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1. 发明申请

WO2010064875A3 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：新颖的吲哚衍生物或其药学上可接受的盐作为蛋白激酶抑制剂用于增殖性疾病治疗，以及含有作为活性成分的药物组合物
公开(公告)号：WO2010064875A3
公开(公告)日：2010-09-10
申请号：PCT/KR2009007247
申请日：2009-12-04
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH , KOREA RES INST OF BIOSCIENCE , SIM TAE BO , SON JUNG BEOM , KIM HWAN , PARK DONG SIK , CHOI HWAN GEUN , HAM YOUNG JIN , HAH JUNG MI , YOO KYUNG HO , OH CHANG HYUN , LEE SO HA , HA JAE DU , CHO SUNG YUN , KWON BYOUNG-MOG , HAN DONG CHO
发明人： SIM TAE BO , SON JUNG BEOM , KIM HWAN , PARK DONG SIK , CHOI HWAN GEUN , HAM YOUNG JIN , HAH JUNG MI , YOO KYUNG HO , OH CHANG HYUN , LEE SO HA , HA JAE DU , CHO SUNG YUN , KWON BYOUNG-MOG , HAN DONG CHO
IPC分类号： C07D231/56
CPC分类号： C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
摘要翻译：公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病增殖。

2. 发明申请

WO2011062372A3 2, 4, 7 -SUBSTITUTED THIENO [3, 2 -D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： 2,4 - 7 - 作为蛋白激酶抑制剂的三羟基[3，2 -D]吡啶化合物
公开(公告)号：WO2011062372A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007275
申请日：2010-10-22
申请人： KOREA INST SCI & TECH , SIM TAE BO , HAH JUNG MI , CHOI HWAN GEUN , HAM YOUNG JIN , LEE JUNG HUN , PARK DONG SIK , KIM HWAN
发明人： SIM TAE BO , HAH JUNG MI , CHOI HWAN GEUN , HAM YOUNG JIN , LEE JUNG HUN , PARK DONG SIK , KIM HWAN
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00 , C07D495/02
CPC分类号： C07D495/04
摘要： Disclosed are a 2,4,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,4,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.
摘要翻译：公开了具有蛋白激酶抑制活性的2,4,7-取代噻吩并[3,2-d]嘧啶化合物，药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其包含化合物作为有效成分。由于新的2,4,7-取代噻吩并[3,2-d]嘧啶化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞引起的疾病生长。

3. 发明申请

WO2014181984A3 HEATING ELEMENT COOLING APPARATUS 审中-公开
标题翻译：加热元件冷却装置
公开(公告)号：WO2014181984A3
公开(公告)日：2015-04-09
申请号：PCT/KR2014003633
申请日：2014-04-25
申请人： PARK DONG SIK
发明人： PARK DONG SIK
IPC分类号： G06F1/20
CPC分类号： H01L23/473 , G06F1/20 , G06F2200/201 , H01L2924/0002 , H01L2924/00
摘要： A heating element cooling apparatus is disclosed. The heating element cooling apparatus according to one embodiment of the present invention comprises: a housing making contact with a heating element and in which cooling water flows; and an impeller provided and rotated in the housing, and the housing comprises: a main body unit coupled with the impeller; a first cover unit, which is a heat conductive member, coupled with the main body part at both sides of the impeller and making contact with the heating element; and a cooling water supply unit coupled with a center part of the impeller to be rotated together with the impeller and supplying the cooling water from the center part of the impeller in the first cover unit direction.
摘要翻译：公开了一种加热元件冷却装置。根据本发明的一个实施例的加热元件冷却装置包括：与加热元件接触并且其中冷却水流动的壳体; 以及在所述壳体中设置和旋转的叶轮，并且所述壳体包括：与所述叶轮联接的主体单元; 第一盖单元，其是导热构件，其与主体部分在叶轮的两侧耦合并与加热元件接触; 以及冷却水供应单元，其与叶轮的中心部分联接以与叶轮一起旋转，并且在第一盖单元方向上从叶轮的中心部分供应冷却水。

