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1. 发明申请

WO2009020346A3 A GASTRIC CARCINOMA GENE ZNF312B, A PROTEIN TRANSLATED FROM THE GENE, AND A DIAGNOSTIC KIT AND A SCREENING METHOD FOR ANTICANCER AGENTS USING THE SAME 审中-公开
标题翻译：胃癌基因ZNF312B，从基因翻译的蛋白质，诊断试剂盒和用于抗癌剂的筛选方法使用相同的方法
公开(公告)号：WO2009020346A3
公开(公告)日：2009-04-16
申请号：PCT/KR2008004566
申请日：2008-08-06
申请人： KOREA RES INST OF BIOSCIENCE , KIM NAM-SOON , SONG IN-SUNG , OH NANG-SU , JEONG SO-YOUNG , HA GA-HEE , JEON YEO-JIN , KIM JEONG-MIN , KIM CHEOL-HEE , KIM HYUN-TAEK
发明人： KIM NAM-SOON , SONG IN-SUNG , OH NANG-SU , JEONG SO-YOUNG , HA GA-HEE , JEON YEO-JIN , KIM JEONG-MIN , KIM CHEOL-HEE , KIM HYUN-TAEK
IPC分类号： C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
摘要翻译：本发明涉及含有ZNF312b基因及其片段的诊断用标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。该基因的过量表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并最终导致胃癌。因此，ZNF312b标记基因可以有效用于胃癌的诊断，胃癌动物模型的构建，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

2. 发明申请

WO2009020346A9 A GASTRIC CARCINOMA GENE ZNF312B, A PROTEIN TRANSLATED FROM THE GENE, AND A DIAGNOSTIC KIT AND A SCREENING METHOD FOR ANTICANCER AGENTS USING THE SAME 审中-公开
标题翻译：一种GASTRIC CARCINOMA基因ZNF312B，一种从该基因翻译的蛋白质，以及一种诊断试剂盒和一种使用该抗生素的抗病毒剂的筛选方法
公开(公告)号：WO2009020346A9
公开(公告)日：2010-02-25
申请号：PCT/KR2008004566
申请日：2008-08-06
申请人： KOREA RES INST OF BIOSCIENCE , KIM NAM-SOON , SONG IN-SUNG , OH NANG-SU , JEONG SO-YOUNG , HA GA-HEE , JEON YEO-JIN , KIM JEONG-MIN , KIM CHEOL-HEE , KIM HYUN-TAEK
发明人： KIM NAM-SOON , SONG IN-SUNG , OH NANG-SU , JEONG SO-YOUNG , HA GA-HEE , JEON YEO-JIN , KIM JEONG-MIN , KIM CHEOL-HEE , KIM HYUN-TAEK
IPC分类号： C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
摘要翻译：本发明涉及含有ZNF312b基因及其片段的诊断标记物，胃癌的诊断方法以及使用其的胃癌诱导剂或抑制剂的筛选方法。 ZNF312b基因表达在胃癌中特异性增加。并且该基因的过表达或低表达影响胃癌细胞系和细胞增殖信号转导系统的细胞增殖和肿瘤形成的激活或抑制，并且最终诱导胃癌。因此，ZNF312b标记基因可以有效地用于胃癌的诊断，胃癌动物模型的建立，胃癌的预防和治疗以及胃癌特异性抗癌剂的开发。

