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1. 发明申请

WO2010005148A3 NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：具有对T型钙通道的抑制活性的新型异吲哚啉酮衍生物及其制备方法
公开(公告)号：WO2010005148A3
公开(公告)日：2010-07-01
申请号：PCT/KR2008005784
申请日：2008-10-01
申请人： KOREA INST SCI & TECH , CHO YONG SEO , PAE AE NIM , CHOO HYUNAH , LEE JAE KYUN , OH YOU NA , SHIN HEE SUP , KIM DONG JIN , HAHN HOH GYU , CHOI KYUNG IL , NAM GHILSOO , SHIN KYE JUNG , KANG SOON BANG , ROH EUN JOO , SHIN DONG YUN , SEO SEON HEE , RHIM HYEWHON , KEUM GYO CHANG , KIM KEY-SUN , CHEONG CHAN SEONG , KIM EUNICE EUN-KYEONG , LEE CHEOLJU , KIM YOUNGSOO , CHOI KEE HYUN , NAM KEE DAL , PARK WOONG SEO , KANG YONG KOO , CHUNG HYE JIN
发明人： CHO YONG SEO , PAE AE NIM , CHOO HYUNAH , LEE JAE KYUN , OH YOU NA , SHIN HEE SUP , KIM DONG JIN , HAHN HOH GYU , CHOI KYUNG IL , NAM GHILSOO , SHIN KYE JUNG , KANG SOON BANG , ROH EUN JOO , SHIN DONG YUN , SEO SEON HEE , RHIM HYEWHON , KEUM GYO CHANG , KIM KEY-SUN , CHEONG CHAN SEONG , KIM EUNICE EUN-KYEONG , LEE CHEOLJU , KIM YOUNGSOO , CHOI KEE HYUN , NAM KEE DAL , PARK WOONG SEO , KANG YONG KOO , CHUNG HYE JIN
IPC分类号： C07D403/12
CPC分类号： C07D401/12 , A61K31/454
摘要： Disclosed are isoindolinone derivatives having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient.
摘要翻译：公开了具有抑制T-型钙通道活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法以及包含其作为活性成分的药物组合物。

2. 发明申请

WO2012115446A2 COMPOUND BASED ON 5-(SUBSTITUTED ALKYL-AMINOMETHYL) ISOXAZOLE ACTING AS A T-TYPE CALCIUM CHANNEL ANTAGONIST 审中-公开
标题翻译：基于5-（取代的烷基氨基甲酰基）异噻唑作为T型钙通道拮抗剂的化合物
公开(公告)号：WO2012115446A2
公开(公告)日：2012-08-30
申请号：PCT/KR2012001340
申请日：2012-02-22
申请人： KOREA INST SCI & TECH , CHOO HYUN AH , PAE AE NIM , CHO YONG SEO , LEE HYO SEON , LEE JIE EUN , CHO GYEONG HI , RHIM HYE WHON , SEO SEON HEE , SONG CHI MAN , CHUNG HYE JIN , NAM GHIL SOO , KEUM GYO CHANG , KIM DONG JIN , CHOI KYUNG IL , CHOI KEE HYUN , LEE JAE KYUN , KANG YONG KOO , PARK WOONG SEO , LEE JU HYEON , SHIN SUN MI , AHMED ABDUL WAHEED , KIM YOUNG SOO , MIN SUN JOON
发明人： CHOO HYUN AH , PAE AE NIM , CHO YONG SEO , LEE HYO SEON , LEE JIE EUN , CHO GYEONG HI , RHIM HYE WHON , SEO SEON HEE , SONG CHI MAN , CHUNG HYE JIN , NAM GHIL SOO , KEUM GYO CHANG , KIM DONG JIN , CHOI KYUNG IL , CHOI KEE HYUN , LEE JAE KYUN , KANG YONG KOO , PARK WOONG SEO , LEE JU HYEON , SHIN SUN MI , AHMED ABDUL WAHEED , KIM YOUNG SOO , MIN SUN JOON
IPC分类号： C07D413/12 , A61K31/497 , A61P25/00 , A61P35/00
CPC分类号： C07D413/12
摘要： The present invention relates to: a compound based on 5-(substituted alkyl-aminomethyl) isoxazole which exhibits pharmaceutical activity with respect to T-type calcium channels; a pharmaceutically acceptable salt thereof; a production method for such a compound; and to a pharmaceutical composition containing such a compound as an active ingredient.
摘要翻译：本发明涉及：基于相对于T型钙通道具有药物活性的基于5-（取代的烷基 - 氨基甲基）异恶唑的化合物; 其药学上可接受的盐; 这种化合物的制备方法; 以及含有这种化合物作为活性成分的药物组合物。

3. 发明申请

WO2008027912A3 PREDICTION OF AN AGENT'S OR AGENTS' ACTIVITY ACROSS DIFFERENT CELLS AND TISSUE TYPES 审中-公开
标题翻译：预测代理商或代理商在不同细胞和组织类型中的活动
公开(公告)号：WO2008027912A3
公开(公告)日：2008-10-09
申请号：PCT/US2007077022
申请日：2007-08-28
申请人： THEODORESCU DAN , LEE JAE KYUN
发明人： THEODORESCU DAN , LEE JAE KYUN
IPC分类号： A61K31/00 , G01N33/48 , G06F7/60 , G06F17/10 , G06F19/18 , G06F19/20
CPC分类号： G06F19/18 , G06F19/20
摘要： The present invention relates to a novel algorithm that uses molecular profile signatures to extrapolate the physiological processes of one type of cell set (e.g., cell line, tissue, normal or diseased) to predict the activity of an agent or agents against another type of cell set that has never been exposed to the agent in question (drug efficacy prediction). The novel algorithm also allows one to predict the therapeutic response of a patient to a therapeutic regimen even though the patient (or patients) may have never been exposed to that agent before, thereby allowing for selecting a therapeutic agent or combination of agents that would best suit the patient (i.e., personalized medicine). The present invention also relates to methods of using the agents identified by the novel algorithm to treat a variety of diseases, including cancer.
摘要翻译：本发明涉及一种新的算法，其使用分子谱特征来推断一种类型的细胞集合（例如，细胞系，组织，正常或患病）的生理过程以预测一种或多种试剂针对另一种类型的细胞的活性从未接触过相关药物的药物（药物疗效预测）。新的算法还允许人们预测患者对治疗方案的治疗反应，即使患者（或多个患者）以前从未接触过该药剂，从而允许选择最好的治疗剂或药剂组合适合患者（即个性化医疗）。本发明还涉及使用由新算法鉴定的药剂来治疗多种疾病，包括癌症的方法。

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