4. 发明申请

WO2012018191A3 AUGER WITH FOUR-STAGE SPEEDS 审中-公开
标题翻译：具有四段速度
公开(公告)号：WO2012018191A3
公开(公告)日：2012-05-10
申请号：PCT/KR2011005494
申请日：2011-07-27
申请人： ILRYUN HEAVY MACHINERY CO LTD , PARK DONG SIK
发明人： PARK DONG SIK
IPC分类号： E21B3/02
CPC分类号： E21B3/02
摘要： An auger of the present invention has four-stage speeds, and the auger comprises: an auger driving unit which has a frame capable of being attached to an excavator or a crane, and supplies rotary power for excavation; and a lower drilling device unit which is attached to the lower part of said auger driving unit, and directly performs drilling work on the ground. Said auger driving unit comprises: two motors which supply rotary power with electricity; speed reduction device units which are combined with the lower part of each said motor, and reduce the rotating speed; a rotation device unit which receives the rotary power transmitted from said speed reduction device units, and transmits the rotary power to said lower drilling unit in connection with said lower drilling unit such as a screw or a bottom bit or the like for performing the drilling work; and an auger base frame on which said motors, the speed reduction units, and the rotation unit are installed, and which is capable of being attached to said excavator or the crane, wherein: pole change motors capable of converting poles into 4 poles and 6 poles or 4 poles and 8 poles are used as said motors; said speed reduction units comprise a first speed reduction unit for reducing the number of rotations, a second speed reduction until which reduces the number of rotations that had been reduced from the first speed reduction unit again, a third speed reduction unit which reduces number of rotations that had been reduced from the second speed reduction unit again, said first, second, and third speed reduction units are reduced in speed in a planetary-geared shift gear that comprises a ring gear, a planetary gear installed on a planetary gear carrier, and a linear gear; and a speed reduction opening/closing device is formed between said first speed reduction unit and the second speed reduction unit, wherein the speed reduction opening/closing device enables the linear gear of said first speed reduction unit to be in contact with an internal gear of the planetary gear carrier such that the linear gear is primarily reduced in speed, or enables the linear gear to be separated from the contact to prevent the linear gear from being primarily reduced in speed. According to the present invention, the invention enables: the work to be carried out with four speeds by generating the rated torque without losing power transmission of the motors, so that electric loss and torque can be lowered when the speed is reduced by using an inverter, thereby avoiding an increase of drilling costs by preventing the eventual increase of equipment costs due to large motors and the mechanical speed reduction parts which increase in size according to the large motors; large-hole drilling or small-hole drilling work can be performed by the same piece of equipment; and four types of speed changes are available according to the condition of the ground, whereby labor costs and equipment costs are reduced by an improvement of work efficiency.
摘要翻译：本发明的螺旋钻具有四级速度，螺旋推运器包括：螺旋推动器单元，其具有能够附接到挖掘机或起重机的框架，并提供用于挖掘的旋转动力; 以及下部钻孔装置单元，其附接到所述螺旋推进器的下部，并且直接在地面上进行钻孔作业。所述螺旋驱动单元包括：两个电动机，其向旋转动力提供电力; 减速装置单元，其与每个所述电动机的下部组合，并且降低转速; 旋转装置单元，其接收从所述减速装置单元传递的旋转动力，并且将所述旋转动力传递到与所述下钻井单元（例如螺钉或底钻头等）相关的用于执行钻井作业的所述下钻井单元 ; 以及安装有所述电动机，减速单元和旋转单元并且能够附接到所述挖掘机或起重机的螺旋推运器基架，其中：能够将极点转换成4极和6的极点电动机所用电动机使用极或4极和8极; 所述减速单元包括用于减少转数的第一减速单元，再次减少已经从第一减速单元减少的转数的第二减速，减少转数的第三减速单元已经从第二减速单元再次减速，所述第一，第二和第三减速单元在包括安装在行星齿轮架上的环形齿轮，行星齿轮的行星齿轮变速齿轮中减速，以及线性齿轮; 并且在所述第一减速单元与所述第二减速单元之间形成有减速开闭装置，所述减速开闭装置能够使所述第一减速单元的直线齿轮与内齿轮行星齿轮架使得线性齿轮的速度主要降低，或者使得线性齿轮能够与接触件分离，以防止线性齿轮主要降低速度。根据本发明，本发明能够通过在不失去电动机的动力传递的情况下产生额定转矩而以四个速度进行工作，从而当通过使用变频器减速时能够降低电力损失和转矩从而通过防止由于大型电动机而导致的设备成本的最终增加以及根据大型电动机的尺寸增大的机械减速部件而增加钻井成本。大孔钻孔或小孔钻孔工作可由同一台设备进行; 根据实地情况可提供四种速度变化，通过提高工作效率降低劳动力成本和设备成本。

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