3. 发明申请

WO2011122916A2 COMPOSITION FOR INCREASING TRAIL SENSITIVITY, CONTAINING AN INHIBITOR FOR INHIBITING THE EXPRESSION OR ACTIVITY OF TIP41 WHICH IS A TRAIL SENSITIZER TARGET GENE 审中-公开
标题翻译：用于增加TRAIL敏感性的组合物，其含有抑制TIP41的表达或活性的抑制剂，其为TRAIL SENSITIZER目标基因
公开(公告)号：WO2011122916A2
公开(公告)日：2011-10-06
申请号：PCT/KR2011002300
申请日：2011-04-01
申请人： KOREA RES INST OF BIOSCIENCE , KIM NAM-SOON , SONG IN-SUNG , KIM CHEOL-HEE , HA GA HEE , KIM HYUN-TAEK , JEONG SO-YOUNG , KIM JEONG-MIN , KIM JOO HEON , KIM JIN-MAN
发明人： KIM NAM-SOON , SONG IN-SUNG , KIM CHEOL-HEE , HA GA HEE , KIM HYUN-TAEK , JEONG SO-YOUNG , KIM JEONG-MIN , KIM JOO HEON , KIM JIN-MAN
IPC分类号： A61K38/16 , A61K31/7105 , A61P35/00
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a composition for increasing TRAIL sensitivity, which contains an inhibitor for inhibiting the expression or activity of the TIP41 protein. More particularly, it has been found that, when a hepatocellular carcinoma cell line which has TRAIL tolerance is treated with TIP41 siRNA and TRAIL, carcinoma-cell-specific apoptosis is induced, and apoptosis is induced not only in liver cancer but also in lung cancer and colorectal cancer which have TRAIL tolerance, and it has been found that, through animal experimentation, the size of a tumor is reduced and cancer cell apoptosis is induced, and the thus-induced apoptosis is caused by the activation of the MKK7/JNK delivery pathway due to the inhibition of TIP41 expression. Therefore, the composition containing the inhibitor for inhibiting the expression or activity of the TIP41 protein according to the present invention can be valuably used in the prevention and treatment of cancer or as anticancer adjuvants.
摘要翻译：本发明涉及增加TRAIL敏感性的组合物，其含有抑制TIP41蛋白表达或活性的抑制剂。更具体地，已经发现，当用TIP41 siRNA和TRAIL处理具有TRAIL耐性的肝细胞癌细胞系时，诱导癌细胞特异性凋亡，并且不仅在肝癌中而且在肺癌中诱导凋亡和具有TRAIL耐受性的结肠直肠癌，并且已经发现，通过动物实验，肿瘤的大小减少并且诱导癌细胞凋亡，并且由此诱导的凋亡是由MKK7 / JNK递送的激活引起的由于抑制TIP41的表达，因此，含有抑制本发明的TIP41蛋白的表达或活性的抑制剂的组合物可以有效地用于预防和治疗癌症或作为抗癌佐剂。

4. 发明申请

WO2011122916A3 COMPOSITION FOR INCREASING TRAIL SENSITIVITY, CONTAINING AN INHIBITOR FOR INHIBITING THE EXPRESSION OR ACTIVITY OF TIP41 WHICH IS A TRAIL SENSITIZER TARGET GENE 审中-公开
标题翻译：用于增加TRAIL敏感性的组合物，其含有抑制TIP41的表达或活性的抑制剂，其为TRAIL SENSITIZER目标基因
公开(公告)号：WO2011122916A3
公开(公告)日：2012-04-19
申请号：PCT/KR2011002300
申请日：2011-04-01
申请人： KOREA RES INST OF BIOSCIENCE , KIM NAM-SOON , SONG IN-SUNG , KIM CHEOL-HEE , HA GA HEE , KIM HYUN-TAEK , JEONG SO-YOUNG , KIM JEONG-MIN , KIM JOO HEON , KIM JIN-MAN
发明人： KIM NAM-SOON , SONG IN-SUNG , KIM CHEOL-HEE , HA GA HEE , KIM HYUN-TAEK , JEONG SO-YOUNG , KIM JEONG-MIN , KIM JOO HEON , KIM JIN-MAN
IPC分类号： A61K38/16 , A61K31/7105 , A61P35/00
CPC分类号： A61K38/16 , A61K31/7105
摘要： The present invention relates to a composition for increasing TRAIL sensitivity, which contains an inhibitor for inhibiting the expression or activity of the TIP41 protein. More particularly, it has been found that, when a hepatocellular carcinoma cell line which has TRAIL tolerance is treated with TIP41 siRNA and TRAIL, carcinoma-cell-specific apoptosis is induced, and apoptosis is induced not only in liver cancer but also in lung cancer and colorectal cancer which have TRAIL tolerance, and it has been found that, through animal experimentation, the size of a tumor is reduced and cancer cell apoptosis is induced, and the thus-induced apoptosis is caused by the activation of the MKK7/JNK delivery pathway due to the inhibition of TIP41 expression. Therefore, the composition containing the inhibitor for inhibiting the expression or activity of the TIP41 protein according to the present invention can be valuably used in the prevention and treatment of cancer or as anticancer adjuvants.
摘要翻译：本发明涉及增加TRAIL敏感性的组合物，其含有抑制TIP41蛋白表达或活性的抑制剂。更具体地，已经发现，当用TIP41 siRNA和TRAIL处理具有TRAIL耐性的肝细胞癌细胞系时，诱导癌细胞特异性凋亡，并且不仅在肝癌中而且在肺癌中诱导凋亡和具有TRAIL耐受性的结肠直肠癌，并且已经发现，通过动物实验，肿瘤的大小减少并且诱导癌细胞凋亡，并且由此诱导的凋亡是由MKK7 / JNK递送的激活引起的由于抑制TIP41的表达，因此，含有抑制本发明的TIP41蛋白的表达或活性的抑制剂的组合物可以有效地用于预防和治疗癌症或作为抗癌佐剂。

