷基。

3. 发明申请

WO1996035665A1 PROPENONE DERIVATIVES 审中-公开
标题翻译：丙酮衍生物
公开(公告)号：WO1996035665A1
公开(公告)日：1996-11-14
申请号：PCT/JP1996001156
申请日：1996-04-26
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： KYOWA HAKKO KOGYO CO., LTD. , IKEDA, Shun-ichi , KANAZAWA, Junji , GOMI, Katsushige , SAITO, Hiromitsu , ASHIZAWA, Tadashi
IPC分类号： C07D209/12
CPC分类号： C07D405/06 , C07D209/12
摘要： Propenone derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R represents hydrogen or lower alkyl; R and R are the same or different and each represents hydrogen, lower alkyl or optionally susbtituted aralkyl, or R and R form together optionally substituted methylene or ethylene; R represents hydrogen, hydroxy, lower alkyl, optionally substituted aralkyl, lower alkoxy, optionally substituted aralkyloxy or halogeno; and X represents optionally substituted indolyl, provided that when OR is located at the 2- or 6-position of the benzene ring, then R is not hydrogen, while when R is located at the 2- or 6-position of the benzene ring, then R is not hydroxy, and the case where OR , OR and R represent together 3,4-dimethoxy or 3,4,5-trimethoxy is excepted.
摘要翻译：由通式（I）表示的丙烯酮衍生物或其药学上可接受的盐，其中R 1表示氢或低级烷基; R 2和R 3相同或不同，各自表示氢，低级烷基或任选取代的芳烷基，或R 2和R 3一起形成任选取代的亚甲基或亚乙基; R 4表示氢，羟基，低级烷基，任选取代的芳烷基，低级烷氧基，任选取代的芳烷氧基或卤素; 并且X表示任选取代的吲哚基，条件是当OR 3位于苯环的2-或6-位时，则R 3不是氢，而当R 4位于2-位时，或苯环的6-位，那么R 4不是羟基，OR 2，OR 3和R 4共同表示3,4-二甲氧基或3,4,5-三甲氧基，三甲氧基除外。

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