5. 发明申请

WO2011013930A3 EYE HEALTH ENHANCEMENT DEVICE INTEGRATED WITH NOSE-PADS 审中-公开
标题翻译： EYE健康增强装置与NOP-PADS集成
公开(公告)号：WO2011013930A3
公开(公告)日：2011-04-28
申请号：PCT/KR2010004677
申请日：2010-07-19
申请人： KIM JEONG-MIN
发明人： KIM JEONG-MIN
IPC分类号： G02C11/00 , A61H39/04
CPC分类号： G02C11/00 , A61H39/04 , A61H2205/022 , A61H2205/024 , G02C5/12
摘要： The present invention relates to an eye health enhancement device integrated with nose-pads for the promotion of eye health comprising a support (10) having a "?" shape, made of metal or nonferrous metal and assembled into the rim of an eyeglass with a fixture (3), wherein three to eight protrusions (11) are integrally formed with suitable intervals therebetween that face toward an eye, and another protrusion (12) having knurling formed at the surface of the lower-end thereof and facing toward the bridge of a nose; an elastic tube (13) inserted into the lower protrusion (12) of the support (10) and other elastic tubes (17) inserted into the protrusions (11) except for the lower protrusion (12) of the support, and the lengths of the elastic tubes are longer the further one goes to the right and left sides from the center of the support (10); a connector (14) which allows a protrusion (15) having knurling on the surface thereof to be inserted into the lower-end of the elastic tube (13) and a nose-pad (5) to be assembled by a screw (16); and silver pins (18) having a surface in the shape of a hemisphere, which contact the eyelid and stimulate acupuncture points and neuropils on the surface of an eye and around an eye, extraocular muscles, and capillary vessels, as the pins are each inserted into the ends of the elastic tubes (17).
摘要翻译：本发明涉及一种与用于促进眼睛健康的鼻垫整合的眼部健康增强装置，其包括具有“○”的支撑件（10）形状，由金属或有色金属制成，并且用夹具（3）组装到眼镜的边缘中，其中三至八个突起（11）一体地形成，其间面向眼睛的适当间隔，另一突起（12）具有形成在其下端的表面并且面向鼻梁的滚花; 插入到支撑件（10）的下突起（12）中的弹性管（13）和插入到突出部（11）中的除了支撑件的下突起（12）之外的其他弹性管（17）弹性管从支撑件（10）的中心向右侧和左侧延伸; 允许在其表面上具有滚花的突起（15）插入弹性管（13）的下端的连接器（14）和由螺钉（16）组装的鼻垫（5） ; 和具有半球形状的表面的银针（18），其接触眼睑并刺激眼睛表面上和眼睛周围的眼睛，眼外肌和毛细血管的针灸点和神经纤维，因为每个插入进入弹性管（17）的端部。

6. 发明申请

WO2012102575A3 OLEFIN BLOCK COPOLYMER 审中-公开
标题翻译： OLEFIN嵌段共聚物
公开(公告)号：WO2012102575A3
公开(公告)日：2012-11-29
申请号：PCT/KR2012000636
申请日：2012-01-27
申请人： LG CHEMICAL LTD , LEE YONG-HO , JEON MAN-SEONG , KIM JEONG-MIN , KWON HEON-YONG , CHO MIN-SEOK , KIM SEON-KYOUNG , HONG DAE-SIK , LEE KI-SOO , LIM KYOUNG-CHAN
发明人： LEE YONG-HO , JEON MAN-SEONG , KIM JEONG-MIN , KWON HEON-YONG , CHO MIN-SEOK , KIM SEON-KYOUNG , HONG DAE-SIK , LEE KI-SOO , LIM KYOUNG-CHAN
IPC分类号： C08F297/08 , C08F210/16 , C08L23/16 , C08L53/00
CPC分类号： C08F297/06 , C08F4/63927 , C08F4/65927 , C08F210/06 , C08F210/08 , C08F210/14 , C08F210/16 , C08F297/08 , C08F297/083 , C08L23/16 , C08F2500/08
摘要： The present invention relates to an olefin block copolymer having improved processability as well as excellent elasticity and heat resistance and a preparation method thereof. The olefin block copolymer comprises first and second segments which include an ethylene- or propylene-based repeating unit and an a-olefin-based repeating unit in a different molar fraction. In a TEM (transmission electron microscope) image, the olefin block copolymer is in a form where the second segment is dispersed on the first segment as a dispersed phase having a closed curve shape.
摘要翻译：本发明涉及具有改善的加工性以及优异的弹性和耐热性的烯烃嵌段共聚物及其制备方法。烯烃嵌段共聚物包含第一和第二链段，其包括不同摩尔分数的基于乙烯或丙烯的重复单元和α-烯烃基重复单元。在TEM（透射电子显微镜）图像中，烯烃嵌段共聚物是其中第二链段作为具有闭合曲线形状的分散相分散在第一链段上的形式。

7. 发明申请

WO2004029064A8 (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF 审中-公开
标题翻译：（+） - （1-膦酰基-2-甲基-2-环丙基）甲基核苷衍生物的转移异构体，其制备方法及其抗病毒剂的用途
公开(公告)号：WO2004029064A8
公开(公告)日：2005-05-19
申请号：PCT/KR0301932
申请日：2003-09-22
申请人： LG LIFE SCIENCES LTD , CHOI JONG-RYOO , HWANG JAE-TAEG , CHO DONG-GYU , ROH KEE-YOON , KIM CHUN-HYUNG , KIM CHUNG-MI , HAN MIN-JOON , KIM JEONG-MIN , CHO WOO-YOUNG , KIM GYOUNG-WON , AHN SINBYOUNG
发明人： CHOI JONG-RYOO , HWANG JAE-TAEG , CHO DONG-GYU , ROH KEE-YOON , KIM CHUN-HYUNG , KIM CHUNG-MI , HAN MIN-JOON , KIM JEONG-MIN , CHO WOO-YOUNG , KIM GYOUNG-WON , AHN SINBYOUNG
IPC分类号： C07F9/40 , C07F9/6512 , C07F9/6561 , A61K31/675 , C07F9/6509
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
摘要翻译：本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的式（1）的（1-膦基甲氧基-2-烷基环丙基）甲基核苷衍生物的（+） - 反式异构体，其药学上可接受的盐，水合物或溶剂合物，以及制备式（1）化合物的立体异构体的方法和用于治疗病毒性疾病（特别是针对乙型肝炎病毒）的组合物，其包含（+） - 反式异构体式（1）的化合物，其药学上可接受的盐，水合物或溶剂合物作为活性物质。

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